LOCUS       NM_001081363           11130 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus centromere protein F (Cenpf), mRNA.
ACCESSION   NM_001081363 XM_899897
VERSION     NM_001081363.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11130)
  AUTHORS   Sun,B., Reynolds,K., Saha,S.K., Zhang,S., McMahon,M. and Zhou,C.J.
  TITLE     Ezh2-dependent methylation in oral epithelia promotes secondary
            palatogenesis
  JOURNAL   Birth Defects Res 115 (19), 1851-1865 (2023)
   PUBMED   37435868
REFERENCE   2  (bases 1 to 11130)
  AUTHORS   Zhou,C.J., Wang,X.Y., Dong,Y.H., Wang,D.H., Han,Z., Zhang,X.J.,
            Sun,Q.Y., Carroll,J. and Liang,C.G.
  TITLE     CENP-F-dependent DRP1 function regulates APC/C activity during
            oocyte meiosis I
  JOURNAL   Nat Commun 13 (1), 7732 (2022)
   PUBMED   36513638
  REMARK    GeneRIF: CENP-F-dependent DRP1 function regulates APC/C activity
            during oocyte meiosis I.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11130)
  AUTHORS   Lee,D.R., Rhodes,C., Mitra,A., Zhang,Y., Maric,D., Dale,R.K. and
            Petros,T.J.
  TITLE     Transcriptional heterogeneity of ventricular zone cells in the
            ganglionic eminences of the mouse forebrain
  JOURNAL   Elife 11, e71864 (2022)
   PUBMED   35175194
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11130)
  AUTHORS   Li,X., Li,Y., Xu,A., Zhou,D., Zhang,B., Qi,S., Chen,Z., Wang,X.,
            Ou,X., Cao,B., Qu,C. and Huang,J.
  TITLE     Apoptosis-induced translocation of centromere protein F in its
            corresponding autoantibody production in hepatocellular carcinoma
  JOURNAL   Oncoimmunology 10 (1), 1992104 (2021)
   PUBMED   34676150
  REMARK    GeneRIF: Apoptosis-induced translocation of centromere protein F in
            its corresponding autoantibody production in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11130)
  AUTHORS   He,H., Chen,J., Zhao,J., Zhang,P., Qiao,Y., Wan,H., Wang,J.,
            Mei,M., Bao,S. and Li,Q.
  TITLE     PRMT7 targets of Foxm1 controls alveolar myofibroblast
            proliferation and differentiation during alveologenesis
  JOURNAL   Cell Death Dis 12 (9), 841 (2021)
   PUBMED   34497269
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11130)
  AUTHORS   Goodwin,R.L., Pabon-Pena,L.M., Foster,G.C. and Bader,D.
  TITLE     The cloning and analysis of LEK1 identifies variations in the
            LEK/centromere protein F/mitosin gene family
  JOURNAL   J Biol Chem 274 (26), 18597-18604 (1999)
   PUBMED   10373470
REFERENCE   7  (bases 1 to 11130)
  AUTHORS   Fowler,K.J., Saffery,R., Irvine,D.V., Trowell,H.E. and Choo,K.H.
  TITLE     Mouse centromere protein F (Cenpf) gene maps to the distal region
            of chromosome 1 by interspecific backcross analysis
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 180-181 (1998)
   PUBMED   9858811
REFERENCE   8  (bases 1 to 11130)
  AUTHORS   Zhu,X., Mancini,M.A., Chang,K.H., Liu,C.Y., Chen,C.F., Shan,B.,
            Jones,D., Yang-Feng,T.L. and Lee,W.H.
  TITLE     Characterization of a novel 350-kilodalton nuclear phosphoprotein
            that is specifically involved in mitotic-phase progression
  JOURNAL   Mol Cell Biol 15 (9), 5017-5029 (1995)
   PUBMED   7651420
REFERENCE   9  (bases 1 to 11130)
  AUTHORS   Zhu,X., Chang,K.H., He,D., Mancini,M.A., Brinkley,W.R. and Lee,W.H.
  TITLE     The C terminus of mitosin is essential for its nuclear
            localization, centromere/kinetochore targeting, and dimerization
  JOURNAL   J Biol Chem 270 (33), 19545-19550 (1995)
   PUBMED   7642639
REFERENCE   10 (bases 1 to 11130)
  AUTHORS   Liao,H., Winkfein,R.J., Mack,G., Rattner,J.B. and Yen,T.J.
