LOCUS       NM_017392              10628 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cadherin, EGF LAG seven-pass G-type receptor 2
            (Celsr2), transcript variant 1, mRNA.
ACCESSION   NM_017392
VERSION     NM_017392.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10628)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   2  (bases 1 to 10628)
  AUTHORS   Liu,A., Yu,L., Li,X., Zhang,K., Zhang,W., So,K.F., Tissir,F., Qu,Y.
            and Zhou,L.
  TITLE     Celsr2-mediated morphological polarization and functional phenotype
            of reactive astrocytes in neural repair
  JOURNAL   Glia 71 (8), 1985-2004 (2023)
   PUBMED   37186402
  REMARK    GeneRIF: Celsr2-mediated morphological polarization and functional
            phenotype of reactive astrocytes in neural repair.
REFERENCE   3  (bases 1 to 10628)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10628)
  AUTHORS   Basta,L.P., Sil,P., Jones,R.A., Little,K.A., Hayward-Lara,G. and
            Devenport,D.
  TITLE     Celsr1 and Celsr2 exhibit distinct adhesive interactions and
            contributions to planar cell polarity
  JOURNAL   Front Cell Dev Biol 10, 1064907 (2023)
   PUBMED   36712970
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10628)
  AUTHORS   Li,C., Wei,J.A., Wang,D., Luo,Z., Pang,C., Chen,K., Duan,J.,
            Chen,B., Zhou,L., Tissir,F., Shi,L., So,K.F., Zhang,L. and Qu,Y.
  TITLE     Planar cell polarity protein Celsr2 maintains structural and
            functional integrity of adult cortical synapses
  JOURNAL   Prog Neurobiol 219, 102352 (2022)
   PUBMED   36089108
  REMARK    GeneRIF: Planar cell polarity protein Celsr2 maintains structural
            and functional integrity of adult cortical synapses.
REFERENCE   6  (bases 1 to 10628)
  AUTHORS   Formstone,C.J. and Little,P.F.
  TITLE     The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit
            distinct patterns of expression during embryonic development
  JOURNAL   Mech Dev 109 (1), 91-94 (2001)
   PUBMED   11677057
REFERENCE   7  (bases 1 to 10628)
  AUTHORS   Vincent,J.B., Skaug,J. and Scherer,S.W.
  TITLE     The human homologue of flamingo, EGFL2, encodes a brain-expressed
            large cadherin-like protein with epidermal growth factor-like
            domains, and maps to chromosome 1p13.3-p21.1
  JOURNAL   DNA Res 7 (3), 233-235 (2000)
   PUBMED   10907856
REFERENCE   8  (bases 1 to 10628)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   9  (bases 1 to 10628)
  AUTHORS   Formstone,C.J., Barclay,J., Rees,M. and Little,P.F.
  TITLE     Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3
            is a candidate for the tippy (tip) lethal mutant on chromosome 9
  JOURNAL   Mamm Genome 11 (5), 392-394 (2000)
   PUBMED   10790539
REFERENCE   10 (bases 1 to 10628)
  AUTHORS   Usui,T., Shima,Y., Shimada,Y., Hirano,S., Burgess,R.W.,
            Schwarz,T.L., Takeichi,M. and Uemura,T.
  TITLE     Flamingo, a seven-pass transmembrane cadherin, regulates planar
            cell polarity under the control of Frizzled
  JOURNAL   Cell 98 (5), 585-595 (1999)
   PUBMED   10490098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672200.10 and AL671899.11.
