LOCUS       NM_001014996            4362 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus centrosome assembly and centriole elongation protein
            (Cpap), transcript variant 1, mRNA.
ACCESSION   NM_001014996 XM_127861
VERSION     NM_001014996.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4362)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4362)
  AUTHORS   Meneses Iack,P., Rayee,D., Lent,R., Ribeiro-Resende,V.T. and
            Garcez,P.P.
  TITLE     Microcephaly gene Cenpj regulates axonal growth in cortical neurons
            through microtubule destabilization
  JOURNAL   J Neurochem 161 (4), 320-334 (2022)
   PUBMED   34940974
  REMARK    GeneRIF: Microcephaly gene Cenpj regulates axonal growth in
            cortical neurons through microtubule destabilization.
REFERENCE   3  (bases 1 to 4362)
  AUTHORS   Xie,C., Abrams,S.R., Herranz-Perez,V., Garcia-Verdugo,J.M. and
            Reiter,J.F.
  TITLE     Endoderm development requires centrioles to restrain p53-mediated
            apoptosis in the absence of ERK activity
  JOURNAL   Dev Cell 56 (24), 3334-3348 (2021)
   PUBMED   34932949
REFERENCE   4  (bases 1 to 4362)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4362)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4362)
  AUTHORS   McIntyre,R.E., Lakshminarasimhan Chavali,P., Ismail,O.,
            Carragher,D.M., Sanchez-Andrade,G., Forment,J.V., Fu,B., Del
            Castillo Velasco-Herrera,M., Edwards,A., van der Weyden,L.,
            Yang,F., Ramirez-Solis,R., Estabel,J., Gallagher,F.A., Logan,D.W.,
            Arends,M.J., Tsang,S.H., Mahajan,V.B., Scudamore,C.L., White,J.K.,
            Jackson,S.P., Gergely,F. and Adams,D.J.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Disruption of mouse Cenpj, a regulator of centriole biogenesis,
            phenocopies Seckel syndrome
  JOURNAL   PLoS Genet 8 (11), e1003022 (2012)
   PUBMED   23166506
  REMARK    GeneRIF: we have developed a mouse (Cenpj(tm/tm)) that
            recapitulates many of the clinical features of Seckel syndrome,
            thus providing clear confirmation that specific mutations of CENPJ
            can cause Seckel syndrome.
REFERENCE   7  (bases 1 to 4362)
  AUTHORS   Passemard,S., El Ghouzzi,V., Nasser,H., Verney,C., Vodjdani,G.,
            Lacaud,A., Lebon,S., Laburthe,M., Robberecht,P., Nardelli,J.,
            Mani,S., Verloes,A., Gressens,P. and Lelievre,V.
  TITLE     VIP blockade leads to microcephaly in mice via disruption of
            Mcph1-Chk1 signaling
  JOURNAL   J Clin Invest 121 (8), 3071-3087 (2011)
   PUBMED   21737879
REFERENCE   8  (bases 1 to 4362)
  AUTHORS   Pfaff,K.L., Straub,C.T., Chiang,K., Bear,D.M., Zhou,Y. and Zon,L.I.
  TITLE     The zebra fish cassiopeia mutant reveals that SIL is required for
            mitotic spindle organization
  JOURNAL   Mol Cell Biol 27 (16), 5887-5897 (2007)
   PUBMED   17576815
REFERENCE   9  (bases 1 to 4362)
  AUTHORS   Basto,R., Lau,J., Vinogradova,T., Gardiol,A., Woods,C.G.,
            Khodjakov,A. and Raff,J.W.
  TITLE     Flies without centrioles
  JOURNAL   Cell 125 (7), 1375-1386 (2006)
   PUBMED   16814722
REFERENCE   10 (bases 1 to 4362)
  AUTHORS   Peng,B., Sutherland,K.D., Sum,E.Y., Olayioye,M., Wittlin,S.,
            Tang,T.K., Lindeman,G.J. and Visvader,J.E.
  TITLE     CPAP is a novel stat5-interacting cofactor that augments
            stat5-mediated transcriptional activity
  JOURNAL   Mol Endocrinol 16 (9), 2019-2033 (2002)
   PUBMED   12198240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154837.2.
