LOCUS       NM_009734               3575 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus centrosomal protein 131 (Cep131), transcript variant
            1, mRNA.
ACCESSION   NM_009734 NM_001109658
VERSION     NM_009734.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3575)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3575)
  AUTHORS   Hall,E.A., Keighren,M., Ford,M.J., Davey,T., Jarman,A.P.,
            Smith,L.B., Jackson,I.J. and Mill,P.
  TITLE     Acute versus chronic loss of mammalian Azi1/Cep131 results in
            distinct ciliary phenotypes
  JOURNAL   PLoS Genet 9 (12), e1003928 (2013)
   PUBMED   24415959
REFERENCE   3  (bases 1 to 3575)
  AUTHORS   Mahjoub,M.R. and Tsou,M.F.
  TITLE     The AmAZI1ng roles of centriolar satellites during development
  JOURNAL   PLoS Genet 9 (12), e1004070 (2013)
   PUBMED   24385938
REFERENCE   4  (bases 1 to 3575)
  AUTHORS   Aoto,H., Miyake,Y., Nakamura,M. and Tajima,S.
  TITLE     Genomic organization of the mouse AZ1 gene that encodes the protein
            localized to preacrosomes of spermatids
  JOURNAL   Genomics 40 (1), 138-141 (1997)
   PUBMED   9070930
REFERENCE   5  (bases 1 to 3575)
  AUTHORS   Aoto,H., Tsuchida,J., Nishina,Y., Nishimune,Y., Asano,A. and
            Tajima,S.
  TITLE     Isolation of a novel cDNA that encodes a protein localized to the
            pre-acrosome region of spermatids
  JOURNAL   Eur J Biochem 234 (1), 8-15 (1995)
   PUBMED   8529672
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL807824.10.
            
            On Apr 4, 2022 this sequence version replaced NM_009734.3.
            
            Summary: The protein encoding this gene is a centriolar satellite
            protein that localizes around the basal body via transport along
            microtubules. Knockdown in mouse fibroblasts results in a reduction
            in ciliogenesis. Null mutant mice display no discernible ciliary
            phenotypes and embryonic patterning and adult homeostasis are
            largely unaffected. Male mice are infertile, however, due to
            defects in microtubule trafficking in the sperm manchette and
            flagella. In addition, the protein binds to a complex of proteins
            associated with Bardet-Biedl syndrome called the BBSome, and
            depletion of this protein results in an accumulation of the BBSome
            in cilia. [provided by RefSeq, Oct 2014].
            
            CCDS Note: The coding region has been updated to represent
            alternative splice sites at the exon 9-10 splice junction. The
            update is supported by transcripts that support the reference
            genome allele, which lacks a TAC triplet in exon 10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141108.1, AK133245.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AL807824.10        34127-34290         c
            165-358             AL807824.10        31271-31464         c
            359-453             AL807824.10        28719-28813         c
            454-568             AL807824.10        24802-24916         c
            569-690             AL807824.10        24394-24515         c
            691-804             AL807824.10        23564-23677         c
            805-951             AL807824.10        23039-23185         c
            952-1069            AL807824.10        21216-21333         c
            1070-1186           AL807824.10        20603-20719         c
            1187-1325           AL807824.10        20313-20451         c
            1326-1420           AL807824.10        19885-19979         c
            1421-1603           AL807824.10        19352-19534         c
            1604-1780           AL807824.10        18834-19010         c
            1781-1891           AL807824.10        18267-18377         c
            1892-2017           AL807824.10        17960-18085         c
            2018-2134           AL807824.10        17764-17880         c
            2135-2237           AL807824.10        16173-16275         c
            2238-2439           AL807824.10        15421-15622         c
            2440-2547           AL807824.10        14605-14712         c
            2548-2665           AL807824.10        14396-14513         c
            2666-2740           AL807824.10        14169-14243         c
            2741-2883           AL807824.10        13386-13528         c
            2884-3061           AL807824.10        13113-13290         c
