LOCUS       NM_007683               3203 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus centromere protein C1 (Cenpc1), transcript variant 2,
            mRNA.
ACCESSION   NM_007683
VERSION     NM_007683.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3203)
  AUTHORS   Kong,W., Hara,M., Tokunaga,Y., Okumura,K., Hirano,Y., Miao,J.,
            Takenoshita,Y., Hashimoto,M., Sasaki,H., Fujimori,T.,
            Wakabayashi,Y. and Fukagawa,T.
  TITLE     CENP-C-Mis12 complex establishes a regulatory loop through Aurora B
            for chromosome segregation
  JOURNAL   Life Sci Alliance 8 (1), e202402927 (2024)
   PUBMED   39433344
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3203)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3203)
  AUTHORS   Das,A., Iwata-Otsubo,A., Destouni,A., Dawicki-McKenna,J.M.,
            Boese,K.G., Black,B.E. and Lampson,M.A.
  TITLE     Epigenetic, genetic and maternal effects enable stable centromere
            inheritance
  JOURNAL   Nat Cell Biol 24 (5), 748-756 (2022)
   PUBMED   35534577
REFERENCE   4  (bases 1 to 3203)
  AUTHORS   Kumon,T., Ma,J., Akins,R.B., Stefanik,D., Nordgren,C.E., Kim,J.,
            Levine,M.T. and Lampson,M.A.
  TITLE     Parallel pathways for recruiting effector proteins determine
            centromere drive and suppression
  JOURNAL   Cell 184 (19), 4904-4918 (2021)
   PUBMED   34433012
  REMARK    GeneRIF: Parallel pathways for recruiting effector proteins
            determine centromere drive and suppression.
REFERENCE   5  (bases 1 to 3203)
  AUTHORS   Perpelescu,M. and Fukagawa,T.
  TITLE     The ABCs of CENPs
  JOURNAL   Chromosoma 120 (5), 425-446 (2011)
   PUBMED   21751032
  REMARK    Review article
REFERENCE   6  (bases 1 to 3203)
  AUTHORS   Kalitsis,P., Fowler,K.J., Earle,E., Hill,J. and Choo,K.H.
  TITLE     Targeted disruption of mouse centromere protein C gene leads to
            mitotic disarray and early embryo death
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 1136-1141 (1998)
   PUBMED   9448298
REFERENCE   7  (bases 1 to 3203)
  AUTHORS   Kalitsis,P., MacDonald,A.C., Newson,A.J., Hudson,D.F. and Choo,K.H.
  TITLE     Gene structure and sequence analysis of mouse centromere proteins A
            and C
  JOURNAL   Genomics 47 (1), 108-114 (1998)
   PUBMED   9465302
REFERENCE   8  (bases 1 to 3203)
  AUTHORS   Fowler,K.J., Newson,A.J., MacDonald,A.C., Kalitsis,P., Lyu,M.S.,
            Kozak,C.A. and Choo,K.H.
  TITLE     Chromosomal localization of mouse Cenpa gene
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 298-301 (1997)
   PUBMED   9605877
REFERENCE   9  (bases 1 to 3203)
  AUTHORS   Burkin,D.J., Jones,C., Burkin,H.R., McGrew,J.A. and Broad,T.E.
  TITLE     Sheep CENPB and CENPC genes show a high level of sequence
            similarity and conserved synteny with their human homologs
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 86-89 (1996)
   PUBMED   8893808
REFERENCE   10 (bases 1 to 3203)
  AUTHORS   McKay,S., Thomson,E. and Cooke,H.
  TITLE     Sequence homologies and linkage group conservation of the human and
            mouse Cenpc genes
  JOURNAL   Genomics 22 (1), 36-40 (1994)
   PUBMED   7959789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107634.8, AK143566.1,
            BC150700.1, AC101846.8 and BY718033.1.
            
            On Sep 17, 2016 this sequence version replaced NM_007683.3.
