LOCUS       NM_001359572           11846 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus cadherin, EGF LAG seven-pass G-type receptor 3
            (Celsr3), transcript variant 1, mRNA.
ACCESSION   NM_001359572 XM_006511621
VERSION     NM_001359572.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11846)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   2  (bases 1 to 11846)
  AUTHORS   Nasello,C., Poppi,L.A., Wu,J., Kowalski,T.F., Thackray,J.K.,
            Wang,R., Persaud,A., Mahboob,M., Lin,S., Spaseska,R., Johnson,C.K.,
            Gordon,D., Tissir,F., Heiman,G.A., Tischfield,J.A., Bocarsly,M. and
            Tischfield,M.A.
  TITLE     Human mutations in high-confidence Tourette disorder genes affect
            sensorimotor behavior, reward learning, and striatal dopamine in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2307156121 (2024)
   PUBMED   38683996
REFERENCE   3  (bases 1 to 11846)
  AUTHORS   Young,T.R., Yamamoto,M., Kikuchi,S.S., Yoshida,A.C., Abe,T.,
            Inoue,K., Johansen,J.P., Benucci,A., Yoshimura,Y. and Shimogori,T.
  TITLE     Thalamocortical control of cell-type specificity drives circuits
            for processing whisker-related information in mouse barrel cortex
  JOURNAL   Nat Commun 14 (1), 6077 (2023)
   PUBMED   37770450
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11846)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11846)
  AUTHORS   Chen,B., Li,F., Jia,B., So,K.F., Wei,J.A., Liu,Y., Qu,Y. and
            Zhou,L.
  TITLE     Celsr3 Inactivation in the Brainstem Impairs Rubrospinal Tract
            Development and Mouse Behaviors in Motor Coordination and
            Mechanic-Induced Response
  JOURNAL   Mol Neurobiol 59 (8), 5179-5192 (2022)
   PUBMED   35678978
  REMARK    GeneRIF: Celsr3 Inactivation in the Brainstem Impairs Rubrospinal
            Tract Development and Mouse Behaviors in Motor Coordination and
            Mechanic-Induced Response.
REFERENCE   6  (bases 1 to 11846)
  AUTHORS   Shima,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Chisaka,O.,
            Takeichi,M. and Uemura,T.
  TITLE     Differential expression of the seven-pass transmembrane cadherin
            genes Celsr1-3 and distribution of the Celsr2 protein during mouse
            development
  JOURNAL   Dev Dyn 223 (3), 321-332 (2002)
   PUBMED   11891983
  REMARK    GeneRIF: Differential expression of the seven-pass transmembrane
            cadherin genes Celsr1-3 and distribution of the Celsr2 protein
            during mouse development
REFERENCE   7  (bases 1 to 11846)
  AUTHORS   Tissir,F., De-Backer,O., Goffinet,A.M. and Lambert de Rouvroit,C.
  TITLE     Developmental expression profiles of Celsr (Flamingo) genes in the
            mouse
  JOURNAL   Mech Dev 112 (1-2), 157-160 (2002)
   PUBMED   11850187
  REMARK    GeneRIF: Developmental expression profiles of Celsr (Flamingo)
            genes in the mouse
REFERENCE   8  (bases 1 to 11846)
  AUTHORS   Formstone,C.J. and Little,P.F.
  TITLE     The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit
            distinct patterns of expression during embryonic development
  JOURNAL   Mech Dev 109 (1), 91-94 (2001)
   PUBMED   11677057
REFERENCE   9  (bases 1 to 11846)
  AUTHORS   Formstone,C.J., Barclay,J., Rees,M. and Little,P.F.
  TITLE     Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3
            is a candidate for the tippy (tip) lethal mutant on chromosome 9
  JOURNAL   Mamm Genome 11 (5), 392-394 (2000)
   PUBMED   10790539
REFERENCE   10 (bases 1 to 11846)
  AUTHORS   Fukunishi,Y., Suzuki,H., Yoshino,M., Konno,H. and Hayashizaki,Y.
  TITLE     Prediction of human cDNA from its homologous mouse full-length cDNA
            and human shotgun database
  JOURNAL   FEBS Lett 464 (3), 129-132 (1999)
   PUBMED   10618491
  REMARK    Erratum:[FEBS Lett 2000 Apr 14;471(2-3):261]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC168054.4.
