LOCUS       NP_848801                988 aa            linear   ROD 28-APR-2025
DEFINITION  centrosomal protein of 120 kDa [Mus musculus].
ACCESSION   NP_848801
VERSION     NP_848801.2
DBSOURCE    REFSEQ: accession NM_178686.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 988)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 988)
  AUTHORS   Langner,E., Cheng,T., Kefaloyianni,E., Gluck,C., Wang,B. and
            Mahjoub,M.R.
  TITLE     Cep120 is essential for kidney stromal progenitor cell growth and
            differentiation
  JOURNAL   EMBO Rep 25 (1), 428-454 (2024)
   PUBMED   38177914
  REMARK    GeneRIF: Cep120 is essential for kidney stromal progenitor cell
            growth and differentiation.
REFERENCE   3  (residues 1 to 988)
  AUTHORS   Cheng,T., Agwu,C., Shim,K., Wang,B., Jain,S. and Mahjoub,M.R.
  TITLE     Aberrant centrosome biogenesis disrupts nephron and collecting duct
            progenitor growth and fate resulting in fibrocystic kidney disease
  JOURNAL   Development 150 (24) (2023)
   PUBMED   37982452
REFERENCE   4  (residues 1 to 988)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 988)
  AUTHORS   Tyc,K.M., El Yakoubi,W., Bag,A., Landis,J., Zhan,Y., Treff,N.R.,
            Scott,R.T., Tao,X., Schindler,K. and Xing,J.
  TITLE     Exome sequencing links CEP120 mutation to maternally derived
            aneuploid conception risk
  JOURNAL   Hum Reprod 35 (9), 2134-2148 (2020)
   PUBMED   32772081
  REMARK    GeneRIF: Exome sequencing links CEP120 mutation to maternally
            derived aneuploid conception risk.
REFERENCE   6  (residues 1 to 988)
  AUTHORS   Lin,Y.N., Lee,Y.S., Li,S.K. and Tang,T.K.
  TITLE     Loss of CPAP in developing mouse brain and its functional
            implication for human primary microcephaly
  JOURNAL   J Cell Sci 133 (12) (2020)
   PUBMED   32501282
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 988)
  AUTHORS   Wu,C., Yang,M., Li,J., Wang,C., Cao,T., Tao,K. and Wang,B.
  TITLE     Talpid3-binding centrosomal protein Cep120 is required for
            centriole duplication and proliferation of cerebellar granule
            neuron progenitors
  JOURNAL   PLoS One 9 (9), e107943 (2014)
   PUBMED   25251415
  REMARK    GeneRIF: The loss of Talpid3-binding centrosomal protein Cep120
            results in failed centriole duplication and consequently
            ciliogenesis, which together underlie Cep120 mutant cerebellar
            hypoplasia.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 988)
  AUTHORS   Mahjoub,M.R., Xie,Z. and Stearns,T.
  TITLE     Cep120 is asymmetrically localized to the daughter centriole and is
            essential for centriole assembly
  JOURNAL   J Cell Biol 191 (2), 331-346 (2010)
   PUBMED   20956381
  REMARK    GeneRIF: Cep120 is required for centriole assembly and that the
            observed defect in neuronal migration might derive from a defect in
            this process.
REFERENCE   9  (residues 1 to 988)
  AUTHORS   Xie,Z., Moy,L.Y., Sanada,K., Zhou,Y., Buchman,J.J. and Tsai,L.H.
  TITLE     Cep120 and TACCs control interkinetic nuclear migration and the
            neural progenitor pool
  JOURNAL   Neuron 56 (1), 79-93 (2007)
   PUBMED   17920017
REFERENCE   10 (residues 1 to 988)
  AUTHORS   Iwakoshi,N.N., Pypaert,M. and Glimcher,L.H.
  TITLE     The transcription factor XBP-1 is essential for the development and
            survival of dendritic cells
  JOURNAL   J Exp Med 204 (10), 2267-2275 (2007)
   PUBMED   17875675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038916.1 and BC053439.1.
            
            On Mar 13, 2005 this sequence version replaced NP_848801.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053439.1, SRR7652917.1267851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 29.07 cM"
     Protein         1..988
                     /product="centrosomal protein of 120 kDa"
                     /note="coiled-coil domain-containing protein 100"
                     /calculated_mol_wt=112448
     Region          9..114
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          118..340
                     /region_name="DUF3668"
                     /note="Cep120 protein; pfam12416"
                     /db_xref="CDD:463569"
     Region          354..425
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSG1.1)"
     Region          624..644
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TSG1.1)"
     Region          <687..>958
                     /region_name="Smc"
                     /note="Chromosome segregation ATPase Smc [Cell cycle
                     control, cell division, chromosome partitioning]; COG1196"
                     /db_xref="CDD:440809"
     Site            934
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TSG1.1)"
     Site            938
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q7TSG1.1)"
     CDS             1..988
                     /gene="Cep120"
                     /gene_synonym="A230075C01; Ccdc100"
                     /coded_by="NM_178686.4:139..3105"
                     /db_xref="CCDS:CCDS37822.1"
                     /db_xref="GeneID:225523"
                     /db_xref="MGI:MGI:2147298"
ORIGIN      
        1 mvpksdqlli vvsilegrhf pkrpkhllvv eakfdgeqla tdpvdhtdqp efatelawei
       61 drkvlhqhrl qrtpiklqcf aldpqtsake tvgyivldlr taqetkqapk wyqllsnkyt
      121 kfkaevqisl tletdtkaqv dsykakaapp rdgkvlasla gvdpkdivav lneeggyhqi
      181 gpaehctdpf ilsvtiafat qleqlipctm klperqpeff fyysllgndv tnepfsdlin
      241 pnfeperasv rirssveilr vylalhsklq ihlccgdqsl gsteiplngl lkkgsteinq
      301 hpvtvegaft ldppnrakqk lapvpldlap tvgvsvalqr egidsqslie lktqngheae
      361 hsqkrvltpi kektltgpks prespapppp pnqtpptkdd ateseveslq ydkdpkptvk
      421 gigsvpasla qpeatcgase vvtsgqkiav paashhfcfs vdlrsvhdle lsfpvncilr
      481 ysypffgsaa pimtnppvev rknmevflpq sycafdfatm phqlqdtflr ipllvelwhk
      541 dkmskdlllg variqlsnil ssektrflga ngeqcwrqty sesvpviaaq gsnnrildls
      601 ytmtledygl vkmreifvse ssqgvpavdq kpsspppapc pseiqmepre tleykaalel
      661 emwkemqedi fesqlkqkel ahmqalaeew kkrdreresl vkkkvaeysi legklqkalt
      721 eletreqqla saeaelqrer kelqlerern lqelqdsvrr arddcvyqve lerlklkqle
      781 edkqrlqqql ndagnkyktl ekefqqfkdq qnnkpeirlq seinlltlek velerklesa
      841 tksklhykqq wgralkelar lkqreqesqm arlkkqqeel eqmrlrylaa eeketvrteq
      901 qelldirnel nrlrqqeqnq yqdckeiasg klgsprgsgl eeglddyltr lieerdtlmr
      961 tgvynhedri iseldrqire vltknsas
//