            
            On Mar 31, 2022 this sequence version replaced NM_001014996.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092399.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC154837.2         121166-121273       c
            109-607             AC154837.2         114097-114595       c
            608-731             AC154837.2         113381-113504       c
            732-995             AC154837.2         108001-108264       c
            996-1107            AC154837.2         104518-104629       c
            1108-1210           AC154837.2         103088-103190       c
            1211-2837           AC154837.2         101351-102977       c
            2838-2991           AC154837.2         98852-99005         c
            2992-3157           AC154837.2         92193-92358         c
            3158-3400           AC154837.2         84779-85021         c
            3401-3485           AC154837.2         84184-84268         c
            3486-3550           AC154837.2         82004-82068         c
            3551-3664           AC154837.2         81664-81777         c
            3665-3805           AC154837.2         79478-79618         c
            3806-3890           AC154837.2         79318-79402         c
            3891-4011           AC154837.2         79116-79236         c
            4012-4362           AC154837.2         76189-76539         c
FEATURES             Location/Qualifiers
     source          1..4362
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.28 cM"
     gene            1..4362
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /note="centrosome assembly and centriole elongation
                     protein"
                     /db_xref="GeneID:219103"
                     /db_xref="MGI:MGI:2684927"
     exon            1..108
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            109..607
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..4204
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CENP-J; centromere protein J; centrosomal P4.1-associated
                     protein"
                     /codon_start=1
                     /product="centrosomal P4.1-associated protein isoform 1"
                     /protein_id="NP_001014996.2"
                     /db_xref="CCDS:CCDS27150.1"
                     /db_xref="GeneID:219103"
                     /db_xref="MGI:MGI:2684927"
                     /translation="MFLMPTSSELNSGQNFLTQWMTSPSRAGVILNRGFPILEADDKQ
                     AATNVSTSFPAKATHFSNSFSISSEEDSFHEEQKLEAGGPYKPWSENPEAPPVFPSVR
                     KEPIASRQDAPGCQEDNNNDLTPHLESEFKEVANKNPLFKKLEQLKEIQQKKQEQLKR
                     QQLEQLQRLMEEQEKLLTMVSAQHAFPGTLLPDDQSQKHRSPGDLTLPPHSYSNPTQE
                     NSCASNVLPDEQSNFCRATQDSVLTSKNASDLFYESQYQEAHVKRNDLKEESPAHPSG
                     EGALPRWEKKMGRSQEGKDVNLQKCGDSSEVVNIDERPIKAAVREKQQTFEDYLEEQI
                     QLEERELRQKQLQEAEGPLLAKTKPKQPFLKRGEGLARFTNAKSKFQKGKESKLASTQ
                     SPSEDQPGSKVDRQHLQRKTALINKDLCAETPTVKKDSKARPKAGFASLRQKPKVTKT
                     NMRESLSPPGLKVQTGKKRDGQFRHQVKGERNAHASNKENVPACIKPWDAGCKMWSKT
                     QGRERLPLSTGPVGCVVSRSPIRETDRETESSLDFSLQKKLEIWEREKEKENLELDEF
                     LFLERAADEISFSSNSSFVLRILERDQQICDGHRLSSTPVKAVQQREAQQADPRGQSN
                     CSEIPRYGVAHENESECEAMLLSWGSGSPDGLRELSCKRSMKAFQTSTSEIQSQWDAR
                     DDGVANSDSSTESEEQHDITIKPSTEVGDRVFSNREDSPQVCDAKGPIRDTGAQEDKW
                     RDADLDLSDKECSSDESVIVESLNNKVLEPLRLPSSQAGSKIDFDDERSWTDLEENPY
                     EHGVIHREEAIYGTPQTQCHSKSEGCVLDKTIKRKIAPVKKGEDFKCDRRISPPPPSD
                     LMVKFFPSLKPKPKLDSHLENESKLNLSQDQPPEFMVCFIGDSVRSQVLREKVTELES