            
            On Jan 13, 2018 this sequence version replaced XM_006511621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KJ954288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3996              AC168054.4         103542-107537
            3997-4647           AC168054.4         109175-109825
            4648-4873           AC168054.4         110185-110410
            4874-4989           AC168054.4         110662-110777
            4990-5078           AC168054.4         111150-111238
            5079-5236           AC168054.4         111351-111508
            5237-5400           AC168054.4         112046-112209
            5401-5526           AC168054.4         112498-112623
            5527-5696           AC168054.4         112718-112887
            5697-5882           AC168054.4         113283-113468
            5883-5999           AC168054.4         114027-114143
            6000-6171           AC168054.4         114489-114660
            6172-6313           AC168054.4         114814-114955
            6314-6434           AC168054.4         115052-115172
            6435-6618           AC168054.4         115464-115647
            6619-6720           AC168054.4         115961-116062
            6721-6735           AC168054.4         116257-116271
            6736-6830           AC168054.4         117497-117591
            6831-7040           AC168054.4         117789-117998
            7041-7236           AC168054.4         118252-118447
            7237-7392           AC168054.4         118689-118844
            7393-7564           AC168054.4         119179-119350
            7565-7732           AC168054.4         119990-120157
            7733-7859           AC168054.4         120371-120497
            7860-8066           AC168054.4         120591-120797
            8067-8241           AC168054.4         121041-121215
            8242-8354           AC168054.4         121423-121535
            8355-8434           AC168054.4         121960-122039
            8435-8561           AC168054.4         122539-122665
            8562-8678           AC168054.4         123199-123315
            8679-8827           AC168054.4         123411-123559
            8828-8937           AC168054.4         123817-123926
            8938-9096           AC168054.4         124205-124363
            9097-9297           AC168054.4         125042-125242
            9298-10177          AC168054.4         126093-126972
            10178-11846         AC168054.4         128798-130466
FEATURES             Location/Qualifiers
     source          1..11846
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.63 cM"
     gene            1..11846
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /note="cadherin, EGF LAG seven-pass G-type receptor 3"
                     /db_xref="GeneID:107934"
                     /db_xref="MGI:MGI:1858236"
     exon            1..3996
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            3997..4647
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            4648..4873
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            4874..4989
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            4990..5078
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            5079..5236
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            5237..5400
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5526
