LOCUS       NM_001362308            4151 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CUGBP, Elav-like family member 4 (Celf4), transcript
            variant 34, mRNA.
ACCESSION   NM_001362308 XM_017317794
VERSION     NM_001362308.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4151)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    GeneRIF: Celf4 controls mRNA translation underlying synaptic
            development in the prenatal mammalian neocortex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4151)
  AUTHORS   Shen,Y., Zhang,C., Xiao,K., Liu,D. and Xie,G.
  TITLE     CELF4 regulates spine formation and depression-like behaviors of
            mice
  JOURNAL   Biochem Biophys Res Commun 605, 39-44 (2022)
   PUBMED   35306363
  REMARK    GeneRIF: CELF4 regulates spine formation and depression-like
            behaviors of mice.
REFERENCE   4  (bases 1 to 4151)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   5  (bases 1 to 4151)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4151)
  AUTHORS   Ladd,A.N., Taffet,G., Hartley,C., Kearney,D.L. and Cooper,T.A.
  TITLE     Cardiac tissue-specific repression of CELF activity disrupts
            alternative splicing and causes cardiomyopathy
  JOURNAL   Mol Cell Biol 25 (14), 6267-6278 (2005)
   PUBMED   15988035
  REMARK    GeneRIF: CELF protein activity is required for normal alternative
            splicing in the heart in vivo and normal CELF-mediated alternative
            splicing regulation is in turn required for normal cardiac
            function.
REFERENCE   7  (bases 1 to 4151)
  AUTHORS   Meins,M., Schlickum,S., Wilhelm,C., Missbach,J., Yadav,S.,
            Glaser,B., Grzmil,M., Burfeind,P. and Laccone,F.
  TITLE     Identification and characterization of murine Brunol4, a new member
            of the elav/bruno family
  JOURNAL   Cytogenet Genome Res 97 (3-4), 254-260 (2002)
   PUBMED   12438720
  REMARK    GeneRIF: cloning and characterization
REFERENCE   8  (bases 1 to 4151)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (bases 1 to 4151)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (bases 1 to 4151)
  AUTHORS   Yulug,I.G., Egan,S.E., See,C.G. and Fisher,E.M.
  TITLE     Mapping GRB2, a signal transduction gene in the human and the mouse
  JOURNAL   Genomics 22 (2), 313-318 (1994)
   PUBMED   7806216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121094.8 and AC144938.3.
            
            On Apr 12, 2018 this sequence version replaced XM_017317794.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.170366.1,
                                           SRR1660819.44819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-816               AC121094.8         7568-8383
            817-899             AC121094.8         82230-82312
            900-948             AC144938.3         102544-102592       c
            949-1074            AC144938.3         69727-69852         c
            1075-1154           AC144938.3         69326-69405         c
            1155-1298           AC144938.3         68976-69119         c
            1299-1446           AC144938.3         67770-67917         c
            1447-1596           AC144938.3         66038-66187         c
            1597-1662           AC144938.3         62302-62367         c
            1663-1743           AC144938.3         61059-61139         c
            1744-1887           AC144938.3         55918-56061         c
            1888-2059           AC144938.3         51631-51802         c
            2060-4151           AC144938.3         42457-44548         c
FEATURES             Location/Qualifiers
     source          1..4151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 13.92 cM"
     gene            1..4151
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="CUGBP, Elav-like family member 4"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
