LOCUS       NM_021316               1804 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cell cycle exit and neuronal differentiation 1
            (Cend1), transcript variant 2, mRNA.
ACCESSION   NM_021316 XM_001001289 XM_001001299
VERSION     NM_021316.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Xie,W., Guo,D., Li,J., Yue,L., Kang,Q., Chen,G., Zhou,T., Wang,H.,
            Zhuang,K., Leng,L., Li,H., Chen,Z., Gao,W. and Zhang,J.
  TITLE     CEND1 deficiency induces mitochondrial dysfunction and cognitive
            impairment in Alzheimer's disease
  JOURNAL   Cell Death Differ 29 (12), 2417-2428 (2022)
   PUBMED   35732922
  REMARK    GeneRIF: CEND1 deficiency induces mitochondrial dysfunction and
            cognitive impairment in Alzheimer's disease.
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Hwang,I., Kim,B.S., Ko,H.R., Cho,S., Lee,H.Y., Cho,S.W., Ryu,D.,
            Shim,S. and Ahn,J.Y.
  TITLE     Cerebellar dysfunction and schizophrenia-like behavior in
            Ebp1-deficient mice
  JOURNAL   Mol Psychiatry 27 (4), 2030-2041 (2022)
   PUBMED   35165395
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Dong,X. and Kwan,K.M.
  TITLE     Yin Yang 1 is critical for mid-hindbrain neuroepithelium
            development and involved in cerebellar agenesis
  JOURNAL   Mol Brain 13 (1), 104 (2020)
   PUBMED   32703236
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Segklia,K., Stamatakis,A., Stylianopoulou,F., Lavdas,A.A. and
            Matsas,R.
  TITLE     Increased Anxiety-Related Behavior, Impaired Cognitive Function and
            Cellular Alterations in the Brain of Cend1-deficient Mice
  JOURNAL   Front Cell Neurosci 12, 497 (2019)
   PUBMED   30760981
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Katsimpardi,L., Gaitanou,M., Malnou,C.E., Lledo,P.M., Charneau,P.,
            Matsas,R. and Thomaidou,D.
  TITLE     BM88/Cend1 expression levels are critical for proliferation and
            differentiation of subventricular zone-derived neural precursor
            cells
  JOURNAL   Stem Cells 26 (7), 1796-1807 (2008)
   PUBMED   18499894
  REMARK    GeneRIF: BM88/Cend1 participates in cell cycle control and neuronal
            differentiation mechanisms during neonatal SVZ neurogenesis and
            becomes crucial for the transition from neuroblasts to mature
            neurons when reaching high levels
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   Politis,P.K., Makri,G., Thomaidou,D., Geissen,M., Rohrer,H. and
            Matsas,R.
  TITLE     BM88/CEND1 coordinates cell cycle exit and differentiation of
            neuronal precursors
  JOURNAL   Proc Natl Acad Sci U S A 104 (45), 17861-17866 (2007)
   PUBMED   17971443
  REMARK    GeneRIF: Results implicate BM88 in the synchronization of cell
            cycle exit and differentiation of neuronal precursors in the
            developing nervous system.
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Politis,P.K., Rohrer,H. and Matsas,R.
  TITLE     Expression pattern of BM88 in the developing nervous system of the
            chick and mouse embryo
  JOURNAL   Gene Expr Patterns 7 (1-2), 165-177 (2007)
   PUBMED   16949349
  REMARK    GeneRIF: BM88 is widely expressed in the embryonic CNS and PNS, in
            both nestin-positive neuroepithelial cells and post-mitotic
            betaIII-tubulin positive neurons.
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Koutmani,Y., Hurel,C., Patsavoudi,E., Hack,M., Gotz,M.,
            Thomaidou,D. and Matsas,R.
  TITLE     BM88 is an early marker of proliferating precursor cells that will
            differentiate into the neuronal lineage
  JOURNAL   Eur J Neurosci 20 (10), 2509-2523 (2004)
   PUBMED   15548196
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Gaitanou,M., Buanne,P., Pappa,C., Georgopoulou,N., Mamalaki,A.,
            Tirone,F. and Matsas,R.
  TITLE     Cloning, expression and localization of human BM88 shows that it
            maps to chromosome 11p15.5, a region implicated in
            Beckwith-Wiedemann syndrome and tumorigenesis
  JOURNAL   Biochem J 355 (Pt 3), 715-724 (2001)
   PUBMED   11311134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158224.6, AK079045.1 and AC163434.5.