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            5527..5696
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            5697..5882
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            5883..5999
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6171
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6172..6313
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6314..6434
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6435..6618
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6619..6720
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6721..6735
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6736..6830
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            6831..7040
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            7041..7236
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            7237..7392
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            7393..7564
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            7565..7732
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            7733..7859
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            7860..8066
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8067..8241
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8242..8354
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8355..8434
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8435..8561
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8562..8678
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8679..8827
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8828..8937
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            8938..9096
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            9097..9297
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            9298..10177
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     exon            10178..11846
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11826..11831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /note="hexamer: AATAAA"
     polyA_site      11846
                     /gene="Celsr3"
                     /gene_synonym="Adgrc3; flamingo; Fmi1; mKIAA0812"
                     /note="major polyA site"
ORIGIN      
        1 atcggagcgg ccgggagcca tgttggagcg tcgggaggcg gcagcggcgt cggggatgct
       61 gtggtggggg cggcaaaagc cggggccgta tgccaaaggg gctctggccg cggagtagat
      121 ggtgcccaga gagcagtggc ggcgcggagc gacgggcaga ggggcggagg gccggggcgg
      181 cggcaggggc ccaggagggg gccagagcag cggggcgggc ccaaggcccg gacccgggcg
      241 gggggcggcg gaggccgtga cgggaggcgg gggtgatggc gaggcggcct ctatggtggg
      301 gtctcccggg accgtcgacc ccggtactac tgctccttct cctctctttg ttccctttta
      361 gccgggagga gctggggggc ggtggggacc aggactggga cccaggggtt gctactacta
      421 ctgggccaag agcgcaaatc ggcagtggag ccgtagctct ttgtcccgaa tctcccggcg
      481 tctgggaaga tggagatcct ggcctggggg tcagggagcc tgtcttcatg aggctccgag
      541 taggtaggca aaacgcccgg aatggtcgag gggcccctga gcaaccaaac gcggaggtgg
      601 tggtccaggc attgggtagt cgcgagcaag aggcaggtca gggtccaggg tatctgttat
      661 gttggcaccc agagatctcc tcttgtgggc ggacagggcc tttacgaaga ggtagcctgc
      721 cactcgatgc tctgtcccca ggggattctg atctgaggaa cagctctcct cacccttcag
      781 aacttctggc tcagcctgat ggctccaggc cagtggcctt ccagcgtaat gctaggagaa
      841 gcatccgcaa aagagtggaa acctctcgct gctgcgggaa gctgtgggag ccaggacaca
      901 agggtcaggg tgagagatcc gcgacttcca cagtggacag gggacccttt cggcgggact