            
            Summary: This gene encodes a centromeric protein component of a
            nucleosome-associated complex that plays a central role in
            kinetochore protein assembly, mitotic progression and chromosome
            segregation. The human ortholog encodes a protein with DNA-binding
            activity, that associates constitutively to kinetochores throughout
            the cell cycle, as part of a prekinetochore complex, together with
            centromeric protein-A and centromeric protein-B. Multiple
            pseudogenes of this gene have been identified. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and the
            5' coding region, compared to variant 1. The encoded isoform (2) is
            shorter and has a distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03113.1, BC150700.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC107634.8         63609-63611         c
            4-204               AK143566.1         5-205
            205-3166            BC150700.1         1-2962
            3167-3191           AC101846.8         159722-159746       c
            3192-3203           BY718033.1         314-325
FEATURES             Location/Qualifiers
     source          1..3203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..3203
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /note="centromere protein C1"
                     /db_xref="GeneID:12617"
                     /db_xref="MGI:MGI:99700"
     exon            1..256
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..2959
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /note="isoform 2 is encoded by transcript variant 2;
                     centromere autoantigen C1"
                     /codon_start=1
                     /product="centromere protein C isoform 2"
                     /protein_id="NP_031709.2"
                     /db_xref="CCDS:CCDS39123.1"
                     /db_xref="GeneID:12617"
                     /db_xref="MGI:MGI:99700"
                     /translation="MASFHLDHLKNYHRRYCRSSRAPNIHTKKGQNMLEILQDCFEDQ
                     SKASFLDDFTESLTSSTQKKKANYSQSSSKKCPESHSKPVPVSSRTGEASLQASAEPS
                     EAAGGSVQANEVHHGASDELDLCVGSPVVLLDANVNTLQKAASPAGQKRVASVSRSPV
                     DRQASNKNISFKTRKRLNFEDKVTLSTAETENSVLQVEDNLSKGQEGTSSEITQKRDD
                     LSSDVQSRSKKNFSELFLETVKRKSKSSSVVRHTAAVPFSPPPPSDMKLLEDEFIIDR
                     SDRSFSSRLWVMIPSKDRHLSAHKPSPENTALLQGKKSREKSHSLSAMTFARNTQSDK
                     AHPIEEAQLSVEENPATTCTDELENDCRSPENKMQSETAKTPPAWERTTKQSQRRVSK
                     PKAAEELRKGQSSWENSNVSNTGQDKLQINSKRNMKDCEEVRNEPNPKKQKPALENKK
                     KTNSTQTNKEKSGKKFFSGGSKNKFVPKKVTLTSRRSCRISQRPSEWWRVKSDESSVD
                     RNPSKENNSPVVYPNKKKQTKRNHVSKRAGKKPGSSKRQKTEMSPRVQKSLNVKDSGG
                     TVSGHDDTSRSQRKPLKIIEADPTQKSLAISRPKRGCKYRNNVMTSPNVHLKSHTEEY
                     TSKTQMESASNSEMSKRSVWEESGPSRFKNYEMPGSSNSEMGDEQDQKSLHFTTRSFN
                     MVPDKKLHHKLVLPSNSPNVRRSNRIRLKPLEYWRGERVDYQESSSGQLVLEIISPSS
                     VPTKIKAQRNLGKVNKKVTKKPTHLNSHEKAKMELPLDMRLGDPFQATLAKDPETAEL
                     VPMDLIRPRDTYRFFVEQHGLKVFKTLDTIYFSTGKLVLGPYEEKGKQHVGQDILVFY
                     VNFGDLLCTLHETPYKLTTGDSFYVPSGNHYNIKNLLNVESSLLFTQIKR"
     exon            257..300
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            301..392
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            393..463
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            464..563
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            564..765
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            766..975
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1577
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1751
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2031
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2178
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2261
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2318
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2423
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2546
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2642
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2797
