LOCUS       NP_796124                515 aa            linear   ROD 30-APR-2024
DEFINITION  centromere protein T [Mus musculus].
ACCESSION   NP_796124 XP_001476743
VERSION     NP_796124.1
DBSOURCE    REFSEQ: accession NM_177150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 515)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 515)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 515)
  AUTHORS   Wang,Y., Li,J., Dong,F., Yue,W., Ouyang,Y.C., Wang,Z.B., Hou,Y.,
            Schatten,H. and Sun,Q.Y.
  TITLE     CENP-T regulates both the G2/M transition and anaphase entry by
            acting through CDH1 in meiotic oocytes
  JOURNAL   J Cell Sci 133 (3) (2020)
   PUBMED   31964702
  REMARK    GeneRIF: CENP-T regulates both the G2/M transition and anaphase
            entry by acting through CDH1 in meiotic oocytes.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 515)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   6  (residues 1 to 515)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
REFERENCE   7  (residues 1 to 515)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK090340.1.
            
            On Sep 4, 2008 this sequence version replaced XP_001476743.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090340.1, AK167376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..515
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.05 cM"
     Protein         1..515
                     /product="centromere protein T"
                     /note="CENP-T"
                     /calculated_mol_wt=56111
     Region          1..374
                     /region_name="CENP-T_N"
                     /note="Centromere kinetochore component CENP-T N-terminus;
                     pfam16171"
                     /db_xref="CDD:465039"
     Region          24..156
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q96BT3; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Region          94..375
                     /region_name="Flexible stalk domain.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Region          271..411
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q561R1; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BT3; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            345
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BT3; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            346
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BT3; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q96BT3; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Site            376
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q561R1; propagated from
                     UniProtKB/Swiss-Prot (Q3TJM4.2)"
     Region          411..506
                     /region_name="HFD_SF"
                     /note="histone fold domain (HFD) superfamily; cl45933"
                     /db_xref="CDD:480273"
     Site            order(420..421,424..430,432..433,436..437,440..446,
                     448..449,451,453,455,463..466,469,472..473,475..478,
                     488..489,492..493,497,500..501)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:467045"
     Site            order(447,450..451,454..455,458..459,461,467..468,471,
                     474..475,481)
                     /site_type="other"
                     /note="heterotetramer interface [polypeptide binding]"
                     /db_xref="CDD:467045"
     CDS             1..515
                     /gene="Cenpt"
                     /gene_synonym="G630055P03Rik"
                     /coded_by="NM_177150.2:26..1573"
                     /db_xref="CCDS:CCDS22615.1"
                     /db_xref="GeneID:320394"
                     /db_xref="MGI:MGI:2443939"
ORIGIN      
        1 madlsfsdgd ptvrtllrrv letadsrtpm rrrstrinaq rrrsqtpysn rqgsqtktsa
       61 rkqshgarsv grstrvqgrg rleeqtprtl lrnilltape sstvmpdpvv kpaqvpevar
      121 ssrressrgs lelhlpelep pstlapglta pgkrkqklrl svfqqevdqg lplsqeprrs
      181 rsadvsslas sfnltfvlpg qpetverpgl arrrpirqlv nagallqdle dnslasalpg
      241 dshrtpvaal pmdvgledtq pfsqslaafs lsgkhslpsp srpgvedver vmgppssgtr
      301 lqsrmsrsgp aaspspflep qpppaeprea vgsneaaepk dqegssgyee tsarpasgel
      361 sssthdslpa eqpppspgva vlsseplesv takcpsrtqt agprrrqdph kaglspyvkf
      421 fsfctkmpve ktaleivekc ldkyfqhlcn dlevfashag rkivkpedll llmrrqglvt
      481 dqvsqhvlve rylpleyrqq lipcafsgns vfpaq
//
