LOCUS       NM_026419                897 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus chymotrypsin-like elastase family, member 3B (Cela3b),
            mRNA.
ACCESSION   NM_026419 XM_914442
VERSION     NM_026419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 897)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 897)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 897)
  AUTHORS   Liu,S., Young,S.M. and Varisco,B.M.
  TITLE     Dynamic expression of chymotrypsin-like elastase 1 over the course
            of murine lung development
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 306 (12), L1104-L1116 (2014)
   PUBMED   24793170
REFERENCE   5  (bases 1 to 897)
  AUTHORS   Westmoreland,J.J., Kilic,G., Sartain,C., Sirma,S., Blain,J.,
            Rehg,J., Harvey,N. and Sosa-Pineda,B.
  TITLE     Pancreas-specific deletion of Prox1 affects development and
            disrupts homeostasis of the exocrine pancreas
  JOURNAL   Gastroenterology 142 (4), 999-1009 (2012)
   PUBMED   22178591
REFERENCE   6  (bases 1 to 897)
  AUTHORS   Martinez-Romero,C., Rooman,I., Skoudy,A., Guerra,C., Molero,X.,
            Gonzalez,A., Iglesias,M., Lobato,T., Bosch,A., Barbacid,M.,
            Real,F.X. and Hernandez-Munoz,I.
  TITLE     The epigenetic regulators Bmi1 and Ring1B are differentially
            regulated in pancreatitis and pancreatic ductal adenocarcinoma
  JOURNAL   J Pathol 219 (2), 205-213 (2009)
   PUBMED   19585519
REFERENCE   7  (bases 1 to 897)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 897)
  AUTHORS   Kilic,G., Wang,J. and Sosa-Pineda,B.
  TITLE     Osteopontin is a novel marker of pancreatic ductal tissues and of
            undifferentiated pancreatic precursors in mice
  JOURNAL   Dev Dyn 235 (6), 1659-1667 (2006)
   PUBMED   16518820
REFERENCE   9  (bases 1 to 897)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL645468.11.
            
            On Nov 17, 2006 this sequence version replaced NM_026419.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061066.1, AK009129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL645468.11        176971-177031       c
            62-147              AL645468.11        174980-175065       c
            148-245             AL645468.11        171552-171649       c
            246-380             AL645468.11        171297-171431       c
            381-517             AL645468.11        170356-170492       c
            518-660             AL645468.11        169758-169900       c
            661-813             AL645468.11        168411-168563       c
            814-897             AL645468.11        167519-167602       c
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 69.9 cM"
     gene            1..897
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /note="chymotrypsin-like elastase family, member 3B"
                     /db_xref="GeneID:67868"
                     /db_xref="MGI:MGI:1915118"
     exon            1..61
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..831
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /EC_number="3.4.21.70"
                     /note="elastase 3B, pancreatic; elastase 3, pancreatic;
                     protease E; elastase-3B; elastase IIIB"
                     /codon_start=1
                     /product="chymotrypsin-like elastase family member 3B
                     precursor"
                     /protein_id="NP_080695.1"
                     /db_xref="CCDS:CCDS18817.1"
                     /db_xref="GeneID:67868"
                     /db_xref="MGI:MGI:1915118"
                     /translation="MLRLLSSLLLVALASGCGQPSHNPSSRVVNGEEAVPHSWPWQVS
                     LQYEKDGSFHHTCGGSLITPDWVLTAGHCISTSRTYQVVLGEHERGVEEGQEQVIPIN
                     AGDLFVHPKWNSMCVSCGNDIALVKLSRSAQLGDAVQLACLPPAGEILPNGAPCYISG
                     WGRLSTNGPLPDKLQQALLPVVDYEHCSRWNWWGLSVKTTMVCAGGDIQSGCNGDSGG
                     PLNCPADNGTWQVHGVTSFVSSLGCNTLRKPTVFTRVSAFIDWIEETIANN"
     exon            62..147
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     exon            148..245
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     exon            246..380
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     exon            381..517
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     exon            518..660
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     exon            661..813
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
     exon            814..897
                     /gene="Cela3b"
                     /gene_synonym="0910001F22Rik; 2310074F01Rik; Ela3; Ela3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaatcaccc tgaagctcac catgctccga ctgctgagtt ccctcctgct tgtggccctt
       61 gcctcaggct gtggacagcc ttcccacaac ccctccagcc gagttgtcaa tggcgaggaa
      121 gctgttcccc acagctggcc ctggcaggtc tcccttcagt atgagaagga tgggagcttc
      181 caccatacct gtggtggctc cctcattacc cctgactggg ttctgactgc gggccactgc
      241 atctcgactt ctcgcaccta ccaggttgta cttggggagc atgaacgtgg tgtggaggaa
      301 ggccaagaac aggtgatccc catcaacgct ggagacctct ttgtgcaccc caagtggaac
      361 tctatgtgtg tgagctgtgg caatgacatc gccctggtca agctctcaag aagtgcccag
      421 ctgggagatg cagtccagct tgcctgcctc cctcctgctg gtgaaatcct acccaacgga
      481 gcaccctgtt acatcagcgg ctggggccgg ctctccacca atggacctct gccagacaag
      541 ctgcagcagg ccttgctgcc tgtggtggac tatgaacact gctccaggtg gaactggtgg
      601 ggcttgtctg tgaagacgac catggtgtgc gccggcggcg atatccagtc tggctgcaac
      661 ggtgactctg gaggacccct caactgtccc gctgacaatg gcacctggca ggtccacggt
      721 gtgaccagct ttgtgtcctc cttgggctgc aacaccctga ggaagcccac agtgttcacc
      781 cgtgtctcag ccttcattga ctggattgag gagaccattg ccaacaacta gatccaaggt
      841 tcggctggca gagaggaccc ccaggtcctc taaagaataa agacctttct gaaagtc
//