                     EIEKFKAENTSLAKLRIERESALEKLRKEIADFEQQKARELARIEEYRKEETRKLQKE
                     RKVFEKYTAAARTFPDKKEREEIQALKQQIADLQEDLKRKETKWSSTQSRLRSQIEML
                     VKENTDLREEIKVMERFRLDAWKRAEAMENSPKACQYMMATKKDESMNSSFQFQKSHV
                     SSGVQVEKYKKKYLPAQGNLSRRIKSAPPRDLGSSDKGQAALPREPLQQVNFPDLEYK
                     NKEEKEEEIQGEISHPDGKVEKIYKNGRRVVLFPNGTRKEVSADGKSVTVTFFNGDVK
                     QVMPDERVVYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHFPDGRKEITFPDQTIKTLF
                     ADGQEESIFPDGTIVRVQRDGNKIIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQ
                     ETKYTSGRVRVKDKDGNVLMDTEM"
     exon            608..731
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            732..995
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1107
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1210
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..2837
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2991
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            2992..3157
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..3400
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3485
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3550
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3664
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3805
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3890
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4011
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4362
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4313..4318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /note="hexamer: AATAAA"
     polyA_site      4362
                     /gene="Cpap"
                     /gene_synonym="4932437H03Rik; Cenpj; Gm81; LAP; LIP1;
                     Sas4"
                     /note="major polyA site"
ORIGIN      
        1 gctctggctg cagcgatggt tgtggcggct cattcgtaaa tgccgggcca gctaagtggt
       61 gactatcgct ggtcggagcg gtctgaacag ctgtttcttc gaagaacggt gttggaagtc
      121 aataggtgtt ctggattttc cagggcttaa atcgggtcat tagattaaaa tgttcctgat
      181 gccaacctct tcagaattaa acagtgggca gaatttccta acccagtgga tgaccagtcc
      241 ttctcgggct ggggtcatac taaatcgagg atttcctatt ttggaagcag atgataagca
      301 agcagctaca aatgtttcta cgagcttccc tgctaaagcc acccattttt caaatagctt
      361 cagtattagt agtgaagagg attcatttca tgaagaacag aagttggagg ctggaggacc
      421 ttataaacca tggtcagaaa accctgaagc tcctccggtc tttccttcag ttagaaagga
      481 gccaattgca tcacgtcagg atgccccggg atgccaggag gataacaaca atgatcttac
      541 gcctcatctc gagagtgaat tcaaagaagt ggctaataaa aacccacttt ttaaaaaact
      601 ggaacagctg aaagagatcc agcagaagaa gcaggagcag ctgaagaggc agcagctgga
      661 acagctgcag aggctcatgg aggagcaaga gaagctgctc accatggtgt ctgcacagca
      721 cgcgtttcca ggtacattac tgcctgatga tcagagccag aagcatcgct ctcccggaga
      781 tttaactctg ccaccacaca gctactcaaa tccaacccaa gaaaactcct gtgcttccaa
      841 cgttttaccc gatgaacaga gtaatttctg tagagccact caagattccg tattaacttc
      901 aaaaaatgct tcggatttgt tttacgagtc acagtatcaa gaagcacatg tgaaaagaaa
      961 tgatttaaag gaggaaagtc ctgcccaccc ttcaggggaa ggtgctttgc cacgttggga
     1021 aaagaagatg gggaggagtc aggaagggaa ggatgtgaac ttacaaaaat gtggagattc
     1081 ttcagaagtg gttaatattg atgaaaggcc catcaaagct gctgttagag agaagcagca
     1141 gacatttgag gactacttag aagagcagat ccaactggaa gagcgggagc ttagacagaa
     1201 gcagctgcag gaagcagaag gaccattgct agcgaaaacg aaacccaagc aaccattttt
     1261 aaaacgagga gaaggtttag ctaggtttac taatgctaaa tctaaatttc aaaaggggaa
     1321 agaaagtaag ctagcaagta cgcagagccc atcagaggac cagcctgggt ctaaagtaga
     1381 cagacagcat ttgcagagga aaactgctct cataaataaa gacctgtgtg cagaaacccc