            
            On Feb 22, 2019 this sequence version replaced NM_017392.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3395              AL672200.10        19521-22915         c
            3396-4043           AL672200.10        14086-14733         c
            4044-4266           AL672200.10        11685-11907         c
            4267-4382           AL672200.10        11233-11348         c
            4383-4471           AL672200.10        10960-11048         c
            4472-4629           AL672200.10        10557-10714         c
            4630-4793           AL672200.10        10041-10204         c
            4794-4919           AL672200.10        9784-9909           c
            4920-5086           AL672200.10        9273-9439           c
            5087-5374           AL672200.10        8736-9023           c
            5375-5549           AL672200.10        8482-8656           c
            5550-5691           AL672200.10        8114-8255           c
            5692-5812           AL672200.10        7839-7959           c
            5813-5996           AL672200.10        7218-7401           c
            5997-6098           AL672200.10        6953-7054           c
            6099-6193           AL672200.10        6215-6309           c
            6194-6403           AL672200.10        5805-6014           c
            6404-6587           AL672200.10        5096-5279           c
            6588-6716           AL672200.10        4838-4966           c
            6717-6897           AL672200.10        4566-4746           c
            6898-7065           AL672200.10        4283-4450           c
            7066-7192           AL672200.10        4055-4181           c
            7193-7393           AL672200.10        3769-3969           c
            7394-7568           AL672200.10        3279-3453           c
            7569-7681           AL672200.10        2896-3008           c
            7682-7761           AL672200.10        2664-2743           c
            7762-7888           AL672200.10        2452-2578           c
            7889-8011           AL672200.10        2221-2343           c
            8012-8139           AL671899.11        132324-132451       c
            8140-8228           AL671899.11        132047-132135       c
            8229-8411           AL671899.11        131761-131943       c
            8412-8582           AL671899.11        131451-131621       c
            8583-8817           AL671899.11        131122-131356       c
            8818-10628          AL671899.11        128959-130769       c
FEATURES             Location/Qualifiers
     source          1..10628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.02 cM"
     gene            1..10628
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /note="cadherin, EGF LAG seven-pass G-type receptor 2"
                     /db_xref="GeneID:53883"
                     /db_xref="MGI:MGI:1858235"
     exon            1..3395
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..8845
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; flamingo homolog; cadherin, EGF LAG seven-pass
                     G-type receptor 2 (flamingo homolog, Drosophila)"
                     /codon_start=1
                     /product="cadherin EGF LAG seven-pass G-type receptor 2
                     isoform 1 precursor"
                     /protein_id="NP_059088.2"
