LOCUS       NM_009886              11050 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cadherin, EGF LAG seven-pass G-type receptor 1
            (Celsr1), mRNA.
ACCESSION   NM_009886
VERSION     NM_009886.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11050)
  AUTHORS   Housset,M., Filion,D., Cortes,N., Vali,H., Mandato,C.A.,
            Casanova,C. and Cayouette,M.
  TITLE     Identification of a non-canonical planar cell polarity pathway
            triggered by light in the developing mouse retina
  JOURNAL   Dev Cell 60 (3), 447-458 (2025)
   PUBMED   39561777
REFERENCE   2  (bases 1 to 11050)
  AUTHORS   Paramore,S.V., Goodwin,K., Fowler,E.W., Devenport,D. and
            Nelson,C.M.
  TITLE     Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and
            widening independently of the planar cell polarity complex
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39225402
REFERENCE   3  (bases 1 to 11050)
  AUTHORS   Paramore,S.V., Trenado-Yuste,C., Sharan,R., Nelson,C.M. and
            Devenport,D.
  TITLE     Vangl-dependent mesenchymal thinning shapes the distal lung during
            murine sacculation
  JOURNAL   Dev Cell 59 (10), 1302-1316 (2024)
   PUBMED   38569553
REFERENCE   4  (bases 1 to 11050)
  AUTHORS   Stansak,K.L., Baum,L.D., Ghosh,S., Thapa,P., Vanga,V. and
            Walters,B.J.
  TITLE     PCP auto count: a novel Fiji/ImageJ plug-in for automated
            quantification of planar cell polarity and cell counting
  JOURNAL   Front Cell Dev Biol 12, 1394031 (2024)
   PUBMED   38827526
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11050)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 11050)
  AUTHORS   Shima,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Chisaka,O.,
            Takeichi,M. and Uemura,T.
  TITLE     Differential expression of the seven-pass transmembrane cadherin
            genes Celsr1-3 and distribution of the Celsr2 protein during mouse
            development
  JOURNAL   Dev Dyn 223 (3), 321-332 (2002)
   PUBMED   11891983
  REMARK    GeneRIF: Differential expression of the seven-pass transmembrane
            cadherin genes Celsr1-3 and distribution of the Celsr2 protein
            during mouse development
REFERENCE   7  (bases 1 to 11050)
  AUTHORS   Tissir,F., De-Backer,O., Goffinet,A.M. and Lambert de Rouvroit,C.
  TITLE     Developmental expression profiles of Celsr (Flamingo) genes in the
            mouse
  JOURNAL   Mech Dev 112 (1-2), 157-160 (2002)
   PUBMED   11850187
  REMARK    GeneRIF: Developmental expression profiles of Celsr (Flamingo)
            genes in the mouse
REFERENCE   8  (bases 1 to 11050)
  AUTHORS   Formstone,C.J. and Little,P.F.
  TITLE     The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit
            distinct patterns of expression during embryonic development
  JOURNAL   Mech Dev 109 (1), 91-94 (2001)
   PUBMED   11677057
REFERENCE   9  (bases 1 to 11050)
  AUTHORS   Hadjantonakis,A.K., Formstone,C.J. and Little,P.F.
  TITLE     mCelsr1 is an evolutionarily conserved seven-pass transmembrane
            receptor and is expressed during mouse embryonic development
  JOURNAL   Mech Dev 78 (1-2), 91-95 (1998)
   PUBMED   9858697
REFERENCE   10 (bases 1 to 11050)
  AUTHORS   Hadjantonakis,A.K., Sheward,W.J., Harmar,A.J., de Galan,L.,
            Hoovers,J.M. and Little,P.F.
  TITLE     Celsr1, a neural-specific gene encoding an unusual seven-pass
            transmembrane receptor, maps to mouse chromosome 15 and human
            chromosome 22qter
  JOURNAL   Genomics 45 (1), 97-104 (1997)
   PUBMED   9339365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116764.10, AC139513.10, AF031572.1, BQ180311.1, BQ942572.1 and
            CV561900.1.
