LOCUS       NM_001110228            7662 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus CUGBP, Elav-like family member 2 (Celf2), transcript
            variant 1, mRNA.
ACCESSION   NM_001110228
VERSION     NM_001110228.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7662)
  AUTHORS   Huang,P., Meng,L., Pang,J., Huang,H., Ma,J., He,L. and Lin,X.
  TITLE     miR-208a-3p regulated by circUQCRC2 suppresses
            ischemia/reperfusion-induced acute kidney injury by inhibiting
            CELF2-mediated tubular epithelial cell apoptosis, inflammation and
            ferroptosis
  JOURNAL   Shock 61 (6), 942-950 (2024)
   PUBMED   38664873
  REMARK    GeneRIF: miR-208a-3p regulated by circUQCRC2 suppresses
            ischemia/reperfusion-induced acute kidney injury by inhibiting
            CELF2-mediated tubular epithelial cell apoptosis, inflammation and
            ferroptosis.
REFERENCE   2  (bases 1 to 7662)
  AUTHORS   Guo,T., Wang,Y., Sun,X., Hou,S., Lan,Y., Yuan,S., Yang,S., Zhao,F.,
            Chu,Y., Ma,Y., Cheng,T., Yu,J., Liu,B., Yuan,W. and Wang,X.
  TITLE     Loss of RNA-binding protein CELF2 promotes acute leukemia
            development via FAT10-mTORC1
  JOURNAL   Oncogene 43 (19), 1476-1487 (2024)
   PUBMED   38514854
  REMARK    GeneRIF: Loss of RNA-binding protein CELF2 promotes acute leukemia
            development via FAT10-mTORC1.
REFERENCE   3  (bases 1 to 7662)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 7662)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7662)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7662)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7662)
  AUTHORS   Zhang,W., Liu,H., Han,K. and Grabowski,P.J.
  TITLE     Region-specific alternative splicing in the nervous system:
            implications for regulation by the RNA-binding protein NAPOR
  JOURNAL   RNA 8 (5), 671-685 (2002)
   PUBMED   12022233
  REMARK    GeneRIF: NAPOR may be one of a group of closely related proteins
            involved in splicing regulation within the brain.
REFERENCE   8  (bases 1 to 7662)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (bases 1 to 7662)
  AUTHORS   Choi,D.K., Ito,T., Tsukahara,F., Hirai,M. and Sakaki,Y.
  TITLE     Developmentally-regulated expression of mNapor encoding an
            apoptosis-induced ELAV-type RNA binding protein
  JOURNAL   Gene 237 (1), 135-142 (1999)
   PUBMED   10524244
REFERENCE   10 (bases 1 to 7662)
  AUTHORS   Lu,X., Timchenko,N.A. and Timchenko,L.T.
  TITLE     Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG
            repeats expanded in myotonic dystrophy
  JOURNAL   Hum Mol Genet 8 (1), 53-60 (1999)
   PUBMED   9887331
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF536042.1, AF090697.1, AL845515.5 and BC033049.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 8 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF090697.1, SRR14777530.651830.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                CF536042.1         1-27
            28-2596             AF090697.1         1-2569
            2597-6764           AL845515.5         122116-126283       c
            6765-7662           BC033049.1         1-898
