LOCUS       NM_134046               2206 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus centromere protein O (Cenpo), transcript variant 1,
            mRNA.
ACCESSION   NM_134046
VERSION     NM_134046.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2206)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162932.2 and CT572999.10.
            
            On Mar 29, 2018 this sequence version replaced NM_134046.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134266.1, BC036278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC162932.2         75420-75633         c
            215-341             AC162932.2         75199-75325         c
            342-508             CT572999.10        631-797
            509-623             CT572999.10        14991-15105
            624-883             CT572999.10        15535-15794
            884-1055            CT572999.10        16883-17054
            1056-2206           CT572999.10        17683-18833
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 2.02 cM"
     gene            1..2206
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /note="centromere protein O"
                     /db_xref="GeneID:52504"
                     /db_xref="MGI:MGI:1923800"
     exon            1..214
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     exon            215..341
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1192
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="centromere protein O isoform 1"
                     /protein_id="NP_598807.2"
                     /db_xref="CCDS:CCDS25788.1"
                     /db_xref="GeneID:52504"
                     /db_xref="MGI:MGI:1923800"
                     /translation="MESANTLCPGRKCKGGVLAHLERLEAQTNISNRKSEEPAVRKKE
                     SSLRTKIRELRQQRDKLRAEVKQWGARVKEPPAKEDPSRTVISEQEVLEREWRNVDAI
                     LEAYRFTGLSGKLTSRGVCMCISTAFEGNLLDSYFVDLVIEKPLRIHHHSVPVFIPLE
                     KIAAAHLQTDVQRFLFRLWEYLNAYAGRKYQADQLESDFCDVLTGPLQRNALCNLLSF
                     TYKVEQRCQTFSFSARLLYEDPTAALPTNVTVTRPGVEASSPPWEEHRASHQMLFRTK
                     PLHKVFASFSKETEKLHLNLVS"
     exon            342..508
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     exon            509..623
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     exon            624..883
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1055
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..2206
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2181..2186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /note="hexamer: AATAAA"
     polyA_site      2206
                     /gene="Cenpo"
                     /gene_synonym="2810429O05Rik; 8430427C03Rik; D12Ertd482e"
                     /note="major polyA site"
ORIGIN      
        1 actctgggat cagtgggtta cgttgttact tcagttgctc tcggcgggaa ttcttaaact
       61 gcatcctgag tgagggagct ttggcgagaa agcaagaccc agtggtagac agattagcat
      121 tactgtacag cttctttggg tgttcgagga agcccggctg gaccatagtg gccacggcgg
      181 tgaggtaggc gtggacaggg ctgaccagtc caagttaagg acgttcgggt ccatgttaac
      241 cctgccttgt acgtccagca tcgtaagaaa aaacacttga gaacccgaag aggagatgga
      301 gtctgcaaat actttgtgtc caggcaggaa gtgcaaagga ggtgttttag ctcacctgga
      361 aagactagag gctcaaacga acatatcgaa tagaaagtct gaagaaccag cagttcgtaa
      421 aaaggaaagt tctcttagaa ccaagattcg agaactgcgg caacaacgag ataagctgag
      481 ggcagaagtg aagcagtggg gagccagagt taaagaacct cctgccaaag aagacccaag
      541 cagaaccgtg atcagtgaac aggaagttct ggaaagggag tggagaaatg tggacgccat
      601 tctggaggca tatcgcttta cggggctcag cgggaagttg accagtcgtg gcgtctgcat
      661 gtgcatcagc acagcctttg aggggaacct actagattcc tactttgtgg acctcgtcat
      721 agagaaacca ctccggattc atcaccattc cgtcccagtc ttcatccctc tggaaaagat
      781 agccgcagca cacctacaga ctgatgttca gcgcttcctg tttagactct gggaatacct
      841 aaatgcctac gcggggagga agtaccaggc agaccaactt gagagtgact tctgcgatgt
      901 cctcacggga cctttgcaga gaaacgccct gtgcaacttg ctgtcgttca cctataaagt
      961 ggaacagaga tgccagacct tctccttcag tgccaggttg ctgtatgagg accccacagc
     1021 agctcttccc acgaatgtca ctgtgacaag gccaggtgtg gaggcatcat cccctccttg
     1081 ggaagagcac agagcatccc atcagatgct cttccgtacc aagcccctgc acaaggtgtt
     1141 tgcttcattt tccaaagaaa ccgaaaagct gcatttgaac ctggtctcct gaaaaactgt
     1201 ttctctattt gggggacagc agaaatgaac acacttgtgc tgcctccagt tcaggaccag
     1261 tcagcaaaag ctgttgggag agtgcttgcc tggatgccac catgagaaca gatacccacg
     1321 tcatgggaat gacagggagc ttgcgtgtac acatagacaa gtccgtatct gtaggcactg
     1381 ggcagttgga acagttctcc aaagtggccg cttgttcact gttcactcag cccagtgctc
     1441 cagaatatct cttcctcctg taagcaccag tgctgacttg gttgtatgca tatgttcttg
     1501 ctggaatcag ctagaatggg ggtaactgaa gaccttttgt aagcatctct agctttcctg
     1561 gaagctataa atccatgata gggcttgtgg ttaagaaggg aattttttag tcttgggttt
     1621 ggagcagcat gtgctgggcc actatttggt gagagacagt atttttatac ttgggggttc
     1681 tatgtattta atgtttccta aaacagttgg gcagagaaca gcatgcgtaa agtcctttta
     1741 aggaaacact gttggaaatc tacacataga tcaggggacg ctcctctgtc atggctgtcc
     1801 tcttcccatt tcctagagac tgttaatgta ccttttctct ttcaccacgg ctctgtgctg
     1861 tgcagtgtgt gttgttcctc ggcttagggc ttcttgacat cttaggcctg cctgctggtc
     1921 atgccctctc attacaacgc ctgcgctctc tgctagttag tcccagatag gatctttact
     1981 ccacaggccc agcgtttggg cttcactcta acttagctgc ttcctagaaa tctccatgtg
     2041 tcggagctcc agcaaactcc aggaagaatg catggaacgt aagccatggg tcccctaaca
     2101 ggtttggaat aaaaggttca tggtctgtgt cacagtaaca gaattgccac aacagtctca
     2161 tcaagttgag taaagctttt aataaaacag tcctgttctt tatcaa
//