     exon            1..816
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             531..2015
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="isoform 30 is encoded by transcript variant 34;
                     CUG-BP- and ETR-3-like factor 4; bruno-like protein 4;
                     RNA-binding protein BRUNOL-4; bruno-like 4, RNA binding
                     protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 4 isoform 30"
                     /protein_id="NP_001349237.1"
                     /db_xref="GeneID:108013"
                     /db_xref="MGI:MGI:1932407"
                     /translation="MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPS
                     TIPMKDHDAIKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTY
                     CERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGDRKLFVGMLNKQQSEDDVRRL
                     FEAFGNIEECTILRGPDGNSKGCAFVKYSSHAEAQAAINALHGSQTMPGASSSLVVKF
                     ADTDKERTMRRMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNP
                     MAAFAAAQMQQMAALNMNGLAAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLP
                     PQANGQPAAEAVFANGIHPYPAQSPTAADPLQQAYAGVQQYAGPAYPAAYGQISQAFP
                     QPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQMFLPFGNVISSKVFVDRATNQSK
                     CFGFVSFDNPASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY"
     exon            817..899
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..948
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1074
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1154
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1298
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1446
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1596
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1662
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1743
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1887
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2059
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..4151
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2298..2303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2315
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
                     /note="major polyA site"
     polyA_site      4137
                     /gene="Celf4"
                     /gene_synonym="A230070D14Rik; Brul4; BRUNOL-4; Brunol4;
                     C130060B05Rik"
ORIGIN      
        1 gggaacttga accggtccag cctgtttaaa ccgaaaggac agagatcctg tctgttcaat
       61 gtaaaaaaaa aaaaaagaag aagaagaaaa aaatcacatc agaccgagag agagagagag
      121 agagagaggg agagagagag agagagagag agagagagag agagagagag aaggaagaag
      181 aagagggaga gagagagaga gagagagaag agagaagaga gagagaagag agagagaaga
      241 gagaaataga acgagagccc agagcagagc aaggtgtagg aaaccaaagg ggagagaacc
      301 cgagtgtgtg cgtgtgtgta tgagtgtgtg tgagtgtgtg tgtgtgtgtg cgcgcgtgtg
      361 tgagtgtgtg tgtgtgagtg tgtgtgtgtg tgtgtgtgag agtgtgtgtg cgtgtgtgtg
      421 tgtgtgtgag tgtgtgtgtg tgcgtgtgcg tgtgtgagcg cgagcgagcg agtgagggag
      481 aggagcgaga gagtgcgagc gagaaagaat aaaaggaaag atttttctct atgtatataa
      541 agatggccac gttagcaaac ggacaggctg acaacgcgag cctcagtacc aacgggctag
      601 gcagcagccc gggcagcgcc gggcatatga acggattaag ccacagcccg gggaacccgt
      661 cgaccattcc catgaaggac cacgatgcca tcaagctgtt cattgggcag atcccccgaa
      721 acctggatga gaaggacctc aagcccctct tcgaggagtt cggcaagatc tacgagctta
      781 cggttctgaa ggacaggttc acaggcatgc acaaaggctg cgctttcctc acctactgcg
      841 agcgtgagtc agcgctgaag gcccagagcg cgctgcacga gcagaagacc ctgcccggga
      901 tgaaccggcc gatccaggtg aagcctgcgg acagcgagag ccgaggagat agaaaactct
      961 tcgtgggtat gctcaacaag caacaatctg aggacgacgt gcgccgcctc ttcgaggcct
     1021 tcgggaacat cgaggagtgc actatcctgc gcgggccgga cggcaacagc aaggggtgcg
