LOCUS       NM_001406164            7785 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus CUGBP, Elav-like family member 1 (Celf1), transcript
            variant 5, mRNA.
ACCESSION   NM_001406164 XM_036158016
VERSION     NM_001406164.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7785)
  AUTHORS   Siddam,A.D., Duot,M., Coomson,S.Y., Anand,D., Aryal,S.,
            Weatherbee,B.A.T., Audic,Y., Paillard,L. and Lachke,S.A.
  TITLE     High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens
            Identifies Downstream Networks Linked to Cataract Pathology
  JOURNAL   Cells 12 (7), 1070 (2023)
   PUBMED   37048143
  REMARK    GeneRIF: High-Throughput Transcriptomics of Celf1 Conditional
            Knockout Lens Identifies Downstream Networks Linked to Cataract
            Pathology.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7785)
  AUTHORS   Yu,T.X., Kalakonda,S., Liu,X., Han,N., Chung,H.K., Xiao,L.,
            Rao,J.N., He,T.C., Raufman,J.P. and Wang,J.Y.
  TITLE     Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains
            intestinal epithelial homeostasis and response to tissue injury
  JOURNAL   JCI Insight 7 (19), e156612 (2022)
   PUBMED   36214222
  REMARK    GeneRIF: Long noncoding RNA uc.230/CUG-binding protein 1 axis
            sustains intestinal epithelial homeostasis and response to tissue
            injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7785)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7785)
  AUTHORS   Chang,K.T., Wang,L.H., Lin,Y.M., Cheng,C.F. and Wang,G.S.
  TITLE     CELF1 promotes vascular endothelial growth factor degradation
            resulting in impaired microvasculature in heart failure
  JOURNAL   FASEB J 35 (5), e21512 (2021)
   PUBMED   33811692
  REMARK    GeneRIF: CELF1 promotes vascular endothelial growth factor
            degradation resulting in impaired microvasculature in heart
            failure.
REFERENCE   6  (bases 1 to 7785)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 7785)
  AUTHORS   Silver,A., Moody,J., Dunford,R., Clark,D., Ganz,S., Bulman,R.,
            Bouffler,S., Finnon,P., Meijne,E., Huiskamp,R. and Cox,R.
  TITLE     Molecular mapping of chromosome 2 deletions in murine
            radiation-induced AML localizes a putative tumor suppressor gene to
            a 1.0 cM region homologous to human chromosome segment 11p11-12
  JOURNAL   Genes Chromosomes Cancer 24 (2), 95-104 (1999)
   PUBMED   9885975
REFERENCE   8  (bases 1 to 7785)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   9  (bases 1 to 7785)
  AUTHORS   Neophytou,P.I., Muir,E.M. and Hutton,J.C.
  TITLE     A subtractive cloning approach to the identification of mRNAs
            specifically expressed in pancreatic beta-cells
  JOURNAL   Diabetes 45 (2), 127-133 (1996)
   PUBMED   8549854
REFERENCE   10 (bases 1 to 7785)
  AUTHORS   Alexander,B.J., Rasko,J.E., Morahan,G. and Cook,W.D.
  TITLE     Gene deletion explains both in vivo and in vitro generated
            chromosome 2 aberrations associated with murine myeloid leukemia
  JOURNAL   Leukemia 9 (12), 2009-2015 (1995)
   PUBMED   8609710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672241.6.
