LOCUS       NM_007681               1364 bp    mRNA    linear   ROD 14-MAY-2024
DEFINITION  Mus musculus centromere protein A (Cenpa), transcript variant 1,
            mRNA.
ACCESSION   NM_007681
VERSION     NM_007681.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Leon,N.Y., Le,T.N.U., Garvie,A., Wong,L.H., Bagheri-Fam,S. and
            Harley,V.R.
  TITLE     Y chromosome damage underlies testicular abnormalities in ATR-X
            syndrome
  JOURNAL   iScience 27 (5), 109629 (2024)
   PUBMED   38616920
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Arora,U.P., Sullivan,B.A. and Dumont,B.L.
  TITLE     Variation in the CENP-A sequence association landscape across
            diverse inbred mouse strains
  JOURNAL   Cell Rep 42 (10), 113178 (2023)
   PUBMED   37742188
  REMARK    GeneRIF: Variation in the CENP-A sequence association landscape
            across diverse inbred mouse strains.
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Kuzelova,A., Dupacova,N., Antosova,B., Sunny,S.S., Kozmik,Z. Jr.,
            Paces,J., Skoultchi,A.I., Stopka,T. and Kozmik,Z.
  TITLE     Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell
            Proliferation and Photoreceptor Maintenance
  JOURNAL   Cells 12 (7), 1035 (2023)
   PUBMED   37048108
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1364)
  AUTHORS   Liu,Y., Wang,K., Huang,L., Zhao,J., Chen,X., Wu,Q., Yu,Z. and Li,G.
  TITLE     Ser68 phosphoregulation is essential for CENP-A deposition,
            centromere function and viability in mice
  JOURNAL   Sci China Life Sci 65 (9), 1881-1889 (2022)
   PUBMED   35391626
  REMARK    GeneRIF: Ser68 phosphoregulation is essential for CENP-A
            deposition, centromere function and viability in mice.
REFERENCE   5  (bases 1 to 1364)
  AUTHORS   Das,A., Iwata-Otsubo,A., Destouni,A., Dawicki-McKenna,J.M.,
            Boese,K.G., Black,B.E. and Lampson,M.A.
  TITLE     Epigenetic, genetic and maternal effects enable stable centromere
            inheritance
  JOURNAL   Nat Cell Biol 24 (5), 748-756 (2022)
   PUBMED   35534577
REFERENCE   6  (bases 1 to 1364)
  AUTHORS   Biterge,B. and Schneider,R.
  TITLE     Histone variants: key players of chromatin
  JOURNAL   Cell Tissue Res 356 (3), 457-466 (2014)
   PUBMED   24781148
  REMARK    Review article
REFERENCE   7  (bases 1 to 1364)
  AUTHORS   Craig,J.M., Earnshaw,W.C. and Vagnarelli,P.
  TITLE     Mammalian centromeres: DNA sequence, protein composition, and role
            in cell cycle progression
  JOURNAL   Exp Cell Res 246 (2), 249-262 (1999)
   PUBMED   9925740
  REMARK    Review article
REFERENCE   8  (bases 1 to 1364)
  AUTHORS   Kalitsis,P., MacDonald,A.C., Newson,A.J., Hudson,D.F. and Choo,K.H.
  TITLE     Gene structure and sequence analysis of mouse centromere proteins A
            and C
  JOURNAL   Genomics 47 (1), 108-114 (1998)
   PUBMED   9465302
REFERENCE   9  (bases 1 to 1364)
  AUTHORS   Fowler,K.J., Newson,A.J., MacDonald,A.C., Kalitsis,P., Lyu,M.S.,
            Kozak,C.A. and Choo,K.H.
  TITLE     Chromosomal localization of mouse Cenpa gene
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 298-301 (1997)
   PUBMED   9605877
REFERENCE   10 (bases 1 to 1364)
  AUTHORS   Clarke,L. and Carbon,J.
  TITLE     The structure and function of yeast centromeres
  JOURNAL   Annu Rev Genet 19, 29-55 (1985)
   PUBMED   3909945
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY136144.1, AF012709.1,
            AK011399.1, BQ748418.1 and AC105298.21.
            
            On Oct 3, 2014 this sequence version replaced NM_007681.2.
            
            Summary: Centromeres are the differentiated chromosomal domains
            that specify the mitotic behavior of chromosomes. This gene encodes
            a centromere protein which contains a histone H3 related histone
            fold domain that is required for targeting to the centromere.
