LOCUS       NM_145924               3692 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus centromere protein I (Cenpi), transcript variant 1,
            mRNA.
ACCESSION   NM_145924 XM_904578 XM_918889 XM_918906 XM_918912 XM_918920
VERSION     NM_145924.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3692)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK161473.1, AK043344.1 and
            AK085048.1.
            
            On Mar 24, 2015 this sequence version replaced NM_145924.2.
            
            Summary: This gene encodes a protein that may be constitutively
            associated with centromeres and might be involved in recruiting
            centromere protein A to the centromere for kinetochore assembly. A
            similar gene in human is involved in the response of gonadal
            tissues to follicle-stimulating hormone. Alternatively spliced
            transcript variants have been identified. [provided by RefSeq, Mar
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145200.1, AK161473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-920               AK161473.1         2-921
            921-921             AK043344.1         783-783
            922-3224            AK161473.1         923-3225
            3225-3692           AK085048.1         2244-2711
FEATURES             Location/Qualifiers
     source          1..3692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 56.08 cM"
     gene            1..3692
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /note="centromere protein I"
                     /db_xref="GeneID:102920"
                     /db_xref="MGI:MGI:2147897"
     exon            1..145
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..213
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..334
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..566
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..2590
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /note="FSH primary response protein 1;
                     follicle-stimulating hormone primary response protein"
                     /codon_start=1
                     /product="centromere protein I"
                     /protein_id="NP_666036.1"
                     /db_xref="CCDS:CCDS30393.1"
                     /db_xref="GeneID:102920"
                     /db_xref="MGI:MGI:2147897"
                     /translation="MATQRVTRNSQQQNRISQGSNSRQTSLLDWMVKDKSGNFKSVLK
                     ESSSVEDSTRTDDRTEGALQVAVGYFQKGPKKASLSKDKVLEKHLTTVENVALSNGLA
                     PEAIDILLNVALSGKFGNAVNSRILKCMIPESHISEDSVLKAVSWLCVDKCSGNTKVL
                     FYRWLVAMFDFIDHKKQISSLYGFFFASLQDDTLCPYVCHLLYLLTKRENVKPFRVRK
                     LLDLQAKMGMQPHLQALLSLYKFFAPTLISVSLPVRKKIFFNNSKNLWTSASLAVRLR
                     NQGAFPEPLNLPLRPTTGRSLKRKWNSHSVIPALNSANKEYGEKTASLFDYLSSERSL
                     PLEQLQRFPQLLESIHCLELPSQMCSVLNSPLLLHYINCVKDESILLRISYWLSQALQ
                     EECVWYNINNYEQEKEFINFLDLVIRVQCFLQEGFYSCEAFLYKSLPLWDGSSCRSQY
                     LQLLAWIPFSSFSEVKPLLSDHLAPLFFTSSIYFKCSVLQSLQELLQNWLLWLSTDAH
                     VQPTTDSPLETTLGGSMSSVSQLIEYTGWLCVVAMRLESSSTLLLHFILDFYEKVCDI
                     YINYDLPIVVLFPPVIFHSALLSLDATILNQLCYIMYRYRNNWTAAKKNRYLQKAKPE
                     FSLSSKICKEYNYYLTAMVCCLWTSRPFKAGVYTDPETIENTGGTQYKSTLNIVYHPS
                     LLSYAASFLLQESPEEMTEHLSSIQGKKWNWYLDYLYSEGFQGLKLFIKSSVHSSVPK
                     PEENTE"
     exon            567..704
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..823
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..931
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..980
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1027
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1117
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1246
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1408
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1529
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1621
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1739
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1804
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1899
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2035
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2160
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2209
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2428
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2470
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..3692
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3206..3211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /note="hexamer: AATAAA"
     polyA_site      3231
                     /gene="Cenpi"
                     /gene_synonym="CENP-I; Fshprh1"