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2888
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3192
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctttaaaa aacgccaatt aacggccggc taagctaggc ttgtgcgcag gcgtggctcg
       61 tttgactttt attcatttat ttttcttggt ggctgctgtt tatttacggc tgagtgttaa
      121 gtgcgggtcg cgcagctctg gggacgcctc cgtccgcaat cttactctaa ccctcctgga
      181 accctggccg gcttgggttt ccctctcagg cctccgtttg acctagtggg ccggaaccat
      241 ggcctcgttc catctggatc atctaaagaa ctaccacaga agatattgcc ggtcttccag
      301 agcacccaac attcatacaa aaaaaggcca gaacatgctg gaaatcttac aagattgttt
      361 tgaagatcag agtaaggctt catttcttga tgattttaca gagtcattga cttcttcaac
      421 acaaaaaaag aaagccaatt atagtcaatc atcaagcaaa aagtgcccag agtcacattc
      481 caaaccagtt ccagtgtctt caaggacagg agaagcttct ctgcaagcgt ctgcagagcc
      541 cagtgaagcc gctggtggat cagttcaggc taatgaagtt caccatggtg cgtctgatga
      601 attggactta tgtgttggct cccctgtggt tctcctggat gcaaacgtca acacgttaca
      661 gaaagccgct tcacctgccg gccaaaagag agtggcttct gtctcaagga gtccagtaga
      721 taggcaggct tcaaataaaa acatttcttt taaaaccagg aaaaggttaa actttgaaga
      781 taaagttact ttgagcacag cagaaacaga gaacagtgtg ttacaagtag aggataactt
      841 atccaaggga caagaaggga catcatcaga aatcactcag aaaagagacg atctgagttc
      901 tgatgtccaa tcacgttcta agaagaattt ttcggagttg tttttagaga ctgtcaagag
      961 gaaaagtaaa tccagttctg tggtcaggca cacagcagca gttccatttt ctccgcctcc
     1021 tccaagtgac atgaaattat tagaagatga atttattatt gatcggtcag atagaagttt
     1081 ttcaagtcga ctttgggtga tgataccaag caaagacagg catctgagcg cccacaagcc
     1141 atctcctgaa aacactgcac tgcttcaagg taagaagtca agagagaaat ctcatagttt
     1201 atctgcaatg acgtttgcaa gaaacacaca gtctgataag gctcacccaa tagaggaagc
     1261 tcagctctct gttgaagaaa acccggcaac tacttgtaca gatgagttgg aaaatgattg
     1321 tcgatctcct gaaaataaaa tgcaatctga gactgccaaa accccacccg catgggaaag
     1381 gactacgaaa cagagccaga ggagagtgtc taagcctaaa gcagctgaag agctcaggaa
     1441 gggacagagt agctgggaaa atagcaatgt gtcaaacact ggccaagaca agctacagat
     1501 caactcgaaa agaaatatga aggactgtga agaggtgagg aatgagccta atcccaagaa
     1561 acagaagcca gctcttgaaa ataagaaaaa aaccaatagc acccaaacca ataaggaaaa
     1621 atctggaaag aaattttttt ctggtgggtc caagaacaaa tttgttccca aaaaagtaac
     1681 tttgacttcc aggagaagtt gtagaatttc tcagcgtcca tctgagtggt ggagggtaaa
     1741 atcagatgaa agttctgttg atagaaatcc ttcaaaagaa aataactcac cagtggtata
     1801 tcccaataaa aagaagcaga ctaagagaaa tcatgtatct aagagggctg ggaagaaacc
     1861 tggttcatca aaaagacaga agacagagat gagcccaaga gtacagaagt ctttaaatgt
     1921 aaaggattct ggaggaactg ttagtggcca tgatgacact tctcgttccc agaggaagcc
     1981 attgaaaatc attgaggcag acccaactca gaagagcctt gctatttctc gacctaaaag
     2041 aggctgtaag tatcgaaaca atgttatgac atcaccgaat gttcatttaa agtctcatac
     2101 tgaggaatat acaagcaaga cacaaatgga gtctgcttcc aattcagaaa tgtctaaacg
     2161 ttcagtgtgg gaagaaagtg gaccttccag gttcaagaat tatgaaatgc cagggagcag
     2221 taattctgag atgggtgatg aacaggacca gaagagtttg cattttacaa caagaagttt
     2281 taatatggta ccagataaaa aattacatca caaattagta ctgccctcca actcaccaaa
     2341 tgttcgtcga tctaatagaa tacgtttgaa acctctggag tattggcgag gggaacgggt
     2401 agattatcaa gaaagttcgt cgggacaact tgtgcttgaa ataatatccc catcttcagt
     2461 acccacgaaa ataaaggcac aaagaaacct cggcaaagtc aacaaaaaag ttaccaagaa
     2521 gccgacccat ctcaatagcc atgaaaaggc taagatggag ctgcctctgg atatgcgtct
     2581 gggagatccc tttcaggcaa cattggcgaa ggacccagaa accgcagagc ttgtccccat
     2641 ggatcttata agaccacgag atacataccg cttttttgtt gagcaacatg gtttgaaagt
     2701 ttttaaaaca ttggatacaa tatatttttc tactggaaaa ttggttttag gaccttatga
     2761 agagaaagga aaacagcatg ttggccaaga tatattggtt ttttatgtta actttggtga
     2821 ccttttatgt acattacatg aaacacctta taagttaact actggggatt cattctatgt
     2881 tccttcaggt aatcattaca acattaaaaa cctcttgaat gtggaaagta gtcttctttt
     2941 tactcaaata aaaaggtgaa ataaatgtgt atgtatataa aatacgttgt ttatatgtac
     3001 attttaataa ctgattattt taaagtaaaa tttttgttta gttttgcatt agttaatcat
     3061 ttcgtactcc ttgttaaaca tttcataatc ttgtatgtat cttttgattt ttccttgagt
     3121 gtaaatactg tgtttagtga tgactatttt gttggtattg ctttcataat attaaaaatt
     3181 aaaaaacaca aaaaaaaaaa aaa
//