            
            On Oct 7, 2006 this sequence version replaced NM_009886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031572.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3596              AC116764.10        198116-201711
            3597-4235           AC139513.10        197734-198372       c
            4236-4458           AC139513.10        182216-182438       c
            4459-4519           AC139513.10        179254-179314       c
            4520-4836           AF031572.1         4520-4836
            4837-4985           AC139513.10        158679-158827       c
            4986-5664           AF031572.1         4986-5664
            5665-5753           AC139513.10        149645-149733       c
            5754-6324           AF031572.1         5754-6324
            6325-6846           BQ180311.1         61-582
            6847-7440           BQ942572.1         31-624
            7441-7636           AC139513.10        135746-135941       c
            7637-7932           AF031572.1         7637-7932
            7933-8004           AC139513.10        124571-124642       c
            8005-8131           AC139513.10        123058-123184       c
            8132-8419           AF031572.1         8132-8419
            8420-8898           CV561900.1         192-670
            8899-9136           AF031572.1         8899-9136
            9137-11050          AC139513.10        117890-119803       c
FEATURES             Location/Qualifiers
     source          1..11050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 40.42 cM"
     gene            1..11050
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /note="cadherin, EGF LAG seven-pass G-type receptor 1"
                     /db_xref="GeneID:12614"
                     /db_xref="MGI:MGI:1100883"
     exon            1..3596
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..9112
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /note="seven-pass transmembrane receptor; cadherin, EGF
                     LAG seven-pass G-type receptor 1 (flamingo homolog,
                     Drosophila)"
                     /codon_start=1
                     /product="cadherin EGF LAG seven-pass G-type receptor 1
                     precursor"
                     /protein_id="NP_034016.2"
                     /db_xref="CCDS:CCDS37172.1"
                     /db_xref="GeneID:12614"
                     /db_xref="MGI:MGI:1100883"
                     /translation="MAPSSPRVLPALVLLAAAALPALELGAAAWELRVPGGARAFALG
                     PGWSYRLDTTRTPRELLDVSREGPAAGRRLGLGAGTLGCARLAGRLLPLQVRLVARGA
                     PTAPSLVLRARAYGARCGVRLLRRSARGAELRSPAVRSVPGLGDALCFPAAGGGAASL
                     TSVLEAITNFPACSCPPVAGTGCRRGPICLRPGGSAELRLVCALGRAAGAVWVELVIE
                     ATSGTPSESPSVSPSLLNLSQPRAGVVRRSRRGTGSSTSPQFPLPSYQVSVPENEPAG
                     TAVIELRAHDPDEGDAGRLSYQMEALFDERSNGYFLIDAATGAVTTARSLDRETKDTH
                     VLKVSAVDHGSPRRSAATYLTVTVSDTNDHSPVFEQSEYRERIRENLEVGYEVLTIRA
                     TDGDAPSNANMRYRLLEGAGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGRN
                     PGPLSASATVHIVVEDENDNYPQFSEKRYVVQVPEDVAVNTAVLRVQATDRDQGQNAA
                     IHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPPLINSSGLV
                     SVQVLDVNDNAPIFVSSPFQAAVLENVPLGHSVLHIQAVDADAGENARLQYRLVDTAS
                     TIVGGSSVDSENPASAPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPAM
                     SSSASVSITVLDVNDNDPMFTQPVYELRLNEDAAVGSSVLTLRARDRDANSVITYQLT
                     GGNTRNRFALSSQSGGGLITLALPLDYKQERQYVLAVTASDGTRSHTAQVFINVTDAN
                     THRPVFQSSHYTVSVSEDRPVGTSIATISATDEDTGENARITYVLEDPVPQFRIDPDT
                     GTIYTMTELDYEDQAAYTLAITAQDNGIPQKSDTTSLEILILDANDNAPRFLRDFYQG
                     SVFEDAPPSTSVLQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLD
                     RENVAVYNLWALAVDRGSPNPLSASVGIQVSVLDINDNPPVFEKDELELFVEENSPVG
                     SVVARIRANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLV
                     VQATSAPLVSRATVHIRLLDQNDNPPELPDFQILFNNYVTNKSNSFPSGVIGRIPAHD
                     PDLSDSLNYTFLQGNELSLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTA
                     LCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLSLFVEGVATVLSTTKDDIFVFNI
                     QNDTDVSSNILNVTFSALLPGGTRGRFFPSEDLQEQIYLNRTLLTTISAQRVLPFDDN
                     ICLREPCENYMKCVSVLRFDSSAPFISSTTVLFRPIHPITGLRCRCPPGFTGDYCETE
                     IDLCYSNPCGANGRCRSREGGYTCECFEDFTGEHCQVNVRSGRCASGVCKNGGTCVNL
                     LIGGFHCVCPPGEYEHPYCEVSTRSFPPQSFVTFRGLRQRFHFTVSLAFATQDRNALL
                     LYNGRFNEKHDFIALEIVEEQLQLTFSAGETTTTVTPQVPGGVSDGRWHSVLVQYYNK
                     PNIGHLGLPHGPSGEKVAVVTVDDCDAAVAVHFGSYVGNYSCAAQGTQSGSKKSLDLT
                     GPLLLGGVPNLPEDFPVHSRQFVGCMRNLSIDGRIVDMAAFIANNGTRAGCASQRNFC
                     DGTSCQNGGTCVNRWNTYLCECPLRFGGKNCEQAMPHPQRFTGESVVLWSDLDITISV
                     PWYLGLMFRTRKEDGVLMEATAGTSSRLHLQILNSYIRFEVSYGPSDVASMQLSKSRI
                     TDGGWHHLLIELRSAKEGKDIKYLAVMTLDYGMDQSTVQIGNQLPGLKMRTIVIGGVT
                     EDKVSVRHGFRGCMQGVRMGETSTNIATLNMNDALKVRVKDGCDVEDPCASSPCPPHS
                     HCRDTWDSYSCICDRGYFGKKCVDACLLNPCKHVAACVRSPNTPRGYSCECGPGHYGQ
                     YCENKVDLPCPKGWWGNPVCGPCHCAVSQGFDPDCNKTNGQCQCKENYYKPPAQDACL
                     PCDCFPHGSHSRACDMDTGQCACKPGVIGRQCNRCDNPFAEVTSLGCEVIYNGCPRAF
                     EAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPELFNCTSGSFVDLKALNE
                     KLNRNETRMDGNRSLRLAKALRNATQGNSTLFGNDVRTAYQLLARILQHESRQQGFDL
                     AATREANFHEDVVHTGSALLAPATEASWEQIQRSEAGAAQLLRHFEAYFSNVARNVKR
                     TYLRPFVIVTANMILAVDIFDKLNFTGAQVPRFEDIQEELPRELESSVSFPADTFKPP
                     EKKEGPVVRLTNRRTTPLTAQPEPRAERETSSSRRRRHPDEPGQFAVALVVIYRTLGQ
                     LLPEHYDPDHRSLRLPNRPVINTPVVSAMVYSEGTPLPSSLQRPILVEFSLLETEERS
                     KPVCVFWNHSLDTGGTGGWSAKGCELLSRNRTHVTCQCSHSASCAVLMDISRREHGEV
                     LPLKIITYAALSLSLVALLVAFVLLSLVRTLRSNLHSIHKNLITALFFSQLIFMVGIN
                     QTENPFLCTVVAILLHYVSMGTFAWTLVENLHVYRMLTEVRNIDTGPMRFYHVVGWGI
                     PAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPVGTVIIINTVIFVLSAKVSCQ
                     RKHHYYERKGVVSMLRTAFLLLLLVTATWLLGLLAVNSDTLSFHYLFAAFSCLQGIFV
                     LLFHCVAHREVRKHLRAVLAGKKLQLDDSATTRATLLTRSLNCNNTYSEGPDMLRTAL
                     GESTASLDSTTRDEGVQKLSVSSGPARGNHGEPDASFIPRNSKKAHGPDSDSDSELSL
                     DEHSSSYASSHTSDSEDDGGEAEDKWNPAGGPAHSTPKADALANHVPAGWPDESLAGS
                     DSEELDTEPHLKVETKVSVELHRQAQGNHCGDRPSDPESGVLAKPVAVLSSQPQEQRK
                     GILKNKVTYPPPLPEQPLKSRLREKLADCEQSPTSSRTSSLGSGDGVHATDCVITIKT