                     /db_xref="CCDS:CCDS17759.1"
                     /db_xref="GeneID:53883"
                     /db_xref="MGI:MGI:1858235"
                     /translation="MRSRAASAPLPTPLLPLLLLLLLLPPSPLLGDQVGPCRSLGSGG
                     RSSSGACAPVGWLCPASASNLWLYTSRCRESGIELTGHLVPHHDGLRVWCPESGAHIP
                     LPPSSEGCPWSCRLLGIGGHLSPQGTLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGE
                     GSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTSVASLRAIDPDEGEAGRLEY
                     TMDALFDSRSNHFFSLDPITGVVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLT
                     ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGAGG
                     SPSDAFEIDPRSGVIRTRGPVDREEVESYKLTVEASDQGRDPGPRSSTAIVFLSVEDD
                     NDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNALVHYSIMSGNARGQFYLD
                     AQTGALDVVSPLDYETTKEYTLRIRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVST
                     PFQATVLESVPLGYLVLHVQAIDADAGDNARLEYSLAGVGHDFPFTINNGTGWISVAA
                     ELDREEVDFYSFGVEARDHGTPALTASASVSVTILDVNDNNPTFTQPEYTVRLNEDAA
                     VGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYV
                     LAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED
                     TGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT
                     TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG
                     GDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDV
                     NDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLD
                     IFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILF
                     NNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELRLSRAL
                     DNNRPLEAIMSVLVSDGVHSVTAQCSLRVTIITDEMLTHSITLRLEDMSPERFLSPLL
                     GLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSED
                     LQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVL
                     FRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCLDGYTG
                     EHCEASTHSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPFCQVTTRSFPARSFI
                     TFRGLRQRFHFTLALSFATKERNGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGEST
                     TTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVSVDGCDTGVALR
                     FGAMLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRHFVGCMKDLQVD
                     SRHIDMADFIANNGTVPGCPTKKIVCDSSICHNGGTCVNQWNAFSCECPLGFGGKSCA
                     QEMANPQRFLGSSLVAWHGLSLPISQPWHLSLMFRTRQADGVLLQAVTRGRSTITLQL
                     RAGHVVLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQKA
                     EGNLGPRLHGLHLSNITVGGVPGPASGVARGFRGCLQGVRVSETPEGISSLDPSRGES
                     INVEPGCSWPDPCDSNPCPTNSYCSNDWDSYSCSCVLGYYGDNCTNVCDLNPCEHQSV
                     CTRKPNTPHGYICECLPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCN
                     KTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCD
                     NPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRG
                     WLPPNLFNCTSVTFSELKGFAERLQRNESGLDSGRSQRLALLLRNATQHTSGYFGSDV
                     KVAYQLATRLLAHESAQRGFGLSATQDVHFTENLLRVGSALLDAANKRHWELIQQTEG
                     GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGTKLPRYEAL
                     RGERPPDLETTVILPESVFREMPSMVRSAGPGEAQETEELARRQRRHPELSQGEAVAS
