LOCUS       NM_021886               1218 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus centromere protein H (Cenph), transcript variant 1,
            mRNA.
ACCESSION   NM_021886
VERSION     NM_021886.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1218)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1218)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1218)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 1218)
  AUTHORS   Zhang,T., Zhou,Y., Li,L., Wang,Z.B., Shen,W., Schatten,H. and
            Sun,Q.Y.
  TITLE     CenpH regulates meiotic G2/M transition by modulating the
            APC/CCdh1-cyclin B1 pathway in oocytes
  JOURNAL   Development 144 (2), 305-312 (2017)
   PUBMED   27993978
  REMARK    GeneRIF: A novel role of CenpH in regulating meiotic G2/M
            transition by acting via the APC/C(Cdh1)-cyclin B1 pathway.
REFERENCE   5  (bases 1 to 1218)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1218)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1218)
  AUTHORS   Fukagawa,T., Mikami,Y., Nishihashi,A., Regnier,V., Haraguchi,T.,
            Hiraoka,Y., Sugata,N., Todokoro,K., Brown,W. and Ikemura,T.
  TITLE     CENP-H, a constitutive centromere component, is required for
            centromere targeting of CENP-C in vertebrate cells
  JOURNAL   EMBO J 20 (16), 4603-4617 (2001)
   PUBMED   11500386
REFERENCE   8  (bases 1 to 1218)
  AUTHORS   Sugata,N., Li,S., Earnshaw,W.C., Yen,T.J., Yoda,K., Masumoto,H.,
            Munekata,E., Warburton,P.E. and Todokoro,K.
  TITLE     Human CENP-H multimers colocalize with CENP-A and CENP-C at active
            centromere--kinetochore complexes
  JOURNAL   Hum Mol Genet 9 (19), 2919-2926 (2000)
   PUBMED   11092768
REFERENCE   9  (bases 1 to 1218)
  AUTHORS   Lo,A.W., Longmuir,D.F., Fowler,K.J., Kalitsis,P. and Choo,K.H.
  TITLE     Assignment of the centromere protein H (Cenph) gene to mouse
            chromosome band 13D1 by in situ hybridization and interspecific
            backcross analyses
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 56-57 (2000)
   PUBMED   11060445
REFERENCE   10 (bases 1 to 1218)
  AUTHORS   Sugata,N., Munekata,E. and Todokoro,K.
  TITLE     Characterization of a novel kinetochore protein, CENP-H
  JOURNAL   J Biol Chem 274 (39), 27343-27346 (1999)
   PUBMED   10488063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112701.6.
            
            On Jan 10, 2022 this sequence version replaced NM_021886.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017634.1, AK006208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AC112701.6         66244-66428
            186-241             AC112701.6         69334-69389
            242-290             AC112701.6         70412-70460
            291-365             AC112701.6         70846-70920
            366-422             AC112701.6         75234-75290
            423-486             AC112701.6         77883-77946
            487-538             AC112701.6         78514-78565
            539-702             AC112701.6         80191-80354
            703-1218            AC112701.6         81921-82436
FEATURES             Location/Qualifiers
     source          1..1218
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..1218
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /note="centromere protein H"
                     /db_xref="GeneID:26886"
                     /db_xref="MGI:MGI:1349448"
     exon            1..185
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..795
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centromere autoantigen H"
                     /codon_start=1
                     /product="centromere protein H isoform 1"
                     /protein_id="NP_068686.1"
                     /db_xref="CCDS:CCDS26738.1"
                     /db_xref="GeneID:26886"
                     /db_xref="MGI:MGI:1349448"
                     /translation="MEEQPRERSEAGAEACEEKRGLSQAAEERIEDRISLLLRLRAQT
                     KQQLLEYKSMIDTNEEKTPEQIMQEKQIEVKIEELENEIEDVKSNIEMKSLALSRMKL
                     SVALRDNMENMGPENCVLTDDMKHILKLQKLIMKSQEESSELEKKLLDVRKKRLQLKQ
                     ASRSKLLEIQIEKNKQKEDVDKMENSEMIKTMKKKLQTEIKITTVVQHTFQGLILASK
                     TNWAEDPALRETVLQLEKDLNTL"
     exon            186..241
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            242..290
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            291..365
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            366..422
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            423..486
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            487..538
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            539..702
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1218
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /note="hexamer: AATAAA"
     regulatory      1187..1192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /note="hexamer: AATAAA"
     polyA_site      1197
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /note="major polyA site"
     polyA_site      1218
                     /gene="Cenph"
                     /gene_synonym="1700021I11Rik; 2410018A12Rik;
                     2610042E16Rik; 2810046K12Rik; CENP-H; ENP"
                     /note="major polyA site"
ORIGIN      
        1 aaaccaattt cgtggcggga agaactgctg ggttattttc tgtggcgttc aaacctgcgg
       61 gcctttgcaa tggaggagca gccgcgggag aggtctgagg ccggggctga ggcctgcgaa
      121 gagaagcggg gtctgtcgca ggccgcggag gagcgtatcg aggaccgtat cagcctgctg
      181 ctcaggctga gagctcagac aaaacagcag ctcttagaat ataagtccat gatcgacaca
      241 aatgaagaaa aaactccaga acagattatg caagaaaaac agatcgaagt taaaattgaa
      301 gagctggaga atgaaattga agatgtaaaa agtaatattg aaatgaaaag tcttgcactg
      361 agcaggatga aactttcagt tgcacttcgg gataacatgg agaacatggg acctgagaat
      421 tgtgtgctca cagatgacat gaagcacata ttaaagctac aaaagttaat aatgaagtcc
      481 caggaggagt cttcagaact ggagaaaaag ctgcttgatg tcagaaagaa gagactacaa
      541 ctaaagcaag cttcaagaag taagctttta gaaatacaaa tcgagaagaa caaacagaaa
      601 gaggatgttg acaagatgga gaattctgaa atgataaaga ccatgaaaaa aaaactacag
      661 acggagataa agatcactac agttgttcaa catacattcc agggccttat tttggcgagt
      721 aaaaccaact gggcagagga ccctgccctc agagagacag tgctgcagct ggagaaggac
      781 ctcaacacgc tatgagaaga atcccgcagt ttaaaattgg ctttgtgacc aatctgtcat
      841 ttaaatagcc gagttcatgg gaaatgtaaa tggtgttttt ggaaccactc tgctgcttca
      901 gttttggggt tttgagttga tgtgacacag aacctttcgt tttaattgtg ctcattaaag
      961 tggcatcctc tgcaggagtc tggccgtgga ggccttggaa agaagcgggc ggtcctgctg
     1021 ccaccggatg tgcatctcct tgccaacgtt tccccgtgac cccttttgga atatgcttat
     1081 gcatctgcac gctgtgcaaa gttgtgtgtg ttaagtaagg ttgtgtcttc ttttctcctt
     1141 ctctacttag catgcatttt acttttataa cttaaggaat aaaaagaata aacattactg
     1201 cattattaac taaaaaaa
//