            
            On Feb 6, 2018 this sequence version replaced NM_021316.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023032.1, SRR7345562.4474019.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC158224.6         78650-78791         c
            143-1799            AK079045.1         2-1658
            1800-1804           AC163434.5         222677-222681       c
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.77 cM"
     gene            1..1804
                     /gene="Cend1"
                     /gene_synonym="1500001H12Rik; BM88"
                     /note="cell cycle exit and neuronal differentiation 1"
                     /db_xref="GeneID:57754"
                     /db_xref="MGI:MGI:1929898"
     exon            1..246
                     /gene="Cend1"
                     /gene_synonym="1500001H12Rik; BM88"
                     /inference="alignment:Splign:2.1.0"
     exon            247..1804
                     /gene="Cend1"
                     /gene_synonym="1500001H12Rik; BM88"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cend1"
                     /gene_synonym="1500001H12Rik; BM88"
                     /note="hexamer: AATAAA"
     polyA_site      1804
                     /gene="Cend1"
                     /gene_synonym="1500001H12Rik; BM88"
                     /note="major polyA site"
ORIGIN      
        1 agatgtgaga attgaagcta ggcataggca catcccactt cacctctacc tccgggttcc
       61 cagggtgtag caggcgtggc cctgcttacg cagctgtccc cgccccttgc ctctggtcct
      121 cctgtcttgc gcccggagtg gtgcattgtg ggaaactcct gagcactcct cggtatccgc
      181 agccaccgcc cgctgtcatc ccgtgaagcg aatgcgcagc gagaagctgg agggcccaaa
      241 gaagacaccc atataatgcc cagaggtgag ctgtcctgag ccactgtggt ctagccacct
      301 gccagtcaca caagccccaa accagctgcc agcaaaaaac catcatggaa tcccgaggaa
      361 agtcagccag cagccccaag ccagatacca aggtgcctca ggccacagct gaggccaagg
      421 ccactccagc tgcggatggg aaagctccct tgaccaagcc tgtgaagaag gacacccaag
      481 cagagaagca ggagcaagca gcagcccctg ggccagccgc tacgaagaag acaccagcca
      541 aggcagatcc tgtacttctc aacaaccaca gcaacctgaa gccagctccc acagtgccgg
      601 cagcccccag cagtcctgat gcaacctcag agcccaaggg tcctggggat ggggcagagg
      661 aggacgagtc caacactgga ggccgaggtc cctggccttg tgagaacttg acccctttgc
      721 tggtagctgg gggtgtggcc gtggccacca tagctctaat tcttggtgtg gcctttctag
      781 cccggaaaaa atgatacctg gtgtccaggt cggggcacag agccactttc tgtacagacc
      841 tgaatatata gtgcatgcaa ggtcctagat atttatctat acatatacac ctaacaacac
      901 acacacaaca cacacacaca ctcacacgta tatgtatgct acatacatcc gtgcagcagg
      961 aaagaaatag acagtgagcc cacctccact caccccagca caccctctcc caagttctgg
     1021 ggcaggagcc cagctctgca gtttgcagga agcactagcg tggggcaaag gggagagatg
     1081 ctgggtgtgg tctctgaaag ataagtgatg gagtgcgcta gccctgtggg gacattaaag
     1141 ggcatggctg tcttactcct ctcacttgtc ttttgagcag ccaggagcag tctgtctggg
     1201 cctgatgccg ggggactgac ctaagggtgg gtgggattca aatctgcaga gctacctcta
     1261 cccattgtcc ctgtcctggt tggatggaaa aggcaaagtt aacagctgag tttgggatgg
     1321 ggttcccacc tcttccctct gtcagtgtat gccccaggag agcaccggag gctaggacca
     1381 ccttacttcc tgcccagagc agccaattgt tccggggagg gggtggttct gaaagcctgg
     1441 cagggaggca ggaagcacga aggagccaca ctacagttct gcctgcccaa tattccccaa
     1501 tactgtcctt cctgcctgca cccaacaccc ccccccttga gtttaacagc gtataaatgc
     1561 aataacacag gtagagtaga actgcccggt gagtggcaat cgctcactgc ctgcaggaag
     1621 acctgctgtg cagcccctct ttagtgcatc tggccccagc ttgccccttg gtgtggtgac
     1681 agtgagcagc tttccggaaa actgcagtgg gctctaagga aacattgccc tcacctggcc
     1741 agtggcggcg gggaccttgg gccggagtgg agactgagtt tgaaataaac cgttacaata
     1801 taaa
//
