LOCUS       NM_001406966            9265 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus CUGBP, Elav-like family member 2 (Celf2), transcript
            variant 71, mRNA.
ACCESSION   NM_001406966
VERSION     NM_001406966.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9265)
  AUTHORS   Huang,P., Meng,L., Pang,J., Huang,H., Ma,J., He,L. and Lin,X.
  TITLE     miR-208a-3p regulated by circUQCRC2 suppresses
            ischemia/reperfusion-induced acute kidney injury by inhibiting
            CELF2-mediated tubular epithelial cell apoptosis, inflammation and
            ferroptosis
  JOURNAL   Shock 61 (6), 942-950 (2024)
   PUBMED   38664873
  REMARK    GeneRIF: miR-208a-3p regulated by circUQCRC2 suppresses
            ischemia/reperfusion-induced acute kidney injury by inhibiting
            CELF2-mediated tubular epithelial cell apoptosis, inflammation and
            ferroptosis.
REFERENCE   2  (bases 1 to 9265)
  AUTHORS   Guo,T., Wang,Y., Sun,X., Hou,S., Lan,Y., Yuan,S., Yang,S., Zhao,F.,
            Chu,Y., Ma,Y., Cheng,T., Yu,J., Liu,B., Yuan,W. and Wang,X.
  TITLE     Loss of RNA-binding protein CELF2 promotes acute leukemia
            development via FAT10-mTORC1
  JOURNAL   Oncogene 43 (19), 1476-1487 (2024)
   PUBMED   38514854
  REMARK    GeneRIF: Loss of RNA-binding protein CELF2 promotes acute leukemia
            development via FAT10-mTORC1.
REFERENCE   3  (bases 1 to 9265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 9265)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9265)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9265)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 9265)
  AUTHORS   Zhang,W., Liu,H., Han,K. and Grabowski,P.J.
  TITLE     Region-specific alternative splicing in the nervous system:
            implications for regulation by the RNA-binding protein NAPOR
  JOURNAL   RNA 8 (5), 671-685 (2002)
   PUBMED   12022233
  REMARK    GeneRIF: NAPOR may be one of a group of closely related proteins
            involved in splicing regulation within the brain.
REFERENCE   8  (bases 1 to 9265)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (bases 1 to 9265)
  AUTHORS   Choi,D.K., Ito,T., Tsukahara,F., Hirai,M. and Sakaki,Y.
  TITLE     Developmentally-regulated expression of mNapor encoding an
            apoptosis-induced ELAV-type RNA binding protein
  JOURNAL   Gene 237 (1), 135-142 (1999)
   PUBMED   10524244
REFERENCE   10 (bases 1 to 9265)
  AUTHORS   Lu,X., Timchenko,N.A. and Timchenko,L.T.
  TITLE     Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG
            repeats expanded in myotonic dystrophy
  JOURNAL   Hum Mol Genet 8 (1), 53-60 (1999)
   PUBMED   9887331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929240.18, AL845492.10 and AL845515.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2474066.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               AL929240.18        94635-95113         c
            480-676             AL845492.10        167527-167723       c
            677-759             AL845492.10        110225-110307       c
            760-808             AL845492.10        70781-70829         c
            809-943             AL845492.10        61798-61932         c
            944-1102            AL845492.10        50134-50292         c
            1103-1166           AL845492.10        46144-46207         c
            1167-1301           AL845492.10        32084-32218         c
            1302-1421           AL845492.10        6781-6900           c
            1422-1601           AL845515.5         135326-135505       c
