LOCUS       NM_178686               4633 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus centrosomal protein 120 (Cep120), mRNA.
ACCESSION   NM_178686
VERSION     NM_178686.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4633)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4633)
  AUTHORS   Langner,E., Cheng,T., Kefaloyianni,E., Gluck,C., Wang,B. and
            Mahjoub,M.R.
  TITLE     Cep120 is essential for kidney stromal progenitor cell growth and
            differentiation
  JOURNAL   EMBO Rep 25 (1), 428-454 (2024)
   PUBMED   38177914
  REMARK    GeneRIF: Cep120 is essential for kidney stromal progenitor cell
            growth and differentiation.
REFERENCE   3  (bases 1 to 4633)
  AUTHORS   Cheng,T., Agwu,C., Shim,K., Wang,B., Jain,S. and Mahjoub,M.R.
  TITLE     Aberrant centrosome biogenesis disrupts nephron and collecting duct
            progenitor growth and fate resulting in fibrocystic kidney disease
  JOURNAL   Development 150 (24) (2023)
   PUBMED   37982452
REFERENCE   4  (bases 1 to 4633)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4633)
  AUTHORS   Tyc,K.M., El Yakoubi,W., Bag,A., Landis,J., Zhan,Y., Treff,N.R.,
            Scott,R.T., Tao,X., Schindler,K. and Xing,J.
  TITLE     Exome sequencing links CEP120 mutation to maternally derived
            aneuploid conception risk
  JOURNAL   Hum Reprod 35 (9), 2134-2148 (2020)
   PUBMED   32772081
  REMARK    GeneRIF: Exome sequencing links CEP120 mutation to maternally
            derived aneuploid conception risk.
REFERENCE   6  (bases 1 to 4633)
  AUTHORS   Lin,Y.N., Lee,Y.S., Li,S.K. and Tang,T.K.
  TITLE     Loss of CPAP in developing mouse brain and its functional
            implication for human primary microcephaly
  JOURNAL   J Cell Sci 133 (12) (2020)
   PUBMED   32501282
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4633)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    GeneRIF: The loss of Talpid3-binding centrosomal protein Cep120
            results in failed centriole duplication and consequently
            ciliogenesis, which together underlie Cep120 mutant cerebellar
            hypoplasia.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4633)
  AUTHORS   Mahjoub,M.R., Xie,Z. and Stearns,T.
  TITLE     Cep120 is asymmetrically localized to the daughter centriole and is
            essential for centriole assembly
  JOURNAL   J Cell Biol 191 (2), 331-346 (2010)
   PUBMED   20956381
  REMARK    GeneRIF: Cep120 is required for centriole assembly and that the
            observed defect in neuronal migration might derive from a defect in
            this process.
REFERENCE   9  (bases 1 to 4633)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   10 (bases 1 to 4633)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038916.1 and BC053439.1.
            
            On Jul 20, 2018 this sequence version replaced NM_178686.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053439.1, SRR7652917.1267851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK038916.1         2-62
            62-4633             BC053439.1         1-4572
FEATURES             Location/Qualifiers
     source          1..4633
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 29.07 cM"
     gene            1..4633
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /note="centrosomal protein 120"
                     /db_xref="GeneID:225523"
                     /db_xref="MGI:MGI:2147298"
     exon            1..121
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            122..187
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..3105
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /note="coiled-coil domain-containing protein 100"
                     /codon_start=1
                     /product="centrosomal protein of 120 kDa"
                     /protein_id="NP_848801.2"
                     /db_xref="CCDS:CCDS37822.1"
                     /db_xref="GeneID:225523"
                     /db_xref="MGI:MGI:2147298"
                     /translation="MVPKSDQLLIVVSILEGRHFPKRPKHLLVVEAKFDGEQLATDPV
                     DHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTA
                     QETKQAPKWYQLLSNKYTKFKAEVQISLTLETDTKAQVDSYKAKAAPPRDGKVLASLA