                     PRREPGREHLNGVAMNVRTGSAQANGSDSEKP"
     exon            3597..4235
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4458
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            4459..4574
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4663
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4821
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            4822..4985
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            4986..5111
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            5112..5278
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            5279..5464
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5578
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            5579..5753
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            5754..5895
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            5896..6016
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6017..6200
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6201..6302
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6303..6397
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6398..6607
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6608..6791
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6792..6935
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            6936..7140
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            7141..7308
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            7309..7435
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            7436..7636
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            7637..7811
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            7812..7924
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            7925..8004
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8005..8131
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8132..8257
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8258..8352
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8353..8456
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8457..8606
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8607..8840
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            8841..9102
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     exon            9103..11050
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10854..10859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /note="hexamer: AATAAA"
     polyA_site      10879
                     /gene="Celsr1"
                     /gene_synonym="Adgrc1; crash; Crsh; Scy"
                     /note="major polyA site"
ORIGIN      
        1 ccgggccatg gcgccgtcat cgccgcgcgt gctgcccgcg ctggtgttgc tggccgccgc
       61 cgccctgcca gccctggagt tgggagcagc cgcttgggag ctgcgggtgc ctggcggggc
      121 ccgcgccttc gctctcggac ccggctggag ctacaggttg gacaccacgc gcacgcctcg
      181 ggagctgctg gacgtgagcc gcgaggggcc agcagccggt cggaggcttg ggcttggcgc
      241 ggggactctg ggctgtgccc gcttggccgg gaggctgctg ccgctgcagg tccggctggt
      301 cgcccgcggc gccccgacgg ccccgagctt ggtactaagg gcacgcgcct atggtgcccg
      361 ctgtggggtc cggctgttgc gccgctcggc ccgcggtgca gagctgcgct ctccggccgt
      421 ccgctcagtt cctggacttg gagatgcgct ctgcttcccg gccgcaggcg gcggcgcagc
