LOCUS       NM_001373899            3379 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus centrosomal protein 112 (Cep112), transcript variant
            4, mRNA.
ACCESSION   NM_001373899
VERSION     NM_001373899.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3379)
  AUTHORS   Zhang,X., Huang,G., Jiang,T., Meng,L., Li,T., Zhang,G., Wu,N.,
            Chen,X., Zhao,B., Li,N., Wu,S., Guo,J., Zheng,R., Ji,Z., Xu,Z.,
            Wang,Z., Deng,D., Tan,Y. and Xu,W.
  TITLE     CEP112 coordinates translational regulation of essential fertility
            genes during spermiogenesis through phase separation in humans and
            mice
  JOURNAL   Nat Commun 15 (1), 8465 (2024)
   PUBMED   39349455
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3379)
  AUTHORS   Smith,K.R., Oliver,P.L., Lumb,M.J., Arancibia-Carcamo,I.L.,
            Revilla-Sanchez,R., Brandon,N.J., Moss,S.J. and Kittler,J.T.
  TITLE     Identification and characterisation of a Maf1/Macoco protein
            complex that interacts with GABAA receptors in neurons
  JOURNAL   Mol Cell Neurosci 44 (4), 330-341 (2010)
   PUBMED   20417281
REFERENCE   3  (bases 1 to 3379)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   4  (bases 1 to 3379)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935172.8, BX511139.4, AL645974.7 and AL662893.12.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.1607536.1,
                                           SRR7345562.2034642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL935172.8         42722-42807
            87-200              AL935172.8         51582-51695
            201-391             AL935172.8         54662-54852
            392-564             AL935172.8         57880-58052
            565-655             AL935172.8         87748-87838
            656-733             AL935172.8         89473-89550
            734-781             AL935172.8         104049-104096
            782-859             AL935172.8         104369-104446
            860-946             AL935172.8         115700-115786
            947-1046            AL935172.8         120522-120621
            1047-1165           AL935172.8         123995-124113
            1166-1309           AL935172.8         125678-125821
            1310-1464           AL935172.8         136135-136289
            1465-1594           AL935172.8         136586-136715
            1595-1687           AL935172.8         137352-137444
            1688-1747           AL935172.8         140775-140834
            1748-1827           BX511139.4         8228-8307
            1828-1963           BX511139.4         47130-47265
            1964-2071           BX511139.4         67846-67953
            2072-2254           BX511139.4         83055-83237
            2255-2485           AL645974.7         37390-37620
            2486-2548           AL645974.7         125472-125534
            2549-2698           AL645974.7         130564-130713
            2699-2788           AL662893.12        47410-47499
            2789-2890           AL662893.12        94543-94644
            2891-2955           AL662893.12        98103-98167
            2956-3379           AL662893.12        98952-99375
FEATURES             Location/Qualifiers
     source          1..3379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.83 cM"
     gene            1..3379
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /note="centrosomal protein 112"
                     /db_xref="GeneID:76380"
                     /db_xref="MGI:MGI:1923673"
     exon            1..86
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            87..200
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2959
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /note="isoform 2 is encoded by transcript variant 4;
                     centrosomal protein of 112 kDa; coiled-coil
                     domain-containing protein 46; coiled-coil domain
                     containing 46"
                     /codon_start=1
