LOCUS       NM_025639               1218 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus centromere protein M (Cenpm), transcript variant 1,
            mRNA.
ACCESSION   NM_025639
VERSION     NM_025639.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1218)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1218)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   3  (bases 1 to 1218)
  AUTHORS   Bierie,B., Edwin,M., Melenhorst,J.J. and Hennighausen,L.
  TITLE     The proliferation associated nuclear element (PANE1) is conserved
            between mammals and fish and preferentially expressed in activated
            lymphoid cells
  JOURNAL   Gene Expr Patterns 4 (4), 389-395 (2004)
   PUBMED   15183305
REFERENCE   4  (bases 1 to 1218)
  AUTHORS   Renou,J.P., Bierie,B., Miyoshi,K., Cui,Y., Djiane,J.,
            Reichenstein,M., Shani,M. and Hennighausen,L.
  TITLE     Identification of genes differentially expressed in mouse mammary
            epithelium transformed by an activated beta-catenin
  JOURNAL   Oncogene 22 (29), 4594-4610 (2003)
   PUBMED   12881717
  REMARK    GeneRIF: A new 20 kDa protein (PANE1) induced upon
            transdifferentiation was nuclear in nonconfluent cells and
            cytoplasmic in confluent or dividing cells.
REFERENCE   5  (bases 1 to 1218)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1218)
  AUTHORS   Hentges,K.E., Yarlagadda,S.P. and Justice,M.J.
  TITLE     Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia
            virus insertions at Lvis22
  JOURNAL   Genomics 80 (2), 204-212 (2002)
   PUBMED   12160734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY710734.1, AK011227.1 and
            AI853711.1.
            
            On Jan 18, 2007 this sequence version replaced NM_025639.3.
            
            Summary: This gene encodes a protein that is present in the nucleus
            of actively growing cells but is excluded from the nucleus during
            cell division or during growth arrest as a result of contact
            inhibition. In human, this protein is a component of the CENP-A
            nucleosome-associated complex that regulates kinetochore protein
            assembly, mitotic cell-cycle progression, and chromosome
            segregation. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011464.1, BY710734.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY710734.1         2-18
            18-897              AK011227.1         2-881
            898-1218            AI853711.1         1-321               c
FEATURES             Location/Qualifiers
     source          1..1218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.56 cM"
     gene            1..1218
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="centromere protein M"
                     /db_xref="GeneID:66570"
                     /db_xref="MGI:MGI:1913820"
     exon            1..125
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..611
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proliferation associated nuclear element 1; CENP-M;
                     proliferation-associated nuclear element protein 1"
                     /codon_start=1
                     /product="centromere protein M isoform 1"
                     /protein_id="NP_079915.1"
                     /db_xref="CCDS:CCDS27685.1"
                     /db_xref="GeneID:66570"
                     /db_xref="MGI:MGI:1913820"
                     /translation="MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKDDCASEL
                     RVHLANSLPLPSNVNRPRIDLIVFVINLHSKYSLQKVEEFLQHVDSSFFLGKVCFLVT
                     GAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVESFRAAMARRLVRILQICAGHVPGV
                     SALNLMSLLRSPENPPSKEL"
     exon            126..205
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            206..298
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..378
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            379..470
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..1218
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      886..891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="hexamer: AAGAAA"
     polyA_site      904
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="major polyA site"
     polyA_site      1126
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
ORIGIN      
        1 agagaggcgg gccttgcgac ggtttgaaag cgccatgcgc tgagccgagt ggcgctgctg
       61 ccgctgagat gtcggtgctg aggtcgatgg acaagctgcc cgacctgaac agggctaccg
      121 tcttgctggt gagcaccgag gatgcgcttc tgcagcagct ggcggagtcg atgctcaaag
      181 atgactgtgc gtccgagctg agggtccact tggccaactc cctccctctg ccctccaatg
      241 tgaaccggcc ccgaattgac ctgattgtgt ttgtgattaa cctgcacagc aaatacagtc
      301 tccagaaagt ggaggagttt ctgcagcacg tggacagcag cttcttcctg gggaaagtgt
      361 gcttccttgt cacaggggcg ggacaggaaa gccactgcag cgtccaccag aacacagtta
      421 taaaactggc ccacacctac cgaagcccgc tgctcctctg tgatttacag gtggaaagct
      481 ttcgtgcagc catggcgcgg cgtctggtgc gcattctgca gatctgcgct ggccatgtgc
      541 caggcgtctc cgcgctgaac ctgatgtcct tgctgcggag ccccgagaac cccccatcca
      601 aggagctgtg agcattactg ccctccacac gtttgctgcc agttccaaaa gcagccactg
      661 ttggtgaaga ccagtcaggg cctgacaggc ccagaggcag cctgctcact gcaggactga
      721 gctccaccag ggaggtctgc tgggcaggag tcgggagaga gcccagcgag accccagcag
      781 cctcccgttt ctcgtctcac cccacagagg tcccatctgc acctgtctaa catcataatc
      841 cacctaagat tttggaacaa agagccatgg ctttaaaaaa aaaaaaagaa aggaaggaag
      901 gaaatgtgtt gtagatgcag aaactgactc agtacaattg cgggggcaaa gtgtggcttc
      961 caggagccca gggaaaatgt caggtccagg ccctgcgttt cttacagccc ggctgttgta
     1021 ttctggtgcc tgtttttcct cgtgtaagtg gagctggttc tactcacatt gagagggctg
     1081 aaggaaatgg caggtggctt gctgcccaag accacattgc tccctacaac ttgttggtct
     1141 ctcttgtaga tcacacacag tgtcatgcct cacactgtaa cagcaagcta ccaatcacat
     1201 taaaaaaaaa aaaaaaaa
//
