LOCUS       NM_001033759            6620 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus cell migration inducing hyaluronidase 2 (Cemip2),
            transcript variant 2, mRNA.
ACCESSION   NM_001033759
VERSION     NM_001033759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6620)
  AUTHORS   Huang,H., Hu,X., Wu,J., Song,C., Tian,Z. and Jiang,B.
  TITLE     Hyaluronan degradation by HYAL2 is essential for odontoblastic
            differentiation and migration of mouse dental papilla cells
  JOURNAL   Matrix Biol 129, 1-14 (2024)
   PUBMED   38490466
REFERENCE   2  (bases 1 to 6620)
  AUTHORS   Zhao,X., Liu,D., Zhao,Y., Wang,Z., Wang,Y., Chen,Z., Ning,S.,
            Wang,G., Meng,L., Yao,J. and Tian,X.
  TITLE     HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated
            apoptosis through a non-canonical pathway in intestinal
            ischemia/reperfusion
  JOURNAL   Cell Death Dis 15 (2), 154 (2024)
   PUBMED   38378757
  REMARK    GeneRIF: HRD1-induced TMEM2 ubiquitination promotes ER
            stress-mediated apoptosis through a non-canonical pathway in
            intestinal ischemia/reperfusion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6620)
  AUTHORS   Li,H., Min,J., Yang,Y., Suo,W., Wang,W., Tian,J. and Qin,Y.
  TITLE     TMEM2 inhibits the development of Graves' orbitopathy through the
            JAK-STAT signaling pathway
  JOURNAL   J Biol Chem 300 (2), 105607 (2024)
   PUBMED   38159864
  REMARK    GeneRIF: TMEM2 inhibits the development of Graves' orbitopathy
            through the JAK-STAT signaling pathway.
REFERENCE   4  (bases 1 to 6620)
  AUTHORS   Narita,T., Tobisawa,Y., Bobkov,A., Jackson,M., Ohyama,C., Irie,F.
            and Yamaguchi,Y.
  TITLE     TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic
            activity
  JOURNAL   J Biol Chem 299 (9), 105120 (2023)
   PUBMED   37527776
  REMARK    GeneRIF: TMEM2 is a bona fide hyaluronidase possessing intrinsic
            catalytic activity.
REFERENCE   5  (bases 1 to 6620)
  AUTHORS   Nag,P., Inubushi,T., Sasaki,J.I., Murotani,T., Kusano,S.,
            Nakanishi,Y., Shiraishi,Y., Kurosaka,H., Imazato,S., Yamaguchi,Y.
            and Yamashiro,T.
  TITLE     Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft Enamel in
            Mouse
  JOURNAL   J Dent Res 102 (10), 1162-1171 (2023)
   PUBMED   37449307
  REMARK    GeneRIF: Tmem2 Deficiency Leads to Enamel Hypoplasia and Soft
            Enamel in Mouse.
REFERENCE   6  (bases 1 to 6620)
  AUTHORS   Shimogori,T., Lee,D.A., Miranda-Angulo,A., Yang,Y., Wang,H.,
            Jiang,L., Yoshida,A.C., Kataoka,A., Mashiko,H., Avetisyan,M.,
            Qi,L., Qian,J. and Blackshaw,S.
  TITLE     A genomic atlas of mouse hypothalamic development
  JOURNAL   Nat Neurosci 13 (6), 767-775 (2010)
   PUBMED   20436479
REFERENCE   7  (bases 1 to 6620)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   8  (bases 1 to 6620)
  AUTHORS   Amanai,M., Brahmajosyula,M. and Perry,A.C.
  TITLE     A restricted role for sperm-borne microRNAs in mammalian
            fertilization
  JOURNAL   Biol Reprod 75 (6), 877-884 (2006)
   PUBMED   16943360
REFERENCE   9  (bases 1 to 6620)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   10 (bases 1 to 6620)
  AUTHORS   Scott,D.A., Drury,S., Sundstrom,R.A., Bishop,J., Swiderski,R.E.,
            Carmi,R., Ramesh,A., Elbedour,K., Srikumari Srisailapathy,C.R.,
            Keats,B.J., Sheffield,V.C. and Smith,R.J.