      481 ctcgctgact tcggtgcttg aggccatcac caacttcccc gcctgcagct gcccgccggt
      541 cgccgggacc ggctgcaggc gcggacccat ttgcctgcgg ccaggaggtt cagctgagct
      601 gcgtctggtg tgcgccctgg gacgcgcggc aggcgccgtt tgggtagagc tggtaataga
      661 ggcgacctct gggacgccct cagagtcgcc ctcggtgtcg ccatcgttgc ttaacctgtc
      721 ccaacctcgg gcgggggtgg tgcgacggtc taggcggggc acgggcagca gcacgagccc
      781 gcagttcccg ctgcccagct accaggtgtc agtgcctgag aatgagcctg cgggcactgc
      841 ggtcatcgaa ctgcgcgcgc acgacccaga cgaaggcgat gcaggacgcc ttagctacca
      901 gatggaggcg ctgttcgatg agcgctctaa tggctacttc ctcatcgatg ccgccacggg
      961 tgcagtgacc acagcccgct ccctggaccg ggagaccaag gacactcatg tactcaaagt
     1021 tagtgctgtg gaccacggct ccccgaggcg ctcagctgcc acctacctca ccgtaactgt
     1081 cagtgacact aacgaccaca gcccagtctt tgagcagtct gagtatcgag agcgaattcg
     1141 agaaaacctg gaggtgggct atgaggttct gaccatccgt gccaccgacg gggatgcccc
     1201 ttccaacgca aacatgcgct atcgtctgct ggagggcgca ggtggtgtct ttgagataga
     1261 cgcacgatca ggtgtcgtgc gcacacgggc tgtggtggac cgtgaggagg cggctgagta
     1321 ccagctgctg gtggaggcca atgaccaggg tcgcaatcca ggcccactca gtgcctcagc
     1381 caccgtccac atagtggtag aagacgagaa tgacaactac ccccagttca gtgagaagcg
     1441 ctatgtggtt caagtcccag aagacgtagc cgtcaacacg gctgtgcttc gagtccaggc
     1501 cactgaccgg gaccaggggc agaatgcagc catacactac agcatcgtta gtggcaacct
     1561 gaagggtcag ttctacctgc attcgcttag tgggagcctg gatgttatca acccgctgga
     1621 cttcgaggcc atccgggagt acaccctgcg catcaaagcc caggatgggg gccggcctcc
     1681 tctcattaat tcctcaggac tggtctcggt gcaggtgtta gatgtgaacg acaatgcgcc
     1741 catctttgtg agcagcccct ttcaggctgc cgtgctagag aatgtgcccc tcggccactc
     1801 agtcctgcac atccaagcgg tggacgcaga tgcaggggag aacgccaggc tgcagtaccg
     1861 tctagtggac acagcctcca ctatcgtggg gggcagcagt gtcgactctg agaaccctgc
     1921 ctctgcccca gacttcccct tccaaatcca caacagctcc ggttggatta ctgtgtgcgc
     1981 ggagctggac cgtgaggagg tggaacacta tagctttgga gtagaagcag tggaccatgg
     2041 ctcaccagcc atgagctcct ctgccagcgt gtccatcaca gtgctggatg taaatgataa
     2101 cgaccccatg ttcacgcagc ctgtgtatga gctgcgtctg aatgaggatg cggctgtcgg
     2161 gagcagcgtg ctgaccctca gggcccgaga ccgtgatgcc aatagtgtga tcacctacca
     2221 gctgacgggt gggaacaccc gcaaccgctt cgcactcagc agccagagcg gcggtggcct
     2281 tatcaccttg gcactgcccc tggactacaa gcaggaacgg cagtatgtgc tggctgtgac
     2341 cgcgtccgat ggcacgcgtt cacacaccgc gcaggtcttt atcaacgtta cagatgccaa
     2401 cacccacagg ccggtcttcc agagttccca ctacacggtc agtgtgagtg aagaccggcc
     2461 cgtgggcacc tccatcgcta ccatcagtgc cacggatgag gatacgggtg agaacgcccg
     2521 catcacctat gtgctagagg atcccgtacc acagttccgc attgacccgg acactggcac
     2581 catctatacc atgacggaac tggactatga ggaccaggct gcctacacgc tggccatcac
     2641 ggctcaggac aatggcattc ctcagaagtc agacactacc tctctggaga tccttatcct
     2701 cgacgccaat gacaacgcgc ccaggttcct gcgagatttc taccagggtt ctgttttcga
     2761 ggatgccccc ccatctacca gtgtcctcca ggtctctgct acagaccgtg actcaggccc
     2821 taatggccgc ctcctgtaca ctttccaggg tggggatgat ggagatggag atttctacat
     2881 tgagcccacg tctggtgtga tccgtaccca gcgccggctg gacagagaga atgtggccgt
     2941 gtacaacctt tgggctctcg ctgtggatcg gggcagcccg aatcccctca gtgcgtcagt
     3001 gggaattcag gtgagtgtgt tggacattaa cgacaacccc ccagtgtttg agaaggacga
     3061 gctggagctg tttgtggaag agaacagccc tgtgggttca gtggtagcaa gaataagggc