            1602-1745           AL845515.5         131373-131516       c
            1746-9265           AL845515.5         121235-128754       c
FEATURES             Location/Qualifiers
     source          1..9265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.69 cM"
     gene            1..9265
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="CUGBP, Elav-like family member 2"
                     /db_xref="GeneID:14007"
                     /db_xref="MGI:MGI:1338822"
     exon            1..479
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            480..676
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..759
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            760..808
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..943
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1102
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1031..1873
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="isoform 37 is encoded by transcript variant 71; CUG
                     triplet repeat, RNA binding protein 2; CUG-BP- and
                     ETR-3-like factor 2; bruno-like protein 3; RNA-binding
                     protein BRUNOL-3; neuroblastoma apoptosis-related
                     RNA-binding protein; elav-type RNA-binding protein 3;
                     mNapor"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 2 isoform 37"
                     /protein_id="NP_001393895.1"
                     /db_xref="GeneID:14007"
                     /db_xref="MGI:MGI:1338822"
                     /translation="MQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQM
                     AGMNALQLQNLATLAAAAAAAQTSATSTNANPLSSTSSALGALTSPVAASTPNSTAGA
                     AMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYS
                     GIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPF
                     GNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKND
                     SKPY"
     exon            1103..1166
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1301
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1421
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1601
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1745
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..9265
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7071..7076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="hexamer: ATTAAA"
     polyA_site      7090
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="major polyA site"
     regulatory      9239..9244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="hexamer: AATAAA"
     polyA_site      9265
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
ORIGIN      
        1 gcccgccgca cctggcgctc ggcagccagg ccgccccggc gccggctcgc ggaggggatt
       61 ggtggagcgc gcgagggaga gaatgtgaca agtgcccgct tcggcggccg cccggggagg
      121 ccgcgcgcac ctgtccctgc ctgtctcgcg ccgcccgcgg ccgctcggac gcgcgcacag
      181 ccccccgccg ccgccgccgc cgctgccgcc gccgccgcct ccgctaccgc cgccgccgcc
      241 gctgcgtgcg ccgagaacat gacttctgcc ttcaagctgg atttcctccc ggacatgatg
      301 gtcgagggcc gcctgctcgt tgctgacaga atgtgagtgg ccgagggccc gagggggccg
      361 cgcggccgag agtggggcgt cgtctcctca gaggcagcgg ccgcctcccc tccgcgtctt
      421 ctcttcagag gacgcggctg ggacggcgca gggccgagcg gggcgagcgg gagagcgggt
      481 aacggcacag ccaacaagat gaacggagct ttggatcatt cagaccagcc agacccagat
      541 gccattaaga tgtttgtcgg acagatccct aggtcctggt cggaaaagga gctgaaagaa
      601 ctttttgagc cttatggagc tgtctaccag atcaacgtcc tccgggaccg gagtcagaac
      661 cctccccaga gtaaaggttg ttgtttcgta acattttata caagaaaagc tgcacttgag
