LOCUS       NM_030728               7114 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cell migration inducing protein, hyaluronan binding
            (Cemip), mRNA.
ACCESSION   NM_030728 XM_356044
VERSION     NM_030728.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7114)
  AUTHORS   Chen,L., Shi,K., Ditzel,N., Qiu,W., Figeac,F., Nielsen,L.H.D.,
            Tencerova,M., Kowal,J.M., Ding,M., Andreasen,C.M., Andersen,T.L.
            and Kassem,M.
  TITLE     KIAA1199 deficiency enhances skeletal stem cell differentiation to
            osteoblasts and promotes bone regeneration
  JOURNAL   Nat Commun 14 (1), 2016 (2023)
   PUBMED   37037828
  REMARK    GeneRIF: KIAA1199 deficiency enhances skeletal stem cell
            differentiation to osteoblasts and promotes bone regeneration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7114)
  AUTHORS   Schmaus,A., Rothley,M., Schreiber,C., Moller,S., Rosswag,S.,
            Franz,S., Garvalov,B.K., Thiele,W., Spataro,S., Herskind,C.,
            Prunotto,M., Anderegg,U., Schnabelrauch,M. and Sleeman,J.
  TITLE     Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and
            regulates the HA metabolism, proliferation and differentiation of
            fibroblasts
  JOURNAL   Matrix Biol 109, 173-191 (2022)
   PUBMED   35405271
  REMARK    GeneRIF: Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP
            and regulates the HA metabolism, proliferation and differentiation
            of fibroblasts.
REFERENCE   3  (bases 1 to 7114)
  AUTHORS   Deroyer,C., Poulet,C., Paulissen,G., Ciregia,F., Malaise,O.,
            Plener,Z., Cobraiville,G., Daniel,C., Gillet,P., Malaise,M.G. and
            de Seny,D.
  TITLE     CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis
            in osteoarthritis synovial membrane
  JOURNAL   Cell Mol Life Sci 79 (5), 260 (2022)
   PUBMED   35474501
  REMARK    GeneRIF: CEMIP (KIAA1199) regulates inflammation, hyperplasia and
            fibrosis in osteoarthritis synovial membrane.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7114)
  AUTHORS   Momoeda,M., de Vega,S., Kaneko,H., Yoshinaga,C., Shimoda,M.,
            Nakamura,T., Endo,Y., Yoshida,H., Kaneko,K., Ishijima,M. and
            Okada,Y.
  TITLE     Deletion of Hyaluronan-Binding Protein Involved in Hyaluronan
            Depolymerization (HYBID) Results in Attenuation of Osteoarthritis
            in Mice
  JOURNAL   Am J Pathol 191 (11), 1986-1998 (2021)
   PUBMED   34390681
REFERENCE   5  (bases 1 to 7114)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7114)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   7  (bases 1 to 7114)
  AUTHORS   Usami,S., Takumi,Y., Suzuki,N., Oguchi,T., Oshima,A., Suzuki,H.,
            Kitoh,R., Abe,S., Sasaki,A. and Matsubara,A.
  TITLE     The localization of proteins encoded by CRYM, KIAA1199, UBA52,
            COL9A3, and COL9A1, genes highly expressed in the cochlea
  JOURNAL   Neuroscience 154 (1), 22-28 (2008)
   PUBMED   18448257
REFERENCE   8  (bases 1 to 7114)
  AUTHORS   Abe,S., Usami,S. and Nakamura,Y.
  TITLE     Mutations in the gene encoding KIAA1199 protein, an inner-ear
            protein expressed in Deiters' cells and the fibrocytes, as the
            cause of nonsyndromic hearing loss
  JOURNAL   J Hum Genet 48 (11), 564-570 (2003)
   PUBMED   14577002
REFERENCE   9  (bases 1 to 7114)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
REFERENCE   10 (bases 1 to 7114)
  AUTHORS   Wines,M.E., Shi,Y., Lindor,M. and Holdener,B.C.
  TITLE     Physical localization of the mesoderm development (mesd) functional
            region
  JOURNAL   Genomics 68 (3), 322-329 (2000)
   PUBMED   10995574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101659.12, AK162689.1, AK036809.1, AC154141.7 and BC086772.1.