            
            On May 10, 2022 this sequence version replaced XM_036158016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.13173.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL672241.6         113146-113263
            119-270             AL672241.6         135718-135869
            271-458             AL672241.6         146633-146820
            459-541             AL672241.6         149059-149141
            542-590             AL672241.6         149515-149563
            591-725             AL672241.6         151264-151398
            726-805             AL672241.6         151864-151943
            806-967             AL672241.6         152754-152915
            968-1043            AL672241.6         154673-154748
            1044-1172           AL672241.6         156225-156353
            1173-1283           AL672241.6         157258-157368
            1284-1469           AL672241.6         158446-158631
            1470-1613           AL672241.6         160752-160895
            1614-1778           AL672241.6         161291-161455
            1779-7785           AL672241.6         161544-167550
FEATURES             Location/Qualifiers
     source          1..7785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.44 cM"
     gene            1..7785
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /note="CUGBP, Elav-like family member 1"
                     /db_xref="GeneID:13046"
                     /db_xref="MGI:MGI:1342295"
     exon            1..118
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            119..270
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1741
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /note="isoform 1 is encoded by transcript variant 5;
                     CUG-BP- and ETR-3-like factor 1; embryo deadenylation
                     element-binding protein homolog; CELF-1; EDEN-BP homolog;
                     brain protein F41; bruno-like protein 2; deadenylation
                     factor CUG-BP; RNA-binding protein BRUNOL-2; deadenylation
                     factor EDEN-BP; CUG triplet repeat RNA-binding protein 1;
                     50 kDa nuclear polyadenylated RNA-binding protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 1 isoform 1"
                     /protein_id="NP_001393093.1"
                     /db_xref="GeneID:13046"
                     /db_xref="MGI:MGI:1342295"
                     /translation="MAAFKLDFLPEMMVDHCSLNSSPVSKKMNGTLDHPDQPDLDAIK
                     MFVGQVPRTWSEKDLRELFEQYGAVYEINILRDRSQNPPQSKGCCFVTFYTRKAALEA
                     QNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQ
                     IEECRILRGPDGLSRGCAFVTFTTRTMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKD
                     KEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTASSGNLNTLSS
                     LHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSN
                     SVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSG
                     IQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMP
                     FGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKN
                     DSKPY"
     exon            271..458
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            459..541
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            542..590
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            591..725
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            726..805
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            806..967
