LOCUS       NP_109653               1361 aa            linear   ROD 04-JUN-2024
DEFINITION  cell migration-inducing and hyaluronan-binding protein precursor
            [Mus musculus].
ACCESSION   NP_109653 XP_356044
VERSION     NP_109653.3
DBSOURCE    REFSEQ: accession NM_030728.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1361)
  AUTHORS   Chen,L., Shi,K., Ditzel,N., Qiu,W., Figeac,F., Nielsen,L.H.D.,
            Tencerova,M., Kowal,J.M., Ding,M., Andreasen,C.M., Andersen,T.L.
            and Kassem,M.
  TITLE     KIAA1199 deficiency enhances skeletal stem cell differentiation to
            osteoblasts and promotes bone regeneration
  JOURNAL   Nat Commun 14 (1), 2016 (2023)
   PUBMED   37037828
  REMARK    GeneRIF: KIAA1199 deficiency enhances skeletal stem cell
            differentiation to osteoblasts and promotes bone regeneration.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1361)
  AUTHORS   Schmaus,A., Rothley,M., Schreiber,C., Moller,S., Rosswag,S.,
            Franz,S., Garvalov,B.K., Thiele,W., Spataro,S., Herskind,C.,
            Prunotto,M., Anderegg,U., Schnabelrauch,M. and Sleeman,J.
  TITLE     Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and
            regulates the HA metabolism, proliferation and differentiation of
            fibroblasts
  JOURNAL   Matrix Biol 109, 173-191 (2022)
   PUBMED   35405271
  REMARK    GeneRIF: Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP
            and regulates the HA metabolism, proliferation and differentiation
            of fibroblasts.
REFERENCE   3  (residues 1 to 1361)
  AUTHORS   Deroyer,C., Poulet,C., Paulissen,G., Ciregia,F., Malaise,O.,
            Plener,Z., Cobraiville,G., Daniel,C., Gillet,P., Malaise,M.G. and
            de Seny,D.
  TITLE     CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis
            in osteoarthritis synovial membrane
  JOURNAL   Cell Mol Life Sci 79 (5), 260 (2022)
   PUBMED   35474501
  REMARK    GeneRIF: CEMIP (KIAA1199) regulates inflammation, hyperplasia and
            fibrosis in osteoarthritis synovial membrane.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1361)
  AUTHORS   Momoeda,M., de Vega,S., Kaneko,H., Yoshinaga,C., Shimoda,M.,
            Nakamura,T., Endo,Y., Yoshida,H., Kaneko,K., Ishijima,M. and
            Okada,Y.
  TITLE     Deletion of Hyaluronan-Binding Protein Involved in Hyaluronan
            Depolymerization (HYBID) Results in Attenuation of Osteoarthritis
            in Mice
  JOURNAL   Am J Pathol 191 (11), 1986-1998 (2021)
   PUBMED   34390681
REFERENCE   5  (residues 1 to 1361)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1361)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   7  (residues 1 to 1361)
  AUTHORS   Usami,S., Takumi,Y., Suzuki,N., Oguchi,T., Oshima,A., Suzuki,H.,
            Kitoh,R., Abe,S., Sasaki,A. and Matsubara,A.
  TITLE     The localization of proteins encoded by CRYM, KIAA1199, UBA52,
            COL9A3, and COL9A1, genes highly expressed in the cochlea
  JOURNAL   Neuroscience 154 (1), 22-28 (2008)
   PUBMED   18448257
REFERENCE   8  (residues 1 to 1361)
  AUTHORS   Abe,S., Usami,S. and Nakamura,Y.
  TITLE     Mutations in the gene encoding KIAA1199 protein, an inner-ear
            protein expressed in Deiters' cells and the fibrocytes, as the
            cause of nonsyndromic hearing loss
  JOURNAL   J Hum Genet 48 (11), 564-570 (2003)
   PUBMED   14577002
REFERENCE   9  (residues 1 to 1361)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
REFERENCE   10 (residues 1 to 1361)
  AUTHORS   Wines,M.E., Shi,Y., Lindor,M. and Holdener,B.C.
  TITLE     Physical localization of the mesoderm development (mesd) functional
            region
  JOURNAL   Genomics 68 (3), 322-329 (2000)
   PUBMED   10995574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101659.12, AK162689.1, AK036809.1, AC154141.7 and BC086772.1.