            
            On Nov 17, 2009 this sequence version replaced NM_030728.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An upstream
            AUG codon was not annotated as the start codon because it lacks a
            Kozak signal and disrupts the signal peptide sequence. This uAUG
            would add 23 aa to the N-terminus. The annotated start codon
            encodes 1361 aa and has a predicted signal peptide at aa 1-30.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB103331.1, BC115873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC101659.12        189939-190139
            202-1146            AK162689.1         200-1144
            1147-2249           AK036809.1         1147-2249
            2250-2250           AC154141.7         78253-78253
            2251-2903           AK036809.1         2251-2903
            2904-2904           AC154141.7         89316-89316
            2905-3601           AK036809.1         2905-3601
            3602-6426           BC086772.1         524-3348
            6427-7114           AC154141.7         108712-109399
FEATURES             Location/Qualifiers
     source          1..7114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.35 cM"
     gene            1..7114
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /note="cell migration inducing protein, hyaluronan
                     binding"
                     /db_xref="GeneID:80982"
                     /db_xref="MGI:MGI:2443629"
     exon            1..248
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            249..358
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..4350
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /EC_number="3.2.1.35"
                     /note="protein 12H19.01.T7; cell migration-inducing and
                     hyaluronan-binding protein; hyaluronan binding protein
                     involved in hyaluronan depolymerization"
                     /codon_start=1
                     /product="cell migration-inducing and hyaluronan-binding
                     protein precursor"
                     /protein_id="NP_109653.3"
                     /db_xref="CCDS:CCDS21416.1"
                     /db_xref="GeneID:80982"
                     /db_xref="MGI:MGI:2443629"
                     /translation="MRASGRHDVSLKIVLATGCLLLANFSGASSAVATECPDQSPELQ
                     PWSPGHNRDYQVHIGHGRKLLLTSSATVHSITISGGGKLVIKDHHEHIVLRTRYILID
                     DGGELHAGSALCPFEGNFSIVLYGRADENILPDPYYGLKYIGVDKGGTLELHGQKKLS
                     WTFLNKTLHPGGMQEGGYFFERSWGHRGVIVHVIDAKLGTVVHSDRFDTYRSKKESER
                     LVQYLNAVPDGRILSVAVNDEGSRNLDDTARKAMTKLGSKHFLHLGFRHPWSFITVKG
                     NPSSSVEDHIEYHGHKGSAAARVFKLFQTEHGEHFNVSSSSEWVQDVEWTEWFDHDKV
                     PQSKGGEKISDLRAAYPGKICNRPIDIQATTMDGVALSTEVVYKNGQDYRFACYTRGR
                     ACRSYRVRFLCGKPVRPKLTVSIDTNVNSTILSLVDNVRSWRPGDTLVVASTDYSMYQ
                     AEEFRVLPCKACTSTQVKVAGKPQYLHIGEEIDGVDMRAEVGLLTRNIVVMGEMEDRC
                     YPYTNHICDFFDFDTFGGHIKFALGFKAAHLEGVELKYMGQQLVGQYPIHFHLAGDLD
                     EQGGYDPPTYIRDLSIHHTFSRCITVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNT
                     FDHCLGLLVKSGTLLPSDRDSRMCKVITEDSYPGYIPKPRQDCNAVSTFWMANPNNNL
                     INCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIID
                     NGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFTAYKNQDHGAWLRG
                     GDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWG
                     PGGLDHSGRTLPIGQNFPIRGIQFYDGPINIQNCTFRKFAALEGRHTSALAFRLNNAW
                     QSCPHNNVTNIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDLDGSVSEYPGSY
                     LTKDDNWLVRHPDCINVPDWRGAICSGRYAQMYIQAYKSSNLRMKIIKNDFPSHPLYL
                     EGALTRSTHYQQYQPVITLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGT
                     TFSILSDVHNRLLKQTSKTGTFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQN
                     EREKFAFCSMKGCERIKIKALLPRNAGISDCTATAYPRFTERAIVDVPMPRKLFGAQL
                     KTKDHFLEVKMESSRQHFFHLRNDFAYIEVDGRRYPCSEDGIQIVVIDGSRGHVVSHG
                     SFRNAILQGIPWQLFNYVAAIPDNSIVLMASKGRYITRGPWTRVLEKLGADKGLKLKE
                     KMAFVGFKGSFRPIWVTLETEDHKAKIFQVVPIPVVRKKKL"
     exon            359..505
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            506..644
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            645..881
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1061
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1132
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1228
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1350
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1483
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1675
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1851
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2061
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2267
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2337
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2466
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2552
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2684
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2720
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2876
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3057
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3273
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3485
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3671
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3876
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            3877..3963
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            3964..4121
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            4122..4222
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     exon            4223..7114
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7093..7098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /note="hexamer: ATTAAA"
     polyA_site      7114
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /note="major polyA site"
ORIGIN      
        1 tccgagctag ctactaagcc agtgagcgcg cggagtcgag cgaggagcgc cttctgcgct
       61 gagtggcagt ggtctggtgc tgctggagca ctgtgccgag tgaggtcgga atctgcaccc
      121 cactttccgc cagctcccgt cccacttgct tacgctcagg agctcaacgc gtgggatcag
      181 atactagact acgggatgct gcactccaga tccccgaggc gtggcagggt ctcggtcatc
      241 aacctgaggg aggaagctgt tggaatgaga gcttctggga ggcacgatgt ctccctcaag
      301 attgtgctgg ccacgggctg cctcctcctg gccaacttct caggggcctc atctgcagtg
      361 gcaactgagt gtcctgatca gagtcctgag ctgcagcctt ggagccctgg ccataacaga
      421 gactatcaag tacacattgg ccatggcagg aaactactgc tcacctcttc tgccacagtc
      481 cactccatca ctatctcagg gggaggaaag cttgtcatta aagaccacca tgagcacatt
      541 gtgctgcgta cccggtacat cctgattgat gacggtggag agctgcatgc tgggagtgcc
      601 ctttgccctt ttgagggcaa tttcagtatt gtgctgtatg gaagggctga tgaaaacatc
      661 ctgccagacc cttactatgg cctgaagtac atcggagtag acaaaggagg cactcttgaa
      721 ttacatgggc agaaaaagct ttcctggact tttctaaaca agacccttca tcctggtggc
      781 atgcaggagg gaggatattt ttttgaaagg agctggggcc accgtggagt cattgtccat
      841 gtcattgatg ccaaattggg cacagttgtc cattctgacc ggtttgacac ttacagatcc
      901 aaaaaagaga gtgaacgtct ggtccagtat ttgaatgcag tgcccgatgg caggattctt
      961 tctgtcgcag tgaatgatga aggctctaga aacctggatg acacagcccg gaaggcaatg
     1021 accaaactgg gcagcaagca cttcctccac cttggattta gacacccttg gagcttcatc
     1081 actgtgaaag gaaatccctc ctcttcagtt gaagaccaca ttgaatacca tggtcacaaa