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1043
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1172
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1283
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1469
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1613
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1778
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..7785
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7766..7771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /note="hexamer: ATTAAA"
     polyA_site      7785
                     /gene="Celf1"
                     /gene_synonym="1600010O03Rik; Brunol2; CUG-BP; CUG-BP1;
                     CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50"
                     /note="major polyA site"
ORIGIN      
        1 acattgcttc agacctgctc aggattcagc cagggcttga agtttgtgtt cttaacgtgc
       61 gtccatctgt ctgtctgtgt acatttctgt ggaggactaa ggttttcaag taaaagagga
      121 agctaaagct gtgtatattt gtggatcaga caagtgcagc aagttattat cattggcttc
      181 tgaaggggag agtgaggtga tggctgcgtt taagttggat ttccttccag aaatgatggt
      241 ggatcattgc tctttgaatt ccagtcctgt ctcaaagaaa atgaacggca ccctggacca
      301 cccagaccaa ccagatcttg atgctatcaa gatgtttgtg ggccaggttc caaggacctg
      361 gtctgagaaa gacttgaggg agctttttga gcagtatggt gctgtctatg aaatcaacat
      421 cctaagggat aggagccaaa accctcctca gagcaaaggg tgctgttttg ttacatttta
      481 cacccgtaaa gctgcattag aagctcagaa tgctctccat aacatgaagg tcctccctgg
      541 gatgcatcac cctatacaga tgaagcctgc tgacagtgaa aagaacaatg ctgtggaaga
      601 caggaagctc tttattggta tgatttccaa gaagtgtact gaaaatgaca tccgagtcat
      661 gttttcttcg tttggacaga ttgaagagtg ccggatattg cggggacctg atggcttgag
      721 cagaggttgt gcatttgtga cttttactac aagaaccatg gcacagacag ctatcaaagc
      781 aatgcaccaa gcacaaacca tggagggttg ctcatcccca atggtggtaa agtttgccga
      841 cacccagaag gacaaagaac agaagagaat ggcccagcag ctccagcagc agatgcagca
      901 gatcagtgca gcgtctgtgt ggggaaacct ggctggtctg aacacacttg gaccccagta
      961 cttagcactt tatttgcagc tcctacagca gactgcctcc tctgggaacc tcaacaccct
     1021 gagcagcctc cacccaatgg gagggttaaa tgcaatgcag ctacagaatt tggctgcact
     1081 agctgctgca gctagtgcag ctcagaacac accaagtggt accaatgctc tcactacatc
     1141 cagcagtccc ctcagcgtac tcaccagttc agggtcttca ccgagctcca gcagcagtaa
     1201 ttctgtcaac cccatagcct cacttggagc cctgcaaaca ttggccggag caacagctgg
     1261 cctcaacgtt ggctcattgg cagggatggc tgctttgaat ggtggtctgg gcagcagtgg
     1321 cctttccaat ggcactggga gtaccatgga agccctcacc caggcgtatt ctggtatcca
     1381 gcaatatgct gctgcagccc tccccactct gtacaaccag aatttattga cacagcagag
     1441 tattggtgct gctggaagcc agaaggaagg tccagaagga gccaacctgt tcatctatca
     1501 cctgccccag gagtttggag accaggactt actgcagatg tttatgccct ttgggaatgt
     1561 cgtgtcggcc aaggttttca tagacaagca gacaaacctg agcaagtgct ttggttttgt
     1621 aagttatgac aatcctgtct cagctcaagc tgccatccag tccatgaacg gctttcaaat
     1681 tggaatgaag aggcttaaag tgcagctcaa acgttcgaag aatgatagta agccctactg
     1741 agtgctcccc tctgagactg gagtgagaag atcttctggc acagcttgcc ctgaagactc
     1801 agctactgcc ttctgtggga gtgtcgcttc gtacagagga caagtttgtg ctttggtttc
     1861 cagtgtttta ctttggagtt taggtgccat atcctgaggg gttttgtttt gttttgtttt
     1921 gttttgtttc tttttccctt tatttaaagt ttgctgtgtt tgtaaccagt ttgttgagaa
     1981 ggaccaacac cagtccacct tgaggaagag ggaaatgggt ttaaaagata attagaacat
     2041 gccccaaacc atggaaagag agggctgagc agaacagaaa gttgatcccc gaagtctctc
     2101 tccctgtgtg gaaagagtga gaactaagtc taatgaggta cggggtgggt gagtgggtga