                     GVDPKDIVAVLNEEGGYHQIGPAEHCTDPFILSVTIAFATQLEQLIPCTMKLPERQPE
                     FFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIRSSVEILRVYLALHSKLQIHLCCG
                     DQSLGSTEIPLNGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPVPLDLAPTVGV
                     SVALQREGIDSQSLIELKTQNGHEAEHSQKRVLTPIKEKTLTGPKSPRESPAPPPPPN
                     QTPPTKDDATESEVESLQYDKDPKPTVKGIGSVPASLAQPEATCGASEVVTSGQKIAV
                     PAASHHFCFSVDLRSVHDLELSFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFL
                     PQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGVARIQLSNILSSEKTR
                     FLGANGEQCWRQTYSESVPVIAAQGSNNRILDLSYTMTLEDYGLVKMREIFVSESSQG
                     VPAVDQKPSSPPPAPCPSEIQMEPRETLEYKAALELEMWKEMQEDIFESQLKQKELAH
                     MQALAEEWKKRDRERESLVKKKVAEYSILEGKLQKALTELETREQQLASAEAELQRER
                     KELQLERERNLQELQDSVRRARDDCVYQVELERLKLKQLEEDKQRLQQQLNDAGNKYK
                     TLEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALK
                     ELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKETVRTEQQELLDIRNELNRLR
                     QQEQNQYQDCKEIASGKLGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIIS
                     ELDRQIREVLTKNSAS"
     exon            188..344
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            345..459
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            460..601
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            602..750
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            751..948
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1176
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1399
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1577
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1727
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1910
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2007
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2160
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2250
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2343
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2505
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2628
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2727
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2728..2873
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..4615
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /note="hexamer: AATAAA"
     polyA_site      4615
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /note="major polyA site"
ORIGIN      
        1 gtcctccagc ctcccccggg ctctcggcct gcgggcctgg ttgctaggcg gaagcggggc
       61 gcggcggcgt ccgctgcggc tgcccgggcg tttgaatagc ggcttagcag gcggcaaaaa
      121 gaccctgccg ccgcgaccat ggtccccaag tccgaccaac tgctcatcgt cgtatccatc
      181 ctcgaaggtc gccatttccc caaacgtcca aagcatctgc tcgtggtgga agcaaagttt
      241 gatggggagc agctggctac tgatcctgtc gaccatactg accagccaga atttgctact
      301 gagctagcct gggagattga caggaaagtc cttcatcagc accggttaca gcgcacgccg
      361 atcaaactcc agtgctttgc cttggacccg cagacttctg ccaaggaaac cgtaggctac
      421 attgttttgg acttaagaac agctcaagaa acaaagcagg ctcccaaatg gtaccagctg
      481 ctgagtaaca aatacaccaa gttcaaggcc gaggtgcaga tcagcctcac tttggagaca
      541 gatacaaagg cccaggtgga tagttataaa gcaaaagcag ccccgcctcg ggatggaaaa
      601 gttcttgcta gcctggcagg agttgacccg aaggacattg ttgcagtatt gaatgaggaa
      661 ggaggctacc atcagattgg accagcggag cactgtactg acccctttat tttgtcggtg
      721 acgattgcat ttgccaccca gttggaacag ttaattccat gtaccatgaa gcttccagaa
      781 aggcagcctg agtttttctt ttactattct ttactgggaa acgatgttac aaacgagcct
      841 ttcagtgatt tgatcaaccc aaactttgag cccgagaggg catctgttcg tatacgcagc
      901 agtgtggaga ttctgcgtgt gtacctggct cttcactcta aactgcagat ccatctctgc
      961 tgtggagacc agtcacttgg cagtacagaa atacctttaa atggattact gaagaagggc
     1021 agtacagaga ttaaccagca tccggtcaca gtagaaggtg cttttaccct tgaccctcca
     1081 aaccgagcca agcagaagct agctccagtc cctctggacc tggccccaac tgtgggcgtg
     1141 tccgtggctc tgcagagaga aggcatcgat tcccagtctt taattgaatt aaagacccag
     1201 aatggacatg aggcagaaca ttcacagaag agagttttaa cccccataaa ggagaagaca