            
            On Nov 17, 2009 this sequence version replaced NP_109653.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. An upstream
            AUG codon was not annotated as the start codon because it lacks a
            Kozak signal and disrupts the signal peptide sequence. This uAUG
            would add 23 aa to the N-terminus. The annotated start codon
            encodes 1361 aa and has a predicted signal peptide at aa 1-30.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB103331.1, BC115873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1361
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.35 cM"
     Protein         1..1361
                     /product="cell migration-inducing and hyaluronan-binding
                     protein precursor"
                     /EC_number="3.2.1.35"
                     /note="protein 12H19.01.T7; cell migration-inducing and
                     hyaluronan-binding protein; hyaluronan binding protein
                     involved in hyaluronan depolymerization"
                     /calculated_mol_wt=149977
     sig_peptide     1..30
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
                     /calculated_mol_wt=3076
     mat_peptide     31..1361
                     /product="Cell migration-inducing and hyaluronan-binding
                     protein. /id=PRO_0000021539"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BI06.4)"
                     /calculated_mol_wt=149977
     Region          47..165
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Site            119
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          141..303
                     /region_name="PANDER_like_TMEM2"
                     /note="PANDER-like domain of the transmembrane protein
                     TMEM2; cd13938"
                     /db_xref="CDD:260112"
     Site            165
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          295..591
                     /region_name="Necessary for its endoplasmic reticulum (ER)
                     retention and interaction with HSPA5.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BI06.4)"
     Site            312
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          325..403
                     /region_name="Mucin2_WxxW"
                     /note="Mucin-2 protein WxxW repeating region; pfam13330"
                     /db_xref="CDD:463846"
     Site            420
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          572..594
                     /region_name="PbH1 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          595..617
                     /region_name="PbH1 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          719..741
                     /region_name="PbH1 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          798..819
                     /region_name="PbH1 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BI06.4)"
     Site            889
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
     Site            921
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8BI06.4)"
     Region          1205..1361
                     /region_name="PANDER_like"
                     /note="Domains similar to the Pancreatic-derived factor;
                     cl19122"
                     /db_xref="CDD:473142"
     CDS             1..1361
                     /gene="Cemip"
                     /gene_synonym="12H19.01.T7; 6330404C01Rik; 9930013L23Rik;
                     Hybid; Kiaa1199"
                     /coded_by="NM_030728.4:265..4350"
                     /db_xref="CCDS:CCDS21416.1"
                     /db_xref="GeneID:80982"
                     /db_xref="MGI:MGI:2443629"
ORIGIN      
        1 mrasgrhdvs lkivlatgcl llanfsgass avatecpdqs pelqpwspgh nrdyqvhigh
       61 grkllltssa tvhsitisgg gklvikdhhe hivlrtryil iddggelhag salcpfegnf
      121 sivlygrade nilpdpyygl kyigvdkggt lelhgqkkls wtflnktlhp ggmqeggyff
      181 erswghrgvi vhvidaklgt vvhsdrfdty rskkeserlv qylnavpdgr ilsvavndeg
      241 srnlddtark amtklgskhf lhlgfrhpws fitvkgnpss svedhieyhg hkgsaaarvf
      301 klfqtehgeh fnvssssewv qdvewtewfd hdkvpqskgg ekisdlraay pgkicnrpid
      361 iqattmdgva lstevvykng qdyrfacytr gracrsyrvr flcgkpvrpk ltvsidtnvn
      421 stilslvdnv rswrpgdtlv vastdysmyq aeefrvlpck actstqvkva gkpqylhige
      481 eidgvdmrae vglltrnivv mgemedrcyp ytnhicdffd fdtfgghikf algfkaahle
      541 gvelkymgqq lvgqypihfh lagdldeqgg ydpptyirdl sihhtfsrci tvhgsnglli
      601 kdvvgynslg hcfftedgpe erntfdhclg llvksgtllp sdrdsrmckv itedsypgyi
      661 pkprqdcnav stfwmanpnn nlincaaags eetgfwfifh hvptgpsvgm yspgysehip
      721 lgkfynnrah snyragmiid ngvktteasa kdkrpflsii sarysphqda dplkprepai
      781 irhftayknq dhgawlrggd vwldscrfad ngigltlasg gtfpyddgsk qeiknslfvg
      841 esgnvgtemm dnriwgpggl dhsgrtlpig qnfpirgiqf ydgpiniqnc tfrkfaaleg
      901 rhtsalafrl nnawqscphn nvtniafedv pitsrvffge pgpwfnqldm dgdktsvfhd
      961 ldgsvseypg syltkddnwl vrhpdcinvp dwrgaicsgr yaqmyiqayk ssnlrmkiik
     1021 ndfpshplyl egaltrsthy qqyqpvitlq kgytihwdqt apaelaiwli nfnkgdwirv
     1081 glcyprgttf silsdvhnrl lkqtsktgtf vrtlqmdkve qsypgrshyy wdedsgllfl
     1141 klkaqnerek fafcsmkgce rikikallpr nagisdctat ayprfterai vdvpmprklf
     1201 gaqlktkdhf levkmessrq hffhlrndfa yievdgrryp csedgiqivv idgsrghvvs
     1261 hgsfrnailq gipwqlfnyv aaipdnsivl maskgryitr gpwtrvlekl gadkglklke
     1321 kmafvgfkgs frpiwvtlet edhkakifqv vpipvvrkkk l
//