      721 gcccagaatg cactgcacaa tattaaaact ttacctggga tgcatcatcc cattcagatg
      781 aaacctgcag atagtgaaaa gtcaaacgct gtggaagaca gaaaattgtt cataggaatg
      841 gtttccaaga aatgtaacga gaatgatatc agagtgatgt tttctccatt cggtcagata
      901 gaagaatgcc ggattctccg gggacctgat gggctgagtc gagggctgct cttcaccaat
      961 cgtggtgaag tttgctgaca ctcagaagga caaagagcaa aggcgcctcc agcagcagct
     1021 tgcacagcag atgcaacagc tcaacactgc cacttggggg aacctaacag gactgggtgg
     1081 acttaccccg cagtacctgg cgcttctgca gcaggccacc tcctccagca acctgggtgc
     1141 attcagtggc attcagcaaa tggctggcat gaatgcttta cagttacaga atctggcaac
     1201 actggctgct gctgcagctg ctgctcaaac ctcagccacc agcaccaatg caaaccctct
     1261 gtctagcaca agcagtgccc tgggagccct cacaagccct gtggctgctt caacccccaa
     1321 ttccaccgct ggtgcggcca tgaattcctt gacctctctt gggactctac aaggattggc
     1381 tggagccact gtcggattga ataatattaa tgcactagca ggtatggcgg ctctgaatgg
     1441 aggacttggc gccacaggct tgacgaatgg tacggctggc accatggacg ccctgaccca
     1501 ggcctactca ggaattcagc agtatgcggc agctgcactg cccactttgt acagccagag
     1561 cttgctgcaa cagcagagtg ctgcaggcag ccagaaggaa ggtccagagg gggcaaacct
     1621 ctttatttac caccttccac aggagtttgg agaccaggac attctgcaga tgttcatgcc
     1681 ctttggaaat gttatctctg ctaaagtctt cattgacaaa cagaccaatc tgagcaagtg
     1741 ctttggtttt gttagctatg acaatccagt ctctgcacaa gctgcaatcc aggctatgaa
     1801 cggctttcag atcggcatga aacgcttgaa ggtgcagctg aaacgctcca aaaacgacag
     1861 caaaccttac tgatcctaac cccagaagct ccctgctctt attttagctt tcttagggta
     1921 agtcccacaa gccagcctgt tctgaacagg gaaggcagag gagggaccac gatgccaact
     1981 tttaccaaga gagacggtta tttttacaat aaggcctcca tttcttccac tcacacccca
     2041 cccaatctgc cataattaaa acctgggcta ccttgttttt attgagtaaa cccctcctcc
     2101 ggttgtgcca ctgtattctc tttgtttgca atttgaatat ccttactctt ttaaaaaaaa
     2161 ttgttttgct tttttaaaga aaaacatata aacaagtaaa tgacatcttg agaatgtgaa
     2221 aggcaagcaa acactaatgt gcagttctaa ctctgaacca ctggtgcccc gagagcactg
     2281 cctggagaac tcaccctcct gcccgcccgc ccgcccgccc gcccgcccct cagagggccc
     2341 cacggttaga gatgatgtgg tggcccagca gagggagaag ccaggagaag cacttaaaac
     2401 tccacaaaac accctcccac tacattggtt tcttttaata taagtaggat tttattttag
     2461 ggttcaaaga aacatgacat ttattggtca gattattaca ctggttgtct attttgttat
     2521 tgttttattt ttgtttttag aaaggattaa tgtaaaaaaa aaagatttag agatctgttt
     2581 cttaaagcta cagggtttaa aaataaaata aaaatgagtg aaaatacttg atgtttcttg
     2641 aaagataaat ttaataataa ataaatacat aaataataca taaataaaaa agaaagccac
     2701 aggcctgtaa attttatttg taaaaaagca tttctatttt tatacaaaat ttttactgcc
     2761 tcagaaatac tggaagctat ttattgccta ttgttaactt attgggtatc taagagcagt
     2821 tctctgtcta gctggaacct tctgaagtag tctccagagg aattgttcta ggaatgggct
     2881 tttttcaccg ttgaacccta gacctaaagt tcatgctttt ccctcttgtc gtttgtattt
     2941 gtctgattat tttgtttgta atttccatta tctagtttac gattcagttg tcttgacttc
     3001 cccatatgtc acctttgttc aaactggacc ctctccgctg tcccttgcta gtccttcacc
     3061 ccaaaacacc cagaatccat cccctctcac tctctccaga tggattctct tggggtttca
     3121 ttgtgctgtg gaaaaagagt gtaagaaatg caaattatgt gaatggctca tagactccct
     3181 gaagacccaa gatttgcatt agttttctcc cgcacccttg aaagtgacgt tgctgctgcg
     3241 tagactctgt gtaacttctg actctccctt gttttctccc cagacatctt catgcccgtt
     3301 agtcatcgtt tgcctagcat gtccctgtgg cgtctcaaaa acagtttcat cgtcccgtca
     3361 ttgtttctga tgtctttctg acctcacatc atatttggtt ctcctactga cctttgatct
     3421 agttttgacc tttgaaattt gcatgtgacc tcatctagct atgaattctg ggaagtcaat
     3481 gtgaaaaaca ttgctgcatt catgcaagac tgaaattatt agacaaatta tagaaaacaa