     1261 ctcactgggc caaaatcacc aagggagtcc cctgccccgc ccccacctcc aaaccagacg
     1321 cctccaacca aggatgatgc aacagaaagt gaagtggaga gcctgcagta tgacaaggat
     1381 ccaaagccca ctgtgaaggg catcggttct gtacctgctt cgctggccca gccagaggcc
     1441 acctgtggtg cgtcagaagt ggtgacatca ggacagaaga ttgctgttcc agcggcgtca
     1501 caccacttct gcttctcagt agacttaaga agcgtccatg acttggaact cagttttcca
     1561 gtcaactgca tattgaggta ctcctaccca ttcttcggca gtgcagctcc tattatgact
     1621 aaccctcccg tagaagttcg gaaaaacatg gaggtttttc ttcctcagtc ttactgtgcg
     1681 tttgattttg caactatgcc tcaccagctc caagacacct tcctacggat tcctctgctg
     1741 gtggagttat ggcacaagga taaaatgagt aaagatttac tccttggggt cgcaagaatc
     1801 cagctttcta atatcttgtc ttcagaaaag acccggtttt taggtgctaa tggtgagcag
     1861 tgctggcgac agacgtacag tgagagcgtg cctgtgatag cagcccaggg gtcaaataac
     1921 aggatattag acctttctta tacaatgaca ctggaagact atggcctagt gaaaatgcgt
     1981 gagatctttg tatcggagtc atctcagggt gtgcctgctg tggatcagaa gccatcttcg
     2041 cctcctcccg ctccctgccc ttctgagatc cagatggaac ccagagagac cttagagtac
     2101 aaggctgccc tcgagctgga gatgtggaaa gagatgcagg aagacatatt tgaaagtcag
     2161 ctgaagcaaa aagaactggc tcacatgcaa gctcttgcag aagagtggaa aaaaagggac
     2221 cgggaaagag agtcactagt gaagaaaaag gtagctgaat acagtattct agaaggcaaa
     2281 cttcagaagg ccctcacgga gctagagacc cgtgagcagc agctggccag tgcagaagca
     2341 gagcttcaga gagagagaaa ggagctgcag ttagaacggg agcggaacct tcaagagctg
     2401 caggactctg tccgaagggc cagagacgac tgtgtgtacc aagtggagct ggagaggctg
     2461 aagctgaagc agctggaaga ggacaaacag cggcttcagc agcagcttaa tgatgctggc
     2521 aataagtata agactttgga aaaagagttt cagcagttca aggatcaaca gaacaacaaa
     2581 ccagaaatcc ggctgcagtc agaaataaac ctcctcacct tggagaaggt tgaacttgaa
     2641 agaaagttgg aatctgcaac caagtctaaa ctgcattaca agcagcagtg gggccgagct
     2701 ttgaaagaac ttgccagact aaagcagagg gagcaagaaa gtcaaatggc ccgccttaaa
     2761 aaacagcagg aggagttgga gcagatgcgg ctgcgttacc tggcggctga ggagaaagaa
     2821 acagtgagaa ctgagcagca ggaactgctg gatataagga acgagctgaa caggttaagg
     2881 cagcaagaac agaaccagta ccaggactgc aaagagattg caagtgggaa gctgggcagc
     2941 ccgaggggct ctgggctgga agaaggcttg gatgactacc tgacacgcct gatagaggaa
     3001 agggacactc tgatgagaac gggtgtctat aaccatgagg accgcataat aagtgaactc
     3061 gaccggcaga tcagagaggt tttgaccaaa aacagtgcca gttaaaaacc accggggaaa
     3121 cgtttgcaga tacgctaggt ctgcagtttg atattttgta aaatcctcaa aagcaaggga
     3181 agtggctact ttggaatgct ctttataatt tttataagct gaattttata tgttactgta
     3241 tatagtattt atttgatttt acttacgcta cctctccaat gctggcttca ttttaattgt
     3301 gttttatatg ctcatttaaa atgacttttc agtgttcttc agtttaaaat ctgttgtttg
     3361 actttaaaaa cagcctttca caacttgtcc caggagaact gaccacagta gttcccactg
     3421 tataattttt atgttgagcc aagagagaat atgttgcact ttaaacacgc tgtgtcctgc
     3481 tccctttgag tgtagatatc ttcaagttga agccaattat aagtgtagcc atttttaaaa
     3541 agcatttata tgaccagtct ttttcccctc aacctgtggt atttgcagat gacaactttg
     3601 aaaataaagc agtctcgggc agagacgctg tgtgacatgt tggctgacaa attagtcatt
     3661 gcttaaacac agttcatgca gattaaacac aaatcaagtt ccaaatttca ttggactcca
     3721 cttgaagacc atgagaaaat agcttggtct gaccacaatc tcctgctcat gactctctga
     3781 ggcttcttgt taaaatggtt gcctttgttt ctcagtgata gcgatacagc tcaggaatgg
     3841 actatggaaa ctgataccta gcgacattag ctgagaacac cacggagctg cttccctccc
     3901 tctgcagtca gtctgttttc agaggcaccc cagcgagccc agtgcaagcc cgtaaccctc
     3961 cagagctcct tcacactgcg ctctccaaac caccccatcc tcacagcgag cttatcccta
     4021 cctctgcgtg acactgagca ggcagattag caatctccca ggtcatgcag catcttgaaa
     4081 caaagtaaga attctgattc ccaaaaataa caaatttaag tgtatacttt agcaggtgtg
     4141 tactaattac cagtaacttc aacacaagca aagcaggtta catggtaatg ttcattcagt
     4201 atatttcttg tttgtgaaat tgaaacctct ataggcatca tatgcttctt gtctttaaca
     4261 aagtctttgt cttctaagag caaccccgca gtaaacaaca gaggggttgc tggacttgag
     4321 ggtgacgaga cagatgatca tagcagggat ttgaaatatg aattatggtt acatggtcct
     4381 gatttttttt ttttggtgac atgaatggaa cagaagtatt ttgttttaga aggtcctggc
     4441 ccagcgttgg ttcttcctcc tgtatcctgt gaggcctgga gcttttcaaa cactagaggg
     4501 ggccttagag taagtggaaa ggacttctaa aatgtgtgtg tgctttgcct tccagaaagc
     4561 catctttggg ctactgtaat atgacaaata aaatcctcac tgtgtgcatc cttgaaaaaa
     4621 aaaaaaaaaa aaa
//