     2161 ggtgtcttag cttctagacc ccttagaact ggctgctttc tgtggaaatg ctgaatttat
     2221 gccacctatt tttctaattt ttgtcctgga tttctgccct tctttcctaa aagggggtaa
     2281 gcaagtctca tgaaataatg cacttttcag ttagcctgaa atatgcaaat aggagggaga
     2341 tacccatgac taggcagccc agcccgacat tcgtgttata ttgattgccc tgcctggttg
     2401 gtggctgttt aggggaagca gccagagagg tcattttcat taattttaac atgaagttag
     2461 aatgtaccca tttccagtag tctcttttgt agaaagtata tggaagttca taacaccaag
     2521 gaatgttgcc tccttctctg gccacagttt tctcatgagg ggacataaga cactcttaac
     2581 agcatctcta gccaacaagg gtgcagttca tgggcagagc agtcaagaag ccatctgatt
     2641 aagggaagag agacctgctt cttggtgtgc ctgaatcaag gtcacttcaa gccactttgc
     2701 tatatttgag cagagcctag tattcaagaa ggttcagaag tgcatttctg attccttaat
     2761 gaaggtactc caaaagctgt gttcccataa ggtctggcag gcctctcctc tagccccatt
     2821 ttctgtcctt gaagacagaa gaaagtatag gacgtttaca ggctccatat ggatttagtg
     2881 ttcatttacc tcagtattaa cccatgttca ttttgtcatc atgcttacag taagctccct
     2941 gctgcctttc atgggtctta actccagcct ttgccagtgt cccacatagc ctctgggctc
     3001 tcctgctcta agagaagctg tgggaatgtg catctgagca gaggtagccc tataaatata
     3061 tgattagtag tcacagccag ggcctgggtt cctgggtcat tggaagctta aacctcataa
     3121 gttacaagtc ttgactccta gcagcagaga ttagaagggg ctaacctgct ttaagtcaga
     3181 tagggactct ccttgtcatg ctgtccctgt ggataacaaa cagggattga ccatcttgct
     3241 gttgtacagg aagttgttag tggtgtgtta tcccattgat gctgggacag ctgttctctt
     3301 atagtgataa gttgagtctg ttgtcctctt aaacatgaaa catacacttc ttaagctgaa
     3361 ccacgtaaac ttgaattctg tgcactggga gaaaagtgtc ctgtgtttca agataaaact
     3421 gttctaaagg cttccagggt attgatggaa ttttttaaaa taatgcaaaa aaaataaaaa
     3481 ataaaaaact ttaaaaggaa aaaaaagaaa aaaatgctag gttgggcagg cactgctcag
     3541 aatcccaacc ggccggaacc aagaatgttg tttctatttt tatagaagtt ttatacagct
     3601 ccggggtgga gaatatttat tacctaaatt atatctctgg aaaaggccag gattttgtag
     3661 aatccagaat gtgattgttg tacacacagg gtgctgtgta tgattgaaac tactgacttt
     3721 ctgtgaccgt ttgcagccca ggtaacctgt ccaaggggaa ggctaacatt aatgctgtga
     3781 attggcagag gcgagagctg tgctccacag ggagctgcca gtgctgtgct ccctaacctt
     3841 ctgttctgcc ttcctcctcg gccagaacat cacgttctcc ctgctcctct ggttccctct
     3901 agctctccca tttcattgtc cacagatttg tcctgtgctc caggaccaaa tgaaactttc
     3961 ctaatgatat tagaagcaaa ggagtgaccc cacctttgga acagacccca aacttcatac
     4021 ctacttgtga tttctaaaag gagcacttgc cccagcagag ccatggtcag ccatggctgg
     4081 ctcagttagc cagctagcca gctggggaga ccatgtactt ccattatccc gtttgcccag
     4141 tgcattagca cagcactagc actgtcctcg agcacagttc cctccccagg ccaaagatgg
     4201 ttttgttgaa gaagctgctc ccctataagt cttgatgtga aagggctcag cttagagtgg
     4261 agactgaagt gacgtcttaa gcagtccatt tctgttgtgt ggaggtttca cttacagtgt
     4321 tttctgctgt agttttgttt cgtggattat atcatgccat tgatttgcct tcagtgcagc
     4381 ccaaccacta tctcctgggt tccacaagag tgcccagggc gtatgtggaa ccttagggct
     4441 tggatttctg ggaacaaggg tgggccatcc taggattgag caagaaactc tggccctcta
     4501 tctaccctaa gtagtctccc tcccactcta gttagcatct tttgttgctg agaccctgct
     4561 tgcccagaga ctgtcttcat gtgttaggtg ctttgcagga aatccaagcc ttaggttccc
     4621 ctctgtctct ggcagttgga tgttctcttg gtgtccttca tgtccttttg aactttcccc
     4681 tgtgtccatt gttagcatgt gcaaaagttc ttgtcatttc ccacccctgc ccttccccgt
     4741 ctcctcattt cagggctgca tacagtgagt gtcctgttct ctctctctgt ttggatgtat
     4801 tgctctgtgt aactcagtgg atctccctct ttctggtttg tttttttttc tagattcctg
     4861 ccgtttgttc atcgttgtgc ctaaagcatg tcgatgtggc gtcaagtaca tcgtccaaat
     4921 ccctgtctct tcagcttctc tgatgcttga actctcacct ttgaccttgt gttgaccttt