     3541 aacctgtggc aaaaatgttt ctttcttatt tttttttctt ttcataaaac agacttgaaa
     3601 gtattacaca gggattggca ttctgcccgg tcactggtga caatagcaat atgtgtccag
     3661 ggacacagaa tgttggtttc taacagacta cttccaaaaa cagtttgaga aaaaaaaaaa
     3721 aactgtctga ttttaagtct ctagaggtct gtaatagttt ttacattttt caggcagtgt
     3781 aaagtttttt gataaggcca ttttaggtgg ctcactttct cattaagata tatatataga
     3841 accacttttt gtagattagt ataagaaaaa tatttaccct gttttggggc aaatgctacc
     3901 tatttgtgtc accttttgct gaactgactc acagttagac aatccatggt ttaatgcaca
     3961 tgaaattacc tatattttat actgttccaa tgtacaggag aaaggctact gtaagctgcg
     4021 tcatgttggt gcttctgtgg attaagttgt gctctcatca caagtcttaa ggtcttaatg
     4081 ttatttgttg ataagacaag cttagaattg gtttacttaa aacaaaaaaa aaaaagaatt
     4141 tcaaaaaaaa aagttgtttg cttaaaaaaa aaaagttcat gtgagagaaa aaagaaaaaa
     4201 aaagaaaaaa aaaaaactat tccagactaa gttttgtgtt ggcctgagaa gcattggcgt
     4261 cacttttttt tattgtggac tattagatgt gtttgtgttc agcaaaatgt gatgttttgt
     4321 tttttctttt aaagaaaaaa gtgaaaacta tctagtgcca aattccaaag gtacttcctc
     4381 cctagagctt cgcgtgtttc ctgtgagaag tgatttgata acatggtatt ttattatgtg
     4441 ttttgtataa atccctaata tttaaaacaa acaaaaaaaa aaaaaaggtt acaaagtttg
     4501 ttaacttgct attccgtggt cttgttgcct gaaattgtta ttgtttgtta tttctctatg
     4561 ctgttttttg taagacattg tataagtgcc gtgtgtcact tttctaacct ctccacgtca
     4621 atgctgtgac ggcagccctc acaatgtatt ctcttcataa tatctggaaa cctctaaggt
     4681 gagaaagtcc tgaactttta accctttcta cccagagcta tctggaatgt tggtgacttt
     4741 ttatactgtc atccttgggt ttgttttggg gtgtttagat atttttttcc atttgtatct
     4801 tctgagttat tttttgtttt ttgagtcaca caccttccca aaaaaccctt aagtcttttt
     4861 cctaaaccgt tttttatttt cttttttatc ccctccttcc tatcaccctg tgctccttca
     4921 gtttaaatat aagagactga gtagaccctg ggaagggaaa aacaggtaga gcttagccct
     4981 acacaaaccc taaagaccgt gtctgctttt tgataagggt ttcatggtat gccctcgtgt
     5041 acaatatttt tatacaccct ggagttaaat ggctttttgg tggtccaatc tttcaagaag
     5101 ttttactttt gtttcttaaa cacccctatg taatgctgag tcagcctttg gctcgggatt
     5161 ctcagacgca tgtggacacc tgaatatgca aggtgtcttc ctgaaaagcc cacacatttc
     5221 aagtggttgg ccatgtaaga ggagatcagc tgctcttcac cacaattact accaaatact
     5281 aggactagtt cctgctgttg ctctcgaaag tgccatattc ctgagtctgg cttcatatga
     5341 gcagatgtct tgttctgaca gaccccaatg tcatgcctac agtccaaaca cacacccagc
     5401 ctctgggaaa acacaccctg caagcttctg gtctcagctc ccttttcctt cacaccctcc
     5461 ctccatttga tttaatgtgt gtgtgaatgt gatagccctg agatggaaag gattagcctc
     5521 tcacaatgca aaaaaaaaaa aaaaaaaaaa aagttccctc cttccagcac gcgcacttcc
     5581 agtgacatga ttggtgttag cccactgttt accactgccg gggccttcct tcatccttga
     5641 gggctatttt gtactttctg cagcactcag ctcactaaca gtgatcacac acattctcag
     5701 tctctctatg gtggtgtgta ggtacacgtg tagaaacaca agagaatacc agttgtattt
     5761 catagaccat ctcgttcaca atctatttag ttattaatga tataaatctc aaaaaaaaat
     5821 cttgactttt ttttttcccc ccatggaagc caactgccct ccttcctctt aacccacctg
     5881 cggcccccgc agaggctcgg gtcaggcagg tactttctgt tgagctcggt ttctgatttt
     5941 gcaggcgacc aagaccgtcc attgaggcga gggcttggtt ttgcatgttt cattgttaga
     6001 aagttagcct tcctcagaga cagactgtcc ttcctctctc agtatcaaaa ggaaacgctg
     6061 caagggtgcg cagggcctgt ttccggaaga caaaacacag ggaaactgca tttttaaaaa
     6121 tcaagtgtaa agcatataga cttttaaaac tcactcagag aactctgatc agatggcacc
     6181 tccacggtgt gacaagttca tctttccttc accgcagggg ttctagttcc ttggcttgtg
     6241 ctactctgga atcatttact gtttctgtct ttattatctt aagtgctaat taaaagaaaa
     6301 taaaacttaa aaaaatgtag tttcattacc ttttgaataa tgtcatacaa aaatgtattt
     6361 gtgtttttgt gctgtgggaa ttgttgtttg tagattaata ataccatttt gtttagaact