  TITLE     CENP-F is a protein of the nuclear matrix that assembles onto
            kinetochores at late G2 and is rapidly degraded after mitosis
  JOURNAL   J Cell Biol 130 (3), 507-518 (1995)
   PUBMED   7542657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140679.4.
            
            On Jun 6, 2008 this sequence version replaced NM_001081363.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ642022.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC140679.4         12264-12374
            112-305             AC140679.4         15212-15405
            306-502             AC140679.4         16386-16582
            503-609             AC140679.4         17399-17505
            610-701             AC140679.4         17898-17989
            702-987             AC140679.4         19844-20129
            988-1190            AC140679.4         21209-21411
            1191-1316           AC140679.4         27716-27841
            1317-1445           AC140679.4         29174-29302
            1446-1568           AC140679.4         31712-31834
            1569-1704           AC140679.4         38218-38353
            1705-5132           AC140679.4         40278-43705
            5133-7964           AC140679.4         45258-48089
            7965-8117           AC140679.4         49050-49202
            8118-8277           AC140679.4         49629-49788
            8278-8754           AC140679.4         51263-51739
            8755-8933           AC140679.4         53370-53548
            8934-11130          AC140679.4         57548-59744
FEATURES             Location/Qualifiers
     source          1..11130
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 95.03 cM"
     gene            1..11130
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="centromere protein F"
                     /db_xref="GeneID:108000"
                     /db_xref="MGI:MGI:1313302"
     exon            1..111
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            112..305
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..9137
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="leucine, glutamic acid, lysine family 1 protein;
                     centromere autoantigen F"
                     /codon_start=1
                     /product="centromere protein F"
                     /protein_id="NP_001074832.2"
                     /db_xref="CCDS:CCDS35820.2"
                     /db_xref="GeneID:108000"
                     /db_xref="MGI:MGI:1313302"
                     /translation="MSWALEEWKEGLPSRALQKIQELEGQLEKLKKEKQQRQFQLDSL
                     EAALQKQKQKVEDGKTEGADLKRENQRLMEICEHLEKSRQKLSHELQVKESQVNLQES
                     QLSSCKKQIEKLEQELKRCKSEFERSQQVAQSADVSLNPCSTPQKLFATPLTPSSTYE
                     DLKEKYNKEVEERKRLEEEVKALHAKKVSLPVSQATMNHRDIARHQASSSVFPWQQEN
                     TPSRLSSDALKTPLRRDGSAAHFLGEEVSPNKSSMKTGRGDCSSLPGEPHSAQLLHQA
                     KAQNQDLKSKMTELELRLQGQEKEMRSQVNKCQDLQLQLEKTKVELIEKERILNKTRD
                     EVVRSTAQYDQAAAKCTTLEQKLKTLTEELSCHRQNAESAKRSLEQRIKEKEKELQEE
                     LSRQHQSFQALDSEYTQMKTRLTQELQQVKHLHSTLQLELEKVTSVKQQLERNLEEIR
                     LKLSRAEQALQASQVAENELRRSSEEMKKENSLIRSQSEQRTREVCHLEEELGKVKVS
                     LSKSQNFAEEMKAKNTSQEIMLRDLQEKLNQQENSLTLEKLKLALADLERQRNCSQDL
