LOCUS       NM_001080158            1217 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus centromere protein M (Cenpm), transcript variant 3,
            mRNA.
ACCESSION   NM_001080158
VERSION     NM_001080158.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Kumada,T., Yamanaka,Y., Kitano,A., Shibata,M., Awaya,T., Kato,T.,
            Okawa,K., Abe,T., Oshima,N., Nakahata,T. and Heike,T.
  TITLE     Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic
            reticulum, is required for early embryonic development
  JOURNAL   Dev Dyn 239 (8), 2233-2245 (2010)
   PUBMED   20568244
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Bierie,B., Edwin,M., Melenhorst,J.J. and Hennighausen,L.
  TITLE     The proliferation associated nuclear element (PANE1) is conserved
            between mammals and fish and preferentially expressed in activated
            lymphoid cells
  JOURNAL   Gene Expr Patterns 4 (4), 389-395 (2004)
   PUBMED   15183305
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Renou,J.P., Bierie,B., Miyoshi,K., Cui,Y., Djiane,J.,
            Reichenstein,M., Shani,M. and Hennighausen,L.
  TITLE     Identification of genes differentially expressed in mouse mammary
            epithelium transformed by an activated beta-catenin
  JOURNAL   Oncogene 22 (29), 4594-4610 (2003)
   PUBMED   12881717
  REMARK    GeneRIF: A new 20 kDa protein (PANE1) induced upon
            transdifferentiation was nuclear in nonconfluent cells and
            cytoplasmic in confluent or dividing cells.
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Hentges,K.E., Yarlagadda,S.P. and Justice,M.J.
  TITLE     Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia
            virus insertions at Lvis22
  JOURNAL   Genomics 80 (2), 204-212 (2002)
   PUBMED   12160734
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG276334.1, AK011227.1 and
            AI853711.1.
            
            Summary: This gene encodes a protein that is present in the nucleus
            of actively growing cells but is excluded from the nucleus during
            cell division or during growth arrest as a result of contact
            inhibition. In human, this protein is a component of the CENP-A
            nucleosome-associated complex that regulates kinetochore protein
            assembly, mitotic cell-cycle progression, and chromosome
            segregation. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting protein (isoform 3) has a shorter
            N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG276334.1, BE623024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               BG276334.1         1-504
            505-896             AK011227.1         490-881
            897-1217            AI853711.1         1-321               c
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.56 cM"
     gene            1..1217
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="centromere protein M"
                     /db_xref="GeneID:66570"
                     /db_xref="MGI:MGI:1913820"
     exon            1..204
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..610
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     proliferation associated nuclear element 1; CENP-M;
                     proliferation-associated nuclear element protein 1"
                     /codon_start=1
                     /product="centromere protein M isoform 3"
                     /protein_id="NP_001073627.1"
                     /db_xref="GeneID:66570"
                     /db_xref="MGI:MGI:1913820"
                     /translation="MLKDDCASELRVHLANSLPLPSNVNRPRIDLIVFVINLHSKYSL
                     QKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVE
                     SFRAAMARRLVRILQICAGHVPGVSALNLMSLLRSPENPPSKEL"
     exon            205..297
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..377
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..469
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1217
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      885..890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="hexamer: AAGAAA"
     polyA_site      903
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
                     /note="major polyA site"
     polyA_site      1125
                     /gene="Cenpm"
                     /gene_synonym="2610019I03Rik; Pane1"
ORIGIN      
        1 gaaatggctc cctccgagcc gcctctagct gagtgtgtac ccccaggagg gattcggagt
       61 gcggggccct ccaaaggagc cgccctgctc ggatctccat ctgcctggtt ctctcccttc
      121 gcagctggtg agcaccgagg atgcgcttct gcagcagctg gcggagtcga tgctcaaaga
      181 tgactgtgcg tccgagctga gggtccactt ggccaactcc ctccctctgc cctccaatgt
      241 gaaccggccc cgaattgacc tgattgtgtt tgtgattaac ctgcacagca aatacagtct
      301 ccagaaagtg gaggagtttc tgcagcacgt ggacagcagc ttcttcctgg ggaaagtgtg
      361 cttccttgtc acaggggcgg gacaggaaag ccactgcagc gtccaccaga acacagttat
      421 aaaactggcc cacacctacc gaagcccgct gctcctctgt gatttacagg tggaaagctt
      481 tcgtgcagcc atggcgcggc gtctggtgcg cattctgcag atctgcgctg gccatgtgcc
      541 aggcgtctcc gcgctgaacc tgatgtcctt gctgcggagc cccgagaacc ccccatccaa
      601 ggagctgtga gcattactgc cctccacacg tttgctgcca gttccaaaag cagccactgt
      661 tggtgaagac cagtcagggc ctgacaggcc cagaggcagc ctgctcactg caggactgag
      721 ctccaccagg gaggtctgct gggcaggagt cgggagagag cccagcgaga ccccagcagc
      781 ctcccgtttc tcgtctcacc ccacagaggt cccatctgca cctgtctaac atcataatcc
      841 acctaagatt ttggaacaaa gagccatggc tttaaaaaaa aaaaaagaaa ggaaggaagg
      901 aaatgtgttg tagatgcaga aactgactca gtacaattgc gggggcaaag tgtggcttcc
      961 aggagcccag ggaaaatgtc aggtccaggc cctgcgtttc ttacagcccg gctgttgtat
     1021 tctggtgcct gtttttcctc gtgtaagtgg agctggttct actcacattg agagggctga
     1081 aggaaatggc aggtggcttg ctgcccaaga ccacattgct ccctacaact tgttggtctc
     1141 tcttgtagat cacacacagt gtcatgcctc acactgtaac agcaagctac caatcacatt
     1201 aaaaaaaaaa aaaaaaa
//