FEATURES             Location/Qualifiers
     source          1..7662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.69 cM"
     gene            1..7662
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="CUGBP, Elav-like family member 2"
                     /db_xref="GeneID:14007"
                     /db_xref="MGI:MGI:1338822"
     exon            1..145
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1619
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="isoform 1 is encoded by transcript variant 1; CUG
                     triplet repeat, RNA binding protein 2; CUG-BP- and
                     ETR-3-like factor 2; bruno-like protein 3; RNA-binding
                     protein BRUNOL-3; neuroblastoma apoptosis-related
                     RNA-binding protein; elav-type RNA-binding protein 3;
                     mNapor"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 2 isoform 1"
                     /protein_id="NP_001103698.1"
                     /db_xref="CCDS:CCDS50494.1"
                     /db_xref="GeneID:14007"
                     /db_xref="MGI:MGI:1338822"
                     /translation="MFERTSELAFVETISVESMRCPKSAVTMRNEELLLSNGTANKMN
                     GALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKG
                     CCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKK
                     CNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEG
                     CSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQAT
                     SSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSSTSSALGALT
                     SPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTN
                     GTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQ
                     EFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIG
                     MKRLKVQLKRSKNDSKPY"
     exon            146..342
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..425
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..474
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..609
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..689
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            690..848
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..912
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1047
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1167
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1347
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1491
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1663
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..7645
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5451..5456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="hexamer: ATTAAA"
     polyA_site      5470
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="major polyA site"
     regulatory      7619..7624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
                     /note="hexamer: AATAAA"
     polyA_site      7645
                     /gene="Celf2"
                     /gene_synonym="B230218O03; B230345P09Rik; CELF-2; CUG-BP2;
                     Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2"
ORIGIN      