                     /product="centrosomal protein of 112 kDa isoform 2"
                     /protein_id="NP_001360828.1"
                     /db_xref="GeneID:76380"
                     /db_xref="MGI:MGI:1923673"
                     /translation="METGSEEEKWEKLDAEFDHFVVDMKPFVLKLPHRSERQRCALWI
                     RKLCEPSGTGAGLMGRKNRNLYAKLLLHMLRRGILEGPFTHRPEPGTLKTLPSYMSIY
                     FDEPNQAQPKDSSPEKLPDWVRGELQTGEQRLSDSWQCSSGEDNTLVLAASDAHREQY
                     TGKLRMRSHSVSPTYREDKQHITSKICEVHSKTSPISLDDSDIEVRLNSWNLGIENPR
                     YLRQKPLPVSLMTPKGSLRKASSLHDDHFLSRMHEKELDMKTKMMEAKFSEEKLKLQQ
                     KHDAEVQKILERKNNELEELKILYKKKQTETEETIRKLEKKVQILIRDCQVIRETKEN
                     QITELKKICEQSTESLNNDWEKKLHNAVAEMEKDKFELQKHHTETIQELLEDTNVRLS
                     KMEADYVVQMQSTNHMIKELEGRVQQLMGEAENSNLQRQKLTQEKLELERCYQITCNE
                     LQELKTRRNILHKEKEHLVNDYEQNVKLLKTKYDSDINLLRQEHALSTSKTSGVIEEL
                     EQNICQLKQQVQESELQRKQQVKDQENKFHMEKNHLKHTYEKKVHELQSELDKEKEDA
                     QRKIHKFEEALKEKEEQLSRVTEVQRLQAQQADAALEEFKRQVEVNSEKVYGEMKEQM
                     EKVEADLTRSKSLREKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEKTHLLQQHSAEK
                     DSLVRDHDREIENLEKQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREELISVN
                     SQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAETEMTLEKA
                     NSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEK
                     QQLIRDNDQAIKALQDELETRSHQVRSAEKKLHHKELEAQEQIMYIRQEYETKFKGLM
                     PASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQSRR"
     exon            201..391
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            392..564
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            565..655
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            656..733
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            734..781
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            782..859
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            860..946
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1046
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1165
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1309
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1464
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1594
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1687
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1747
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1827
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1963
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2071
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2254
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2485
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2548
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2698
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2788
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2890
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..2955
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3379
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3095..3100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /note="hexamer: CATAAA"
     polyA_site      3115
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /note="major polyA site"
     regulatory      3357..3362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /note="hexamer: ATTAAA"
     polyA_site      3379
                     /gene="Cep112"
                     /gene_synonym="1700001M19Rik; 1700029K01Rik;
                     8430407H02Rik; Ccdc46; Macoco"
                     /note="major polyA site"
ORIGIN      
        1 ggacggcccg caaggatttg aaaccgtttg gctgtggcgg ctgggcgtcg gcggccgagt
       61 ggacggcttg cttgttgggg cgccagacag gattatggaa acaggaagtg aagaagaaaa
      121 atgggagaag ctagatgcag aatttgatca cttcgtggta gatatgaagc cctttgtttt
      181 aaaattaccc cataggtcag aacggcagag gtgtgctctt tggatcagaa agctgtgtga
