LOCUS       NM_001345903            3232 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus centromere protein C1 (Cenpc1), transcript variant 3,
            mRNA.
ACCESSION   NM_001345903 XM_006534739
VERSION     NM_001345903.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Kong,W., Hara,M., Tokunaga,Y., Okumura,K., Hirano,Y., Miao,J.,
            Takenoshita,Y., Hashimoto,M., Sasaki,H., Fujimori,T.,
            Wakabayashi,Y. and Fukagawa,T.
  TITLE     CENP-C-Mis12 complex establishes a regulatory loop through Aurora B
            for chromosome segregation
  JOURNAL   Life Sci Alliance 8 (1), e202402927 (2024)
   PUBMED   39433344
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3232)
  AUTHORS   Tian,T., Chen,L., Dou,Z., Yang,Z., Gao,X., Yuan,X., Wang,C.,
            Liu,R., Shen,Z., Gui,P., Teng,M., Meng,X., Hill,D.L., Li,L.,
            Zhang,X., Liu,X., Sun,L., Zang,J. and Yao,X.
  TITLE     Structural insights into human CCAN complex assembled onto DNA
  JOURNAL   Cell Discov 8 (1), 90 (2022)
   PUBMED   36085283
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3232)
  AUTHORS   Das,A., Iwata-Otsubo,A., Destouni,A., Dawicki-McKenna,J.M.,
            Boese,K.G., Black,B.E. and Lampson,M.A.
  TITLE     Epigenetic, genetic and maternal effects enable stable centromere
            inheritance
  JOURNAL   Nat Cell Biol 24 (5), 748-756 (2022)
   PUBMED   35534577
REFERENCE   4  (bases 1 to 3232)
  AUTHORS   Kumon,T., Ma,J., Akins,R.B., Stefanik,D., Nordgren,C.E., Kim,J.,
            Levine,M.T. and Lampson,M.A.
  TITLE     Parallel pathways for recruiting effector proteins determine
            centromere drive and suppression
  JOURNAL   Cell 184 (19), 4904-4918 (2021)
   PUBMED   34433012
  REMARK    GeneRIF: Parallel pathways for recruiting effector proteins
            determine centromere drive and suppression.
REFERENCE   5  (bases 1 to 3232)
  AUTHORS   Perpelescu,M. and Fukagawa,T.
  TITLE     The ABCs of CENPs
  JOURNAL   Chromosoma 120 (5), 425-446 (2011)
   PUBMED   21751032
  REMARK    Review article
REFERENCE   6  (bases 1 to 3232)
  AUTHORS   Kalitsis,P., Fowler,K.J., Earle,E., Hill,J. and Choo,K.H.
  TITLE     Targeted disruption of mouse centromere protein C gene leads to
            mitotic disarray and early embryo death
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 1136-1141 (1998)
   PUBMED   9448298
REFERENCE   7  (bases 1 to 3232)
  AUTHORS   Kalitsis,P., MacDonald,A.C., Newson,A.J., Hudson,D.F. and Choo,K.H.
  TITLE     Gene structure and sequence analysis of mouse centromere proteins A
            and C
  JOURNAL   Genomics 47 (1), 108-114 (1998)
   PUBMED   9465302
REFERENCE   8  (bases 1 to 3232)
  AUTHORS   Fowler,K.J., Newson,A.J., MacDonald,A.C., Kalitsis,P., Lyu,M.S.,
            Kozak,C.A. and Choo,K.H.
  TITLE     Chromosomal localization of mouse Cenpa gene
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 298-301 (1997)
   PUBMED   9605877
REFERENCE   9  (bases 1 to 3232)
  AUTHORS   Burkin,D.J., Jones,C., Burkin,H.R., McGrew,J.A. and Broad,T.E.
  TITLE     Sheep CENPB and CENPC genes show a high level of sequence
            similarity and conserved synteny with their human homologs
  JOURNAL   Cytogenet Cell Genet 74 (1-2), 86-89 (1996)
   PUBMED   8893808
REFERENCE   10 (bases 1 to 3232)
  AUTHORS   McKay,S., Thomson,E. and Cooke,H.
  TITLE     Sequence homologies and linkage group conservation of the human and
            mouse Cenpc genes
  JOURNAL   Genomics 22 (1), 36-40 (1994)
   PUBMED   7959789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107634.8, AK143566.1,
            BC150700.1, AC101846.8 and BY718033.1.
            
            On Sep 17, 2016 this sequence version replaced XM_006534739.3.
