LOCUS       NM_028448               1044 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus centromere protein V (Cenpv), mRNA.
ACCESSION   NM_028448 XM_203393 XM_916747
VERSION     NM_028448.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1044)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1044)
  AUTHORS   Nabi,D., Drechsler,H., Pschirer,J., Korn,F., Schuler,N., Diez,S.,
            Jessberger,R. and Chacon,M.
  TITLE     CENP-V is required for proper chromosome segregation through
            interaction with spindle microtubules in mouse oocytes
  JOURNAL   Nat Commun 12 (1), 6547 (2021)
   PUBMED   34764261
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1044)
  AUTHORS   Honda,Z., Suzuki,T. and Honda,H.
  TITLE     Identification of CENP-V as a novel microtubule-associating
            molecule that activates Src family kinases through SH3 domain
            interaction
  JOURNAL   Genes Cells 14 (12), 1383-1394 (2009)
   PUBMED   19930468
REFERENCE   4  (bases 1 to 1044)
  AUTHORS   Tadeu,A.M., Ribeiro,S., Johnston,J., Goldberg,I., Gerloff,D. and
            Earnshaw,W.C.
  TITLE     CENP-V is required for centromere organization, chromosome
            alignment and cytokinesis
  JOURNAL   EMBO J 27 (19), 2510-2522 (2008)
   PUBMED   18772885
REFERENCE   5  (bases 1 to 1044)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   6  (bases 1 to 1044)
  AUTHORS   Cronshaw,J.M., Krutchinsky,A.N., Zhang,W., Chait,B.T. and
            Matunis,M.J.
  TITLE     Proteomic analysis of the mammalian nuclear pore complex
  JOURNAL   J Cell Biol 158 (5), 915-927 (2002)
   PUBMED   12196509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596181.10, AK014046.1 and BP771180.1.
            
            On or before Mar 28, 2009 this sequence version replaced
            XM_916747.2, XM_203393.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014046.1, BY713042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AL596181.10        134890-135037
            149-1032            AK014046.1         149-1032
            1033-1044           BP771180.1         34-45               c
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 38.43 cM"
     gene            1..1044
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /note="centromere protein V"
                     /db_xref="GeneID:73139"
                     /db_xref="MGI:MGI:1920389"
     exon            1..406
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..815
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /note="proline-rich polypeptide 6; CENP-V; proline-rich
                     protein 6"
                     /codon_start=1
                     /product="centromere protein V"
                     /protein_id="NP_082724.1"
                     /db_xref="CCDS:CCDS48818.1"
                     /db_xref="GeneID:73139"
                     /db_xref="MGI:MGI:1920389"
                     /translation="MRRTRSAVATGPREQRRSGATGGLSGGESRAQRSRSRTRAGAGG
                     GGGAVGPQPSAKPRPKPPPRAQEAAAEEPPPAVTPAASVSALDLGEQRERWETFQKRQ
                     RLSFEGAAKLLLDTFEYQGLVKHTGGCHCGAVRFEVWASADLHIFDCNCSICKKKQNR
                     HFIVPASRFKLLKGAESITTYTFNTHKAQHTFCKRCGVQSFYTPRSNPGGFGIAPHCL
                     DEGTVRSVVTEEFNGSDWERAMKEHKTIKNMSKE"
     exon            407..505
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /inference="alignment:Splign:2.1.0"
     exon            506..575
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /inference="alignment:Splign:2.1.0"
     exon            576..690
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /inference="alignment:Splign:2.1.0"
     exon            691..1034
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /note="hexamer: AATAAA"
     polyA_site      1034
                     /gene="Cenpv"
                     /gene_synonym="3110013H01Rik; Prr6"
                     /note="major polyA site"
ORIGIN      
        1 atcggccggc gggagcgcgc agagccgaga ggcctgcgag cccggctgag ggagacatgc
       61 ggcggactcg cagtgccgtg gccaccggcc cgcgggagca gcggcgctcg ggggccaccg
      121 ggggcttgag cggcggcgaa agccgcgcgc agcgctcccg gagcaggact agggccgggg
      181 ccgggggcgg gggcggggcg gtcggtccgc agccgtcggc aaagccgcgg cccaagccac
      241 cgccgcgggc ccaggaggcg gccgccgagg agccaccgcc ggcggtcacc cccgccgcct
      301 cggtgtcggc gctcgacctg ggggagcagc gggagcgctg ggagacgttc cagaagcggc
      361 aacggctcag cttcgagggc gccgccaagc tgctgctgga cacctttgag taccagggcc
      421 tggtgaagca cacaggaggc tgccactgtg gagcagttcg ttttgaagtt tgggcttcag
      481 cagacttaca catctttgac tgcaactgta gcatttgcaa gaagaagcag aacagacact
      541 tcattgttcc agcttctcgg ttcaaactcc tgaagggtgc tgagagcata accacataca
      601 cctttaacac gcacaaagcc cagcacacct tctgcaagag atgtggtgtc cagagcttct
      661 atactccgcg ctccaacccc gggggctttg gaatcgcccc ccactgcctg gacgaaggca
      721 ctgtgcggag tgtggtcact gaggagttca atggcagtga ctgggaacga gccatgaagg
      781 agcacaagac catcaagaac atgtcaaagg agtgagcagg gcagtagccc tgtaggttgc
      841 atgggtgtgt gtcgctgtgc aggcctgcct gggctaccat ctccactccc catgtctctg
      901 aggttcactc cagccaccat ttctttaggc agctctgcct taacccaggt ttcgtgtaag
      961 aaacttaacc ttctcccttc ctaccaattt ttgtgtgatc ttttagaaaa taaatatttc
     1021 tgacattaat gctaaaaaaa aaaa
//