                     VIIYHTLAGLLPHNYDPDKRSLRVPKRPVINTPVVSISVHDDEELLPRALDKPVTVQF
                     RLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMD
                     MSRRENGEILPLKTLTYVALGVTLAALMLTFLFLTLLRALRSNQHGIRRNLTAALGLA
                     QLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNASPMR
                     FYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSVYDTLIWSFAGPVAFAVSMSVFLY
                     ILSARASCAAQRQGFEKKGPVSGLRSSFTVLLLLSATWLLALLSVNSDTLLFHYLFAA
                     CNCVQGPFIFLSYVVLSKEVRKALKFACSRKPSPDPALTTKSTLTSSYNCPSPYADGR
                     LYQPYGDSAGSLHSASRSGKSQPSYIPFLLREESTLNPGQVPPGLGDPSGLFLEGQAQ
                     QHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEAAFPGEQGWDSLLGPGAERLPL
                     HSTPKDGGPGSGKVPWLGDFGTTTKENSGSGPLEERPRENGDALTREGSLGPLPGPST
                     QPHKGILKKKCLPTISEKSSLLRLPLEQGTGSSRGSSISEGSRHGPPPRPPPRQSLQE
                     QLNGVMPVAMSIKAGTVDEDSSGSEFLFFNFLH"
     exon            3396..4043
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4044..4266
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4382
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4383..4471
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4629
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4793
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4794..4919
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            4920..5086
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            5087..5374
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            5375..5549
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            5550..5691
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            5692..5812
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            5813..5996
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            5997..6098
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            6099..6193
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..6403
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            6404..6587
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            6588..6716
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            6717..6897
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            6898..7065
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7066..7192
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7193..7393
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7394..7568
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7569..7681
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7682..7761
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7762..7888
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            7889..8011
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            8012..8139
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            8140..8228
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            8229..8411
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            8412..8582
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            8583..8817
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     exon            8818..10628
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10578..10583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /note="hexamer: AATAAA"
     polyA_site      10599