            3062-3225           AL807824.10        12863-13026         c
            3226-3286           AL807824.10        12260-12320         c
            3287-3575           AL807824.10        11896-12184         c
FEATURES             Location/Qualifiers
     source          1..3575
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 83.96 cM"
     gene            1..3575
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /note="centrosomal protein 131"
                     /db_xref="GeneID:12009"
                     /db_xref="MGI:MGI:107440"
     exon            1..164
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            165..358
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..3361
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     5-azacytidine-induced protein 1; pre-acrosome localization
                     protein 1; 5-azacytidine induced gene 1; centrosomal
                     protein of 131 kDa"
                     /codon_start=1
                     /product="centrosomal protein of 131 kDa isoform 1"
                     /protein_id="NP_033864.3"
                     /db_xref="CCDS:CCDS36386.2"
                     /db_xref="GeneID:12009"
                     /db_xref="MGI:MGI:107440"
                     /translation="MKGSRTITATPEGSPEAVDLSLIGLPPPMSQRPGSASATRSIFR
                     SMSVATGSEPRKKALEATGPGGPRAINNLRRSNSTTQVNQSWTGSPRPAEPTDFLMLF
                     EGSTSGRRRVASLSKASSEKEATWNVLDEQPRGLALPASAQSPSTLDSALGPRRKECP
                     LAPSFTANNRSNKGAVGNCVTTMVHNHYASSKMVSPPKSSNQTAPSLNNIVKAAAREG
                     GEGSDLGKPRKNLSSASQSARGTTGLLRRREVTEEEAERFIHQVNQAAVTIQRWYRCQ
                     VQRRRAGAAALEHLLASKREGQRQRLGGGNLLELHRQEEAARKKAREEKARQARQAAI
                     QEQQKRAQKASEAEHRRPKDRPETRAPEQPRPMQEPGCVTHPKANNAGASIYPTGPAD
                     PCPPASESSPEQWQSPEDKPQDIHSQGEARQDLAVSGSSRGKARARATLDDLLDTLKL
                     LEEEPEPLPHPKAYHKDRYAWTDEEEDANSLTADNLEKFGKLSAAPGPPDDGTLLSEA
                     KLQSIMTFLDEMEKSGQERPAPWRESLVLEAGSGSEGSTSVMRLKLELEEKKQAMALL
                     QRALAQQRDLTVRRVKETEKELTRQLRQQKEQYEATIQRHLSFIDQLIEDKKVLSEKC
                     EAVVAELKHGDQRCRERVAQMQEQHELEIKKLKELMSATEKIRREKWINEKTKKIKEI
                     TVRGLEPEIQKLIAKHKQEVRRLRGLHEAELQQREEQAAQRHLRQAEELRQHLDRERE
                     VLGQQERERAQQRFEQHLEQEQRALEQQRRRLYNEVAEEKERLGQQAARQRAELEELR
                     QQLEESSAALTRALRAEFERSREEQERRHQMELKALKDQLEAERQAWVASCAKKEEAW
                     LLTRERELKEEIRKGRDQEIELVIHRLEADMTLAKEESERAAESRVKRVRDKYETELS
                     ELEQSERKLQERCSELKGRLGEAEGEKERLQSLVRQKEKELEDLRAVNTQMCSERASL
                     AQVVRQEFAEQLAASQEETQRVKVELAELQARQQVELDEVHRRVKTALARKEAAVNSL
                     RKQHEAAVKRADHLEELLEQHKGSSLSSK"
     exon            359..453
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..568
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..690
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            691..804
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..951
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1069
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1186
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1325
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1420
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1603
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1780
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1891
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2017
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2134
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2237
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2439
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2547
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2665
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2740
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2883
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..3061
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3225
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3286
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     exon            3287..3575
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3535..3540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /note="hexamer: AGTAAA"
     polyA_site      3562
                     /gene="Cep131"
                     /gene_synonym="AZ1; Azi; Azi1"
                     /note="major polyA site"
ORIGIN      