        1 gagagggggc gcattagtga atagcgactg tggcattgat gtttgagcgc acttctgaac
       61 tggcttttgt tgagactatc agtgtagaaa gcatgcgctg tcccaaatcc gctgttacta
      121 tgagaaatga ggagctgctt ttaagtaacg gcacagccaa caagatgaac ggagctttgg
      181 atcattcaga ccagccagac ccagatgcca ttaagatgtt tgtcggacag atccctaggt
      241 cctggtcgga aaaggagctg aaagaacttt ttgagcctta tggagctgtc taccagatca
      301 acgtcctccg ggaccggagt cagaaccctc cccagagtaa aggttgttgt ttcgtaacat
      361 tttatacaag aaaagctgca cttgaggccc agaatgcact gcacaatatt aaaactttac
      421 ctgggatgca tcatcccatt cagatgaaac ctgcagatag tgaaaagtca aacgctgtgg
      481 aagacagaaa attgttcata ggaatggttt ccaagaaatg taacgagaat gatatcagag
      541 tgatgttttc tccattcggt cagatagaag aatgccggat tctccgggga cctgatgggc
      601 tgagtcgagg ctgtgcgttt gtcacatttt ctacaagggc aatggcacag aatgcaatca
      661 aagccatgca tcagtctcag accatggagg gctgctcttc accaatcgtg gtgaagtttg
      721 ctgacactca gaaggacaaa gagcaaaggc gcctccagca gcagcttgca cagcagatgc
      781 aacagctcaa cactgccact tgggggaacc taacaggact gggtggactt accccgcagt
      841 acctggcgct tctgcagcag gccacctcct ccagcaacct gggtgcattc agtggcattc
      901 agcaaatggc tggcatgaat gctttacagt tacagaatct ggcaacactg gctgctgctg
      961 cagctgctgc tcaaacctca gccaccagca ccaatgcaaa ccctctgtct agcacaagca
     1021 gtgccctggg agccctcaca agccctgtgg ctgcttcaac ccccaattcc accgctggtg
     1081 cggccatgaa ttccttgacc tctcttggga ctctacaagg attggctgga gccactgtcg
     1141 gattgaataa tattaatgca ctagcaggta tggcggctct gaatggagga cttggcgcca
     1201 caggcttgac gaatggtacg gctggcacca tggacgccct gacccaggcc tactcaggaa
     1261 ttcagcagta tgcggcagct gcactgccca ctttgtacag ccagagcttg ctgcaacagc
     1321 agagtgctgc aggcagccag aaggaaggtc cagagggggc aaacctcttt atttaccacc
     1381 ttccacagga gtttggagac caggacattc tgcagatgtt catgcccttt ggaaatgtta
     1441 tctctgctaa agtcttcatt gacaaacaga ccaatctgag caagtgcttt ggttttgtta
     1501 gctatgacaa tccagtctct gcacaagctg caatccaggc tatgaacggc tttcagatcg
     1561 gcatgaaacg cttgaaggtg cagctgaaac gctccaaaaa cgacagcaaa ccttactgat
     1621 cctaacccca gaagctccct gctcttattt tagctttctt aggacatctt catgcccgtt
     1681 agtcatcgtt tgcctagcat gtccctgtgg cgtctcaaaa acagtttcat cgtcccgtca
     1741 ttgtttctga tgtctttctg acctcacatc atatttggtt ctcctactga cctttgatct
     1801 agttttgacc tttgaaattt gcatgtgacc tcatctagct atgaattctg ggaagtcaat
     1861 gtgaaaaaca ttgctgcatt catgcaagac tgaaattatt agacaaatta tagaaaacaa
     1921 aacctgtggc aaaaatgttt ctttcttatt tttttttctt ttcataaaac agacttgaaa
     1981 gtattacaca gggattggca ttctgcccgg tcactggtga caatagcaat atgtgtccag
     2041 ggacacagaa tgttggtttc taacagacta cttccaaaaa cagtttgaga aaaaaaaaaa
     2101 aactgtctga ttttaagtct ctagaggtct gtaatagttt ttacattttt caggcagtgt
     2161 aaagtttttt gataaggcca ttttaggtgg ctcactttct cattaagata tatatataga
     2221 accacttttt gtagattagt ataagaaaaa tatttaccct gttttggggc aaatgctacc
     2281 tatttgtgtc accttttgct gaactgactc acagttagac aatccatggt ttaatgcaca
     2341 tgaaattacc tatattttat actgttccaa tgtacaggag aaaggctact gtaagctgcg
     2401 tcatgttggt gcttctgtgg attaagttgt gctctcatca caagtcttaa ggtcttaatg
     2461 ttatttgttg ataagacaag cttagaattg gtttacttaa aacaaaaaaa aaaaagaatt
     2521 tcaaaaaaaa aagttgtttg cttaaaaaaa aaaagttcat gtgagagaaa aaagaaaaaa