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
                     /note="major polyA site"
     polyA_site      10628
                     /gene="Celsr2"
                     /gene_synonym="Adgrc2; EGFL2; flamingo; Flamingo1; mfmi1;
                     mKIAA0279"
ORIGIN      
        1 ccgggcatga ggcgcggcgg ggccggcagg agccggagga agagccgccg cggctgttga
       61 cccggctggc cgggaacagg gagagatgcg gagccgggct gccagcgccc ccctcccaac
      121 gccgctgctg ccgctgctac tgctgttgct gctgctgcca ccgtcgccac tactgggaga
      181 tcaagtgggg ccctgtcgtt ctctgggatc cgggggacgc agctcctctg gggcctgcgc
      241 ccccgtgggc tggctctgcc cagcctctgc ttcgaacctc tggctctaca ccagccgctg
      301 cagagaatcg ggcattgagc tgaccggcca cctggtgccc caccacgatg gcctgagggt
      361 ttggtgtcca gaatcagggg ctcatatccc tcttccgcca tcctctgaag gctgcccctg
      421 gagctgtcgt ctcctgggta tcggaggaca cctttctcca caaggcacgc tgaccctgcc
      481 tgaagagcac ccttgcttaa aggccccacg gctcagatgc cagtcttgca agctggcaca
      541 ggccccaggg ctcagggctg gggaaggctc accagaggaa tctctgggtg ggcgcaggaa
      601 aaggaatgtg aatacagctc cccagttcca gcctcccagc taccaggcca cagtgcctga
      661 gaaccagcct gctggtacct ctgttgcatc cttaagagcc attgatccag atgagggtga
      721 ggcgggtcga cttgagtaca ccatggatgc cctctttgat agccgctcca atcatttctt
      781 ctccttggac ccaatcaccg gtgttgtcac cacagctgag gagctggatc gggagaccaa
      841 gagcacccac gtcttcaggg tcactgcaca ggatcacggt atgccccgac ggagtgcctt
      901 ggccacgctt accatcttgg tgaccgacac caacgatcac gaccctgttt ttgagcagca
      961 agagtacaag gagagcctca gggagaacct ggaggttggc tatgaggtgc ttacagtcag
     1021 ggccaccgac ggcgacgccc ctcccaatgc caacattctg taccgcctgc tggagggggc
     1081 cggaggcagc ccctcagacg cctttgagat cgatcctcgc tcgggggtga tccgaacccg
     1141 cggccctgta gaccgggagg aagtggaatc ctacaagtta acagtggagg cgagtgacca
     1201 gggccgggac ccaggcccgc ggagttccac agccattgtt ttcctgtcgg tggaggatga
     1261 taatgacaac gccccccagt ttagcgagaa gcgttatgtg gtccaggtgc gggaggatgt
     1321 gaccccagga gccccagttc tccgagtcac cgcctccgat agagacaagg gcagcaatgc
     1381 cctagtgcac tacagcatca tgagtggcaa tgctcggggc cagttctatc tggatgctca
     1441 gactggagcc ctggatgtgg taagcccact cgactatgag acaaccaaag agtatacgct
     1501 tcggatccgg gctcaggacg gtggccgtcc tccactctcc aatgtctctg gcctagtaac
     1561 agtgcaagtc ctagacatca acgataacgc ccccatcttt gtcagcaccc ctttccaggc
     1621 caccgtccta gagagtgtcc ctttaggcta ccttgttctg cacgtccagg caattgatgc
     1681 tgacgctggt gataacgccc gcctcgagta tagcctggca ggggttgggc acgactttcc
     1741 cttcaccatt aacaatggca caggctggat ctctgtggcc gcagagttgg atcgggaaga
     1801 ggttgatttc tacagctttg gtgtagaggc ccgggaccat ggcaccccag cgctcacggc
     1861 ctcagccagt gtcagtgtaa ccatcctgga cgtcaatgac aacaacccaa ccttcacgca
     1921 gccagagtac accgttcggc tcaacgagga cgccgccgtg ggcaccagtg tggtgaccgt
     1981 gtcagccgtg gatcgagacg ctcacagtgt cattacctac cagatcacca gcggcaacac
     2041 ccgcaaccgc ttctctatca ccagccaaag tggtggtgga ctggtctccc ttgccttacc
     2101 gctagactac aaactcgagc ggcagtatgt gctggcagtg actgcctcag atggcacaag
     2161 gcaggacaca gctcagatag tagtgaatgt caccgatgcc aacacccacc gtcccgtctt
     2221 ccagagctcc cactacacag tcaacgttaa tgaagaccgg ccagcaggca ccacagtggt
     2281 gctgatcagc gccacggatg aggacacggg ggagaatgcc cgaatcacct actttatgga
     2341 ggatagcatc ccccagttcc gaatcgacgc ggacactggg gctgtcacca cccaggctga
     2401 gctggactac gaggaccagg tgtcttatac cctggccatc actgctcggg acaatggcat