                     LKKREHHIDQLNNKLNKIEKEFETLLSALELKKKECEELKEEKNQISFWKIDSEKLIN
                     QIESEKEILLGKINHLETSLKTQQVSPDSNERIRTLEMERENFTVEIKNLQSMLDSKM
                     VEIKTQKQAYLELQQKSESSDQKHQKEIENMCLKANKLTGQVESLECKLQLLSSEVVT
                     KDQQYQDLRMEYETLRDLLKSRGSSLVTNEDNQRSSEDNQRSSEDNQRGSLAFEQQPA
                     VSDSFANVMGRKGSINSERSDCSVDGGRSPEHIAILQNRVTSLESSLESQNQMNSDLQ
                     MRCEELLQIKGEVEENLSKAEQIHQNFVAETNQCISKLQEDAAVHQNIVAETLATLES
                     KEKELQLLKEKLEAQQTEVQKLNKNNCLLEGTLKELQLLSDTLSSEKKEMNSIISLSK
                     KNIEELTQANEALKEVNEALEQEKMNLLQKHEKITSCIAEQERSIAELSDQYKQERLQ
                     LLQRCEETEAVLEDLRGNYKTAQENNAKLECMLSECTALCENRKNELEQLKETFAKEQ
                     QEFLTKLAFAEEQNRKLMLELEIEQQTVRSEITNTNKHSMSATDGLRQECLTLNEEQN
                     EQQNEVSNLTHENEQLMELTQTKHDSYLAVEPVENSVKATEDEIGKSSSQYQMDIDTK
                     DISLDSYKAQLVHLEALVRILEVQLDQSEEENKKLHLELQTIREELETKSSQDPQSQA
                     RTGLKDCDTAEEKYVSMLQELSASQNENAHLQCSLQTAVNKLNELGKMCDVLRVEKLQ
                     LESELNDSRTECITATSQMTAEVEKLVSEMKMLNHESALSQNELMKDTSGGEFHDKAN
                     HSSVFLTPLDSSNFCEQMTLSSKEVRVHFAELQEKFSCLQSEHKILHDQHCEVSSKMS
                     ALRSYVDTLKAENSALSMSLRTLQGDLVKEGEPAAEGGHGLPLSFCGADSPSLTNFGE
                     TSFYKDVLEQTGDTCHLSLEGNASANSCDLDEEFSSSLEEETLTEKESPPAPGRTVEG
                     LEVLCQVYLQSLKNLEEKTESQRIMKNKEIEKLEQLLSSERKELSCLRKQYLSEKEQW
                     QQKLTSVTLEMESKLAEEKQQTKTLSLELEVARLQLQELDLSSRSLLGTDLESVVRCQ
                     NDNYDIKESEVYISETTEKTPKQDTDQTCDKDIQQDLGLETSVTESETTRLTGEGCEE
                     QPPKTNCEAPAEDKTQDCSECISELCSSSNVLVPMDVLEDQGSIQNLQLQKDTLNENL
                     RLLPEVEDWDKKVESLLNEIMEADSKLSLQEVQLKMKIATCIQLEKIVKDLRKEKADL
                     SEKLESLPCNQEVCLRVERSEEDLGFNLDMGANELLSKSTKDNATNTEDNYKEKFLDM
                     ERELTRIKSEKANIEHHILSVETNLEVVQAEKLCLERDTESKQKVIIDLKEELFTVIS
                     ERNRLREELDNVSKESKALDQMSKKMKEKIEELESHQRESLRHIGAVESEVKDKADLI
                     QTLSFNVGELTKDKAHLQEQLQNLQNDSQELSLAIGELEIQIGQLNKEKESLVKESQN
                     FQIKLTESECEKQTISKALEVALKEKGEFAVQLSSAQEEVHQLRRGIEKLSVRIEADE
                     KKHLSAVAKLKESQRESDSLKDTVETLERELERSEENQELAILDSENLKAEVETLKAQ
                     KDEMTKSLRIFELDLVTVRTERENLAKQLQEKQSRVSELDERCSSLRRLLEEKEQARV
                     QMEEDSKSAMLMLQMQLKELREEVAALCNDQETLKAQEQSLDQPGEEVHHLKSSIRKL
                     KVHIDADEKKHQNILEQLKESKHHADLLKDRVENLEQELILSEKNMIFQAEKSKAEIQ
                     TLKSEIQRMAQNLQDLQLELISTRSENENLMKELKKEQERVSDLETINSSIENLLKDK
                     EQEKVQMKEEAKITVEMLQTQLKELNETVVSLCNDQEVSKTKEQNLGSQVQTLELEKA
                     QLLQDLGEAKNKYIIFQSSVNALTQEVEAGKQKLEKGEKEIRTLKEQLKSQEQLVCKL
                     AQVEGEQQLWQKQKLELRNVTMALEQKVQVLQSENNTLQSTYEALQNSHKSLESELGL
                     IKLEKVALVERVSTISGKEAELQRELRDMLQKTTQLSEDYNKEKNRLTEEVEVLREEL
                     QNTKAAHLKSVNQLEKELQRAQGKIKLMLKSCRQLEGEKEMLQKELSQLEAAQQQRAG
                     SLVDSNVDEVMTENKALKETLEEKVKEADKYLDKYCSLLISHEELEKAKEILEIEVAR
                     LKSRQSRQDLQSSPLLNSSIPGPSPNTSVSEMKSASGQNKASGKRQRSSGIWEHGKRA
                     APSTAETFSKKSRKSDSKSTRPAEHEQETEFEPEGLPEVVKKGFADIPTGKTSPYILR
                     RTTMATRTSPRFATQKLVGSSPSLGKENVVESSKPTAGGSRSQKVKVVQESSADSHTA