     1141 ggctcggctg ctgcccgggt tttcaaactg ttccagacag agcatggtga acatttcaat
     1201 gtttcttcat ccagcgaatg ggttcaagat gtggaatgga cagagtggtt tgaccatgat
     1261 aaggtgcctc agagcaaagg tggggagaaa atttcagatc tgcgagcagc ttacccagga
     1321 aaaatctgca atcgacccat tgatatacag gccacaacaa tggatggagt cgccctcagc
     1381 actgaggttg tctacaaaaa tggccaagat tacaggtttg cttgctacac ccggggcaga
     1441 gcctgccgaa gctatcgagt gcgattctta tgtggaaaac ccgtgaggcc caagctcacg
     1501 gttagcatcg acaccaacgt aaacagcacc atcctgagtc tggtggacaa tgtgcggtca
     1561 tggaggcctg gagacaccct ggttgttgcc agcactgact attcgatgta ccaggcagaa
     1621 gagttccggg tgctcccctg caaagcttgc acctctacac aggtcaaggt ggcagggaaa
     1681 ccacagtacc tacatattgg ggaggagatt gatggtgtag acatgcgggc tgaggtcgga
     1741 ctcctgactc ggaacattgt ggtgatgggg gagatggagg acagatgcta cccctacacc
     1801 aatcacatct gtgacttctt tgacttcgat acctttgggg gccacatcaa gtttgcactg
     1861 gggtttaaag cagcccactt ggagggcgtg gagctgaagt acatggggca gcagctggtg
     1921 ggccagtacc caattcactt ccacctggct ggagatttgg atgaacaggg aggctatgac
     1981 ccccctacct acatcaggga cctctccatt catcacacat tctcccgctg catcactgtc
     2041 catggctcca acggtctgtt gatcaaggat gttgtgggct ataattcttt gggccactgc
     2101 ttcttcactg aagatgggcc agaggaacgc aacacttttg accactgcct tggcctcctt
     2161 gttaagtcag ggacccttct cccatccgat cgggatagca ggatgtgcaa agtgatcaca
     2221 gaggactcat acccagggta catccccaag cccaggcagg actgcaatgc cgtgtccaca
     2281 ttctggatgg cgaatcccaa caacaatctc atcaactgcg cagctgcagg gtccgaggaa
     2341 actggatttt ggttcatttt tcaccatgtg ccaacgggcc cctctgtggg aatgtactct
     2401 ccaggttatt ctgagcacat tccactgggt aaattctaca acaatcgagc acattctaac
     2461 taccgggctg gcatgatcat agacaacgga gtcaagacaa ctgaggcctc agccaaggat
     2521 aaacggccct tcctctccat catctctgcc aggtacagcc ctcaccagga cgcagaccca
     2581 ctgaaacctc gggaaccagc cattatccga cactttactg cctacaagaa ccaggatcat
     2641 ggagcctggc tgcggggtgg ggatgtgtgg ctggacagct gtcggtttgc tgataatggc
     2701 attggtctga ccctggccag tggtggaacc ttcccatatg atgatggctc caagcaggag
     2761 ataaagaaca gcttgtttgt tggcgagagt ggcaatgtgg gcacagaaat gatggacaac
     2821 aggatctggg gtccaggtgg cttggaccac agtggaagga ccctccctat tggccagaat
     2881 tttcccatta gaggaattca gttctacgat ggccccatca acatccagaa ctgcaccttc
     2941 cgcaagttcg cggccctcga gggcaggcac accagtgcct tggccttccg cctaaacaat
     3001 gcctggcaaa gctgccctca caacaatgtg accaacatag cctttgagga tgtcccgatt
     3061 acttccagag tgttcttcgg agagcccggg ccctggttca accagctgga catggacggg
     3121 gacaagacat ctgtgttcca tgatctggac ggctctgtgt cggagtaccc tggctcctat
     3181 ctcactaagg acgacaactg gctggtccga cacccagact gcatcaatgt cccagactgg
     3241 agaggggcca tctgcagtgg gcgctatgca cagatgtaca tccaggccta caagagcagc
     3301 aatctgcgca tgaagatcat taagaatgac ttccccagcc acccgctcta cctggagggg
     3361 gccctcacca ggagcaccca ctaccagcag tatcagcctg tcatcaccct gcagaagggc
     3421 tatactatcc actgggacca gacagccccc gccgagcttg ccatctggct catcaacttc
     3481 aacaagggtg actggatccg agtggggctc tgctacccaa gaggcaccac cttttccatc
     3541 ctttcagatg ttcacaatcg cctgctaaag caaacgtcca agactgggac ctttgtgagg
     3601 actctgcaga tggacaaagt tgagcagagc tatcctggca ggagccacta ctactgggat
     3661 gaggattctg ggttgctctt cttgaaatta aaagcccaga acgaaaggga gaaatttgct
     3721 ttctgctcca tgaagggctg tgagagaatc aagattaaag ctctgctccc aaggaatgca
     3781 ggcatcagcg actgcacagc cacggcttac cccaggttca ctgagagggc catagtggat
     3841 gtgccaatgc ccaggaagct ctttggggct cagctgaaga caaaagacca cttcctggaa
     3901 gtgaagatgg aaagttccag gcagcacttc ttccaccttc ggaatgactt cgcttatatt
     3961 gaagtggatg ggaggaggta cccttgctca gaagatggca tccagatagt ggtgattgat
     4021 gggagtcgag gtcacgtggt gagccacggc agcttcagaa atgccattct gcagggcata
     4081 ccctggcagc tcttcaacta cgtggcagct atccctgaca attccatagt gctcatggca