            
            Summary: This gene encodes a centromeric protein component of a
            nucleosome-associated complex that plays a central role in
            kinetochore protein assembly, mitotic progression and chromosome
            segregation. The human ortholog encodes a protein with DNA-binding
            activity, that associates constitutively to kinetochores throughout
            the cell cycle, as part of a prekinetochore complex, together with
            centromeric protein-A and centromeric protein-B. Multiple
            pseudogenes of this gene have been identified. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and the
            5' coding region and uses a downstream start codon compared to
            variant 1. The resulting isoform (3) has a shorter N-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2759931.1,
                                           SRR1660813.102884.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC107634.8         63609-63611         c
            4-204               AK143566.1         5-205
            205-300             BC150700.1         1-96
            301-329             AC107634.8         58553-58581         c
            330-3195            BC150700.1         97-2962
            3196-3220           AC101846.8         159722-159746       c
            3221-3232           BY718033.1         314-325
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..3232
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /note="centromere protein C1"
                     /db_xref="GeneID:12617"
                     /db_xref="MGI:MGI:99700"
     exon            1..256
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            257..300
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            301..329
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            330..421
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2988
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /note="isoform 3 is encoded by transcript variant 3;
                     centromere autoantigen C1"
                     /codon_start=1
                     /product="centromere protein C isoform 3"
                     /protein_id="NP_001332832.1"
                     /db_xref="GeneID:12617"
                     /db_xref="MGI:MGI:99700"
                     /translation="MLEILQDCFEDQSKASFLDDFTESLTSSTQKKKANYSQSSSKKC
                     PESHSKPVPVSSRTGEASLQASAEPSEAAGGSVQANEVHHGASDELDLCVGSPVVLLD
                     ANVNTLQKAASPAGQKRVASVSRSPVDRQASNKNISFKTRKRLNFEDKVTLSTAETEN
                     SVLQVEDNLSKGQEGTSSEITQKRDDLSSDVQSRSKKNFSELFLETVKRKSKSSSVVR
                     HTAAVPFSPPPPSDMKLLEDEFIIDRSDRSFSSRLWVMIPSKDRHLSAHKPSPENTAL
                     LQGKKSREKSHSLSAMTFARNTQSDKAHPIEEAQLSVEENPATTCTDELENDCRSPEN
                     KMQSETAKTPPAWERTTKQSQRRVSKPKAAEELRKGQSSWENSNVSNTGQDKLQINSK
                     RNMKDCEEVRNEPNPKKQKPALENKKKTNSTQTNKEKSGKKFFSGGSKNKFVPKKVTL
                     TSRRSCRISQRPSEWWRVKSDESSVDRNPSKENNSPVVYPNKKKQTKRNHVSKRAGKK
                     PGSSKRQKTEMSPRVQKSLNVKDSGGTVSGHDDTSRSQRKPLKIIEADPTQKSLAISR
                     PKRGCKYRNNVMTSPNVHLKSHTEEYTSKTQMESASNSEMSKRSVWEESGPSRFKNYE
                     MPGSSNSEMGDEQDQKSLHFTTRSFNMVPDKKLHHKLVLPSNSPNVRRSNRIRLKPLE
                     YWRGERVDYQESSSGQLVLEIISPSSVPTKIKAQRNLGKVNKKVTKKPTHLNSHEKAK
                     MELPLDMRLGDPFQATLAKDPETAELVPMDLIRPRDTYRFFVEQHGLKVFKTLDTIYF
                     STGKLVLGPYEEKGKQHVGQDILVFYVNFGDLLCTLHETPYKLTTGDSFYVPSGNHYN
                     IKNLLNVESSLLFTQIKR"
     exon            422..492
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            493..592
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            593..794
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1004
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1606
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1780
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2060
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2207
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2290
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2347
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2452
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2575
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2671
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2826
