LOCUS       NM_001413521            4602 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CUGBP, Elav-like family member 6 (Celf6), transcript
            variant 4, mRNA.
ACCESSION   NM_001413521 XM_006511540
VERSION     NM_001413521.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4602)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4602)
  AUTHORS   Veerakumar,A., Yung,A.R., Liu,Y. and Krasnow,M.A.
  TITLE     Molecularly defined circuits for cardiovascular and cardiopulmonary
            control
  JOURNAL   Nature 606 (7915), 739-746 (2022)
   PUBMED   35650438
REFERENCE   3  (bases 1 to 4602)
  AUTHORS   Rieger,M.A., King,D.M., Crosby,H., Liu,Y., Cohen,B.A. and
            Dougherty,J.D.
  TITLE     CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a
            Role in Destabilizing Synaptic Gene mRNAs through Interaction with
            3' UTR Elements
  JOURNAL   Cell Rep 33 (12), 108531 (2020)
   PUBMED   33357440
  REMARK    GeneRIF: CLIP and Massively Parallel Functional Analysis of CELF6
            Reveal a Role in Destabilizing Synaptic Gene mRNAs through
            Interaction with 3' UTR Elements.
REFERENCE   4  (bases 1 to 4602)
  AUTHORS   Maloney,S.E., Rieger,M.A., Al-Hasani,R., Bruchas,M.R., Wozniak,D.F.
            and Dougherty,J.D.
  TITLE     Loss of CELF6 RNA binding protein impairs cocaine conditioned place
            preference and contextual fear conditioning
  JOURNAL   Genes Brain Behav 18 (7), e12593 (2019)
   PUBMED   31215739
  REMARK    GeneRIF: Celf6 mutant mice exhibited impaired conditioned learning
            to both reward and aversive stimuli.
REFERENCE   5  (bases 1 to 4602)
  AUTHORS   Maloney,S.E., Akula,S., Rieger,M.A., McCullough,K.B., Chandler,K.,
            Corbett,A.M., McGowin,A.E. and Dougherty,J.D.
  TITLE     Examining the Reversibility of Long-Term Behavioral Disruptions in
            Progeny of Maternal SSRI Exposure
  JOURNAL   eNeuro 5 (4) (2018)
   PUBMED   30073191
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4602)
  AUTHORS   Shen,X., Soibam,B., Benham,A., Xu,X., Chopra,M., Peng,X., Yu,W.,
            Bao,W., Liang,R., Azares,A., Liu,P., Gunaratne,P.H., Mercola,M.,
            Cooney,A.J., Schwartz,R.J. and Liu,Y.
  TITLE     miR-322/-503 cluster is expressed in the earliest cardiac
            progenitor cells and drives cardiomyocyte specification
  JOURNAL   Proc Natl Acad Sci U S A 113 (34), 9551-9556 (2016)
   PUBMED   27512039
REFERENCE   7  (bases 1 to 4602)
  AUTHORS   Maloney,S.E., Khangura,E. and Dougherty,J.D.
  TITLE     The RNA-binding protein Celf6 is highly expressed in diencephalic
            nuclei and neuromodulatory cell populations of the mouse brain
  JOURNAL   Brain Struct Funct 221 (4), 1809-1831 (2016)
   PUBMED   25682262
  REMARK    GeneRIF: Results suggest that disruption of CUG-BP, Elav-like
            factor 6 expression in hypothalamic nuclei may impact a variety of
            behaviors downstream of neuropeptide activity, while disruption in
            neuromodulatory transmitter expressing areas such as the ventral
            tegmental area, substantia nigra, raphe nuclei and locus coeruleus
            may have far-reaching influences on overall brain activity.
REFERENCE   8  (bases 1 to 4602)
  AUTHORS   Hoekstra,E.J., von Oerthel,L., van der Heide,L.P.,
            Kouwenhoven,W.M., Veenvliet,J.V., Wever,I., Jin,Y.R., Yoon,J.K.,
            van der Linden,A.J., Holstege,F.C., Groot Koerkamp,M.J. and
            Smidt,M.P.