        1 aggctggttg ctagccgccg ccgccgccgc tcgcccctgc ggacagcgtt ttattgtcac
       61 ccacggcgga ggccgcgcca gccccgtggg gccccgggtg gctctgcagc cgcgcccgcc
      121 aggccgagcc cacgggccct gcgccccagg ctaggtccgc gcagggttag cctggtccac
      181 catgaaaggt tcacggacca tcactgccac tcctgaaggc agtccagaag ctgtggactt
      241 gagtctgatt ggcctccctc cgcccatgtc ccagcggccc ggcagtgcct ctgccacaag
      301 gtctattttc cgttccatgt ctgtggctac aggcagcgag ccaagaaaaa aggcactgga
      361 ggccactgga cctggaggcc cccgagctat caacaatctt cgaagatcta acagcactac
      421 acaggtcaac cagtcatgga cgggctcccc caggccagca gagcccaccg acttcctgat
      481 gctctttgag ggcagcacca gtgggagaag aagggtggcc agtcttagca aggcatccag
      541 tgagaaggaa gccacgtgga acgtcctgga tgagcagccc aggggcttgg ctttgccagc
      601 cagtgctcag agtcccagca cccttgactc tgccttgggc ccacggagga aggagtgtcc
      661 tctggcaccc agcttcaccg ctaacaacag gagcaacaaa ggtgctgtgg gcaactgtgt
      721 caccaccatg gtgcataacc actatgcctc ctcgaagatg gtgtcgcccc ccaagagctc
      781 caaccagaca gccccctccc tcaacaatat tgtgaaggca gcagcccgtg agggaggtga
      841 gggcagcgac ttggggaagc ctcggaagaa tttgtccagt gccagtcagt ccgctcgagg
      901 cactaccggc ctgctgaggc ggagggaggt gactgaagag gaagccgaga ggttcatcca
      961 tcaggtaaac caggctgcag ttaccatcca gcgctggtac cgctgccagg tacagaggcg
     1021 ccgagcggga gcagcagccc tcgagcacct gctagcgtcc aagcgagagg ggcagaggca
     1081 acggttggga ggtgggaacc ttctggaact gcaccggcag gaggaggcag caaggaagaa
     1141 ggcccgggag gaaaaggctc gtcaggccag gcaggcagcc attcaggaac aacagaaacg
     1201 agcccagaag gcaagtgagg ccgaacacag acggcctaag gacagaccag agacccgagc
     1261 accggagcag cctcgaccca tgcaggagcc aggctgcgtc acacacccta aggccaacaa
     1321 cgctggtgcc agcatctacc ccacaggccc cgcggacccc tgccctcctg cctctgaatc
     1381 atctccagag caatggcagt ctccagagga caagccacag gacatccatt cccaggggga
     1441 agccagacaa gacctggcag tgtcaggctc ttccaggggc aaggccaggg ccagagcaac
     1501 cctggacgat cttctggaca cactgaagct gctggaggag gagccagagc cgctgcctca
     1561 ccccaaggcc taccataagg acagatatgc ctggactgac gaggaagagg atgccaactc
     1621 cctgacagct gacaacctgg agaagtttgg gaaactcagc gcagcccctg gcccccctga
     1681 tgacgggacc ctgctctcgg aggccaagct tcagagcatt atgaccttcc tggatgagat
     1741 ggagaagtca ggacaggagc ggccagcacc ctggcgggag agcctggtgc tagaggcggg
     1801 ctcaggatcc gagggaagca cgtctgtgat gcggctgaag ctggagctgg aggagaagaa
     1861 acaggccatg gctctgctgc agagagctct ggcgcaacag cgtgacctca ctgttcgacg
     1921 tgttaaggag acagagaagg agctgacccg gcagctgcgg cagcagaagg agcagtatga
     1981 ggccaccatc caacggcact tgtccttcat tgaccagctg attgaagaca agaaagttct
     2041 gagcgagaag tgtgaggcag tggtggccga gctgaagcac ggggaccagc ggtgtcggga
     2101 gcgcgtggcc cagatgcagg agcagcacga actggagatc aagaaactca aagaactcat
     2161 gagtgccacc gagaaaatcc ggcgtgagaa gtggatcaat gagaaaacga agaagatcaa
     2221 ggaaatcaca gtcagaggtc tagagcctga gatccagaaa ctaattgcca agcacaagca
     2281 agaggtgagg cggctcaggg gcctgcacga ggctgagctg cagcagcgtg aagagcaggc
     2341 cgcacagcgc cacctgcgtc aggcggaaga gctgcggcag cacctggacc gggagaggga
     2401 ggtgctgggc cagcaggagc gggagcgcgc ccagcagagg tttgagcagc acctggagca
     2461 ggaacagagg gcactggagc agcagcggcg gcgactctac aatgaggtgg ccgaggagaa
     2521 ggagcgactg ggccagcagg cagccaggca gcgggcagag ttggaggagc tgaggcagca
     2581 gctggaggag agcagcgcgg ccctgactcg ggccctgaga gccgagttcg agaggagccg
     2641 agaggagcag gagcggaggc accagatgga gctgaaggcc ctgaaggacc agctggaagc
     2701 tgagagacag gcgtgggtgg ccagctgtgc caagaaggag gaagcatggc tgctgaccag
     2761 ggaacgtgag ctgaaggaag agatccgaaa aggccgagac caggagattg agttggtcat
     2821 ccaccggctg gaggccgata tgacactggc caaggaggag agcgagagag cagccgagag
     2881 ccgtgtgaag cgtgtgcgtg ataagtatga aacagagctc tcggagctgg agcagtcgga
     2941 gcggaagctt caggagcggt gctcggagct gaaaggccgc ctgggggagg ccgaagggga
     3001 gaaggagcgg ctgcagtccc tagtaaggca gaaggagaag gaactagaag acctgcgggc
     3061 ggtgaacaca cagatgtgca gtgagcgggc cagcctggcc caggtggtac ggcaggagtt
     3121 tgcagagcag ctggcagcct cccaggagga gacccagagg gtgaaagtgg agctcgcaga
     3181 gctgcaggcc cgccagcagg tggagctaga cgaggtgcac cggagggtga agacggctct
     3241 agcgaggaag gaggcagccg tgaacagtct ccgcaaacag catgaggctg ctgtgaagcg
     3301 ggcggaccac ctagaggaac tgctggagca acacaaaggg tcatctctga gttctaagtg
     3361 acatcgccct tgggatgacg agccaagcct gaggctgaca ctcagtcctg cggctggtgt
     3421 ccaggtcacg ctccaagaca cagggctaag ggtaggacag cagctggtgt gtgagaggca
     3481 ccatggagcc cagtgcccgg gacgttactg tcagcatgcc tgcagctgtt ctatagtaaa
     3541 atggttaggt ggcttttttt aactgcttca tgtca
//