     3121 caacgacccg gacgaaggtc cgaatgctca gatcatgtat cagatcgtgg agggcaatgt
     3181 gcccgaggtc ttccagctgg acctactgag tggtgacctc cgtgccctgg tcgagttgga
     3241 ttttgaggtc cggagggact atatgttggt ggtgcaggcc acgtctgctc ctctggtaag
     3301 ccgggccacc gtgcacatcc gtctcctgga ccagaatgac aacccaccgg agttgcctga
     3361 cttccagatc cttttcaaca actatgtcac caataaatcc aacagcttcc ccagtggtgt
     3421 gatcggccgc atcccagccc acgaccctga cctatctgac agcctcaatt acacctttct
     3481 gcaaggcaac gagctgagcc tgctgctgct ggatcccgcc acaggagagt tgcagctcag
     3541 ccgggatctg gacaacaacc ggccactgga ggcgctcatg gaggtgtctg tgtcagatgg
     3601 tatccacagt gtcaccgctc tctgcactct gcgcgtgacc atcattacag atgacatgct
     3661 gaccaacagc atcactgtcc gcctggagaa catgtcgcag gagaagttcc tgtccccgct
     3721 gctgtccctc tttgtagaag gggtggccac agtactgtcc accaccaagg atgacatctt
     3781 tgtcttcaac atccagaacg acacggacgt cagctccaac atcctgaacg tgactttctc
     3841 ggcactgctc cccggtggca cccgtggccg gttcttcccg tcagaggacc tgcaggagca
     3901 gatctacctg aaccggacac tgctcaccac catctccgcc cagcgagtgc tgcccttcga
     3961 tgacaacatc tgcctgaggg agccctgcga gaactacatg aaatgcgtgt ctgtgcttag
     4021 gtttgacagt tcggccccct tcattagttc caccacggtg ctcttccggc ctatccatcc
     4081 catcacgggc ctgcgctgcc gctgcccgcc gggtttcacc ggggactact gcgagactga
     4141 aattgatctt tgctactcca atccgtgcgg ggccaatggc cggtgccgga gccgtgaggg
     4201 tggctacact tgtgagtgct tcgaggactt cactggggag cattgccagg tgaacgttcg
     4261 ctcaggccgc tgtgccagtg gagtatgcaa aaacgggggc acctgcgtga acctgctcat
     4321 tggaggcttc cactgtgtgt gcccacccgg cgagtatgag catccctact gtgaagtgag
     4381 caccaggagc ttcccacccc agtccttcgt taccttccga ggcctgcggc aacgcttcca
     4441 cttcaccgtc tccctggcgt ttgccaccca ggacaggaac gccctgctgc tctacaatgg
     4501 ccgcttcaat gagaagcatg acttcatcgc cctggagatt gtggaggagc agctgcagct
     4561 cacgttctcg gcaggtgaga ccacaaccac ggtgacaccg caggttcctg gaggtgtgag
     4621 cgatgggcgg tggcattcgg tgctggtgca gtactacaac aagcccaaca ttggccacct
     4681 gggcctgccc cacgggccgt ctggagagaa ggtggctgtg gtgactgtgg atgactgtga
     4741 cgcagcggtg gccgtgcact ttggaagtta cgtggggaac tacagctgcg ctgcccaggg
     4801 cactcagagc ggctccaaga agtcactgga tctgaccggt cctctgcttc tgggtggtgt
     4861 ccccaacctg ccagaagact tccccgtgca cagccgtcag tttgtgggat gcatgcgaaa
     4921 cctgtccatc gatggccgga ttgtggacat ggctgcgttt attgccaaca atggtaccag
     4981 ggcaggctgt gcttctcaga ggaacttctg cgatgggacc tcatgccaga acgggggcac
     5041 ctgtgtgaac aggtggaaca cgtacttatg tgagtgcccg ctccgctttg gtggaaagaa
     5101 ctgtgaacaa gctatgccac accctcagcg cttcactggt gagagcgtcg tgttgtggag
     5161 tgaccttgac atcaccatct ctgtgccttg gtacctgggg ctcatgttcc ggacccggaa
     5221 ggaggatggt gtgctgatgg aagccacagc tggcacgtct tccaggctcc atctccagat
     5281 tctcaacagc tacatccgct ttgaggtctc ctacggcccc tctgacgtgg catccatgca
     5341 gctgtccaag tcccggataa ctgacggggg gtggcatcac ctgctcatag aactgaggag
     5401 tgccaaggag ggcaaggaca tcaaatacct ggcagtcatg accttggact atgggatgga
     5461 ccagagcaca gtgcagattg ggaatcagct tcctgggttg aagatgcgga ctattgtcat
     5521 cggaggtgtg accgaggaca aggtctctgt ccgccatggt ttccgaggct gtatgcaggg
     5581 agtgaggatg ggagagacgt ccaccaacat tgccaccctg aacatgaatg acgccctcaa
     5641 ggtcagggtg aaggacggct gtgacgtgga ggacccatgt gcctcaagcc cctgccctcc
     5701 ccatagccac tgccgtgaca catgggacag ctactcctgc atctgtgaca gagggtactt