     2581 aaagaaaaaa aaaaaactat tccagactaa gttttgtgtt ggcctgagaa gcattggcgt
     2641 cacttttttt tattgtggac tattagatgt gtttgtgttc agcaaaatgt gatgttttgt
     2701 tttttctttt aaagaaaaaa gtgaaaacta tctagtgcca aattccaaag gtacttcctc
     2761 cctagagctt cgcgtgtttc ctgtgagaag tgatttgata acatggtatt ttattatgtg
     2821 ttttgtataa atccctaata tttaaaacaa acaaaaaaaa aaaaaaggtt acaaagtttg
     2881 ttaacttgct attccgtggt cttgttgcct gaaattgtta ttgtttgtta tttctctatg
     2941 ctgttttttg taagacattg tataagtgcc gtgtgtcact tttctaacct ctccacgtca
     3001 atgctgtgac ggcagccctc acaatgtatt ctcttcataa tatctggaaa cctctaaggt
     3061 gagaaagtcc tgaactttta accctttcta cccagagcta tctggaatgt tggtgacttt
     3121 ttatactgtc atccttgggt ttgttttggg gtgtttagat atttttttcc atttgtatct
     3181 tctgagttat tttttgtttt ttgagtcaca caccttccca aaaaaccctt aagtcttttt
     3241 cctaaaccgt tttttatttt cttttttatc ccctccttcc tatcaccctg tgctccttca
     3301 gtttaaatat aagagactga gtagaccctg ggaagggaaa aacaggtaga gcttagccct
     3361 acacaaaccc taaagaccgt gtctgctttt tgataagggt ttcatggtat gccctcgtgt
     3421 acaatatttt tatacaccct ggagttaaat ggctttttgg tggtccaatc tttcaagaag
     3481 ttttactttt gtttcttaaa cacccctatg taatgctgag tcagcctttg gctcgggatt
     3541 ctcagacgca tgtggacacc tgaatatgca aggtgtcttc ctgaaaagcc cacacatttc
     3601 aagtggttgg ccatgtaaga ggagatcagc tgctcttcac cacaattact accaaatact
     3661 aggactagtt cctgctgttg ctctcgaaag tgccatattc ctgagtctgg cttcatatga
     3721 gcagatgtct tgttctgaca gaccccaatg tcatgcctac agtccaaaca cacacccagc
     3781 ctctgggaaa acacaccctg caagcttctg gtctcagctc ccttttcctt cacaccctcc
     3841 ctccatttga tttaatgtgt gtgtgaatgt gatagccctg agatggaaag gattagcctc
     3901 tcacaatgca aaaaaaaaaa aaaaaaaaaa aagttccctc cttccagcac gcgcacttcc
     3961 agtgacatga ttggtgttag cccactgttt accactgccg gggccttcct tcatccttga
     4021 gggctatttt gtactttctg cagcactcag ctcactaaca gtgatcacac acattctcag
     4081 tctctctatg gtggtgtgta ggtacacgtg tagaaacaca agagaatacc agttgtattt
     4141 catagaccat ctcgttcaca atctatttag ttattaatga tataaatctc aaaaaaaaat
     4201 cttgactttt ttttttcccc ccatggaagc caactgccct ccttcctctt aacccacctg
     4261 cggcccccgc agaggctcgg gtcaggcagg tactttctgt tgagctcggt ttctgatttt
     4321 gcaggcgacc aagaccgtcc attgaggcga gggcttggtt ttgcatgttt cattgttaga
     4381 aagttagcct tcctcagaga cagactgtcc ttcctctctc agtatcaaaa ggaaacgctg
     4441 caagggtgcg cagggcctgt ttccggaaga caaaacacag ggaaactgca tttttaaaaa
     4501 tcaagtgtaa agcatataga cttttaaaac tcactcagag aactctgatc agatggcacc
     4561 tccacggtgt gacaagttca tctttccttc accgcagggg ttctagttcc ttggcttgtg
     4621 ctactctgga atcatttact gtttctgtct ttattatctt aagtgctaat taaaagaaaa
     4681 taaaacttaa aaaaatgtag tttcattacc ttttgaataa tgtcatacaa aaatgtattt
     4741 gtgtttttgt gctgtgggaa ttgttgtttg tagattaata ataccatttt gtttagaact
     4801 acaaaatagt ttttaaatat tgtctgagaa aagccaaagt taatgcaacc tagtggaaac
     4861 tgtaagacca tttgagtatt gtttctgttt tattgatgca tttggatttt gttgtttgat
     4921 ggaatttgag ccaaaaaaca aaaatgcagg ctttcctatt tctacaactg attgtactta
     4981 cgcattttgt accagtggga ttttttatac tggagattaa aaaaaaatgg aaatttttgt
     5041 ggcttactct tgtgggcccc ctgacaatga ctgatttcaa gtttgatttc tggttgatag