     4141 tcaaagggca gatacatcac cagaggccca tggaccaggg tgctggaaaa gcttggggca
     4201 gacaaaggtc tcaagttgaa agaaaagatg gcgttcgtcg gcttcaaagg cagcttccga
     4261 cccatctggg tgactctgga gactgaggac cacaaagcca aaatcttcca agtggtgccc
     4321 atccctgtgg tgagaaagaa gaagctgtaa ggagagttgc cacttggtac caccccaggc
     4381 tggaccccta cagcagccgg ggtcaggatg gctaggcccc ctggttctca gctctgctgg
     4441 gctaagggac agatatcaga gaccttggtg ctgccacctg cccctactca agtctacctg
     4501 cagcccctgg gcagtgttgg ccgatgctac aacctcctct tgggtgcttc tctcctatct
     4561 gtgcctcatc ggtaggcatg gggaccatac aaagagacct gagttgtgct ggcagcaaag
     4621 ggccacttgg gcaggagtct gaacccacct aggagatggt ctggataatg tgaccacttg
     4681 cagatttcca tagtcacttt cagatacatt aagtggcaga tggaaggagt acatctttat
     4741 tcctgtaagt gagggtgcgg cttcctgagt ttaggagctg gcgtatggac agagctgtcc
     4801 agcatggcag attgcactgg ggaggagatg gaaccctgtc tacaggggat ccttttttca
     4861 agagacttca gctggcacac tgggacaggg actaggtgga tcctgtttgt ccttcctgag
     4921 attacaggac tcaactgtgc tttgctctgt gcctggagcc catcagtaga agtaatcatt
     4981 gtagttgaca tctccactga gtgccctgga tacagagaat ggagcgatga gagctcagac
     5041 ctgggggtca gctggtgaca ggcagccagg tctcagcaca ctttgatacc aggttgagag
     5101 agcagaggtg gattggagga ggggaacctc accacaccca gaaacatggg gaaggcttct
     5161 tctggaaggt gatggtcctg gcaggaatca aggacagaga tgatgaagag agaagaggtg
     5221 gcctctggca tggctcagag gtgaaggctt tcctgccacc acttgcagca tctgagtcat
     5281 gctaggtcac ctcttgctga cccacttgtg atagagaagc agggtctgcg gagagaaatg
     5341 gactgagtta cgatgcacag aacctcgttc agattggtgt ccagccagcc ccctctgact
     5401 ctgcgagagg gtgaagtgaa gttcacagac ctgaggctgt acaatgggtc tccagtgcac
     5461 ttcagcttgg agctgagcag aagactccag gaaatctgaa catgctctcg ccacagtgaa
     5521 cctggggtgt cagagatgga aaggaccttg ggggcccttg aggaccatct agcccagcat
     5581 tttgtaccta catctgagga aaatggtact caataacaca gccaggtctg tgagccccaa
     5641 gctcagcaac ccactgccac accacattgc ctcagtggct agcctggggt gtccagtatt
     5701 cccaagtagc tttcggaagg gagcatatca cctgaaatgg ggagaagctg ttcgtgattc
     5761 ttgggtgcgc accaaatggg aattgagtgg ggggttcccc actaggttct ttcaatttca
     5821 aaatatacgg tcttttgcaa agggcttttc cctcttgccc ctcagtacac actgcccact
     5881 ctcctctagg cagcagccct gccactgtct ttacactgcc agccacatgt gggcatgggc
     5941 tgctcatgac tgtggaattc ttttggtgcc accttattcc acagtggtgc tggtatgccc
     6001 aatgggtagc atcaggatat gccaatgtgc ttctgctggg ccaattggct ccttgtgggg
     6061 atctgagagt ggttggctcc agaccaggat ctttcagctt atgttcactc tgagcaaata
     6121 gctccgatgc ccagacgagt gaaaactatc catgtccaat attcttcgga gacatcaggg
     6181 tttctctgtg tttcatgaat gagattggtc ccctttcctc cacaaccaca acctttcttt
     6241 ttcaaagaag atttgcttcg gtcccctttg tccagtggta ttaaggagcc ttagtcccag
     6301 agtctactct ccaggttgag ccaactcgca gggggtcttt cctactaatg gatcttgcag
     6361 ctgctgggat gtgtctgtgg gaccatgcct cttaagacat agtggctcca gttgcgagtg
     6421 tcagagaaaa gacctcttct ggggagatga gtgggagggg gagggggagg gggaggggat
     6481 aaaagtgacc tcatgttttt cttgtctaag tttcattgac ttttcaaggc gagggtctca
     6541 cactgtgaac cacttaagac tcgatcactt tcaggtggcc atgaatgttg aatgtctttg
     6601 gctcagttca tttcagcaaa tacctattgg aaagttctct gagttgtaca tatgttgaac
     6661 agtacaggtt ctgtacggaa agcgttcttt cctaaactat tcaccaagag tcgatataca
     6721 ggcattttct tggtagcaca aaagtctttc ttgcttagaa agttgctctt gtcctttctg
     6781 ttggtcagca ttgtcactga gtcaggggcc tttgattgaa aggctcatct gtcctgttgg
     6841 cttaatagct ggctctttct tgtgaattgg atgcatagca tgttttgtat gtaaatgttc
     6901 cttaaaagtg tcaccatgaa caaaggtata ttttctattt atttattata tattcacttc
     6961 aagaagtcac tgtcagagaa gtgaagagtc atcttaagta ttatattaga ggatgtcctt
     7021 tggaccaccg gaaggaggtg tgcccagagc caaggacatc agctctggtt tggaaaaatc
     7081 ctgctgtacc atattaaaca tacaaaggat gtca
//