                     /note="major polyA site"
ORIGIN      
        1 attcgagcca attagttttt ggctgaacta actcctctgc cgccgcgggc tcctccgagg
       61 cgcatgcgcg gggcggagcc cgcgcctttg aatctccagg cggcttttgg gctccagagg
      121 ctgtgtgctc gccgaggttc tctagggtga agagatgaac gtcattccat ctgtcccgat
      181 agatgtttcc cacttgaagc taaaacctga gaatctgccc gagagcatgt gctgccgaat
      241 ggggcatcca gtctgcctct aaatgagtat cttacacttt tacacagcct aggcctactg
      301 taggccagtc atctgctttc attgccaaag cctgaacgtg gatacagcga tggcaactca
      361 aagggttact agaaactccc agcaacaaaa cagaatttct caaggcagta atagccgtca
      421 aaccagtctc ttagactgga tggtgaaaga caaatcaggc aacttcaaga gtgtcttgaa
      481 agaaagcagt tcagtggaag attctacacg cactgatgat cgaactgaag gtgctctgca
      541 ggtagcagta ggatacttcc agaaaggtcc taagaaagct tcactaagta aagataaggt
      601 cttggaaaaa cacttgacaa ctgttgaaaa tgtggctttg agcaatggct tagctccaga
      661 ggcaattgat attttactga atgtggcact cagtggcaag tttgggaatg ctgtaaactc
      721 acggatattg aagtgcatga ttccagaaag tcacatatca gaagattccg tgcttaaagc
      781 agtatcctgg ctctgtgttg acaagtgttc tggtaatacc aaggtacttt tttatcgttg
      841 gttggttgcg atgtttgact ttattgatca taagaagcaa attagttctc tgtatggctt
      901 cttttttgct tcattgcaag atgatactct gtgcccgtac gtttgccatt tgttatattt
      961 actgaccaaa agggagaatg tcaaaccatt tcgtgtgaga aaattgctcg atctccaggc
     1021 caaaatggga atgcagcccc acctccaggc tttgttgtcg ctgtataagt tcttcgctcc
     1081 tactttgatt tctgtatctt tgcctgtaag gaagaagatc tttttcaata attcaaaaaa
     1141 tctgtggact tcagcttccc ttgctgtgag gctaaggaac cagggagctt ttccagaacc
     1201 tctaaacctt ccattacgcc caactacggg ccgttctcta aagaggaaat ggaattctca
     1261 ctcagttata ccagcactaa attctgctaa caaagaatat ggagagaaga cggcgagtct
     1321 gtttgattat ctcagcagtg aaagatcact tccactagaa cagcttcaac gtttccctca
     1381 gcttttagag agcatccatt gtttagagct cccttctcag atgtgctcag tgctaaacag
     1441 ccctctgcta cttcactata ttaattgtgt caaagatgag tcaatcttac tgaggatctc
     1501 ttattggttg agtcaagcat tacaagaaga atgtgtgtgg tataatataa ataattatga
     1561 acaagaaaag gaatttataa actttctgga cctggtcatc agggtacagt gcttcttaca
     1621 agagggattt tactcctgtg aggcattcct gtataaaagc ctgcctctct gggatggctc
     1681 ctcttgtcgg tcacagtacc ttcagcttct ggcctggatt ccattcagta gcttctctga
     1741 ggtgaagcca cttctttctg atcatctagc acctctcttc tttacatcaa gtatttattt
     1801 caagtgtagt gttcttcaaa gtctgcaaga attactgcag aattggctgc tttggctctc
     1861 tacggatgcg catgtgcagc ccacgacaga cagtcctctg gagacaactc tgggtggatc
     1921 catgagttct gtgtctcaat tgattgagta cacaggctgg ctgtgcgtgg ttgcaatgcg
     1981 cttggagagc agcagtacat tgttgttgca ctttattttg gacttctatg agaaggtgtg
     2041 tgatatatat ataaattatg accttccgat agtggtattg tttcctcctg tgatcttcca
     2101 ttctgcactc ctaagcctgg atgccaccat cttgaaccaa ctctgttaca ttatgtacag
     2161 gtatcgcaat aattggacag ctgcgaagaa aaaccgctat ttacagaagg ccaaaccaga
     2221 gttcagtctc agcagcaaga tctgtaaaga gtataattac tatttgacag ctatggtttg
     2281 ttgtctatgg acgtccagac catttaaagc aggagtgtac actgaccccg aaaccataga
     2341 aaatactgga ggaacacagt ataaaagcac cttaaatatt gtctaccatc cttctctact
     2401 gagctatgca gcttccttct tgctacagga gagcccagaa gaaatgacag aacacctgag
     2461 ctctattcag gggaagaaat ggaactggta tttggactat ttatattcag agggttttca
     2521 gggcttaaaa cttttcataa aaagcagtgt ccatagttct gtacccaaac cagaggaaaa
     2581 cacagagtga aaattggcat aaacaaacgc catgctggac tacatttctc actgctagag
     2641 aggctaagta gctcagcatg agtttccatt tcccaagccg actggcattt ttaaggagca
     2701 ctaaaagcct tctgtccata gctcaggaga gccttggggt tgactaactt aattttagta
     2761 ttcagatttt aaggttacca atgaaaaaca accccttcat catccaatcc tgccttcgct
     2821 gacatagaca tgaagagaca catctgcttt ctagtaggca atttgctttg cattttcgtc
     2881 tgctgtgtta gtggaaaaga acaagtaata tctgaagtta ctcctcagac atacttatgc
     2941 agaaccctct gcagtctctg aactcctggg gatattttgc ttttctaaga tactaataat
     3001 agaatgcagc acatgtgact cttaacagtc ccgggtagct catgcttccc ggggcctgta
     3061 ttggcagtaa gtttatgagg gaagggaggt gaaaagataa agaagttcca ttttattgat
     3121 ttgatttctt gaaagcacta tatttgaatg tttatgtgta tgtatgtatt tatgtatata
     3181 ttcagatttt aaattgctgg gcctaaataa acatcttcag cttcaggggt atttccgaat
     3241 tttttttttt taatttatac caggaaagat ccattttcac taaaaatttg ttctaaaatg
     3301 ttgtttcact actgaacaac ttctatttaa tacatctaca ttggtaataa cacctgactt
     3361 ttcagtggag actgtgaaag ccgaaaggga ctgaacagat gttctataag cttccagaga
     3421 ctacagatgc cagcatagac tactataccc agcaaaacta tgatcccagt ctccagcgag
     3481 agaaaaccat ttcacaagaa agcacattta agcaactcct gttcacccat ccatctctac
     3541 agatggcact agaagcaatt cttcaccctg aagagaagca tacaattgag aggacacaag
     3601 gagtaaatac ccctagagca cttagtcgaa atgggtgggg gtgcaggtcc cttacgacaa
     3661 caacaacaac aataaatgaa attaataagc ac
//