     2461 tccccagaag tctgacacca cctatttgga gatcctggtg aatgacgtga acgacaacgc
     2521 cccccagttc ctcagagatt cctaccaggg cagcgtctac gaggacgtgc cgcccttcac
     2581 cagcgtcctg cagatctcag ccacggatcg agactccggt ctgaatggca gggttttcta
     2641 caccttccaa ggaggagatg atggggacgg tgactttatt gtagagtcga catcgggcat
     2701 tgtgcgcaca ctgcggaggc tggatcgtga gaacgtggcc cagtacgtcc tgcgggccta
     2761 tgcggtggac aagggcatgc caccagcccg cacacccatg gaagtgacag ttactgtcct
     2821 ggatgtgaat gacaaccccc ctgtctttga acaggatgag tttgacgtat ttgtggaaga
     2881 gaacagcccc atcgggctgg ccgtggcccg ggtcacagcc actgacccag atgaagggac
     2941 caacgcacag atcatgtacc agattgtgga gggcaatatc cctgaggtct ttcagttgga
     3001 tatattctct ggcgagctaa ctgccctggt agatttggac tatgaggacc ggcctgaata
     3061 tgtcctggtc atccaggcta cgtctgctcc cttggtgagc agggctactg tccatgtccg
     3121 cctccttgac cgcaatgata acccgcccgt gctgggcaac tttgagattc tctttaacaa
     3181 ctatgtcacc aaccgctcca gcagcttccc cggtggtgcc ataggccgtg tgcctgccca
     3241 cgaccccgat atctcagaca gcctgacgta cagcttcgag cgaggaaatg aactcagctt
     3301 ggtcctgctc aatgcctcca ccggtgagct gagactgagc cgggcactgg acaacaaccg
     3361 gcccctggaa gccatcatga gtgtgctggt gtcagatggt gtccacagtg tgacagccca
     3421 gtgctcgcta cgtgtcacca tcatcacgga cgagatgctc acacacagca tcacgctgcg
     3481 cttggaagac atgtctccag aacgctttct ctcaccactg ctgggactct tcattcaggc
     3541 cgtggcagcc acgttggcca cacccccgga tcatgtggtg gtcttcaatg tgcaaaggga
     3601 tactgatgcc ccaggcggcc atatcctcaa cgtaagcctg tcggtgggcc agcctccagg
     3661 acccgggggt gggccaccct ttctgccttc agaggatctc caggagcgcc tgtacctcaa
     3721 ccgcagcctg ctcaccgcca tctcggcgca gcgcgtgctc cccttcgacg acaacatttg
     3781 cctgcgggag ccctgcgaga attacatgcg atgtgtgtct gtgctgcggt tcgactcctc
     3841 tgcgcccttc atcgcttcct cttcggtgct cttccggccc atccaccctg tcgggggtct
     3901 gcgctgtcgc tgcccaccag gcttcacagg cgactactgc gagaccgagg tggacctctg
     3961 ttactcaaga ccttgtggac cccatgggcg ctgccgcagc cgagagggtg gctatacctg
     4021 cctctgtctg gatggctaca cgggcgagca ctgtgaagcg agtacccact caggccgttg
     4081 tactccaggt gtctgcaaga acgggggtac ctgtgtcaac ctgttggtgg gaggtttcaa
     4141 atgtgactgc ccctccgggg actttgagaa acccttctgc caggtgacca cacgcagctt
     4201 ccctgcccgc tccttcatca ccttccgtgg cctgcgccag cgcttccact tcaccctggc
     4261 cctctcgttt gctaccaagg agcgtaacgg gctactgctg tacaatgggc gcttcaatga
     4321 gaagcacgac tttgtggctc tcgaggtgat ccaggaacag gtgcagctca ccttctctgc
     4381 aggggaatcg accaccaccg tgtctccgtt tgtgccggga ggggtcagtg atggccagtg
     4441 gcacacagtg cagctgaagt actataacaa gccactgttg ggtcagacag ggcttcccca
     4501 aggtccatct gagcagaagg tagccgtggt gtccgtggat ggctgtgaca caggggtggc
     4561 tctgcgcttt ggagctatgc tgggcaacta ctcctgtgct gcccagggca cccaaggagg
     4621 cagcaagaag tctctggacc tgacagggcc cttgttgctg ggtggggtgc cggatctgcc
     4681 cgagagcttc cccgtccgaa tgcggcactt tgtgggctgc atgaaggacc tccaggtgga
     4741 tagccggcac atcgacatgg ccgacttcat tgccaacaat ggcactgtgc ctggctgccc
     4801 caccaagaag atcgtgtgcg acagcagcat ttgccacaac ggtggcacct gtgtgaacca
     4861 gtggaatgcg ttcagctgcg agtgtccact aggcttcggg ggcaagagct gcgcccagga
     4921 aatggccaac ccccagcgtt tcctgggcag cagccttgtg gcctggcatg gcctctctct
     4981 gcccatctct cagccctggc acctcagcct catgttccgc acacgccagg cagatggcgt
     5041 cctgctgcag gccgtcacca gggggcgcag caccatcacc ctgcagcttc gggcaggcca
     5101 cgtagtgcta agtgtggagg gcacagggct ccaggcgtca tctctgcgtc ttgagccagg
     5161 ccgagccaat gatggtgact ggcatcatgc acagctggca ctgggagcca gcgggggccc