     6421 acaaaatagt ttttaaatat tgtctgagaa aagccaaagt taatgcaacc tagtggaaac
     6481 tgtaagacca tttgagtatt gtttctgttt tattgatgca tttggatttt gttgtttgat
     6541 ggaatttgag ccaaaaaaca aaaatgcagg ctttcctatt tctacaactg attgtactta
     6601 cgcattttgt accagtggga ttttttatac tggagattaa aaaaaaatgg aaatttttgt
     6661 ggcttactct tgtgggcccc ctgacaatga ctgatttcaa gtttgatttc tggttgatag
     6721 gaagaaagtt gcttttcctt taagaattaa aaactttggc ttgatttctt tttttccctt
     6781 tgcttatatc tagcattaga attttgtctt aaaatacagc ggtaagtttc actctttatt
     6841 ctgtactgtg cagttacaca ataagataat tagatttaga agtactcagt cactttaagt
     6901 ggataaatgt attagttaaa ctttaggagt ttgctttttt gctgtttaga tcgaagtttt
     6961 ttctgaccct tctgtcctca ttgtgaacat aaccgtgtag ttgaaacagt cagacttatt
     7021 tttgtaatgt atgttattgt gtgatgcggt tttttgcttc tgtctccaat attaaaccat
     7081 tttcctaata cttgtttctc tctctgcgtg ttgtattgtt ggtaatcatt ctgtgttggt
     7141 gacacatcta cacaacctca ctgttgcacg tatctgttct tttctttatg ttgtgtaaaa
     7201 agatacagtc gattccacct aagtgaatat ctgatttggg acacgaagaa actacacatc
     7261 ccacctctgg ttcatccaca gcctacccct gactgatgct tccaagacaa tacgcctttc
     7321 cctctgatcc ctctaggacc gcctagaggg ctacacttgg caaggcattt tatggtcttt
     7381 tgaccacaca tgttctttcc tctcccctcc ctcctatcca cagttcctaa catccgtgaa
     7441 gtctctccta taaaccttaa gagggacaga agcagtagac ccagggcttc ttcatctacc
     7501 ttcaggtacg aagtctcatg actacagtca gggttagaga gggttagaaa gcccttataa
     7561 aagaggcaca ccctcaggga gaggtaaaat aaagccagct ggccaacagc gggcagctaa
     7621 aaaccattaa gcttaggtgt gtgctgcact gatcaatggg tatgtataga agtgcatttc
     7681 tattcgctca tcaatttaat ccaggagtag cttcaattat taccactcac agaagtggga
     7741 agacttccag gtattcaatg agggaggtgg ggagaattct gctcaagtcc ttgctgtctg
     7801 tttacaaagg ggagctcaga atgccatagg tccattgtcg tcccccctcc ccctcccccc
     7861 cccccaccgc agtagacaca ggataggaag gagatgtgct ctcactgtac ccaacccctg
     7921 atcagagaag aactgcccca ctgcccatgc tgtgacaagc cctccccgct ctactgtcta
     7981 cttgctcagg agtctggctg ccctcaaaga gtatttccca tggctatctg ctcccttctc
     8041 ttctcgcccg tgccaggaca cctgagctgg tgtcagcgaa agctctggct gcccaccctc
     8101 tggtttcagc tggcccctca ggcccctttc ttcagtcagg tcaacaacca tgggcctacc
     8161 aaacagaaga aaggtggctc tttccctagg ccaaacctct cactgggcat gaggttccga
     8221 gccctgctcc tactctgaca aaagctgatt cctagtgaca cctgtgctgg ctttctcagg
     8281 gcggggcctg cttgctcagt tgcctctgaa aggccactgc ttcactagtg agggaagacc
     8341 aaagtgtggt ttctttttct tttctggagg aatgggcggc atcagggagg gaaggcctgg
     8401 gaaagaggat ggtaaaattt gttccaagat gtgtttcttt ttgaaatcct aatatgacca
     8461 ccattcagca cagggcatga tgttcgcgca ctgaaagaca aactgggctt ttctaccgaa
     8521 gacacaaagg ctcggtcctg taagcacttg tgactataaa gtcagccgct gcttaaattc
     8581 acactcagcg tttatttttt gtgtaactcc caccatggtt gtgagcaggt ctgcccatgc
     8641 acaggccacc atgagaagcc agacaactgt cagcattcac tggctgatgg aagccatatg
     8701 cctgccaggc cgaagcaatg gggtgtgatc tgcaggctcg tagctagcag gctaggcaat
     8761 gcagtgaaca caagcggacc atgcatcgtt cctgataagt gaataaaaca ctgtggccag
     8821 acaatcagct tattcactta tcaggaatcg actgttctac taattcactg gttttgtttt
     8881 tcattctgtt gtagttcact atttttgctg tgttctgttt ttttttcctc tcatgcttgg
     8941 gcaaattcac tggagatatt accttcatgt gaccatgaac cgtttctatc gagtgaaaat
     9001 ggtatcttaa caaaatctat gcacttgcta tcaggaacac aatactggat gtgtcttata
     9061 tatattgaac tatatagtac tcgatttctt aaataaagct taagaaagga tttgtgtgca
     9121 aagtgaatgt gattctttct caaagcagtg tctttaaggg gtattgttca tttaagtctt
     9181 caatgatata ggatattttt cattaaaatt atagcattgt ctttatgaat taatattcaa
     9241 taaatggact ttggaaacaa aaaaa
//