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2917
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3221
                     /gene="Cenpc1"
                     /gene_synonym="CENP-C; Cenpc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctttaaaa aacgccaatt aacggccggc taagctaggc ttgtgcgcag gcgtggctcg
       61 tttgactttt attcatttat ttttcttggt ggctgctgtt tatttacggc tgagtgttaa
      121 gtgcgggtcg cgcagctctg gggacgcctc cgtccgcaat cttactctaa ccctcctgga
      181 accctggccg gcttgggttt ccctctcagg cctccgtttg acctagtggg ccggaaccat
      241 ggcctcgttc catctggatc atctaaagaa ctaccacaga agatattgcc ggtcttccag
      301 gtgcttctca gccattcagt tttcctcaga gcacccaaca ttcatacaaa aaaaggccag
      361 aacatgctgg aaatcttaca agattgtttt gaagatcaga gtaaggcttc atttcttgat
      421 gattttacag agtcattgac ttcttcaaca caaaaaaaga aagccaatta tagtcaatca
      481 tcaagcaaaa agtgcccaga gtcacattcc aaaccagttc cagtgtcttc aaggacagga
      541 gaagcttctc tgcaagcgtc tgcagagccc agtgaagccg ctggtggatc agttcaggct
      601 aatgaagttc accatggtgc gtctgatgaa ttggacttat gtgttggctc ccctgtggtt
      661 ctcctggatg caaacgtcaa cacgttacag aaagccgctt cacctgccgg ccaaaagaga
      721 gtggcttctg tctcaaggag tccagtagat aggcaggctt caaataaaaa catttctttt
      781 aaaaccagga aaaggttaaa ctttgaagat aaagttactt tgagcacagc agaaacagag
      841 aacagtgtgt tacaagtaga ggataactta tccaagggac aagaagggac atcatcagaa
      901 atcactcaga aaagagacga tctgagttct gatgtccaat cacgttctaa gaagaatttt
      961 tcggagttgt ttttagagac tgtcaagagg aaaagtaaat ccagttctgt ggtcaggcac
     1021 acagcagcag ttccattttc tccgcctcct ccaagtgaca tgaaattatt agaagatgaa
     1081 tttattattg atcggtcaga tagaagtttt tcaagtcgac tttgggtgat gataccaagc
     1141 aaagacaggc atctgagcgc ccacaagcca tctcctgaaa acactgcact gcttcaaggt
     1201 aagaagtcaa gagagaaatc tcatagttta tctgcaatga cgtttgcaag aaacacacag
     1261 tctgataagg ctcacccaat agaggaagct cagctctctg ttgaagaaaa cccggcaact
     1321 acttgtacag atgagttgga aaatgattgt cgatctcctg aaaataaaat gcaatctgag
     1381 actgccaaaa ccccacccgc atgggaaagg actacgaaac agagccagag gagagtgtct
     1441 aagcctaaag cagctgaaga gctcaggaag ggacagagta gctgggaaaa tagcaatgtg
     1501 tcaaacactg gccaagacaa gctacagatc aactcgaaaa gaaatatgaa ggactgtgaa
     1561 gaggtgagga atgagcctaa tcccaagaaa cagaagccag ctcttgaaaa taagaaaaaa
     1621 accaatagca cccaaaccaa taaggaaaaa tctggaaaga aatttttttc tggtgggtcc
     1681 aagaacaaat ttgttcccaa aaaagtaact ttgacttcca ggagaagttg tagaatttct
     1741 cagcgtccat ctgagtggtg gagggtaaaa tcagatgaaa gttctgttga tagaaatcct
     1801 tcaaaagaaa ataactcacc agtggtatat cccaataaaa agaagcagac taagagaaat
     1861 catgtatcta agagggctgg gaagaaacct ggttcatcaa aaagacagaa gacagagatg
     1921 agcccaagag tacagaagtc tttaaatgta aaggattctg gaggaactgt tagtggccat
     1981 gatgacactt ctcgttccca gaggaagcca ttgaaaatca ttgaggcaga cccaactcag
     2041 aagagccttg ctatttctcg acctaaaaga ggctgtaagt atcgaaacaa tgttatgaca
     2101 tcaccgaatg ttcatttaaa gtctcatact gaggaatata caagcaagac acaaatggag
     2161 tctgcttcca attcagaaat gtctaaacgt tcagtgtggg aagaaagtgg accttccagg
     2221 ttcaagaatt atgaaatgcc agggagcagt aattctgaga tgggtgatga acaggaccag
     2281 aagagtttgc attttacaac aagaagtttt aatatggtac cagataaaaa attacatcac
     2341 aaattagtac tgccctccaa ctcaccaaat gttcgtcgat ctaatagaat acgtttgaaa
     2401 cctctggagt attggcgagg ggaacgggta gattatcaag aaagttcgtc gggacaactt
     2461 gtgcttgaaa taatatcccc atcttcagta cccacgaaaa taaaggcaca aagaaacctc
     2521 ggcaaagtca acaaaaaagt taccaagaag ccgacccatc tcaatagcca tgaaaaggct
     2581 aagatggagc tgcctctgga tatgcgtctg ggagatccct ttcaggcaac attggcgaag
     2641 gacccagaaa ccgcagagct tgtccccatg gatcttataa gaccacgaga tacataccgc
     2701 ttttttgttg agcaacatgg tttgaaagtt tttaaaacat tggatacaat atatttttct
     2761 actggaaaat tggttttagg accttatgaa gagaaaggaa aacagcatgt tggccaagat
     2821 atattggttt tttatgttaa ctttggtgac cttttatgta cattacatga aacaccttat
     2881 aagttaacta ctggggattc attctatgtt ccttcaggta atcattacaa cattaaaaac
     2941 ctcttgaatg tggaaagtag tcttcttttt actcaaataa aaaggtgaaa taaatgtgta
     3001 tgtatataaa atacgttgtt tatatgtaca ttttaataac tgattatttt aaagtaaaat
     3061 ttttgtttag ttttgcatta gttaatcatt tcgtactcct tgttaaacat ttcataatct
     3121 tgtatgtatc ttttgatttt tccttgagtg taaatactgt gtttagtgat gactattttg
     3181 ttggtattgc tttcataata ttaaaaatta aaaaacacaa aaaaaaaaaa aa
//