      241 gccctcagga acgggtgcag gactcatggg taggaagaat cgaaacctgt atgcaaagct
      301 gttactgcat atgcttaggc gaggaatact tgaaggccct ttcacacacc gcccggagcc
      361 aggaacgctg aaaacattgc catcgtacat gtccatctat tttgatgaac caaatcaagc
      421 acaacccaaa gattcgagcc cagagaagtt acctgactgg gtgaggggtg agctgcagac
      481 gggcgagcag aggttaagtg actcatggca gtgctcttct ggagaggaca acacgctggt
      541 gctggcggcc agtgatgctc acagagaaca gtacactgga aagctccgaa tgaggtccca
      601 ttctgtgagt ccaacttata gagaagacaa acaacacatt acttcaaaga tctgtgaagt
      661 tcattcaaaa acgtctccta tttctttgga tgacagtgac attgaagttc gcctgaacag
      721 ttggaatctt gggattgaaa atccccggta cctgagacag aaacctctcc cagtttctct
      781 gatgactccc aagggcagcc tgaggaaggc tagcagtctt catgatgacc attttctctc
      841 tcgaatgcac gagaaagagt tggacatgaa aacaaaaatg atggaagcaa aattttctga
      901 agagaaactt aagctgcagc agaagcatga tgccgaagtg cagaagattt tagaaagaaa
      961 gaataatgaa ttagaagagt tgaaaatctt atacaaaaag aaacaaactg aaactgagga
     1021 gaccatacga aagcttgaaa agaaagttca gatccttatc cgtgactgtc aggttatcag
     1081 agaaactaaa gaaaaccaga taaccgagct gaagaagatc tgtgagcaaa gcacagagtc
     1141 tctgaataat gattgggaaa aaaagcttca caatgctgta gcagaaatgg aaaaggacaa
     1201 atttgagctt caaaagcacc atacggagac catccaggaa ctgctggagg acacaaatgt
     1261 gcggctgagt aaaatggagg cagactatgt ggtgcagatg cagtccacaa accacatgat
     1321 caaagagctg gagggccgtg tccagcaact gatgggagaa gcagagaaca gcaatctaca
     1381 gaggcagaaa ttgacccaag aaaaattgga gctggaaaga tgctaccaga taacatgtaa
     1441 tgaattgcag gagttaaaga caaggcgcaa catactacat aaagagaaag aacatcttgt
     1501 aaatgactat gagcaaaatg tgaaattatt aaaaactaaa tatgattctg acataaatct
     1561 cctgagacaa gagcatgcac tttcaacttc taagacatct ggtgtgattg aagagttaga
     1621 acagaacatc tgtcaattaa aacagcaggt ccaagaatcg gagcttcaga ggaaacagca
     1681 agtaaaagat caagaaaata agtttcacat ggagaaaaac catttaaaac acacctatga
     1741 gaaaaaggtt catgaactgc agagtgaact tgataaagag aaggaagatg ctcagaggaa
     1801 gatccataaa tttgaggaag ctttgaagga gaaggaggag cagctcagca gagtgactga
     1861 agttcagagg ctgcaagccc agcaggcaga tgctgctctg gaggagttta agcggcaggt
     1921 agaagtgaac tctgagaagg tctatggtga gatgaaagag cagatggaaa aagtggaagc
     1981 agacctaacg agatccaagt ctctccgtga gaagcagtcc aaggagtttc tgtggcagct
     2041 ggaagacgcc aagcagagat atgaacagca gatagtagag ctgaagctgg agcatgaaca
     2101 ggagaagacg cacctattac agcagcacag cgcagagaag gatagcctag tccgagacca
     2161 tgatcgggaa attgaaaacc tggagaaaca gcttcgcgct gccaatatgg agcacgaaaa
     2221 tcaaattcaa gagtccaaga aacgagatgc tcaggttatt gctgacatgg aggcccaggt
     2281 tcataagctg agggaagagc tgattagtgt gaactctcag cggaaacagc agttgataga
     2341 acttggtctt cttcgggaag aagagaagca gagagctgca aaggaccatg agactgctgt
     2401 caagaagctg aaggccgagt cagagagggt gaaaatggag ctcaaaaaga cacacgctgc
     2461 tgagaccgag atgactctgg agaaggccaa cagcaggctg aagcagatcg agaaggaata
     2521 cactcagaag cttgccaaat cttctcagat catagcagaa cttcagacaa ccatttcctc
     2581 tctgaaagag gagagcagtc ggcagcagct tgctgcagaa aggcggctcc aggatgttat
     2641 acaaaagttt gaagatgaga agcagcagct gattagagat aatgaccaag caatcaaggc
     2701 tttacaagat gaactagaaa cccgctctca tcaggtgcga agtgcagaga aaaagttaca
     2761 tcacaaagaa ctggaggcgc aggagcagat aatgtacata cgacaagaat atgaaacaaa
     2821 attcaagggg ttaatgccag cgtctctaag acaagaactt gaggacacca tatcctccct
     2881 aaagtcacag gtcaactttc tacaaaagag ggcatctatc cttcaagaag aactgaccac
     2941 ctaccaaagc agaaggtaac tacatgtgtg gtagagtgtg atacatgact ctcatctggg
     3001 ctgcaccgag ggcttcatcc agcaggtttg aagatctgga tattgtaatc tgtgagatca
     3061 atgggttttt taaatgcttg agtataatta atatcataaa aacatgcatc atccatgcac
     3121 tggttggctt tctttgtgtc tccctaagtt ctgtttttcc atctccttgc tgactccatg
     3181 attgtactgg agcacacgtt gaaaattgtg tatgttggga ggagatgtct gcttgtggtg
     3241 tgccttggtg atgctttgca agggtcttac aagttgtgga tgataagaat cacgattgta
     3301 gtatcatatc aaaatgctta acctgttcat gttgttccca tgttcattgt tcagatatta
     3361 aaatgtcatt tttatacta
//
