LOCUS       NM_001362316            4124 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CUGBP, Elav-like family member 4 (Celf4), transcript
            variant 40, mRNA.
ACCESSION   NM_001362316
VERSION     NM_001362316.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4124)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4124)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4124)
  AUTHORS   Shen,Y., Zhang,C., Xiao,K., Liu,D. and Xie,G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   4  (bases 1 to 4124)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   5  (bases 1 to 4124)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4124)
  AUTHORS   Ladd,A.N., Taffet,G., Hartley,C., Kearney,D.L. and Cooper,T.A.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (bases 1 to 4124)
  AUTHORS   Meins,M., Schlickum,S., Wilhelm,C., Missbach,J., Yadav,S.,
            Glaser,B., Grzmil,M., Burfeind,P. and Laccone,F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (bases 1 to 4124)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (bases 1 to 4124)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (bases 1 to 4124)
  AUTHORS   Yulug,I.G., Egan,S.E., See,C.G. and Fisher,E.M.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2518784.1,
                                           SRR1660813.254341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-816               AC121094.8         7568-8383
            817-899             AC121094.8         82230-82312
            900-978             AC144938.3         102514-102592       c
            979-1107            AC144938.3         69727-69855         c
            1108-1187           AC144938.3         69326-69405         c
            1188-1331           AC144938.3         68976-69119         c
            1332-1476           AC144938.3         67770-67914         c
            1477-1626           AC144938.3         66038-66187         c
            1627-1692           AC144938.3         62302-62367         c
            1693-1776           AC144938.3         61059-61142         c
            1777-1860           AC144938.3         55978-56061         c
            1861-2032           AC144938.3         51631-51802         c
            2033-4124           AC144938.3         42457-44548         c
FEATURES             Location/Qualifiers
     source          1..4124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     gene            1..4124
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="CUGBP, Elav-like family member 4"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
     exon            1..816
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..1988
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="isoform 36 is encoded by transcript variant 40;
                     CUG-BP- and ETR-3-like factor 4; bruno-like protein 4;
                     RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 4 isoform 36"
                     /protein_id="NP_001349245.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
                     /translation="MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPS
                     TIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTY
                     CERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLN
                     KQQSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTM
                     PGASSSLVVKFADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQAMQQQAALMA
                     SVAQGGYLNPMAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSP
                     IGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAAYP
                     AAYGQISQAFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQMFLPFGFVSFDN
                     PASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY"
     exon            817..899
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..978
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1107
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1187
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1331
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1476
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1626
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1692
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1776
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1860
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2032
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..4124
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2288
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="major polyA site"
     polyA_site      4110
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
ORIGIN      
        1 gggaacttga accggtccag cctgtttaaa ccgaaaggac agagatcctg tctgttcaat
       61 gtaaaaaaaa aaaaaagaag aagaagaaaa aaatcacatc agaccgagag agagagagag
      121 agagagaggg agagagagag agagagagag agagagagag agagagagag aaggaagaag