     5761 tggaaaaaag tgtgtggatg cgtgtctcct gaacccctgc aagcacgtgg cagcctgtgt
     5821 gcgctccccc aacactcctc gaggctactc ctgcgagtgc ggacccggcc actatgggca
     5881 gtactgtgag aacaaagtcg accttccgtg ccccaaaggc tggtggggga acccggtgtg
     5941 tggcccctgt cactgtgctg tcagccaagg ctttgatccc gactgcaaca agaccaatgg
     6001 ccaatgccag tgcaaggaga attactacaa gcccccagcc caggatgctt gccttccctg
     6061 tgactgtttc ccccacggct cccacagccg tgcctgcgac atggacactg ggcagtgtgc
     6121 ctgcaagcct ggtgtcatcg gccgtcagtg caaccgctgt gataatcctt tcgcggaggt
     6181 cacctcgctc ggctgtgaag tgatctacaa tgggtgtccc agagcatttg aggctggcat
     6241 ctggtggcca cagacgaaat ttgggcagcc agcagcggtg ccatgcccca aaggatccgt
     6301 gggtaacgca gtccggcact gcagcgggga gaagggctgg cttcccccag agctcttcaa
     6361 ctgcacctct ggctcctttg tggacctcaa ggccttgaac gagaaactga accgcaacga
     6421 gacaagaatg gacgggaacc ggtccctgcg gctggcaaag gctctgagga acgccacgca
     6481 ggggaacagc accctctttg gcaatgatgt gcgcacggcc taccagcttc tggcccgcat
     6541 cttacagcat gagagccgcc agcagggctt tgacctagca gccacccgag aggctaattt
     6601 tcatgaggat gtcgtccata caggcagcgc cctcctggcc ccagctacag aggcatcgtg
     6661 ggaacagatc cagcgaagcg aggctggtgc agcgcagcta ctgaggcatt tcgaggcata
     6721 cttcagcaac gtggcacgaa atgtgaagag gacctatctg aggcccttcg tcatcgtcac
     6781 cgccaacatg attcttgcag ttgacatctt cgacaagctg aacttcacgg gtgcccaggt
     6841 gccaaggttt gaggacattc aggaagagct cccaagggag ctggagtcct ccgtgtcctt
     6901 cccagctgac accttcaagc caccagagaa aaaagaaggc cccgtggtga ggctgaccaa
     6961 ccggaggact accccactca cggcacaacc agagcccagg gctgagaggg aaacctcatc
     7021 cagcagacgg aggagacacc ccgatgagcc tggccagttt gctgttgccc tggttgtcat
     7081 ttaccggacc ctgggtcagc tgctgcctga acactatgac cccgaccatc gcagcctccg
     7141 actgcctaac cggcctgtca tcaacacccc cgtggtgagt gctatggtgt acagtgaggg
     7201 aaccccactc cccagctctc tgcagaggcc tatcctggtg gagttctccc tgttggagac
     7261 ggaggaacga agcaaacctg tctgtgtatt ctggaaccac tccctcgaca ctggtgggac
     7321 tggagggtgg tcagccaagg gctgtgaact tctgtcgagg aaccggaccc acgtcacttg
     7381 ccagtgcagc cattcggcca gctgcgcggt gctcatggac atttccagac gtgagcacgg
     7441 ggaggttctg cccctgaaga tcatcaccta tgccgccctg tccttgtctt tggtggccct
     7501 cctggtggcc tttgtccttc tctcactcgt tcggacactg cgctccaacc tgcacagcat
     7561 ccacaagaac ctcatcacgg ctctgttctt ctcccagctc atcttcatgg tcggcatcaa
     7621 ccagactgag aacccgtttc tctgcacagt ggtcgccatc ctcctgcact acgtctccat
     7681 gggcaccttc gcctggaccc ttgtggagaa cttgcatgtc taccgcatgc tgacagaagt
     7741 gcgcaacatc gacactgggc ccatgcggtt ctaccacgtg gtgggctggg gcatccctgc
     7801 cattgtcaca ggactggctg ttggcttgga ccctcagggc tatggaaacc ctgacttctg
     7861 ctggctgtcc cttcaggata ccctgatttg gagctttgct gggcctgtcg gaacggttat
     7921 aatcatcaac acagtcatct ttgtcctgtc tgcaaaggtt tcctgccaaa gaaagcacca
     7981 ttattatgaa agaaaggggg ttgtctccat gctgaggacg gccttcctcc tgctgctgct
     8041 cgtcactgcc acctggctgc tgggactgct ggcggtcaac agtgacactc ttagctttca
     8101 ctacctcttt gctgccttca gctgcttgca gggcatcttt gtcctcctgt tccactgcgt
     8161 ggcccacagg gaggtgcgga agcacctgag ggcggtgctg gcagggaaga agctgcagct
     8221 ggatgactcg gccaccactc gggccactct gctaacgcgc tccctcaact gcaacaacac
     8281 ctacagcgaa gggccagaca tgctccgcac cgccctgggc gagtccacag cctctctgga
     8341 cagtaccacc agggatgaag gggtccagaa actcagtgtg tcctctggcc cagcccgtgg