      961 gcctccccgg ctctttagga tctggcctgg gggaggattc agcaccacgt gctgtgagga
     1021 cagctcctac gccgggttca gcacctcgcg agtctcggac agctcccggg cgcatgcgct
     1081 cccgcggtct cttccgccgc cgtttcctct ttgagcgccc tgggccgcgc cctcccgggt
     1141 ttccgactgg tcctgaagcc aagcaaatac tctcaactaa ccaggctcgt cctcgtcgtg
     1201 ctgcaaaccg ccacccgcag tttcctcaat acaactacca gacactggta cctgaaaatg
     1261 aggcagcggg cacatcagta ctgcgcgtgg tggcacaaga cccggaccca ggcgaggccg
     1321 ggcgcctcat ctactcgctg gcggcgctca tgaacagccg ctcgctggag cttttcagta
     1381 ttgatcctca gagtggcctc atccgcacgg ctgccgctct ggatcgtgag agtatggaac
     1441 gccactacct tcgagtaaca gcacaggacc acggctcacc gcgcctctca gctaccacca
     1501 tggtggcggt gacagtagct gaccgcaacg atcacgcgcc agtgtttgag caagcccagt
     1561 atcgggaaac acttcgtgag aatgtggaag aaggttaccc catcctgcag ttgcgtgcca
     1621 ccgacggcga cgcgccacct aacgccaacc tgcgctaccg cttcgtggga tcgccagctg
     1681 tgcgcaccgc agccgccgct gctttcgaga ttgatccacg ttcgggtctt atcagcacca
     1741 gtggccgcgt ggacagggaa cacatggaaa gctatgagct agtagtagag gctagtgacc
     1801 agggccagga gcctgggcca cgttcagcca ccgtgcgagt gcacataact gtgctggatg
     1861 agaatgataa tgcgccccag ttcagcgaga agcgctatgt ggcacaggtg cgtgaggatg
     1921 tgcgccctca cacggtggtg ctacgtgtca cggccacgga caaggacaag gatgccaatg
     1981 gtttggtgca ttataacatt atcagcggca acagccgggg ccattttgcc atcgacagtc
     2041 tcacgggtga gatacaggta atggcacccc tggactttga ggcagagaga gagtacgctt
     2101 tgcgaatccg ggcacaagat gcaggccggc cacctttgtc caacaacacg ggcctggcaa
     2161 gcatccaggt ggtagacatc aatgaccatg ctcctatctt tgtcagcaca ccctttcagg
     2221 tctctgtttt ggaaaatgca cccctgggtc actcagtaat tcacattcaa gcagtggatg
     2281 cagatcatgg ggagaactcc aggttagagt attctctaac tggtgtggca tcagacacac
     2341 cctttgtgat aaacagtgcc actggctggg tctctgtgag cggtcccctg gaccgtgaat
     2401 ctgtggaaca ttactttttt ggtgtggagg ctcgagacca tggttcaccc ccactctctg
     2461 cttcagccag tgtcaccgta actgtgttgg atgtcaatga caatcggcct gagttcacca
     2521 tgaaagagta ccaccttcgg ctcaatgagg acgcagctgt aggcaccagt gtggtcagtg
     2581 tgactgcggt agatcgagat gctaacagcg ccatcagcta ccaaatcacg ggtggcaaca
     2641 ctcggaaccg atttgccatc agcacccagg gtggtgtggg cctggtgaca ctggctctgc
     2701 cgctggatta caagcaggaa cgctacttca agctggtgct tactgcatct gatcgtgccc
     2761 ttcatgacca ctgctatgtg catatcaaca tcacagatgc caacacacac aggcctgtct
     2821 ttcaaagtgc ccactactcg gtgagcatga atgaagaccg cccagtgggt agcactgtgg
     2881 tggtcatcag tgcttctgat gatgacgtag gtgaaaatgc ccgcatcacc taccttctgg
     2941 aagacaacct gccccagttc cgaattgatg ctgactctgg ggccattacg ctgcaagctc
     3001 cattggacta tgaggaccaa gtgacctata cactggccat aaccgctcgg gacaatggta
     3061 taccacagaa agcagatacc acctacgtgg aggtaatggt aaatgatgtg aatgacaatg
     3121 ctcctcagtt tgtggcctct cactatacag gcctggtctc cgaggatgcg ccacctttca
     3181 ctagtgtcct gcagatctca gccactgaca gggatgccca tgccaatggc cgcgtccagt
     3241 acactttcca gaatggggaa gacggggatg gggattttac cattgagccc acctctggca
     3301 ttgtcaggac tgtgaggcga ctggaccggg aagcagtgcc agtgtatgag ctgactgcct
     3361 acgcagtgga ccgtggtgtg cccccactga ggactccagt cagcatccag gtgactgtac
     3421 aggacgtaaa cgacaacgca cccgtcttcc cagctgagga gtttgaagtg agggtgaagg
     3481 agaacagcat cgtaggatcc gtggtggctc agatcaccgc agtggacccc gatgatggcc
     3541 ccaacgctca tataatgtac cagattgtgg aagggaacat ccccgagttg ttccaaatgg
     3601 atatcttctc tggagagctc acagcactca ttgacctgga ttatgaggct cgtcaggaat