     1441 cactgttaaa aaggacagta aagctagacc caaggctggc tttgcctcac tcaggcagaa
     1501 acccaaagtg accaagacca atatgagaga aagtctctcc ccaccaggac tgaaagtcca
     1561 gacggggaag aaacgtgatg gacagtttag acaccaggtc aaaggagaac gaaatgcaca
     1621 tgctagtaat aaggaaaatg tgcctgcatg cataaagccc tgggatgctg gttgcaagat
     1681 gtggagtaag acacagggga gagagagact tcctctttcc actggaccag ttggctgtgt
     1741 ggtctctagg agcccgatac gtgagacaga cagagaaaca gaatcttccc ttgatttttc
     1801 tcttcagaaa aaattagaga tttgggaacg agaaaaagaa aaggaaaact tggaattaga
     1861 tgaattttta tttttggaac gggctgctga tgaaatatca ttttctagta attcctcatt
     1921 tgtactgaga atcttagaaa gggaccagca gatctgcgac ggtcacaggc tgtcttctac
     1981 tcctgtcaaa gctgtacagc agcgtgaggc acagcaggca gatcctaggg gtcagagtaa
     2041 ctgcagtgag attccccgtt acggtgtcgc acatgagaac gagagtgaat gcgaggccat
     2101 gctcttgtct tggggttcag ggtcacctga tggtttgagg gaactgtcct gtaaacgtag
     2161 tatgaaagcc ttccaaacca gcacttctga gatccagagc caatgggatg caagggatga
     2221 tggcgttgcc aacagcgaca gtagcactga gtctgaggag cagcatgaca ttaccatcaa
     2281 accgtccacc gaggttgggg acagggtctt cagcaacaga gaggatagtc cacaagtctg
     2341 tgatgccaaa ggacctatta gggacaccgg ggctcaggaa gataaatgga gagacgcaga
     2401 cctggatctg tctgataaag agtgtagcag tgacgagtct gtcatagttg aaagcctgaa
     2461 caataaagta ttggaaccac tgagactgcc ctcctctcaa gctgggagta aaattgactt
     2521 cgatgatgaa agatcgtgga cagaccttga ggagaatcca tacgaacatg gtgttatcca
     2581 cagagaggaa gccatatatg gtacacccca gacacagtgc cacagtaaga gtgaagggtg
     2641 tgttctggac aaaacaataa aaaggaagat tgcaccagtc aagaagggag aagacttcaa
     2701 gtgtgacagg cgcataagcc ctcctcctcc atctgacttg atggtaaaat tcttcccttc
     2761 tttgaaacca aagccaaaat tagattcaca cttggaaaat gaatccaagt taaacctgag
     2821 tcaagatcaa ccaccagaat ttatggtctg ttttataggt gacagtgttc gatctcaggt
     2881 tttaagagag aaagttactg aattggaatc agaaatagaa aaatttaaag ctgagaacac
     2941 atctttagct aaacttcgta ttgaacgaga aagtgccttg gaaaaactga ggaaagaaat
     3001 tgctgacttt gagcaacaaa aagcaagaga gctggctcga atagaagagt atagaaagga
     3061 ggagacaagg aaactacaaa aggagcgcaa agtctttgag aagtacacag cagctgcaag
     3121 aacattccca gataaaaagg agcgcgaaga aatacaggcc ttgaaacagc aaatagcaga
     3181 tttacaggaa gacttgaaaa ggaaggaaac aaagtggtca agcacacaga gtcgcctcag
     3241 aagccagata gagatgctcg tcaaagagaa cacagacctc agggaagaga taaaagtaat
     3301 ggaaaggttc cgactggatg cctggaagag agcagaagct atggagaaca gtcccaaggc
     3361 ctgccagtac atgatggcca caaaaaagga tgagtccatg aactcatcat ttcaatttca
     3421 aaagagtcat gtttcttcag gagtccaggt agaaaaatat aagaaaaagt atttgccagc
     3481 acaaggaaat ctatctagaa gaatcaagtc tgcgcctcct cgtgatttag gcagctccga
     3541 taaaggacaa gctgccttgc ccagagagcc tcttcaacaa gtgaacttcc cagaccttga
     3601 atataaaaac aaagaggaaa aagaggaaga aattcaggga gaaatcagtc atcctgatgg
     3661 aaaggtagaa aaaatttata aaaatgggcg ccgggttgtt ctgtttccca atggaactcg
     3721 gaaagaagtg agtgcggatg ggaagagcgt caccgttaca tttttcaatg gtgatgtgaa
     3781 gcaggtcatg ccagatgaga gagtggtcta ctactatgct gctgcccaga ccacacacac
     3841 cacgtaccca gaaggacttg aagttttaca tttctcaagt ggacaaatag aaaagcattt
     3901 cccagatgga agaaaagaaa tcacatttcc tgaccagacc attaagactt tatttgctga
     3961 tggtcaagaa gagagcatct ttccagatgg cacaattgtc cgagtacaac gtgatggcaa
     4021 caagatcata gaatttaata atggccaaag ggagctccat actgcccagt tcaagagacg
     4081 agagtatccc gatgggactg ttaagactgt ctatgcaaat ggtcatcaag agacaaagta
     4141 cacatctggc cgagttagag tgaaggacaa agacggtaat gtgctaatgg acacagaaat
     4201 gtgaagatct tttgtgggat taatcatgaa gtaacactaa gtgctttttc tgttcagagt
     4261 atgtacatct cttatatgtt caattgttta atttatataa tgtgtgtgtc taaataaaaa
     4321 gattatgttt gaattttaaa attaaagttt taccatactg ca
//