                     FQELPAKSLTASNIPGRNSTESPREGLRAKRAYPASSPAAGPDPTNNENCRVQ"
     exon            306..502
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            503..609
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            610..701
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            702..987
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1190
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1316
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1445
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1568
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1704
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..5132
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            5133..7964
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            7965..8117
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            8118..8277
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            8278..8754
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            8755..8933
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     exon            8934..11130
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9735..9740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="hexamer: ATTAAA"
     polyA_site      9755
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="major polyA site"
     regulatory      9782..9787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="hexamer: TATAAA"
     polyA_site      9803
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
     regulatory      9841..9846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="hexamer: AGTAAA"
     polyA_site      9863
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
     regulatory      9980..9985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="hexamer: ATTAAA"
     polyA_site      10002
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
     regulatory      10105..10110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="hexamer: AATAAA"
     polyA_site      10133
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
     regulatory      10749..10754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
                     /note="hexamer: ATTAAA"
     polyA_site      10769
                     /gene="Cenpf"
                     /gene_synonym="6530404A22Rik; CENF; Lek1; mitosin;
                     PRO1779"
ORIGIN      
        1 agtttgaatc gctcgtgctg gtcggggagg aacggtgcgc tgtgtgagga gctcggcggt
       61 gaggaactcg gggctcgcag agcccggagc caggttctgt gaggagctca gtttacttct
      121 aaatgcttta aaaataaaac aagatgagct gggccctgga agaatggaag gaaggtctcc
      181 cctccagagc tcttcagaag atccaagagc ttgaaggaca gctggagaag ctgaagaagg
      241 agaaacaaca gaggcagttc cagctggact ctctcgaagc tgcgctgcag aagcagaagc
      301 agaaggttga agacggaaag actgagggtg cagacctgaa aagggaaaat caaaggttga
      361 tggagatatg cgaacatttg gagaagtcaa ggcagaagct gtctcatgaa cttcaagtta
      421 aggagtcaca agtgaatctc caagagagcc aactgagctc atgcaaaaag caaatagaaa
      481 aactggaaca ggaacttaag cggtgtaaat ctgaatttga aagaagccaa caagttgcac
      541 aatcggcaga tgtttctctg aatccatgca gtacaccaca gaaactcttt gcaactccac
      601 tcacaccgag ttccacatac gaagatctga aagaaaaata taataaagaa gttgaagaac
      661 ggaagaggtt agaggaagag gttaaagctt tgcatgcaaa aaaagtgagc ctgcctgttt