     3661 atgtgattgt ggtgcaggcc acatctgctc ctctggtcag ccgggccact gtacatgtgc
     3721 gcctagtcga ccagaatgac aacagccctg tgctgaacaa cttccagatt ctctttaaca
     3781 actatgtatc caaccgctcc gacactttcc cctcaggcat cattgggcga atcccagctt
     3841 atgacccgga tgtctctgac cacctctttt actcctttga gaggggcaat gaactgcagc
     3901 tgctggtggt caaccggacc agtggggagc ttcgactcag caggaagttg gacaacaacc
     3961 gcccactagt ggcctccatg ctggtaactg taacagatgg cctgcatagt gttacagccc
     4021 agtgtgttct gcgtgtggtc atcatcacgg aggagttgct ggccaatagc ttgactgttc
     4081 gcctggagaa catgtggcaa gagcgcttcc tgtcaccgct gctgggtcat tttcttgaag
     4141 gcgtggctgc agtgcttgca acaccaaccg aggacgtttt catcttcaac atccagaacg
     4201 acacggatgt ggggggcacc gtgctcaacg tgagcttctc agcgctggca cctcgtgggg
     4261 ctggggcagg cgctgcaggg ccctggttca gctcggagga gctacaggag caactgtatg
     4321 tgcgccgtgc cgccctggcg gcccgctcgc tgctcgacgt gctgcccttt gacgacaacg
     4381 tgtgcctgcg cgagccctgc gagaactaca tgaaatgcgt gtcagtgctc cgctttgact
     4441 cctccgcgcc cttcttggcc tcgacctcca cgctcttccg acccatccag cccatcgcgg
     4501 gtttgcgctg ccgctgccct cctggcttca cgggagactt ctgtgagaca gagctcgacc
     4561 tctgttactc gaacccttgt cgcaatggcg gcgcgtgcgc gcggcgcgag ggaggctaca
     4621 cctgtgtgtg ccgcccgcgc ttcaccgggg aagactgcga gctggacact gaagctggac
     4681 gctgcgtgcc gggtgtctgc cgcaacgggg gcacctgcac caacgcaccc aatggcggct
     4741 ttcgctgcca gtgccccgcg ggcggcgctt tcgagggtcc acgctgtgag gtggccgcac
     4801 gctcctttcc tcccagttcc ttcgtcatgt tccgcggcct tcgacagcgc ttccacctca
     4861 cgctctccct ctcgtttgca actgtgcaac ccagcgggct actcttctac aacgggcgcc
     4921 tgaacgagaa gcatgacttt ttggctctag agcttgtggc tggccaagtg cggcttacat
     4981 attccacggg tgaatccaac acagtggtca gccccacagt tccaggaggc ctgagtgacg
     5041 gacaatggca tacagtgcat ctgagatact acaacaagcc ccggacagat gccctagggg
     5101 gtgctcaggg cccgtcaaag gacaaggtgg ccgtgttgag cgtggatgac tgcaacgtgg
     5161 ctgtggctct gcagttcggt gccgagattg gcaactactc gtgtgcagct gctggtgtgc
     5221 aaacaagctc caagaagtcc ctggacctga cgggccctct gctcttgggg ggtgtcccca
     5281 accttcccga gaacttccct gtgtcccaca aggacttcat tggctgcatg cgagacttgc
     5341 acattgatgg ccgccgaatg gacatggcag cctttgttgc aaacaacggc actatggcag
     5401 gctgccaggc caagtcacac ttttgtgcct caggcccctg caagaacaat ggcttctgct
     5461 ccgagcgctg gggtggcttc agctgtgatt gtcctgtggg ctttggtggc aaagactgtc
     5521 gactcacaat ggcccatccc taccatttcc aaggcaatgg aacactgagt tgggactttg
     5581 gaaatgacat ggctgtgtct gtgccatggt acctgggact atcatttcgg acacgggcaa
     5641 caaaagggat cctgatgcaa gtacagcttg ggccacacag cgtgctcctc tgcaagctag
     5701 atcgagggtt gctgtctgtg acactaaata gggcctcagg ccacactgtc cacctcctgt
     5761 tggaccagat gactgtcagc gatggccggt ggcatgatct tcggctggag ttgcaggagg
     5821 agccaggtgg ccgaaggggc caccatatct ttatggtttc actggacttc accctcttcc
     5881 aggacaccat ggccatgggg ggtgagctgc agggcctgaa agtaaaacag ctccacgtgg
     5941 gaggcctgcc ccccagcagt aaggaggagg ggcatcaggg tctggttggc tgtattcagg
     6001 gggtgtggat tggcttcaca ccctttgggt cctcagccct gctacctccc agccacagag
     6061 tgaatgtgga gcctggctgt actgtgacca acccctgtgc atctgggcct tgtcctcccc
     6121 acgctgattg caaagacctc tggcagacct tttcctgtac ctgtcggcca ggttactatg
     6181 gcccaggctg tgtggatgcc tgcctcctga acccttgtca aaaccaggga tcatgccggc
     6241 acctccaagg ggccccccat ggctatactt gtgactgtgt gagtggctat tttggtcagc
     6301 actgtgagca cagagtggac cagcagtgcc ctcggggatg gtggggaagc ccgacctgtg
     6361 gtccctgcaa ctgtgatgtt cacaagggct ttgaccccaa ctgcaacaag acgaatggcc