     4981 gatgctgatg tgtattttat tatgtttgtt tctttctttg ttttttcttt tttctttctt
     5041 tttttttttt cccttttgtg ctgccaaatt ggttttgcta gaacgactgc tgaagggaaa
     5101 atatttaaac ttgcatttga atataaaaaa aaatctattt ttctagaact tcataagata
     5161 accacttgat tttgtgattc caattctttg taactgtctc agagcagccc tactagcaca
     5221 tgccgtgtgg tgtttgtatc cttgtgaaca cacagccagt ccgcttccag gctttgttcc
     5281 tctgtgtgct tagttttaaa gacaactttg aaataaacaa tgaaataaaa gatgtcacta
     5341 aaatctttga ggctcctgaa cacattttgc tgacatagtt ttggggcttg aggagaccgc
     5401 atgttgttat taatttttgt ttttctgagt tctcaactgc agaaaaatgt ctgaaataca
     5461 cccttacccc cattcccttt tcactgaatg ctgaggtttg ggccccagct agcctttttt
     5521 cttttccttt tgtggttctt cctgaagcag ccctgcaggg aagccctagg gtccctcttc
     5581 ccctcccctc ccctcggctc agccagctca cacccgtgct tcttcctaca gtctccacag
     5641 caaaatgtga tgctttcaac ttttttgggt tttgtattct tttgcctttt tgttttgaat
     5701 ttttcctttc ctactaagat tatgcccaga aaaaacaagt tgtgcatgtt tcctgctgtt
     5761 tcttcacacc ttcgtatgta tcaccttcac ctctctgttt tctatagttt gtgcaaaaac
     5821 tgactgattt aaaggggttt caaagaagat gttttaaatt gttatggggt tgattttttt
     5881 tctcaagatt gtatcgtttt attttgaagt ggcaactttc tcctctattg cccttagagt
     5941 gtttgcctgt gcacttagac tgtcactctt tgtggtggcc tccaggtctc agtgggggat
     6001 ccaggaggct ggctgctctg ctcagggagt acagggggcc agaggcagaa gcagaaccaa
     6061 aggtggctgt gggtaggcag gatgcttagg gcatcaaggc tagatcacgg agggagggag
     6121 ggcaggcggg cagtacttct gattacccag aggaggccat cggtgcactg agtggcaata
     6181 tacctgcctg cctgcgcttt ccctaggtga caagcacaat aaatactaca gtcttcacac
     6241 tgtttacagc tctgggcacc aaccaccccg cactggctct tcactatggc tctgctctta
     6301 cttagctaat agagttgggg taagggcaag aaactgtttt taaattgggt gaagagccag
     6361 atagctactg ttcccgggtg ccaggccagc cagttctttg gtttcctaag ggaaacttac
     6421 cctcttctct tgtagcacca tccagcctca gggtcttggg gacttggaag aatgtgaata
     6481 gaggaggaga ggctagagga aatgagtaga cagggatgga tctgtgaaga gcagaggctg
     6541 cagggaggat ttttgacaga tcccactgag acttaagcac tggtgggagg gaaagtggaa
     6601 gcaaggttgt ccaggaaagg gtggcaaggt gcagcaaagg atgggggtgg ggagagaagc
     6661 acggtctggc atcatccact ctctgcctgg tgttgaagga actccagcac agtttctgct
     6721 ctgggacccc tacaggttgc ccaatatatt atgcttgagg ccaccttact aggaagaaat
     6781 ggcagccaag tgggggactt aagtatgctg cttaaggtcc tggaaggggt ggtaggatgc
     6841 cagcgcctag catgagagag cctgctgtgt gcccacagtc tgactgcaca gagcgcctct
     6901 gtcggcagga ggtgctgcgg tccccttcct gtgtactgag aagctgggct tgccaatata
     6961 gtttgctttc gattccaaga ggagctctgg gaaaacctgt ggataaaacc aaatgccaaa
     7021 tgttggacat tgtttccttt tccttttctc tctgattgtt ttaattgttc cgtagtggtt
     7081 ttaatggatt tgagaccctg gagcggcagc tgcctttctg atttccagct gctttttgtg
     7141 aataatttaa aaagaaaaaa aaaagaaact ttacattttg gagacaaacc tgtgtgagtt
     7201 ttttattggt acaaacgttg tatttaacac taggggtttt gtacagtttt ttgccttttc
     7261 tactagaaaa caatgtaaag tgatttcaca atgtgaagag aaaaaaattg ccactatgac
     7321 caaacgcaca gtctgttctg cagcaacaac gggattcaat caactcaaag tcgtgattca
     7381 gccgtagaaa tgcttttctt gaccttgttt gagctttcct tttttcctgt ttgatttata
     7441 aaagatgtct tttgtgtgtg aacttgtgtt gtactctgta gaaaattatg gattttgctt
     7501 taatggtttt taaaaaaaaa aaagggcaag aagagcccgt gtcgcttttc ttacctaatc
     7561 acagtttgtg tagtggatta aaaaaagaaa aagttgttaa aagtttggag caagggagta
     7621 tgtgtttaaa aggactctcc ttcctttttg tgtgtgtttc cttttgtccc aatggggaac
     7681 ctaaatctgt tttaattgca cagacacaca gacaaaaagt cattttgtat ctgccaagtg
     7741 tggtaccttc ctttgtttat ttgctattaa actgtttgag aagaa
//