      721 cccaagccac catgaaccac cgggacattg cgagacatca ggcttcctca tcagtgtttc
      781 cttggcaaca ggaaaatacc ccaagtcgcc tttcatcgga tgctctgaaa accccactga
      841 ggagagacgg ctctgctgct cactttttgg gggaagaagt gagtcctaac aaatcaagta
      901 tgaagacagg gagaggagac tgcagcagcc tccctggtga gcctcacagc gctcagcttt
      961 tgcaccaggc caaagcccag aatcaagacc taaaaagcaa gatgactgag ttagaactac
     1021 gcctgcaagg gcaagaaaag gaaatgagaa gccaagtgaa taaatgtcaa gacttacagc
     1081 tacagctgga gaagacgaaa gtggaattga ttgaaaagga gagaattttg aataaaacca
     1141 gagatgaagt agtgagaagc acagcacagt atgaccaggc cgcagccaag tgtactacct
     1201 tggaacaaaa gctgaaaact ttgactgagg agttgagttg tcaccgacag aacgcagaga
     1261 gtgctaaacg ttctctggaa cagaggatta aggagaaaga aaaggagctt caagaggagc
     1321 tgtcccgaca gcatcaatct ttccaagctc tggacagtga gtacactcag atgaaaacca
     1381 gacttaccca ggagttacag caagtcaagc atttgcacag caccctccag ctggaactgg
     1441 agaaggtcac atcagtgaag cagcagttag aaaggaattt ggaagaaatt aggcttaagt
     1501 tgagcagagc agaacaagct cttcaggcaa gtcaggtcgc agaaaacgag ctgaggagaa
     1561 gcagtgagga aatgaagaag gagaacagtc tcattaggag tcagtctgag cagaggacca
     1621 gagaagtctg ccacctggag gaagaacttg gtaaagtcaa agtgtctttg agtaagagcc
     1681 agaattttgc agaagaaatg aaggctaaga atacctctca ggaaatcatg ttacgagatc
     1741 ttcaggaaaa actaaatcag caagaaaact cactaacttt agagaagctg aaacttgccc
     1801 tagctgatct ggaaagacag cgaaactgtt ctcaagatct cttgaagaaa agggaacatc
     1861 acattgatca actgaataat aagttaaata agatagagaa agagtttgaa actttgctga
     1921 gtgctttgga attaaaaaag aaagaatgtg aagaattgaa agaagagaaa aatcagattt
     1981 ctttttggaa aattgatagt gaaaaactca taaatcagat agaatcagaa aaagaaatct
     2041 tattgggtaa aattaaccac ttagagacca gcctcaagac acaacaagta agtcctgact
     2101 ctaatgagag aataagaaca ctggagatgg aaagagaaaa ctttactgtg gagattaaaa
     2161 accttcaaag tatgttagac agcaagatgg tagagatcaa gacacagaaa caagcttact
     2221 tggaactgca gcagaaatcc gaatcctcgg accaaaagca tcagaaggag atagagaata
     2281 tgtgcttgaa agcaaataag ctcactgggc aagttgaaag tttggaatgt aagcttcagt
     2341 tattgtcaag tgaagtagtg accaaagacc agcagtacca agacttgcgt atggaatatg
     2401 agacactgag ggatttgctc aagtccagag gatcttctct ggtgacaaat gaggataatc
     2461 agcgaagttc tgaggataat cagagaagtt ctgaggataa tcagagaggc tctttggctt
     2521 ttgaacagca gcctgcagtg agtgattcct ttgcaaatgt aatggggaga aaaggaagca
     2581 taaattcaga aaggagtgac tgctctgtag atgggggccg aagtccagaa catatagcca
     2641 tcttacaaaa tagagtcact tcacttgaaa gttccttgga gtctcaaaac cagatgaatt
     2701 cagatttgca aatgcggtgt gaagagttgc tacaaatcaa aggggaagta gaagaaaacc
     2761 tcagtaaagc agagcagatt catcagaatt ttgtggctga aacaaatcaa tgtattagta
     2821 aattgcagga agatgctgca gttcatcaga atattgttgc tgagacttta gcaacccttg
     2881 agagtaagga aaaagagtta cagcttttga aagaaaaatt agaagctcag caaacagagg
     2941 ttcaaaagtt aaataagaat aactgtcttc ttgaaggtac tctgaaggag ctacagcttt
     3001 tatctgacac tctgagctca gagaagaagg aaatgaattc tatcatctca ttaagtaaaa
     3061 aaaacattga agagttaacc caagcaaacg aggctctcaa ggaagttaat gaggccttag
     3121 agcaggagaa aatgaattta ctccaaaagc atgagaagat tacaagctgt atagcagaac
     3181 aagagagaag cattgcagag ctgtctgatc agtacaagca agaaagactt caattattac
     3241 aacggtgtga agaaacagaa gctgtgttgg aagatctcag gggaaactac aaaacagcac