     5101 gaagaaagtt gcttttcctt taagaattaa aaactttggc ttgatttctt tttttccctt
     5161 tgcttatatc tagcattaga attttgtctt aaaatacagc ggtaagtttc actctttatt
     5221 ctgtactgtg cagttacaca ataagataat tagatttaga agtactcagt cactttaagt
     5281 ggataaatgt attagttaaa ctttaggagt ttgctttttt gctgtttaga tcgaagtttt
     5341 ttctgaccct tctgtcctca ttgtgaacat aaccgtgtag ttgaaacagt cagacttatt
     5401 tttgtaatgt atgttattgt gtgatgcggt tttttgcttc tgtctccaat attaaaccat
     5461 tttcctaata cttgtttctc tctctgcgtg ttgtattgtt ggtaatcatt ctgtgttggt
     5521 gacacatcta cacaacctca ctgttgcacg tatctgttct tttctttatg ttgtgtaaaa
     5581 agatacagtc gattccacct aagtgaatat ctgatttggg acacgaagaa actacacatc
     5641 ccacctctgg ttcatccaca gcctacccct gactgatgct tccaagacaa tacgcctttc
     5701 cctctgatcc ctctaggacc gcctagaggg ctacacttgg caaggcattt tatggtcttt
     5761 tgaccacaca tgttctttcc tctcccctcc ctcctatcca cagttcctaa catccgtgaa
     5821 gtctctccta taaaccttaa gagggacaga agcagtagac ccagggcttc ttcatctacc
     5881 ttcaggtacg aagtctcatg actacagtca gggttagaga gggttagaaa gcccttataa
     5941 aagaggcaca ccctcaggga gaggtaaaat aaagccagct ggccaacagc gggcagctaa
     6001 aaaccattaa gcttaggtgt gtgctgcact gatcaatggg tatgtataga agtgcatttc
     6061 tattcgctca tcaatttaat ccaggagtag cttcaattat taccactcac agaagtggga
     6121 agacttccag gtattcaatg agggaggtgg ggagaattct gctcaagtcc ttgctgtctg
     6181 tttacaaagg ggagctcaga atgccatagg tccattgtcg tcccccctcc ccctcccccc
     6241 cccccaccgc agtagacaca ggataggaag gagatgtgct ctcactgtac ccaacccctg
     6301 atcagagaag aactgcccca ctgcccatgc tgtgacaagc cctccccgct ctactgtcta
     6361 cttgctcagg agtctggctg ccctcaaaga gtatttccca tggctatctg ctcccttctc
     6421 ttctcgcccg tgccaggaca cctgagctgg tgtcagcgaa agctctggct gcccaccctc
     6481 tggtttcagc tggcccctca ggcccctttc ttcagtcagg tcaacaacca tgggcctacc
     6541 aaacagaaga aaggtggctc tttccctagg ccaaacctct cactgggcat gaggttccga
     6601 gccctgctcc tactctgaca aaagctgatt cctagtgaca cctgtgctgg ctttctcagg
     6661 gcggggcctg cttgctcagt tgcctctgaa aggccactgc ttcactagtg agggaagacc
     6721 aaagtgtggt ttctttttct tttctggagg aatgggcggc atcagggagg gaaggcctgg
     6781 gaaagaggat ggtaaaattt gttccaagat gtgtttcttt ttgaaatcct aatatgacca
     6841 ccattcagca cagggcatga tgttcgcgca ctgaaagaca aactgggctt ttctaccgaa
     6901 gacacaaagg ctcggtcctg taagcacttg tgactataaa gtcagccgct gcttaaattc
     6961 acactcagcg tttatttttt gtgtaactcc caccatggtt gtgagcaggt ctgcccatgc
     7021 acaggccacc atgagaagcc agacaactgt cagcattcac tggctgatgg aagccatatg
     7081 cctgccaggc cgaagcaatg gggtgtgatc tgcaggctcg tagctagcag gctaggcaat
     7141 gcagtgaaca caagcggacc atgcatcgtt cctgataagt gaataaaaca ctgtggccag
     7201 acaatcagct tattcactta tcaggaatcg actgttctac taattcactg gttttgtttt
     7261 tcattctgtt gtagttcact atttttgctg tgttctgttt ttttttcctc tcatgcttgg
     7321 gcaaattcac tggagatatt accttcatgt gaccatgaac cgtttctatc gagtgaaaat
     7381 ggtatcttaa caaaatctat gcacttgcta tcaggaacac aatactggat gtgtcttata
     7441 tatattgaac tatatagtac tcgatttctt aaataaagct taagaaagga tttgtgtgca
     7501 aagtgaatgt gattctttct caaagcagtg tctttaaggg gtattgttca tttaagtctt
     7561 caatgatata ggatattttt cattaaaatt atagcattgt ctttatgaat taatattcaa
     7621 taaatggact ttggaaacaa aaaaaaaaaa aaaaaaaaaa aa
//