  TITLE     Lmx1a encodes a rostral set of mesodiencephalic dopaminergic
            neurons marked by the Wnt/B-catenin signaling activator R-spondin 2
  JOURNAL   PLoS One 8 (9), e74049 (2013)
   PUBMED   24066094
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4602)
  AUTHORS   Dougherty,J.D., Maloney,S.E., Wozniak,D.F., Rieger,M.A.,
            Sonnenblick,L., Coppola,G., Mahieu,N.G., Zhang,J., Cai,J.,
            Patti,G.J., Abrahams,B.S., Geschwind,D.H. and Heintz,N.
  TITLE     The disruption of Celf6, a gene identified by translational
            profiling of serotonergic neurons, results in autism-related
            behaviors
  JOURNAL   J Neurosci 33 (7), 2732-2753 (2013)
   PUBMED   23407934
REFERENCE   10 (bases 1 to 4602)
  AUTHORS   Dev,A., Nayernia,K., Meins,M., Adham,I., Lacone,F. and Engel,W.
  TITLE     Mice deficient for RNA-binding protein brunol1 show reduction of
            spermatogenesis but are fertile
  JOURNAL   Mol Reprod Dev 74 (11), 1456-1464 (2007)
   PUBMED   17393433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123817.4.
            
            On Nov 3, 2022 this sequence version replaced XM_006511540.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139,
                              SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AC123817.4         119425-119760
            337-419             AC123817.4         123397-123479
            420-468             AC123817.4         131756-131804
            469-597             AC123817.4         143698-143826
            598-677             AC123817.4         143921-144000
            678-821             AC123817.4         144116-144259
            822-954             AC123817.4         144356-144488
            955-1104            AC123817.4         144569-144718
            1105-1167           AC123817.4         144929-144991
            1168-1248           AC123817.4         145251-145331
            1249-1392           AC123817.4         145421-145564
            1393-1548           AC123817.4         146078-146233
            1549-4602           AC123817.4         147101-150154
FEATURES             Location/Qualifiers
     source          1..4602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 32.02 cM"
     gene            1..4602
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /note="CUGBP, Elav-like family member 6"
                     /db_xref="GeneID:76183"
                     /db_xref="MGI:MGI:1923433"
     exon            1..336
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1520
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /EC_number="3.2.1.52"
                     /note="isoform 4 is encoded by transcript variant 4;
                     CUG-BP- and ETR-3-like factor 6; bruno-like protein 6;
                     RNA-binding protein BRUNOL-6; bruno-like 6, RNA binding
                     protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 6 isoform 4"
                     /protein_id="NP_001400450.1"
                     /db_xref="GeneID:76183"
                     /db_xref="MGI:MGI:1923433"
                     /translation="MAAAPGGSAPPAGPSPRLAFSTADSGGGMSGLNPGPAVPMKDHD
                     AIKLFVGQIPRGLDEQDLKPLFEEFGRIYELTVLKDRLTGLHKGCAFLTYCARDSALK
                     AQSALHEQKTLPGMNRPIQVKPAASEGRGEDRKLFVGMLGKQQGEEDVRRLFQPFGHI
                     EECTVLRSPDGTSKGCAFVKFGSQGEAQAAIQGLHGSRTMTGASSSLVVKLADTDRER
                     ALRRMQQMAGQLGAFHPAPLPLGACGAYTTAILQHQAALLAAAQGPGLGQVAAVAAQM
                     QHVAAFSLVAAPLLPAAANTSPGGNGPGALPGLPAPMGVNGFGSLTPQSNGQPGSDTL