  TITLE     Refining the DFNB7-DFNB11 deafness locus using intragenic
            polymorphisms in a novel gene, TMEM2
  JOURNAL   Gene 246 (1-2), 265-274 (2000)
   PUBMED   10767548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU058152.1, BC089353.1, AK034906.1 and AK078530.1.
            
            On Nov 7, 2013 this sequence version replaced NM_001033759.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089353.1, SRR10223970.20421.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BU058152.1         1-18
            19-4652             BC089353.1         1-4634
            4653-5972           AK034906.1         131-1450
            5973-6325           AK078530.1         938-1290
            6326-6620           AK034906.1         1805-2099
FEATURES             Location/Qualifiers
     source          1..6620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 15.54 cM"
     gene            1..6620
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="cell migration inducing hyaluronidase 2"
                     /db_xref="GeneID:83921"
                     /db_xref="MGI:MGI:1890373"
     exon            1..447
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..790
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..4611
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /EC_number="3.2.1.35"
                     /note="transmembrane protein 2"
                     /codon_start=1
                     /product="cell surface hyaluronidase"
                     /protein_id="NP_001028931.1"
                     /db_xref="CCDS:CCDS37934.1"
                     /db_xref="GeneID:83921"
                     /db_xref="MGI:MGI:1890373"
                     /translation="MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPLRPAPPPKNH
                     ASAKLTSRSQDAPATFAFSPEEQRTPSESRKRKRHKNTFICFAITSFSFFVALAVILG
                     ISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDLFRLTSDATVDSIVIQDGGLL
                     VFGDDKDGSKNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDERESMPIFG
                     KKFIGVEAGGTLELHGAQRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDT
                     ARVLENEKFDTHEYHNESRRLQEFLRAQEPGRIVAIAVGDSAVKSLLQGTIQMIQDRL
                     GSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFS
                     VTAYSEWSQGISLSGFRVDIADGVKLHLLDDVSTWEAGDRIVVASTDYSMYQAEELTL
                     LRCPECSRSQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGEMEDSCYAENHC
                     QFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHMGRYPVHFHLCGDVDSKGGYSQP
                     ASVDGLSVHHSFSRCITVHGTSGLLIKDTIGFDTLGHCFFLEDGVEQRNILYHNLGLL
                     TKPGTLLPTDRNSSMCTVMRDGVFGNYVPVPTTDCMAVSTFWIAHPNNHLINNAAAGS
                     QDAGIWYLFHKEPTGESSGLQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNA
                     SASDPREYLCLDNSARFRPHQDADPEKPRVAAIIDRLIAFKNNDNGAWVRGGDIIVQN
                     SAFADNGKGLTFASDGSFPSDEGSSQEVTESLFVGESRNYGFQGGQNKYMGTGGIDQK
                     PRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNN
                     VSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYL
                     IRHPNCVNVTKWNAVICSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAI
                     SPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKDDWIRVGLCYPANTSFQVTVGFL
                     QRQNGSLSRIEDYEPARSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSS
                     QGCERVKIQAATDSKDISNCMAKAYPQYYKKPSAVKRMPAMLTGLCQGCGTHQMVFTS
                     DPHKSYLPVRFQSPGKAEIQRGDPSIISVNGTDFTFRSAGALLLIVDACSVPFRVKEK
                     RMFLSADVSHMEEYFKASIPPRSIVLLSTRGEIKQLNISDSLAVLGLAKPAHLYSKGS
                     VVFLGFSGNFAPSWTKLFTSPDEQGLGVLEQFLPLQMEEYGCSRTGSVHRRDLDLLQQ
                     ALKVL"
     exon            791..931
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1493
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1663
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1852
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2022
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2232
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2438
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2508
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2637
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2726
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2727..2858
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2894
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3050
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3228
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3444
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3653
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3654..3836
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..4056
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4057..4155
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4310
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4414
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..6620
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6561..6566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="hexamer: AATAAA"
     polyA_site      6587
                     /gene="Cemip2"
                     /gene_synonym="Tmem2"
                     /note="major polyA site"
ORIGIN      
        1 cactctcggc ccagccgagc cggcgcttgt gtggccggag gctgattaga gggaccctag
       61 cgagccgcgg cgcccgccga accggggacc tgcgcggctc gggaacgcgc cctgcctgcc
      121 gctattgtct cggagccgca caggctcgcg ccgcccggac ggcgattccc ctcctcttcc
      181 tccgggaggg aaggatccaa gagcgccaag ccgggctggc tggaggaggt ggccgcgaag
      241 gcggagggag gagcgttact ccccggcccc gactgcttct cctccggcgt aggttgccgc
      301 tgaattcaga gcggcagcgg gacgcgggtt cctggccatg gagaggagat ctgcacgcgg
      361 ggactccagg agctctgctc ccgctcctgc tcctctggcc atcgcgtaga cacctgagta
      421 gaccgacgcc aggaggggga ggggaagtga cagggtatca tgtatgccgc tggttccagg
      481 ggccactccc ctgctttcct gcaacctcaa aacggaaacg gccaccgctc acctggttat
      541 gttcccggga aggtggttcc cttacgtccc gcgcctcctc caaagaacca cgcctccgcc
      601 aaactgacct ccaggagcca agacgcccca gcgacctttg ctttctcccc cgaggagcag
      661 cggactccga gcgagagccg aaagcggaag aggcacaaga acaccttcat ctgcttcgcc
      721 ataaccagct tctcgttctt tgtggcgctt gcggtcattt tgggaatatc ctcaaaatac
      781 gctccagatg agaattgtcc agatcaaaac cctcgtctca ggaactggga tccaggacaa
      841 gattctgcga agcacattgt tatcaaggag ggggatttgt tccgcctgac ctcagatgca
      901 acagtggact ctatagtcat tcaggatgga ggactgcttg tgtttgggga tgataaagat
      961 ggatccaaga atataacttt gaggactcga tacatcctga tccaggatgg tggggcgctt
     1021 catattggag cagaaaaatg ccgctataga tccaaagcga caattacctt gtatggcaag
     1081 tcagatgaac gtgaaagtat gccaatattt ggcaagaagt ttattggcgt ggaggctggc
     1141 gggacactgg agttacacgg ggcacagagg acatcatgga cgatgctggc gaggactctg