     6421 agtgccactg caaggagttc cactatcgac cgaggggcag tgactcatgc ctcccatgtg
     6481 actgctaccc tgtgggctcc acctcccgct catgtgcacc ccacagcggg cagtgcccct
     6541 gccgcccagg agcccttggc cgccagtgta acagctgtga cagccccttt gcggaagtga
     6601 cagccagtgg ttgccgagtg ctctacgatg cctgccccaa gtccctgaga tctggtgtgt
     6661 ggtggcccca gactaagttt ggtgttttgg ccacagtacc ctgtccccgg ggggccttgg
     6721 gattgcgggg tacaggtgct gcggtgcggc tgtgcgatga ggaccagggt tggttggagc
     6781 ctgatctctt caactgtacc tcccctgcct tccgagagct tagtctgctg ttggatggcc
     6841 tagaactgaa caagacagca ctggatactg tggaggccaa gaagctggct cagaggctgc
     6901 gggaggtgac tggccagact gaccactact ttagccaaga tgtccgagtc actgcccgct
     6961 tgctggccta cttgctagct tttgagagcc atcagcaggg cttcgggctg acagccacac
     7021 aagatgccca cttcaatgag aatcttctat gggctggttc tgcactgctg gctccggaga
     7081 caggacactt gtgggcagcc ctggggcagc gggcccctgg gggctccccg ggtagtgcag
     7141 gactggtgca gcatctggag gaatatgcag ccacccttgc aaggaatatg gagctgacat
     7201 atctgaatcc tgttggacta gtcacaccca atatcatgct cagcattgac cgtatggagc
     7261 atcctagttc aactcaggga gcccggcgtt acccccgtta ccacagcaac cttttccggg
     7321 gccaggatgc ctgggatcct catacacacg tgctgttgcc ttcccaggcc tcacagccat
     7381 cgccatctga agttctgccc accagcagca acgcagaaaa cgccacagcc tcaagtgtgg
     7441 tctccccacc tgcacctctg gagcctgagt ctgagcctgg gatttccata gtcattctac
     7501 tggtgtaccg agccttggga gggcttctcc ccgcccagtt ccaagctgag cgccggggtg
     7561 ccaggctccc tcagaaccct gtcatgaact ctccggtggt cagcgtggct gttttccatg
     7621 gtcgcaactt cctcaggggt gtcctggtgt ccccaatcaa ccttgagttc cgcctactac
     7681 agacggcgaa tcggagcaag gcaatctgtg tgcagtggga cccacctggc ccgacagacc
     7741 agcatggtat gtggactgct agggactgcg agctggtgca caggaatgga tcccatgcac
     7801 ggtgtcgctg tagccgcacg ggcacttttg gagtccttat ggatgcctct ccccgggagc
     7861 ggctagaggg agacctagag ctgctggcag tgttcactca cgtggtcgtg gcagtgtctg
     7921 taacggcgct agtactgact gccgctgtcc tgctgagtct gcgcagcctc aagtccaatg
     7981 tgcgtgggat ccatgccaat gtggcagctg ccctgggagt ggcagagctc ctcttcctgc
     8041 tgggaatcca caggacccac aaccagctgc tgtgcaccgc tgtcgccatc ctcctgcatt
     8101 acttcttcct cagcaccttt gcatggctcc tggtgcaggg cctgcacctc taccgaatgc
     8161 aggttgagcc tcgaaatgtg gatcgtggtg ctatgcgctt ctatcatgcc ctgggctggg
     8221 gcgtccctgc tgtgttgttg ggtcttgctg ttgggctgga cccagagggc tatgggaacc
     8281 ctgacttctg ctggatctcc atccatgaac ctcttatctg gagttttgct ggccctatcg
     8341 tcctcgttat tgtgatgaac gggaccatgt ttctcctcgc tgcccgcaca tcctgctcca
     8401 caggacagag ggaggccaag aagacctctg tgctcaggac ccttcgcagc tcctttctgc
     8461 tccttctgct ggtcagtgcc tcctggctct ttggccttct ggcagtcaac cacagcatac
     8521 tggccttcca ctacctccat gctggactct gtggcctcca gggcctggct gtactgctgc
     8581 tcttctgtgt cctgaatgca gacgctcggg ctgcttggac accagcctgt ctaggcaaga
     8641 aggcagctcc tgaggaaaca aggccagccc ccgggccggg gtccggggcc tacaacaaca
     8701 cggctctctt tgaggagagt ggccttatcc gcatcactct cggtgcctct accgtctctt
     8761 cagtgagcag tgcccgctct ggcagggccc aggaccagga cagccagcgg ggccgcagct
     8821 acctcaggga caatgttctg gttcgacacg gctcgactgc tgagcacact gagcgaagcc
     8881 tccaggctca cgccggcccc acggacctgg atgtggctat gttccatcga gacgctggtg
     8941 cagactctga ctctgatagc gacctgtcgt tggaggaaga gagaagttta tccatcccat
     9001 cttcagagag cgaggacaat ggccggactc gagggcgttt ccaacgtcca ctccgcaggg
     9061 cagcccagag tgagaggctc cttgcccacc ccaaagatgt ggacggcaat gacctcctgt