      181 aagagggaga gagagagaga gagagagaag agagaagaga gagagaagag agagagaaga
      241 gagaaataga acgagagccc agagcagagc aaggtgtagg aaaccaaagg ggagagaacc
      301 cgagtgtgtg cgtgtgtgta tgagtgtgtg tgagtgtgtg tgtgtgtgtg cgcgcgtgtg
      361 tgagtgtgtg tgtgtgagtg tgtgtgtgtg tgtgtgtgag agtgtgtgtg cgtgtgtgtg
      421 tgtgtgtgag tgtgtgtgtg tgcgtgtgcg tgtgtgagcg cgagcgagcg agtgagggag
      481 aggagcgaga gagtgcgagc gagaaagaat aaaaggaaag atttttctct atgtatataa
      541 agatggccac gttagcaaac ggacaggctg acaacgcgag cctcagtacc aacgggctag
      601 gcagcagccc gggcagcgcc gggcatatga acggattaag ccacagcccg gggaacccgt
      661 cgaccattcc catgaaggac cacgatgcca tcaagctgtt cattgggcag atcccccgaa
      721 acctggatga gaaggacctc aagcccctct tcgaggagtt cggcaagatc tacgagctta
      781 cggttctgaa ggacaggttc acaggcatgc acaaaggctg cgctttcctc acctactgcg
      841 agcgtgagtc agcgctgaag gcccagagcg cgctgcacga gcagaagacc ctgcccggga
      901 tgaaccggcc gatccaggtg aagcctgcgg acagcgagag ccgaggaggt agtagctgcc
      961 tgcgccagcc cccttcacaa gatagaaaac tcttcgtggg tatgctcaac aagcaacaat
     1021 ctgaggacga cgtgcgccgc ctcttcgagg ccttcgggaa catcgaggag tgcactatcc
     1081 tgcgcgggcc ggacggcaac agcaaggggt gcgcctttgt gaagtactcc tcccatgccg
     1141 aggcacaagc cgccatcaac gctctacatg gcagccagac catgcctgga gcctcctcca
     1201 gcctggtggt caagtttgca gacactgaca aggagcgcac aatgcgacgg atgcagcaga
     1261 tggctggcca gatgggcatg ttcaacccca tggccatccc cttcggagcc tatggcgcct
     1321 atgctcaggc aatgcagcag caagcagccc tcatggcatc ggtcgcgcaa ggaggctacc
     1381 tgaatcccat ggctgccttc gctgccgccc aaatgcagca gatggcggcc ctcaacatga
     1441 atggcctggc agccgcacct atgaccccaa cctcaggtgg cagcacccct ccaggcatca
     1501 ctgcaccagc tgtgcctagc atcccatccc ccattggggt gaacggcttc acgggcctcc
     1561 cccctcaggc caatgggcag cctgctgcgg aagctgtgtt tgccaatggc attcacccct
     1621 acccagcaca gagccccacc gcagccgacc ccctgcagca ggcctacgct ggagtgcagc
     1681 agtatgcagg accagctgcc taccctgctg cctatggtca gattagccag gcctttcctc
     1741 agccaccgcc aatgattccc cagcaacaga gagaagggcc cgagggctgt aacctgctca
     1801 tctaccatct gccccaggag tttggggacg ctgagctgat gcagatgttc ctccctttcg
     1861 gcttcgtgag cttcgacaac ccggccagcg cacagaccgc catccaggcc atgaacggct
     1921 tccagatagg catgaagagg ctcaaggtgc agctgaagcg gcccaaagac gccaatcgcc
     1981 cgtactgagc gccggcggga gcgtcccccg ggggagacca ggactcgcac agggcaggat
     2041 gctgaacggg ctacattaaa aacaaacctc tttctctctc tatttataaa tgagaactgt
     2101 tggacgacac ctttgacata tcagccaata ccaatcaagc tgacgactcc agacactccg
     2161 tgtgactgta acatttcttc aaggaaagta tagcgtctat ggagtgcaga gggcatgtgt
     2221 ttggggaaaa atatacatga cataaagatg acgacgaaga agaaaaatga tataaaacaa
     2281 acaaaaaacc cgcgacttta aaatgaaata acgtgagccc agatggggaa gctgaagggc
     2341 tgggcactag gaggagatgc tgctgccaac cgatcctggg gcttttcccg cccgtaggcg
     2401 cctgaggcag gcaggggcaa gtgtacaatg gggcctagtc cccagcaggc ggctgggagg
     2461 ccgccactga gcatctctat ttgtcattcc tttagctatt tagggaccaa aggaccaaac
     2521 tttttattgc agatgtgtag ctctgtcaat tagaggtgga atggagacca acctccttcc
     2581 tgcctcctgg ctgttcttga aacagcttag agcgattcta tgaaaatgta ataaaaaata
     2641 aaaataaaaa aaaaataaaa aaagaacaaa aaaaacaagg aaaaaaaata atgcttcaac
     2701 gcttttaaaa cagcaagata ctagttcttt gatactttga gaggcgcttt gattaccccg
     2761 attgaagtct ctgaaacttt cctatggttt tctgtattat atgtctggat ggagctgttt
     2821 agatacattg attggtggat atttggagaa agcaacaaag atattaagtc attaaccatg
     2881 aagagaacac gaggggaacc aggggacttc gaaggcaagg taattgttgt gaaaagtctg
     2941 taaatgcttc taattcttcc cccctcttaa aatcataata gttgtacaga attttaaaag
     3001 gaaaagttta aaatacctat atcatagaag aaaaaaaaat tagaggaaag caaaaaaata
     3061 aaaaaaaaaa ggaaaaaaaa accttataga agttagcatt atgctaaaat cccagatgtt
     3121 gtaggactgt acttctgtag agtttagact gagcatcgat cccgtctccc cgcgagtgct
     3181 gtcggactcc gtccccaagg gccaggccgg actgtccaga cctgcaggct ccggccagaa
     3241 gcgccgctcc ggaagcgtcc tgccgcctct cgctttgcca gcctgggagc cgcgcgcatg
     3301 cgcgctctct ctgcccttct cacctctgct tcactcgcct tctgtgcttg ttccggagac
     3361 tttccaggcc agggagaact gggaacttct catcttcaaa caactagaca acacacacac
     3421 acacaaaacc ttaaacaaga gagagaaaac aaacaatctt tgaagaattt ctgaaactgt
     3481 ttacaaggaa ttttgaaaaa cagggatgtt taaatgatgc tggctctgtt tttctgtaaa
     3541 taaatttgca tattttgtag gacttttaat tgtaatgata gagaaaaaac aaggaaaact
     3601 atttaatgaa agcacgatat ttatctttgg taaatgactt tagagcagtt aaagacattg
     3661 cttaaaaact cagaatcaga aaaacactga attatttaag aacacatata ttttaaagta
     3721 taacatattt attataattt atttgcacct tgggaagact tgctttgcat tctgcctcaa
     3781 gagcttctca ttgatgtcca tctggaggcc aggggggtct tggaactacc attttttttt
     3841 cctttagatc aacaaaattc tggttgccct caggcctcct tccttttctt tccatctatt
     3901 ttgttgttgt tttacttcat ttagttttct ttttctttct cttgactcct ccttttagga
     3961 tgtccagatg ttgtaaaaaa acaaaaacaa aaaacccaac agctgcagtt caatacaact
     4021 gctcttttca cacgactccc taaactcctt gtaaccttct gtaactattg gatgacgctt
     4081 tctccagctt agccctaaat aaagcacagt ttaaaaaaaa aacc
//