     1201 cattcttcag gcttgccctt tgggtcttat gccttcgaga aggacttttc ccggggcctt
     1261 aatgtgaggg tcattgatca agacacagcc agagttttag aaaacgagaa gttcgatacc
     1321 cacgagtacc acaatgagag caggaggctg caggagtttt tgagagctca ggagcccggc
     1381 cggattgtgg ctattgctgt tggagactca gcagtcaaga gcctgttaca gggaacaatc
     1441 cagatgatcc aggatcggtt ggggagtaaa ctgatccaag gtctgggcta caggcaagct
     1501 tgggccttag ttggtgtcat cgatggtgga agttcttcct gcaatgaatc tgtgagaaac
     1561 tatgaaaacc atagcactgg ggggaaggcc ctggctcaag gagaattcta caccctggac
     1621 ggtcagaagt tctctgtgac agcctacagt gaatggagtc aaggaatctc cctctcaggc
     1681 ttccgggtgg acattgcgga tggagtgaag cttcacctgt tggacgacgt cagcacttgg
     1741 gaagctggag accgaattgt ggtggccagc accgactatt ccatgtacca agcagaggag
     1801 ctaactcttc tccgctgccc cgagtgcagc cgttctcagg tcaaagtcaa agagatcccc
     1861 cagtacctgc acgtcggtga gatcatagac gggatagaca tgagagctga ggttggactt
     1921 ctcacccgca acattgtgat ccaaggagag atggaggatt catgctatgc agaaaatcac
     1981 tgccagttct tcgattatga cacctttggg ggacacgtca tgatagagaa gaattttact
     2041 tcagtccatc tttcttatgt ggaattgaaa cacatgggcc agcagcatat gggccggtat
     2101 cctgtgcatt ttcacctgtg tggagatgta gattctaaag gagggtacag ccagccagcg
     2161 tctgtggatg gcctgtctgt tcatcacagc ttttcaaggt gcatcaccgt gcacgggacc
     2221 agtggcttgc taatcaaaga caccattggc ttcgacacac taggtcattg cttctttttg
     2281 gaagatggtg ttgaacagcg aaatattttg tatcataact tggggcttct taccaagccg
     2341 ggcactctcc tcccaacgga caggaacagc tccatgtgca ccgtcatgcg tgatggagtg
     2401 tttggaaact acgtccctgt gcctaccaca gactgcatgg ctgtttcaac tttctggatt
     2461 gcccacccca acaaccacct gatcaataac gcagctgcag gctcacagga tgctggaata
     2521 tggtatttat tccacaagga accaactggg gagtccagtg ggctgcagct cctggagaag
     2581 ccagaactca ctccgctggg gatattttat aacaacaggg ttcattcaaa ttttaaggct
     2641 ggtttatttg tggacaaagg tgtcaaaacg accaacgcca gtgcatctga cccaagggag
     2701 tacctctgcc tggataacag tgcaaggttt cggccccatc aggatgcaga ccctgagaag
     2761 ccacgcgttg cagccatcat cgacaggctc attgctttta agaacaatga caacggagcc
     2821 tgggtcagag gaggagatat tattgttcag aattcagcat ttgcagataa cggaaagggg
     2881 ctgacctttg ccagtgatgg gagcttccca agcgatgaag ggtccagtca ggaggtgaca
     2941 gagtccctct ttgtcgggga gagtaggaat tacggctttc aaggtggcca aaacaagtac
     3001 atgggcacag ggggaatcga tcagaagcct cggacgctac ccaggaacag gacattccca
     3061 atccgaggct ttcagattta cgatgggcct attcatctca caaagagtac tttcaaaaag
     3121 tatgtgccaa ctccagacag gtacagcagt gcaattggct tcctcatgaa gaattcctgg
     3181 cagacaacac ccaggaataa cgtttccctt gtgaagtttg gtccacaggt ctctctgaac
     3241 gtcttctttg gaaagcctgg cccctggttt gaggattgtg agctggacgg cgataagaac
     3301 tccatcttcc atgacattga tggctctgtg acaggataca aggacaccta tgtgggaagg
     3361 atggacaact acctgatccg ccatccaaac tgtgtcaatg ttactaagtg gaatgcagtg
     3421 atctgtagcg ggacctacgc ccaggtgtat gttcagacct ggaacactcc gaatcttagc
     3481 atgatcatca cacgggatga atacccatcc cacccaatgg tgcttcgggg tatcaaccag
     3541 agggccatct ctccacagta ccagcctgtt gtcatgctgg agaagggcta caccatccac
     3601 tggaatggtc cagcgccacg aaccactttc ttgtacctcg tgaacttcaa caaggatgac
     3661 tggatccggg ttggcctctg ttacccagcc aacacgagct ttcaggttac cgttggcttt
     3721 ctgcagcggc agaacggctc attatctaga attgaggact atgagcctgc gcggtcgatg
     3781 gaggaactgc agaagaagcc gtctgagaga aaattctatt ttgactctgg cacagggtta
     3841 ttgtttctgt atctcagagc ccacagccac agagatggcc acagttactg ttcatctcag