     3301 aagaaaacaa tgctaagtta gaatgcatgc tcagcgagtg cactgctctt tgtgaaaata
     3361 gaaaaaatga actggagcag ttaaaggaaa catttgcaaa ggaacagcaa gaattcttaa
     3421 caaaattagc tttcgctgaa gagcaaaaca ggaaactaat gctagagttg gagatagagc
     3481 aacaaactgt gagatccgag attacaaaca ccaacaagca ttccatgagt gcgactgatg
     3541 gcttaaggca agaatgcttg actttaaacg aagagcaaaa tgagcagcaa aacgaagtta
     3601 gcaacttaac acatgagaat gagcaactga tggagttaac acagaccaaa catgattctt
     3661 atctcgcagt agagccagtt gagaactctg taaaagcaac cgaagatgag ataggtaaga
     3721 gtagttccca gtaccagatg gatatcgaca ctaaagacat ttctctagat agttataagg
     3781 cacagctggt acatctagaa gctttggtaa gaattctgga agtacagctt gaccaaagtg
     3841 aggaggagaa caagaagctg catctggaat tacagacgat tagagaggag ctagaaacca
     3901 agagttcaca ggacccccag tcacaggcaa ggactgggct taaagactgt gacacagcag
     3961 aagaaaagta tgtgtccatg ctacaggagt tgtcagcaag tcaaaacgag aatgcacact
     4021 tacagtgctc tctacagaca gcagtgaaca aactgaatga gctagggaaa atgtgtgacg
     4081 tattgagagt tgaaaagtta cagctagagt ctgagctgaa tgactcacgg acagagtgta
     4141 tcacggcaac tagtcagatg acggcagagg tcgagaagct agtgagtgaa atgaaaatgc
     4201 taaaccacga gagtgctctg tcccagaatg agctgatgaa ggacacctca ggtggtgaat
     4261 ttcatgataa agcaaaccac agttctgtgt tcttgactcc tttggacagt agcaatttct
     4321 gtgaacagat gaccttgtca agcaaagagg tccgagtgca ctttgctgaa ttacaggaga
     4381 aattctcctg tttacaaagt gaacacaaaa ttttacatga tcagcactgt gaggtgagct
     4441 ctaagatgtc agcactgcgt tcctacgtgg acacattaaa agctgaaaat tctgccttgt
     4501 caatgagtct gagaaccttg cagggtgact tggtaaagga gggggagcct gcagctgagg
     4561 gtgggcatgg tctgccactg tcgttctgtg gggcagacag cccgtctctg acaaattttg
     4621 gagaaacgtc cttttacaaa gacgttttag aacaaactgg agacacatgt catctaagtt
     4681 tagaagggaa cgcttcagca aattcttgtg acttggatga agagttctcc agcagtctgg
     4741 aggaggagac tctgactgag aaggaaagcc cacctgcccc tgggaggact gttgagggac
     4801 ttgaagtcct atgccaggtg tacttgcagt ccctcaagaa tctagaggag aaaactgaga
     4861 gccaaaggat tatgaaaaat aaagaaattg aaaagcttga gcagttactg agttctgaga
     4921 ggaaagagct aagctgcctt aggaagcagt atttgtcaga aaaggagcaa tggcagcaga
     4981 agctaacaag tgtcactttg gaaatggagt ccaagttagc agaggagaag cagcagacca
     5041 agactctgtc ccttgaactt gaggtagcac gacttcagtt acaggagctg gacctgagct
     5101 ccaggtcttt gcttggcact gacttggaaa gtgttgttcg gtgccaaaac gataattatg
     5161 atataaaaga atcagaagta tatatttcag agactacaga gaaaacacca aagcaggaca
     5221 ctgaccaaac ttgtgataaa gatattcagc aggaccttgg tctggaaact tcagtcactg
     5281 agagtgagac taccaggctc acaggagagg ggtgtgaaga gcagcctccg aagaccaatt
     5341 gtgaggcacc agcggaggac aaaacccagg actgctcaga atgcatttct gaattgtgtt
     5401 ctagttccaa tgttttggtg cccatggatg ttctggaaga tcaggggtct atccagaatc
     5461 tccagttgca gaaagacacc ttaaatgaga atttgagatt acttcctgaa gtagaggact
     5521 gggacaaaaa agttgaaagt ttgctaaatg aaattatgga ggcagattca aaactgagtt
     5581 tacaggaagt acagctcaag atgaagattg caacatgcat acaattggaa aaaatagtca
     5641 aggacctcag aaaggaaaaa gctgacttaa gtgaaaagtt ggaatccctt ccatgtaacc
     5701 aggaggtatg tctgagagta gaaaggtcag aagaagatct tggttttaat ttagatatgg
     5761 gagcaaatga gttgttaagt aaatctacta aagataatgc aaccaacaca gaagacaatt
     5821 ataaggagaa gtttcttgat atggaaagag aactgaccag aattaagtct gagaaagcta
     5881 atattgagca tcacatccta tctgtggaaa ctaacttaga ggtggttcaa gcagagaagc