     1081 cctttgtgaa gtactcctcc catgccgagg cacaagccgc catcaacgct ctacatggca
     1141 gccagaccat gcctggagcc tcctccagcc tggtggtcaa gtttgcagac actgacaagg
     1201 agcgcacaat gcgacggatg cagcagatgg ctggccagat gggcatgttc aaccccatgg
     1261 ccatcccctt cggagcctat ggcgcctatg ctcaggcact gatgcagcag caagcagccc
     1321 tcatggcatc ggtcgcgcaa ggaggctacc tgaatcccat ggctgccttc gctgccgccc
     1381 aaatgcagca gatggcggcc ctcaacatga atggcctggc agccgcacct atgaccccaa
     1441 cctcaggtgg cagcacccct ccaggcatca ctgcaccagc tgtgcctagc atcccatccc
     1501 ccattggggt gaacggcttc acgggcctcc cccctcaggc caatgggcag cctgctgcgg
     1561 aagctgtgtt tgccaatggc attcacccct acccagcaca gagccccacc gcagccgacc
     1621 ccctgcagca ggcctacgct ggagtgcagc agtatgcagg acctgcctac cctgctgcct
     1681 atggtcagat tagccaggcc tttcctcagc caccgccaat gattccccag caacagagag
     1741 aagggcccga gggctgtaac ctgctcatct accatctgcc ccaggagttt ggggacgctg
     1801 agctgatgca gatgttcctc cctttcggta atgtcatctc ctcgaaagtg tttgtggatc
     1861 gggcgactaa ccaaagtaaa tgctttggct tcgtgagctt cgacaacccg gccagcgcac
     1921 agaccgccat ccaggccatg aacggcttcc agataggcat gaagaggctc aaggtgcagc
     1981 tgaagcggcc caaagacgcc aatcgcccgt actgagcgcc ggcgggagcg tcccccgggg
     2041 gagaccagga ctcgcacagg gcaggatgct gaacgggcta cattaaaaac aaacctcttt
     2101 ctctctctat ttataaatga gaactgttgg acgacacctt tgacatatca gccaatacca
     2161 atcaagctga cgactccaga cactccgtgt gactgtaaca tttcttcaag gaaagtatag
     2221 cgtctatgga gtgcagaggg catgtgtttg gggaaaaata tacatgacat aaagatgacg
     2281 acgaagaaga aaaatgatat aaaacaaaca aaaaacccgc gactttaaaa tgaaataacg
     2341 tgagcccaga tggggaagct gaagggctgg gcactaggag gagatgctgc tgccaaccga
     2401 tcctggggct tttcccgccc gtaggcgcct gaggcaggca ggggcaagtg tacaatgggg
     2461 cctagtcccc agcaggcggc tgggaggccg ccactgagca tctctatttg tcattccttt
     2521 agctatttag ggaccaaagg accaaacttt ttattgcaga tgtgtagctc tgtcaattag
     2581 aggtggaatg gagaccaacc tccttcctgc ctcctggctg ttcttgaaac agcttagagc
     2641 gattctatga aaatgtaata aaaaataaaa ataaaaaaaa aataaaaaaa gaacaaaaaa
     2701 aacaaggaaa aaaaataatg cttcaacgct tttaaaacag caagatacta gttctttgat
     2761 actttgagag gcgctttgat taccccgatt gaagtctctg aaactttcct atggttttct
     2821 gtattatatg tctggatgga gctgtttaga tacattgatt ggtggatatt tggagaaagc
     2881 aacaaagata ttaagtcatt aaccatgaag agaacacgag gggaaccagg ggacttcgaa
     2941 ggcaaggtaa ttgttgtgaa aagtctgtaa atgcttctaa ttcttccccc ctcttaaaat
     3001 cataatagtt gtacagaatt ttaaaaggaa aagtttaaaa tacctatatc atagaagaaa
     3061 aaaaaattag aggaaagcaa aaaaataaaa aaaaaaagga aaaaaaaacc ttatagaagt
     3121 tagcattatg ctaaaatccc agatgttgta ggactgtact tctgtagagt ttagactgag
     3181 catcgatccc gtctccccgc gagtgctgtc ggactccgtc cccaagggcc aggccggact
     3241 gtccagacct gcaggctccg gccagaagcg ccgctccgga agcgtcctgc cgcctctcgc
     3301 tttgccagcc tgggagccgc gcgcatgcgc gctctctctg cccttctcac ctctgcttca
     3361 ctcgccttct gtgcttgttc cggagacttt ccaggccagg gagaactggg aacttctcat
     3421 cttcaaacaa ctagacaaca cacacacaca caaaacctta aacaagagag agaaaacaaa
     3481 caatctttga agaatttctg aaactgttta caaggaattt tgaaaaacag ggatgtttaa
     3541 atgatgctgg ctctgttttt ctgtaaataa atttgcatat tttgtaggac ttttaattgt
     3601 aatgatagag aaaaaacaag gaaaactatt taatgaaagc acgatattta tctttggtaa
     3661 atgactttag agcagttaaa gacattgctt aaaaactcag aatcagaaaa acactgaatt
     3721 atttaagaac acatatattt taaagtataa catatttatt ataatttatt tgcaccttgg
     3781 gaagacttgc tttgcattct gcctcaagag cttctcattg atgtccatct ggaggccagg
     3841 ggggtcttgg aactaccatt tttttttcct ttagatcaac aaaattctgg ttgccctcag
     3901 gcctccttcc ttttctttcc atctattttg ttgttgtttt acttcattta gttttctttt
     3961 tctttctctt gactcctcct tttaggatgt ccagatgttg taaaaaaaca aaaacaaaaa
     4021 acccaacagc tgcagttcaa tacaactgct cttttcacac gactccctaa actccttgta
     4081 accttctgta actattggat gacgctttct ccagcttagc cctaaataaa gcacagttta
     4141 aaaaaaaaac c
//