     3901 ggatgtgaaa gagtcaagat tcaggcagca acagactcca aagatatcag taactgcatg
     3961 gccaaagcgt acccgcagta ttacaagaag ccctcggcgg tcaagcgcat gccggccatg
     4021 ctcacggggc tctgtcaagg ctgtggaacc caccagatgg tgtttaccag tgaccctcac
     4081 aaaagctacc tccctgtacg attccagtca cctgggaaag cagaaattca gcgaggagat
     4141 ccatccatta tttccgtcaa tggtactgac tttaccttcc ggagtgcggg tgccctcctc
     4201 ctcattgtgg atgcctgcag tgtgcccttc cgggtgaagg aaaagcggat gttcctttct
     4261 gcagacgtca gtcacatgga agaatatttc aaggctagca tccccccaag gtcaatcgtt
     4321 ctgttgagca caagaggaga aattaagcag ctgaatatct cggattcatt agcagttctg
     4381 ggactggcca agccagcaca tctgtacagc aaaggtagtg tcgtattttt gggattcagc
     4441 ggaaacttcg caccgtcatg gacgaagctg ttcaccagtc ccgatgagca gggcctcgga
     4501 gtgcttgagc agtttctccc gttgcagatg gaggaatatg ggtgctcccg gaccggcagt
     4561 gtccacagaa gagaccttga cctgttacag caggctttga aagtgcttta gagacttggt
     4621 tgtaatttaa gtgctgggaa agaaaaaaaa aatgtgaact aacttattta atttatggca
     4681 ttttaagaca acactgttaa cccgatggaa ccattttcct gtttgataga aaagggagag
     4741 aaggaatcca agcagttacc tgagtgtcag cttgcaggcc ttggcactgt gcaggtggta
     4801 gagccctttt gtcttcctga ggctgctgcg ttcagagagc agttggtctc gtggcccttg
     4861 ctttgacaag cacatcgggg gtgctttgct ttttgtatag tggggtgcag ggagtccaag
     4921 ggctccttga acttgctcct tcgaggactg gctgctctag catttcagat acttgaagtc
     4981 caatgctcag tcctgcgcta actccagtcg ctgccctgtt cagtgatgtc tggggctcat
     5041 ttctgtacag cccacgaggg ttttatgtga tgctagatat ggttttaagt ggcaactcag
     5101 gcccagcaca tgtccttttt gcctggtcat gtgctctttt tattcacttg tatactgatt
     5161 acttttgagg gttcaccttt caaagaggga accttattgg gacaaaaggg cttttgaaat
     5221 tttttagatc tgtaaccatt gaggaaaaaa aaagaaagaa agaaacaaca acataaacct
     5281 attacttgca tccaggtgga actttttctg cagctttaat ccttaacctg tcttgacctt
     5341 taaaacgcag agcggaactg aattaatttt ctttaaaagc agcaagccac ttcctaaact
     5401 gtaaaactct tgtcatttga acttgcaaaa gaaagccagg tgtggtggtg cacgcctttg
     5461 atcacagcac tccaggagca ggtggatctc tgagagtttg aggctagcct ggtctacgta
     5521 gtgatccagg acagccaggg ctacgtagag aaaccctgtc tcaaaagaaa caaaacaaaa
     5581 caaaacaaaa caaaatcact ctgtcaacaa aagctaactt gcaaaaggga aacctgtcct
     5641 tggttttggt cttgtacctg tgctttgttg tcttgttgtg tggatttttt ttttttccaa
     5701 gcggctctgc tcattgtcct accagaaaat cccagagagt ttcccgcttg ctcctccata
     5761 aatattgtat tcaaggaaag aaaggagatg ccttcttagg gtggaatcat ggaggcaatg
     5821 gacatgatct tctttgtagc ctttaaaaga gggagtctct tagtgaatgt agctttcaaa
     5881 gacaagaaga aaggactctg ggtctcccag tgctgcttct actggccctt tcttcagcca
     5941 gtggggacac atgtggcaaa ggatgctggc tctgcagcca agagggaaga tggcatcaga
     6001 atgctgctgt gctgcccaaa ggcgggtggc tgaatagcca ggctgacggt agcaattgag
     6061 tgcagaaaag ttcatcttcc tccgtggagg gccgaggctg atgcctgtat gttgtgtcca
     6121 ggagacattc taggacagct ctgtgacttg tgtaacttta cagaacatgc tacctcaaag
     6181 tgctgtgaca aaccatttgg actgtagtgc tcacaggatg ggcacgtgtc ttaatcaaag
     6241 tttggttact tgtttatccg ggttttttgg atgtggggtt ttttgtttgt attttttttt
     6301 ctttttcttt cattcttttt ttttttcttt tttttttgta cagtgagatc ttacctatta
     6361 aatatattta gtgggtcatg gttcctgaag gtgagtgaat tgattgtgtg tgcagatgtg
     6421 tgtgtgttat gacttaaata tatttgtttt gtgctgtttt agagttcctt ttttatatat
     6481 atttggagaa agtatgcaag tttcaaggca ctcagtgttt ctgattttta tgtactaata
     6541 attagggcct aagttaaata aataaaaacg tgtgtgcatg tattttatgt atgtgtattt
     6601 gtgaatctct gtaattgctg
//