     5941 tctgtttgga aagagacact gaaagtaagc aaaaggttat tattgacctt aaagaagaac
     6001 tatttacagt tataagtgag agaaacagac ttcgggaaga attagataat gtgtcaaaag
     6061 aaagcaaagc actggatcag atgtctaaaa agatgaaaga gaaaatagaa gagctggagt
     6121 ctcaccaaag ggagagcctc cgtcacattg gggcagtaga gtctgaggtc aaggacaaag
     6181 cagatcttat tcagactctg tcctttaatg tgggtgagct aacaaaagac aaagctcatc
     6241 tccaggagca gctgcagaat ttgcagaatg actcacaaga attatctttg gcgattggtg
     6301 agctggaaat acaaattgga caactgaata aagagaaaga atcactggtc aaggagtctc
     6361 agaacttcca gatcaagctg actgagtcag agtgtgaaaa gcagacgatc tctaaggcct
     6421 tggaggtggc actcaaggag aaaggtgagt ttgcagtgca gctgagctca gcccaggagg
     6481 aggtgcatca gctgagacga ggcattgaga aactgagcgt ccgcattgag gccgatgaga
     6541 agaagcacct cagtgctgtg gcgaagctga aagaaagcca gcgtgaaagc gactcattga
     6601 aggatacagt ggagactctg gagcgggaac tggagaggtc agaagaaaac caagagctgg
     6661 caattcttga ttctgagaat ttgaaagcag aggtggagac ccttaaggca caaaaggatg
     6721 aaatgaccaa aagcctgaga attttcgaat tagaccttgt tacagttagg actgaaagag
     6781 aaaatctagc aaagcagcta caagagaaac aaagtcgagt gtcagaatta gatgaacggt
     6841 gctcttcctt gagaagactg ttggaagaga aggagcaagc aagagtacag atggaagaag
     6901 actctaagtc tgcaatgctg atgcttcaga tgcagttaaa agaactcagg gaggaagtgg
     6961 cagccttgtg taatgaccaa gaaaccttga aggcccaaga acagagtcta gaccaaccag
     7021 gggaggaagt gcatcatttg aaaagtagca ttcgaaagct caaagttcac atagatgctg
     7081 atgaaaagaa gcatcaaaac atcctagaac aactgaagga aagtaagcac catgcagact
     7141 tgcttaagga ccgagttgag aaccttgaac aagaattgat actatcagag aaaaacatga
     7201 ttttccaagc tgaaaagtcc aaagcagaga tacagacttt aaaatcagaa attcaaagaa
     7261 tggcccaaaa cctccaagac ttgcagttag aacttattag tacaaggtca gaaaatgaaa
     7321 atctcatgaa agaattaaaa aaagagcaag agcgagtatc tgacttagaa acaataaatt
     7381 cttctattga aaacttactg aaagataaag agcaagaaaa agtacagatg aaagaggaag
     7441 ccaaaataac agtggagatg cttcaaactc aattaaagga gctaaacgag acagtggttt
     7501 ccttgtgcaa tgaccaagag gtctctaaga ccaaagaaca gaatctgggt agtcaagtac
     7561 aaactcttga acttgagaag gctcagctgc tacaggacct tggtgaggcc aagaataaat
     7621 atattatttt tcagtcatct gtaaatgccc tcactcaaga agtagaagct ggcaaacaga
     7681 aactagagaa gggggagaaa gagatcagga cactgaaaga gcaacttaaa agtcaggagc
     7741 agcttgtgtg taaacttgcc caagtggaag gagagcagca actctggcag aagcagaaac
     7801 tagagctgag aaatgtgact atggcactgg agcagaaggt ccaagtgctg caatctgaaa
     7861 acaacacgtt gcagagcacc tatgaagcac tgcagaattc ccacaagagt ttagagagtg
     7921 aacttggatt gataaagttg gagaaagtag cgcttgttga aagagttagc acaatatctg
     7981 ggaaggaagc agagctgcag agggagctgc gagatatgct acagaaaaca acacagctga
     8041 gcgaagacta caataaagag aaaaacaggc taacagaaga agtggaagtg ctgcgtgaag
     8101 aactgcagaa caccaaagca gcgcacctga aatctgtgaa tcaacttgag aaggaacttc
     8161 agcgtgctca ggggaaaata aagttgatgc tcaaatcctg tagacagctg gaaggagaaa
     8221 aggagatgct gcagaaggag ctctcccagc ttgaagctgc acagcagcag agagcaggtt
     8281 ctcttgtaga cagtaacgta gatgaagtaa tgactgagaa caaagcgctg aaagagactc
     8341 tggaagaaaa agtcaaggaa gcagataagt acttggataa gtactgttcc ctgctgataa
     8401 gccacgagga gctcgagaaa gccaaggaga tattagaaat agaagttgct cggctgaagt
     8461 cacggcagtc cagacaggat ctccagagtt ctcctttgct taattcttcc attccaggac