     9121 cctactggcc agccctggga gagtgtgagg cagcaccatg tgctctgcag gcatggggct
     9181 ctgaaaggcg ccttggacta gacagcaaca aagatgcagc caacaacaac cagcctgaac
     9241 tggccttgac cagtggagat gaaacctccc tgggcagggc ccagcggcag aggaaaggca
     9301 tcctgaagaa caggttgcag tacccactgg tgcctcagag tcgaggcact cctgagctgt
     9361 cgtggtgccg tgcagctacc ttgggccacc gtgccgtgcc ggctgcctcc tatggtcgca
     9421 tctatgcagg tgggggtaca ggtagtcttt cgcagcctgc cagccgctac tcttcgcgag
     9481 aacagctgga cttgctctta aggcgacagc tgagcaagga gagactagaa gaggtcccag
     9541 ttcctgcacc tgttctgcat cccctgagcc gcccaggctc ccaggaacgc ctggatactg
     9601 caccagcccg cctggaagcc agagataggg gcagcacatt accaagaagg cagccacctc
     9661 gggactaccc tggcaccatg gctggccgct ttgggtcacg agatgcactg gacttagggg
     9721 caccccgaga atggttgagc acactgcccc caccccgccg caaccgggac cttgacccac
     9781 agcacccacc tctgcccctg tctccacagc ggcaactctc aagggacccc ctcttgccat
     9841 ctcggcccct ggactcttta tctaggatct cgaactctcg ggaggggctg gaccaggtgc
     9901 ctagtcggca cccttcacgg gaggcccttg gaccagcccc acagcttctc agagccaggg
     9961 aggacccagc cagcggccct agccatggtc cctccacaga gcaactggac attctctctt
    10021 ctatccttgc ctctttcaac tcctcagccc tctcctctgt gcagtcctca agcactccct
    10081 caggccctca caccaccgcc acagcctctg cacttgggcc ttccacacct cgttccgcca
    10141 cgtctcacag catctcggag ttgtcacctg attcagaagt tcccagaagc gagggtcact
    10201 cctgaggggc tgaccagcga atgaggagcc accaggggtt gcagaggatt tgggctgact
    10261 gaagagcctt caggactgat cgcaaggcag ccttcttcaa gccctcccct cagttcagtg
    10321 cagaaggaag gtccctcctg tgtgcgtctg tgagcatgtg tgtgacaggt gcaggggtgg
    10381 gggctgaggg aggactttta tacatttttg tacctttgta accagagaga tatgcttatg
    10441 ttatttttca gcttttctgt ctcccagggg tctcgagact gggctaggag ggggaagggg
    10501 atgggagaga gacactccac tgggcgctta gctaagcgtc tgctctttca tttcatctta
    10561 cagcagagtg aatgagtcag gccccacctg ctctttcccc ttctcttccc cacattgatc
    10621 tgaacgttgt tgttggggcc cagggtgcaa atttgatctt tgcattttct ccgatgcccc
    10681 taggccaaac tcctgttggg gggggggatt ggtcttggaa acaggggttc ctccatcctc
    10741 ctcctgaggg ctcacgtgct ccactcctcc ctgtgggtgt ggatatgtat tacatggagt
    10801 ccctgccgct tactgcctta agacctagga ctgatgctgc aggtgctggt ggagcagcag
    10861 aagtcatgtt tacagatcaa ggcttccctt tctcccttag ggagggactt gggcctctaa
    10921 tcagacattc ctaggggggt gggtggaggg gaaactcctt tgtccctcct tcacttgtct
    10981 gtggtgccat tggttcatta cactgtcccc ttgagggatg aggggggcag tgagcaaagg
    11041 gagcagaaac aagggaaccc aagacccaga atgtaggtag gtgccaccgc ctctcactgc
    11101 ttacaggatc ctccctggca ccaggctgca gcagtggctg ccccaccttc tgttggtccc
    11161 ttataaaggg acaggtaact gttaggatcc tgctcacaaa actctcttgt tagttgtctg
    11221 atgtccagtg ctggggactt tacatttttg ttactttgtt tacagatcaa gattattttt
    11281 ttaacatggt tgggttttat ttattgttta cagcttcaac cattgaactt acacactttg
    11341 ttttatagtt cagaatgttt ccccctcttt gtttacaagt gaaaggtaga aaaagtgggg
    11401 gaggggccta aaagacccac ctgcgatgcc cctggacctg gccatcttga ggtaggcttc
    11461 taatcccaac ttttcccagg tcaaaggtca gctgagtctt ctaacagctt gccccgaaag
    11521 tggctcagga ccggggttct gtgcagccgc cacccacccc taccctgtgt ttactcttgg
    11581 gaggcagttt ctgagattca aaaaaatccc acttcactgc ctgtgccaaa tcccaccagc
    11641 caggtcccca gctctcttta cccagactga cccctgccct tgaagggctg agaggcctgt
    11701 cggttgggag agtgtccttg ctatgtccta ggttctgtag atgcccgtct ctggggtccc
    11761 cttccaacag tggccctctt tcctgtctgt gtaaattgtt ccgtgaagcc gcgctctgtt
    11821 ttgggaataa acttctatag aaaaca
//