     5221 tggccatgcc attctgtcct ttgactatgg gcaacagaag gcagagggta atctgggccc
     5281 tcggctgcat ggactgcacc tgagcaatat tacagtcggg ggagttcctg ggccagccag
     5341 cggagtggcc cgtggcttcc ggggctgttt gcagggtgtc agggtaagcg agacacctga
     5401 gggtatcagc agtctagatc ccagccgcgg ggagagcatc aatgtggagc caggctgtag
     5461 ctggccagat ccctgtgact cgaatccatg ccctaccaac agctactgca gcaatgactg
     5521 ggacagctat tcttgtagct gtgttctagg ttactatggt gacaactgta caaatgtgtg
     5581 tgacctgaac ccatgcgagc accagtccgt gtgtacccga aaacccaata caccccacgg
     5641 ctacatctgc gagtgtttac caaattacct tgggccatat tgtgagacca ggattgacca
     5701 accttgcccc cgtggctggt ggggacaccc cacatgtggt ccatgcaact gtgatgtcag
     5761 caaaggcttt gacccagatt gcaacaagac aagtggggag tgccactgca aggagaatca
     5821 ctaccggccc cccggcagcc ccacttgtct cttgtgtgac tgttacccca ctggttcttt
     5881 gtcccgagtc tgtgaccccg aggacggcca gtgtccgtgc aagcctggag tcattgggcg
     5941 tcagtgtgac cgctgtgaca acccttttgc tgaggtcacc accaatggct gtgaagtgaa
     6001 ttacgacagc tgcccacggg ccatagaggc tgggatctgg tggccccgca cgcggttcgg
     6061 gctacctgct gctgccccct gccccaaagg ctcctttggg actgctgtgc gccactgtga
     6121 tgagcacagg ggttggctcc ccccaaacct cttcaactgc acgtcagtca ccttctcaga
     6181 gctaaagggc ttcgctgagc ggctgcagag gaacgaatca ggcctggact caggacgctc
     6241 ccagaggcta gccctgctcc tgcgcaatgc cacccagcac acctctggct acttcggcag
     6301 tgatgtcaag gtggcctacc agctggccac acggctcttg gctcatgaga gtgcccagcg
     6361 gggctttggg ctatccgcca cacaggatgt acacttcacg gagaatctgc tgagggtggg
     6421 cagcgccctc ctggatgcag ccaacaagag gcactgggaa ctgatccagc agacagaggg
     6481 tggcaccgcc tggctgctcc agcactatga ggcttacgcc agcgcccttg cccagaatat
     6541 gcggcacacc tacctaagcc ccttcaccat cgtcacaccc aacattgtca tctctgtagt
     6601 gcgcctggat aaggggaact ttgctgggac caagctgccc cgttatgagg cattacgtgg
     6661 ggagcgcccc ccagatcttg agaccacagt cattttgcca gaatctgtct tcagagagat
     6721 gccctccatg gtgaggtctg caggacctgg tgaagcccag gagacggagg agctggcccg
     6781 gcggcagcgg aggcacccag aactgagtca gggagaggca gtggccagtg tcatcatcta
     6841 ccacaccctg gctggactgc tgccccacaa ctatgacccc gataagcgta gcctgagagt
     6901 ccccaagcgc cccgtcatca acacccctgt ggtgagcatc agcgttcacg acgacgagga
     6961 actcctgccg cgggctctgg acaagccagt caccgtgcag ttccggctgc tggagaccga
     7021 ggagcggacc aagcccatct gtgtcttctg gaaccattca atcctggtca gtggcactgg
     7081 cggctggtcc gcccgaggct gcgaagtcgt cttccgtaac gagagccacg tcagctgcca
     7141 gtgcaaccat atgacaagct ttgctgtgct tatggatatg tcacgacgag agaacggtga
     7201 gatcttgcca ctgaagaccc tgacatacgt ggcccttgga gtcaccttgg ctgccctgat
     7261 gctcaccttc ctcttcctca ccctcctccg tgccctccgc tccaaccagc acggcatccg
     7321 acgcaacctc acagctgccc tgggcctggc ccagctggtc tttctcctgg gcatcaacca
     7381 ggctgacctc ccttttgcct gtacagtcat cgctatcctg ctgcatttcc tgtacctctg
     7441 caccttctcc tgggctctgc tggaggcctt acacctgtac cgcgcgctca cagaggtgcg
     7501 cgacgtcaat gccagtccca tgcgtttcta ctacatgctg ggctggggcg tccctgcttt
     7561 catcacaggc ctcgctgtgg gcttggatcc ggaaggctat gggaaccctg acttctgctg
     7621 gctctctgtc tatgataccc tcatctggag ctttgctgga ccagtggcct ttgctgtttc
     7681 gatgagtgtc ttcctgtaca tcctgtcggc ccgagcctcc tgtgctgccc aacggcaggg
     7741 cttcgagaag aaagggcctg tctcgggcct gcgctcctcc ttcacggtcc tcctgctgct
     7801 gagtgccacg tggctgctgg cactgctctc tgtcaacagt gacactctgc tcttccacta
     7861 cctcttcgct gcctgcaatt gtgtccaggg ccccttcatc ttcctctcct acgtggtgct