     8521 cgtctccaaa tacttctgtt agtgagatga agtcagcatc tggccaaaat aaagcttcag
     8581 gcaagaggca aaggtccagt gggatttggg agcatggtaa acgggcagca ccttctacag
     8641 cagagacatt ttctaagaaa agcaggaagt cggacagtaa gagcactcgc cctgctgagc
     8701 acgagcagga aaccgagttt gagccagaag gcctcccaga agtcgttaaa aaagggtttg
     8761 ctgacatccc aactggaaag acaagcccat atatccttcg gagaacaacc atggcaacca
     8821 ggaccagccc ccgctttgct acacagaagt tagtgggatc ttccccatct ctgggcaaag
     8881 aaaatgttgt agagtcctcc aaaccaacag ctggtggcag cagatcacaa aaggtcaagg
     8941 ttgttcagga gagctcagcg gattcacaca ctgccttcca agaactccca gcaaaatctc
     9001 tcacagccag taatattcct gggagaaact ctacagagag ccccagggag ggcctgaggg
     9061 ccaagcgggc ctaccctgcc tccagcccag ctgctgggcc tgatcccacg aacaacgaaa
     9121 actgccgggt ccagtgaagt gtccactcag ggttctggaa ggtggcatta ctcaaaggag
     9181 cctgcctgtg gggacttgtc ttgagccaag gacacattat gtatcactag agaatacctg
     9241 agtctttatg ctgtgtgtgt ggtgctcagg tctcccatat gtaagactgc aaacgttgaa
     9301 agcacccatt acctagtagt cctaatcctt aaccctaagt gtaaatagca gtggatagag
     9361 cgagagcatt tgctgcagtt aaatgggaag cgccatgatt tgtatgtgca ttttacactt
     9421 gctactgcag tgatttgatt aggatcttcc tgtgtagatt gttaggcatc aaatcgttgt
     9481 agatcaagag ttggagctga gttaagtgag gacagcctgt gtgcacagtg tgtggtatgg
     9541 tcctcctttc tgtgtgtttc ataacttcct gcttctctga cctgtccata gcgtgtgggg
     9601 agtttgcagt gtgcacttac tactagttag tctgattgtt tcatacactt ttgtggtggt
     9661 gtagatcatg tttactgtca ctgttttcct gtcatcatag ttcttttggt atatatttct
     9721 gtgtctggtg atatattaaa gtatgtcctt gtaaactttt ttgtaaaagt tatttcctaa
     9781 atataaaaac attatgacta gcaccactat gtcttcttaa ctaaaaccac ctcccataaa
     9841 agtaaaaatg tttgaacaaa tgatacatgt ctttgaatgt gtgatactag tatacttact
     9901 gaacgtgaga catactgtag aatgttggtc atacagatgg tttgagaata tggatatatt
     9961 aaactagtat cttgtgctca ttaaatacta ttagcaaagg tacaagaatg ttcccatctg
    10021 tctgttgata atagggcttg aaaagatgaa ggcattttga ctcaataaca aatgaaaaca
    10081 cttgactaag cctctgtgcc gttgaataaa ggtgaaaggt tttccggctt taagttagta
    10141 gtagatgatc tgttcttggc tttcatttca gattggtatc aaatgttcac aaacacagtc
    10201 attttagatt tgaaaactgt ctcctgctgg tggtttcact gttggaatat aaaccactcc
    10261 atcccctgag agcgatgctc tactctctca ggttgctcct gtcccaaggc caccatgtgc
    10321 tccagcgctg aggtcaggcc agcagcttta agggatgcca caagagatgg aaagatccca
    10381 tgccagggtg tcaccaagta ctttccagcg tccttaggaa tggcgtcctc ttcttgtagg
    10441 ccatagctcc tctgtgacat gggatacttg cattcccaga agcaatggac tcatcttttg
    10501 gttgcgtgcc aagctgaggg taaagaatgg cttgtttgtt gctgcaaatg aggaatatgt
    10561 agacgatggt ccttggagag cagtatctga atagaaagca aaaggctttc attggtgaaa
    10621 taccaggcat catgtgtgga cacatttctg aacatgttct gtgtggggtg agaaggtaat
    10681 gacaggttca ttgtgtagcc tggctgccac aggtctcatc tgcctgcatc tgtctcccag
    10741 gtcctgggat taaatgcgta taccaccaag cttgcaggtc agtgtttgaa ctttaatatt
    10801 tataatccct tttcacatga gactctgtac ctggtatata atacaaatca gatgtgtact
    10861 gataaattga aagtttattt tagactgaga atgtgactca gtgttcaagt attgtgtagt
    10921 atgctcaaga acaggctttg aggggctggt gagatggctc agtgggtaag agcacctgac
    10981 tgctcttctg aaggtccgga gttcaaatcc cagcaaccac atggtggctc acaaccatct
    11041 gtaacgaaat ctggcaccct cttctggagt gactgaagac agctacagtg tacttacata
    11101 taataaataa ataaatcttt aaaaaaaaaa
//