                     YNNGVSPYPAKSPSVADPLQQAYAGIHHYAAAYPSAYAPASTAFSQQPSALPQQQREG
                     PEGCNLFIYHLPQEFGDAELIQTFLPFGAVVSAKVFVDRATNQSKCFGFVSFDNPTSA
                     QTAIQAMNGFQIGMKRLKVQLKRPKDANRPY"
     exon            337..419
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            420..468
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            469..597
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            598..677
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            678..821
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            822..954
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1104
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1167
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1248
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1392
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1548
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..4602
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2839..2844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /note="hexamer: TATAAA"
     polyA_site      2861
                     /gene="Celf6"
                     /gene_synonym="6330569O16Rik; Brunol6"
                     /note="major polyA site"
ORIGIN      
        1 aggccctcgc cagcagtcca gggaagggac ggcgggacag gcgggacgct cgggagggcg
       61 gacggggcgg ggacatggcc gcggcgcctg gagggtctgc gccgcccgcc ggccccagcc
      121 cgcgcttggc tttcagcacc gcggacagcg gcggcggcat gagcgggctg aacccaggtc
      181 ccgcggtgcc catgaaggac cacgacgcca tcaagctctt cgtggggcag atcccgcggg
      241 gcttggacga gcaggacctc aagccgctgt tcgaggagtt cggccgcatc tacgagctga
      301 cggtgctgaa ggaccggctc accggcctcc acaaaggctg tgccttcctc acctactgcg
      361 cccgggactc tgccctcaag gcccagagtg cactgcatga gcagaagacc ctgccaggga
      421 tgaatcgtcc gatccaagtg aagccggctg ccagtgaggg ccgaggagag gaccggaagc
      481 tgtttgtggg gatgttgggc aagcagcagg gtgaggagga tgtcagacgt ctgttccagc
      541 ccttcggcca tatcgaggag tgcactgtcc tgcggagtcc ggacggtacc agtaaaggct
      601 gtgcctttgt gaaattcgga agtcaagggg aagcccaagc tgccatccag ggactacacg
      661 gtagccggac aatgacgggt gcctcctcca gcctggtggt taagctggca gacaccgacc
      721 gggagcgcgc gctgcgaagg atgcagcaaa tggctggcca gctgggtgcc ttccacccgg
      781 caccgctgcc cctcggggcc tgtggcgcct ataccactgc gatcctacag caccaggcag
      841 cgttgctggc cgcagcgcag ggtccggggt taggccaggt ggccgcggtg gccgcccaga
      901 tgcagcacgt ggcggccttc agcttggtgg ctgcaccgct gttgcccgcg gcagccaata
      961 catcccctgg tggcaatggc cctggtgcac tccctggcct tccagcgccc atgggagtca
     1021 atggattcgg ctccttgacc ccccagagca acggacagcc aggctccgac acgctctata
     1081 acaacggggt ttccccttac ccagcgaaga gccccagtgt ggctgacccc ctgcagcagg
     1141 cctacgctgg gatacatcac tatgcagcag cctatccctc ggcctatgcc ccagcgagca
     1201 cagctttttc ccaacagcct tcagctctgc ctcaacaaca aagagaaggc cccgaaggct
     1261 gtaacctctt catctatcac ctgcctcagg agtttgggga tgcagaactc atacagacat
     1321 tcctgccctt cggagctgtt gtctctgcca aagtttttgt ggaccgtgcc accaatcaga
     1381 gcaagtgttt tgggtttgtt agttttgaca atccaaccag tgcccagacc gccatccagg
     1441 ccatgaatgg ctttcaaatc ggcatgaaga ggctcaaggt ccagctaaag agacctaagg
     1501 atgccaacag gccttactga tctgagctca ctgaccagtc acagacagaa actgaagaat
     1561 gaagaaagga aacagaaaag cacagaaatg ctggagaggc ccttccggaa ggagtggcag
     1621 cagacggagg tggatcggac ccagggctgg cgcctggggc tcaggccact catcatgtgg
     1681 gttgttccat ggagtgatca ggctggcagg gcaaccagtg ctggctgagg accgacagct
     1741 ctaaaggaac cagcagaggg cctcgggggt gccaagggct tctcagcaag ggaagcccag
