LOCUS       NM_178141               2422 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus centrosomal protein 15 (Cep15), transcript variant 2,
            mRNA.
ACCESSION   NM_178141
VERSION     NM_178141.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2422)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154682.2, AK076182.1, AK078647.1 and AV151510.2.
            
            On Oct 1, 2013 this sequence version replaced NM_178141.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089971.1, AK076182.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC154682.2         22829-22838         c
            11-902              AK076182.1         2-893
            903-1089            AK078647.1         1344-1530
            1090-1715           AK076182.1         1081-1706
            1716-2028           AK078647.1         2157-2469
            2029-2422           AV151510.2         182-575
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 6.34 cM"
     gene            1..2422
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="centrosomal protein 15"
                     /db_xref="GeneID:218734"
                     /db_xref="MGI:MGI:1917937"
     exon            1..55
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            56..139
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..470
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C3orf14 homolog; centrosomal
                     protein 15 kDa"
                     /codon_start=1
                     /product="centrosomal protein 15 isoform 2"
                     /protein_id="NP_835277.1"
                     /db_xref="CCDS:CCDS26817.1"
                     /db_xref="GeneID:218734"
                     /db_xref="MGI:MGI:1917937"
                     /translation="MASLFTQEIHLSKRHEEILSQRLMLLQKMKNKFGDENTERASLL
                     QATETASRRNLRLLKDIDAAEEAFQTKLIPHPQPSMLSLETRYWASVEEHIPKWELFL
                     LGRAPYPIGAENQNEVPFVQTEAKL"
     exon            140..263
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            264..338
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            339..2422
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1148..1153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1170
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="major polyA site"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1735
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="major polyA site"
     regulatory      2298..2303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
                     /note="hexamer: AATGAA"
     polyA_site      2327
                     /gene="Cep15"
                     /gene_synonym="3830406C13Rik"
ORIGIN      
        1 acgcccaggt cttgcgcagg cgtcgtccat ggcgcgttcc cggaagagct cagagcagaa
       61 aacttatagc ccagctttga ttaaagatgg cttccttgtt tactcaagaa attcaccttt
      121 ctaaaagaca tgaagaaata ttatcacaaa gattaatgtt acttcagaaa atgaaaaaca
      181 aatttggaga tgaaaacaca gaaagggcat ctctcctcca agccactgag actgcttcta
      241 gaagaaacct ccgactcttg aaggacatag atgctgcaga ggaggctttt cagaccaagc
      301 ttatcccaca cccacagcct tcgatgcttt ctcttgagac tcgttactgg gcatcagtag
      361 aagaacatat ccccaagtgg gaactgtttc ttttaggaag agcaccatat ccaattggtg
      421 ctgaaaatca aaatgaggta ccattcgttc aaaccgaggc aaagttgtaa cttattcatg
      481 tgctctttga aacttttttt tttttataaa actatgtaaa tccatggcgg ggacttaggg
      541 aagaagtttc attttgttat tgttttctat tgtctcattg tttcctcagc agcaacgtca
      601 gtttgagagc cctctgaaag gtctcaggtt agatccttgc acagtcatag acttgccaag
      661 aaaagtgtaa aaattaatgg taagacataa tgtttgttaa atatggtatt aaaccagtgt
      721 tatgtgtgct taaaacccac accctcattc ccaactaaac aggttggctg caggtatcct
      781 aaagttgcga tttttcatca ttcactttgg gaacagaagc aggaacaagg tgctgccttc
      841 cttacatgaa agtctgccac gcttagctgc tcttgttcaa tactagttat cagaaaatag
      901 attcctgggg ttgtgtgctt cctacagact cctccaagtc cttaactcga aagcattcaa
      961 tatgtggcca gtttgggaca gcgcgagtgg ttttgaaaaa aaaaaatcta tgagagctgg
     1021 gaatggctac tgaattctga caggcttatt tgaagattac caacgttgtg aaaacaaata
     1081 ccccttccta aatgtcatct ttcaactcgt cctcccctcc tttctattat tatctctaaa
     1141 acttaagaat aaaacccaga aagctgtgga tcacggccct cttgagtctc cagttccttc
     1201 ctggctgccg agcactgggg agaagacaga gcgagctttc ctagctgtgg agacagcttc
     1261 tagtgagggg gagcctacac tgttccacag tggggattcc agtcacaaat gtgccttcac
     1321 tgtggtaaag gttcttcttt tgtttttgtt ttttgttttt attgccttta agataaaaat
     1381 ctcaccctgt agaccaacct ggccttgaag tcacagccat tctcctgttt tagcctctga
     1441 taactgagat tacaggtatg agccccaata tttaggtcat ttgtattttt aaaagaaaac
     1501 aacagaaaaa gttaaaatgc atataagccc tcactacaac aaaaactagt aaatcatcca
     1561 ttgtgtaaca tgttcctgtt cactgccatc ttggaaatgt cctgttgagt gggtgttggt
     1621 gtgggtaaca ataacattgt tttcataata tgtgctggca gattagcaca cttctctgca
     1681 gtgttaacag ttgtaattaa ggaataaaca gcacaaggtg tcagtccgat gacaatttca
     1741 tctatagtgt cacaatacaa aatgtcacaa aatattagag ctgttacata catagctata
     1801 aaaagtatcg gcttaagagc tgaaggcatc tttaagagag gagacagaga ggaggcaatg
     1861 gaacactgac ttagcggcca gaacaatttt atacattctc aagactgtca tgaaaacaaa
     1921 ttgataattt tttctgttac attacagttt gggctccagc catgcagttg atttagcagg
     1981 gaaatgcagg tttctcagca actccaaatc agtaaacaga tttagacgta gacaggaaca
     2041 cgaggaaggg ctctttttaa acatccagtc tcccagcata tgcacataaa aaggtgaatg
     2101 aagcaacgtg aaacgtactt ctcttcagtc aagtgaaaaa ggctaaacat ttgttagctg
     2161 gtaaaatatt gtgtcaagta agccggaaga ttccaaaatt aaacagtggt tgatatgtta
     2221 acgtcctcaa atatttgagt gcacacttcc tttgagatct gtaaattaaa tcaccagtag
     2281 gttgaattac aatacaaaat gaatggcatt gtaacctctc agaaaaagct ttgtgttttc
     2341 tttctcccca cactgattga ctcgctagct tggcttgggt attttttaag tataatctaa
     2401 taaagcttac acaattttgg gc
//