            Centromere protein A is proposed to be a component of a modified
            nucleosome or nucleosome-like structure in which it replaces 1 or
            both copies of conventional histone H3 in the (H3-H4)2 tetrameric
            core of the nucleosome particle. The protein is a
            replication-independent histone that is a member of the histone H3
            family. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF012709.1, AK053763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria          :: based on conservation,
                                               expression
            replication-independent histone :: PMID: 24781148
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY136144.1         110-125
            17-72               AF012709.1         1-56
            73-1313             AK011399.1         2-1242
            1314-1349           BQ748418.1         402-437
            1350-1364           AC105298.21        58223-58237         c
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.76 cM"
     gene            1..1364
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="centromere protein A"
                     /db_xref="GeneID:12615"
                     /db_xref="MGI:MGI:88375"
     exon            1..228
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..548
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone H3-like centromeric protein A; centromere
                     autoantigen A; centrosomin A"
                     /codon_start=1
                     /product="histone H3-like centromeric protein A isoform 1"
                     /protein_id="NP_031707.1"
                     /db_xref="CCDS:CCDS19162.1"
                     /db_xref="GeneID:12615"
                     /db_xref="MGI:MGI:88375"
                     /translation="MGPRRKPQTPRRRPSSPAPGPSRQSSSVGSQTLRRRQKFMWLKE
                     IKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFED
                     AYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP"
     exon            229..335
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /inference="alignment:Splign:2.1.0"
     exon            336..413
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /inference="alignment:Splign:2.1.0"
     exon            414..564
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /inference="alignment:Splign:2.1.0"
     exon            565..1364
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      887..892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="hexamer: AATATA"
     regulatory      908..913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="hexamer: AATAAA"
     polyA_site      909
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="major polyA site"
     polyA_site      936
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="major polyA site"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="hexamer: AATAAA"
     regulatory      1337..1342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
                     /note="hexamer: AATAAT"
     polyA_site      1349
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
     polyA_site      1354
                     /gene="Cenpa"
                     /gene_synonym="Cenp-A"
ORIGIN      
        1 gaggggcggg tgattttttg aactgctggc gaccgagttc tggcggtcct gacgcgcacc
       61 ttgggcttgc tcgcgttcgg tttcggcagc aggaccaaga aggcttaggg aaggcggcgg
      121 gacccggccc ctcgaggcca gccatgggcc cgcgtcgcaa accgcagacc ccaaggagga
      181 gaccctccag cccggcgcct ggaccctcgc gacagagctc cagtgtaggc tctcagacac
      241 tgcgcagaag acagaaattc atgtggctta aggaaatcaa gaccctgcag aagagcacag
      301 acctcttgtt caggaagaag cctttcagca tggttgttag agaaatatgt gagaagttca
      361 gccgtggtgt ggatttttgg tggcaagccc aggccttgtt ggcccttcag gaggcagcag
      421 aagctttcct catccacctc tttgaggacg cctacctcct ctccttacat gctggtcggg
      481 tcacgctttt ccccaaagac attcagttga ccaggagaat ccgaggcttc gagggcggac
      541 tcccctaagc tgccagtgga atgtacatta cctggaagct tttggagttg cagcttgaca
      601 gtggtgtcgg aggagctggc tgggttttgc tgtttttaaa tactggctac acggtgccct
      661 taaaactgtc tctgaaggag aagactgtgg ccttcccccg acacagaggt ctgcccactc
      721 gctcccatgg actcgagtgt ttgcagacca aaggtcaatt tggtttgtga attgctcagc
      781 cctatggctg aaggtttcag acacccgata cctgccatgg tatggttatt tcactcttac
      841 tgctctgttt gcatctttta ctattagttt ttgtactttt atttaaaata taaggaagaa
      901 aaacctgaat aaagcgcttg aatctgttgt atgtgagccg tggcagtccc gccatataaa
      961 tgcctgcctt ccagagtgac ctcatcctgt catccatgtt tgtctgtcag tcagcaaaca
     1021 tgcagctctt ctttaaaacc taagtagaat tacatacaaa atcttttctt ctcttcaaga
     1081 ctggggctcg aattcaaaga tttgtacatg ccaagcatgg actataatgc tgaactacat
     1141 ccacagcctg aagtagatgt ctttctggtt cctaccagtg aattcctatc aaaaacgtcc
     1201 agagtctctt atctttagct ctaaatcata taaaatgtct catatcagtc tggaatttta
     1261 aaatgtgttt tcagaatttt tacagattaa ttttagctta tttggggaga aataataaaa
     1321 aataaataaa aataaaaata attccttaat gaaagaattg aagt
//