     1801 acttactttg ttcaaaatca tatcattcct tagtgtttag ggaccaaagg actattgctt
     1861 ttttaagaat atatatatat ataaattaaa acaaagaaaa aaaaacagga gacaaaaaaa
     1921 agacagtata gagtctcata aaagctgcct ttaaatatcc ccaggagaca gggtgaagga
     1981 gacccttgat agcccagcct aggcagagga ggctgtggaa agattggcct gtgtctcact
     2041 ccttcttaag cgattccctt accccaccct ttaagaatat gataaaggat gtgaagtcca
     2101 ggctcatagt caagcaacaa gagggttgtg gaagcagtga acccgcagtt cccaaatgca
     2161 gatagtatcc caggagagcc tcaggagaag ctcaggcctg ctctggtctt tgctacctta
     2221 ggaggccccc ggccatcgga aatgggaacc tgcctttcct tcctgacccc ctttcctgtg
     2281 gagccacagc ctccccaggt aggaagagag agagagagag agagagagag agagagagag
     2341 agagagagag agagagagag agagagagaa cctttacctt cccagtccag gtagaccaag
     2401 gcttcgcctt tggctgagct gagacacctc ctgtttcccc tcccctttcg actaccccag
     2461 tgtccccttg ctccaggcca ccttctgtct cttagtctaa gtttgcccac ttgtaaagta
     2521 gactcaaggt atatgtagag ggctgtgaca acagacgtgg aaggcttgct gctgtaaata
     2581 ctgccactga gaaggggatc attttcacta tgtagaagct tcagaattag aggtccccct
     2641 ttacccagga cctgggaggg aagtagatgt tttgccaaaa tactaattca ttcctttaaa
     2701 aagtccatct ttcctatgca agcgtgtctc acatgtgctt acccaaggtg cttttagatg
     2761 gtgagcagtg ttcagcttag aagtggtgtg tgctctgtct gtctgtcctt gtctgtatgt
     2821 tgtgtacagt gggtgccata taaagctggt caatggtggt gcttcctgcc tgcttctgtg
     2881 agatgggcaa atgagtcagc ttagcacacc acaactcacc ttgcctccgt cagcctttcc
     2941 taggcctgtg ggaccttgaa tacctttttt ccctgtgtga ataatttata ttcccatcct
     3001 gaagtcatgg atctacctag tgtgaggccc cacagagtgg gagatactct ggtctgacac
     3061 tggagacctg tcatctgata tcactgggac agtgaaagat gtgggtggga gaaaggctct
     3121 gggataattc cttccaggcc ctccctaaga aaatgtgttc ttgcctgtcc cttgtcttta
     3181 actagttttt ggaagtaacg agagtgaaaa ctagatttgt cagtaacatt accgggcaca
     3241 ttgtggttta tatccacaaa taattgccag ctgggagagg aactggtgtt gaggcataga
     3301 cataccagct tgtgctaacc cacagatgga gtacctcagg tacaggtgga gatgtgcaac
     3361 atctgcccac tcaaacagat attcatgggc ctagagacat gctcagtcag tatgtgttta
     3421 ccttgtaagc acaaggaccc tgagctcagt tcctcagaaa caaaaccaaa caaacaaaga
     3481 aacaaaacag aaaaacccac agaacaaaaa caacaaaaca aaacaaaaac caggcactgg
     3541 cctgccattt caacctaatt ggtgagatga gtttgaggac aataagagat cctatctcaa
     3601 aaatagctag gtgatggtgc ctgaggaatg acagctgcaa ttgtattctg gcctcagcat
     3661 gtatgctcac atacactggc acaaacagaa acaaacctca gggactcagg taactaccaa
     3721 gtaccaggag ttaagggaaa tggatagacg catatggtct ataccagcaa gaaaactact
     3781 aactcaggct caaatgttgg gaacgatcca tgaaagtcta cctgaagatt aaggagaaga
     3841 atcaccaagg gtgaccaggg atattcaaag tctttgagca actacatcat tttgaaaaag
     3901 tatggccaag aaataatcac gtatttcaga ttttattatg ttatagataa gtcaagactc
     3961 tcatactatt cctaaatcta ctctgaacct taaatcagat ccatgtcagg gcctttgaaa
     4021 taagcaaact tcatgcttgt agggtgtgag tgaaggcctg gcagacacta gatccccaag
     4081 cttcggggtt tggtgtgatc taaagcaagg gttggccaac tatggtctgt cagccacacc
     4141 tggcctgtga catgttttta tacgacctac aaattaagaa tgattttttt aagaataatt
     4201 ttttaaaaaa atttcaagga ttttgatatt ttaaactgta tgtgcacctg tctctgtggg
     4261 gaagtgccca tgagggcagg tgcccacaga ggtcagaaga gggcattgga tttcctggaa
     4321 ctagaggtac aggtgtttgt cagctgccag atgagggtgc tgcaaactga acttggcact
     4381 ctgcaagagc agtgcacttc ttaaccactg agccctatct ccagtctagg gtttttttgt
     4441 ttgtttgttt gtttgttttt ggttttttgt tttaaaatta tgtcaaaaca aaatgtcgac
     4501 acaaagctct atgtggttta caaagcttga aacatttatc tggtccctta cacgagtttc
     4561 ctgatccttg gtaaagtaat ggaagatttg tagaatgtct ga
//