     8401 taaccatgga gaaccagatg catccttcat ccctaggaac tccaaaaaag ctcacggccc
     8461 tgactctgac tctgacagtg agctgtccct ggacgagcac agtagttcct acgcctcttc
     8521 acacacatcg gacagcgagg atgatggcgg agaggctgaa gacaaatgga atccggctgg
     8581 gggccccgcc catagcaccc caaaagcaga tgctctggcc aaccacgtcc cagctggctg
     8641 gcccgacgag agcctggctg ggagtgacag tgaggagttg gacactgagc cccacctgaa
     8701 ggtggagacc aaggtcagcg tggagttaca ccggcaggcg cagggcaatc actgtggcga
     8761 ccggccctct gacccggaaa gtggggtcct ggccaagcca gtggccgtgc ttagcagcca
     8821 gccccaggag cagcggaaag gcatcctgaa aaacaaagtc acctacccgc cgccattgcc
     8881 agagcagcca ctgaagtccc ggctgcgaga gaagctggct gattgtgagc agagccccac
     8941 atcctcccgc acatcctccc ttggctctgg cgatggtgtc catgccactg actgtgtcat
     9001 taccatcaag actccgagga gggagccagg ccgtgagcat ctcaatgggg tggccatgaa
     9061 tgtacgcaca gggagtgccc aggccaacgg ttctgactca gagaaaccat gaggcacagt
     9121 caaccccaca gactgccggt caagccctca gaccttgaag cctgcctggg actgctgcct
     9181 atgggacaag caggcacctt gtgtgagggt ccctgccata gcagctggct ctacgcagac
     9241 cgtccagacg ggaagccctt gaccctcata ggagctcagg gcccagactc tgacaaagtg
     9301 ccaaagccac agatgtctcc agagggagac gtggacttca ttaaggctgg catagctccg
     9361 tccttagact gaagacagaa tccaaaccat gctgtacaag aggccattga gccagagctg
     9421 gacttggtga atcattgtac cgggcccttc aactgtcccc gcaggcctct ccttgtggta
     9481 caagcccatc accaccagcc tagcggtgcc tctgcaacgg caccctgggt tttaaattgc
     9541 tgtctaaaaa tgtaaataga tataaatctc tccctggact tgggagaaga tgggagctgt
     9601 gtatgcttta cactgctttg actctgcagc cactggagag ccatgaaatg gcatctcact
     9661 ctattgccca aggaagcttg cacagttgta cttgaatctg gaatgagtca actcagctgg
     9721 tcccagtgcc caggtaggga gcatatgggc tgtgaagttg acacagcttc tgcagctgct
     9781 tccggccagg gagtgtgggt gttccgctgg cctttggagc acacggcaca tgtgctgcgt
     9841 atgtgtgcct cagctccatg gatccaggtc agggctcacc tgtgaggagt gggcgccata
     9901 gctatgatat gaaactctga ccaccctgcc acccccacgc cccccccccc cccccccccc
     9961 gctcctgatg cagtgaggcg actctggagc ctttcccagt cagcccagtg cgcagcggga
    10021 ggacttctgc tcctgctccc ataagctctc agagtgctca tgttcctgat tctgagggag
    10081 cccagaggtc ttccacgctg tcacggtcct tcctgccaat gttgtacttt ttcagactcc
    10141 agggctctct aggcaggcag ggtgctccac ccctgaaatc tgaccaatga catcactttg
    10201 cttcaaatga ccaattgtgc aaagaaacaa agccagagtg cccgttttca atggttacca
    10261 cattcttttt ggaatctcac accaaggact gctgtgacca gcccactgag agccacggtg
    10321 cagccaaggc caagggatgg gagcctggag ttactcagac acgtttactt cagcatggac
    10381 tgttgtctga atcaggtccc caaagtacat ggggtgcaca gtcgctcgga atggagaacc
    10441 tcagcgaggc ggtcaaaggc caggacttct caccaagctg tgctctcaga agtgcacagg
    10501 actgctagtg actgactggt gagatgaaag cctacaagac atggcctggg gtcacgcact
    10561 gccaagaggc tgacgggagg cccaggtagc ccaaggatgg caaggataca gagtgaccta
    10621 gcacagggga gcttcagtcc ccaggaggta cagcaccgtg acaactccgc aacccacgcc
    10681 acctcagaag gtgaagtttt tgattcgatc acaactatta gcaaaacaaa ccctgtcagt
    10741 tttaaactgt ttttctgacc taagacttta tagagtcaac actggagatt ttaacaggtg
    10801 tatttattac tgttcagcac tggatggcaa cacaggtgag atgatgcatc tataataaat
    10861 taagattttt ggatttgtac ccgtgctgtg ctgggtggtt actgacccca ctgtcctact
    10921 ctctaaggtg gcatgggagg gaccgctgaa gacagcctca ggcctctgct gggatgcagg
    10981 tggcaggccc atggagggtt gtcataactt tctatttata tttaggcctg ctgtgacatg
    11041 ggtggacctg
//