     7921 cagcaaggag gtccggaaag cactcaagtt cgcctgcagc cggaagccca gtcccgaccc
     7981 tgccttgacc actaagtcta ccctgacctc gtcctataac tgccccagcc cctacgcaga
     8041 cgggaggctg taccagcctt acggagattc ggctggctcg ttgcacagtg ccagccgctc
     8101 cggcaagagt cagcccagct acatcccctt cttgctgagg gaggagtcca cgctgaaccc
     8161 tggccaggtt ccccctggcc taggggaccc aagcggcctg ttcttggaag gccaagccca
     8221 acaacatgat cccgacacgg actctgacag tgacctgtcc ctggaagatg accagagtgg
     8281 ttcctatgcc tccacccact catcagacag cgaggaagag gaggaggagg ccgccttccc
     8341 tggcgagcag ggctgggaca gcctgctggg tcctggagct gagagactgc cccttcacag
     8401 tacccccaag gatgggggtc cgggttctgg gaaggtccct tggctgggag actttgggac
     8461 cacaacaaag gagaatagtg gtagtgggcc ccttgaagag cggccacggg agaatggaga
     8521 tgccctaact cgggaagggt ctctgggacc ccttccgggc ccttctaccc aacctcacaa
     8581 aggcatcctc aagaagaagt gtctgcccac catcagcgaa aagagcagcc tcctaaggct
     8641 gcccctggag cagggcacag ggtcttctcg gggctcctcc atcagtgagg gcagtcggca
     8701 cggacctcct ccccgcccac ctccgcgcca gtctctgcag gaacagctga atggggtcat
     8761 gcctgtcgcc atgagcatca aggcaggcac ggtggatgag gactcctctg gctctgaatt
     8821 tctcttcttt aacttcctgc attaaccctg ggccggtgtt ccttcgtccc cttcccccgc
     8881 tgcgctcatg ccccaatcct gtcttctgct ttatcctgcc cctgctccct accgcccacc
     8941 tgcctgcctt ccgaagcagc agcgacgaac cgtccatctg aggagcctgg gccttgcacc
     9001 cagaaggcca actagtgcca agtccctccc ccacctcccc ctcactgcac tttggaccct
     9061 cgggggggcc aacatctcca agacaaagtt tttcagaaaa aaaaaaaaga ggaaaaaaga
     9121 atttaaaaaa aggatctcca ctcttcatga cttcagggat tacttttgtt tttatacgcc
     9181 ggaagtggac tcccctttcc ccttcccaaa gaggacagga ccacccagga cgtgtcccag
     9241 cctctcttca gtttcatctc ctgtgcctct gggaggagag ggactcttag ggggcctgcc
     9301 cctcatttgc catcaccaaa aggaaaggac aaagccacgt gcaccagggg caggagcccc
     9361 tgcaaggctg caccggacag acggacagac aggcctcagt tggtgagggg tcaggacaaa
     9421 aacaaacaaa caaaaaaaac aaaggcactt tccacccgcc agttccacct ctcccaggaa
     9481 ctgacaagcc ctgtccggcc aggggcagaa ggactcatgg cccctggacc ccccaaatgc
     9541 tgcatgaacc gttttttaag gggaagcctg ttgcccccgt gatggggaag gactacccca
     9601 gcccctctcc ttttcctgga ctctggccat gtgctacagc ccaggtgttt gctcagtttg
     9661 ctgaccccaa agtgcttcat ttctcctgcc cacccttgca ggtagggcca gtcactcttc
     9721 cattgcttct ttgctgtgtg ggcggtccca ggaggaaggg taagcgcaga gctggcatgg
     9781 tggccctgag gggcccccag cacaggtgcc aggtctgggt tctgctgtcc actcaccccc
     9841 tccccgccaa atcagacaaa tgccattttt ttttgtctga cctgctgtgg cctctgagac
     9901 atgttctatt tttaacccct tcctggaatt ggctctcttc ttcaaagaac caggtccttg
     9961 gtccccattg tccccctact tgaccccagc tccctgcgaa gagagagtta atatattttt
    10021 tatttatttg ggtttttttt ttgtgtgtgt gtgtgtgtgt gttgggatgg gtttgtgtct
    10081 ggtccccagg gggtctcatg tgcccattgc aggctgggtg agtccctggc agccctggat
    10141 ttggggccta ccatccttcc tctcgctcca tttgctctcc tcgggttttt gcaaccaccg
    10201 ttcatttgag tccccctctc ctctgagcat gtattccaga cttgtcactg acttcccttc
    10261 tagagcaggt gtagaataaa ggctcgagga ggcaggaaag atgtccctgt ctctcatttg
    10321 gaaggctggc cgctggcttt tctgccatgg attctcacct gccctctgcc ctcttcccct
    10381 cagcaattcc tgtaaagggt taaaaattta actggatata ttttttttta actactgatg
    10441 acttgactta aaaaaaaata caaagatgct ggatgctaac ttgatactaa ccatcagatt
    10501 gtacagtttg attgtcgctg taaatatggt agagttttgt ttttgttttt gttttttttt
    10561 ccccccccat actactgaat aaactagttc tgtgcaggag ccatgtcatc gctggcttct
    10621 gtaaagca
//
