LOCUS       NM_009885               2080 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus carboxyl ester lipase (Cel), mRNA.
ACCESSION   NM_009885
VERSION     NM_009885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Mao,X.T., Zou,W.B., Cao,Y., Wang,Y.C., Deng,S.J., Cooper,D.N.,
            Ferec,C., Li,Z.S., Chen,J.M. and Liao,Z.
  TITLE     The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and
            Pancreatitis in Mice
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (1), 55-74 (2022)
   PUBMED   35398595
  REMARK    GeneRIF: The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme
            Misfolding and Pancreatitis in Mice.
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Khatua,B., Trivedi,R.N., Noel,P., Patel,K., Singh,R., de
            Oliveira,C., Trivedi,S., Mishra,V., Lowe,M. and Singh,V.P.
  TITLE     Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during
            Severe Acute Pancreatitis
  JOURNAL   Am J Pathol 189 (6), 1226-1240 (2019)
   PUBMED   30954473
  REMARK    GeneRIF: Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury
            during Severe Acute Pancreatitis.
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Prevot,P.P., Augereau,C., Simion,A., Van den Steen,G., Dauguet,N.,
            Lemaigre,F.P. and Jacquemin,P.
  TITLE     Let-7b and miR-495 stimulate differentiation and prevent metaplasia
            of pancreatic acinar cells by repressing HNF6
  JOURNAL   Gastroenterology 145 (3), 668-78 (2013)
   PUBMED   23684747
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Mackay,K. and Lawn,R.M.
  TITLE     Characterization of the mouse pancreatic/mammary gland cholesterol
            esterase-encoding cDNA and gene
  JOURNAL   Gene 165 (2), 255-259 (1995)
   PUBMED   8522186
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Pilz,A., Woodward,K., Povey,S. and Abbott,C.
  TITLE     Comparative mapping of 50 human chromosome 9 loci in the laboratory
            mouse
  JOURNAL   Genomics 25 (1), 139-149 (1995)
   PUBMED   7774911
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Wen,P.Z., Warden,C., Fletcher,B.S., Kujubu,D.A., Herschman,H.R. and
            Lusis,A.J.
  TITLE     Chromosomal organization of the inducible and constitutive
            prostaglandin synthase/cyclooxygenase genes in mouse
  JOURNAL   Genomics 15 (2), 458-460 (1993)
   PUBMED   8449520
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772249.6 and AK131818.1.
            
            On Aug 19, 2015 this sequence version replaced NM_009885.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U33169.1, AK131818.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL772249.6         201917-201940       c
            25-2080             AK131818.1         2-2057
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..2080
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /note="carboxyl ester lipase"
                     /db_xref="GeneID:12613"
                     /db_xref="MGI:MGI:88374"
     exon            1..107
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1841
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /EC_number="3.1.1.13"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.6"
                     /note="bile salt-activated lipase; sterol esterase;
                     cholesterol esterase; bile salt-stimulated lipase;
                     pancreatic lysophospholipase"
                     /codon_start=1
                     /product="bile salt-activated lipase precursor"
                     /protein_id="NP_034015.1"
                     /db_xref="CCDS:CCDS15841.1"
                     /db_xref="GeneID:12613"
                     /db_xref="MGI:MGI:88374"
                     /translation="MGRLEVLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLG
                     GDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATNFKKRCLQATITQDNTYGQEDCLY
                     LNIWVPQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVT
                     FNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAA
                     SVSLQTLSPYNKGLIRRAISQSGMALSPWAIQKNPLFWAKTIAKKVGCPTEDTGKMAA
                     CLKITDPRALTLAYKLPVKKQEYPVVHYLAFIPVIDGDFIPDDPINLYNNTADIDYIA
                     GINNMDGHLFATIDVPAVDKTKQTVTEEDFYRLVSGHTVAKGLKGAQATFDIYTESWA
                     QDPSQENMKKTVVAFETDVLFLIPTEIALAQHKAHAKSAKTYSYLFSHPSRMPIYPKW
                     MGADHADDLQYVFGKPFATPLGYRPQDRAVSKAMIAYWTNFARSGDPNMGNSPVPTHW
                     YPYTLENGNYLDITKTITSASMKEHLREKFLKFWAVTFEVLPTVTGDQDTLTPPEDDS
                     EVAPDPPSDDSQVVPVPPTDDSVEAQMPATIGF"
     exon            108..258
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            259..381
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            382..579
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            580..710
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            711..818
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            819..936
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1123
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1327
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1525
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..2080
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
     regulatory      2059..2064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /note="hexamer: AATAAA"
     polyA_site      2080
                     /gene="Cel"
                     /gene_synonym="1810036E18Rik; BAL; BSSL"
                     /note="major polyA site"
ORIGIN      
        1 ggagaagagg agagaaggcc gcctagaggc agacactcac catggggcgc ctggaggttc
       61 tatttcttgg cctcacctgc tgcttggcag cggcttgtgc tgcaaagttg ggggctgtgt
      121 acacagaagg cggtttcgtg gagggcgtca acaagaagct cagtctcttg ggtggtgact
      181 ctgttgacat cttcaagggc atcccctttg ccactgccaa gaccttggag aatcctcagc
      241 gtcaccctgg ctggcaaggg acgctgaagg ctacaaactt caagaaacga tgcctacagg
      301 ccaccatcac ccaggacaac acctatgggc aagaagactg cctctacctc aatatctggg
      361 tgccccaggg caggaagcag gtgtcccaca acctgcctgt gatggtctgg atctatggag
      421 gtgccttcct catgggatct ggccaagggg ccaattttct caaaaactac ctgtatgacg
      481 gggaggagat cgccactcgg ggcaacgtca ttgtggtcac cttcaactac cgtgttggac
      541 ccttgggttt ccttagcacc ggggatgcta accttccagg taactttggt cttcgagatc
      601 agcacatggc tatcgcctgg gtgaagagga acattgcagc ctttgggggg gaccctgata
      661 acatcaccat ctttggggaa tctgctggag ctgccagtgt ctccctgcag accctctccc
      721 catacaacaa gggtctcatc cggagagcca tcagtcagag tggtatggca ctgagcccct
      781 gggccatcca gaagaaccca cttttctggg ccaaaacgat tgctaagaag gtaggatgcc
      841 ccacagagga tactggcaag atggctgcgt gtctgaagat cacagatccc cgggccttga
      901 cactggccta caagttgccc gtgaaaaagc aggagtaccc tgttgtgcac tacctggcct
      961 tcatccctgt catcgatggt gacttcattc ccgatgatcc catcaacctg tacaacaaca
     1021 ctgctgacat tgactacata gcgggcatta acaacatgga cggccaccta tttgctacca
     1081 ttgatgtgcc cgctgtcgac aagaccaagc agactgtcac cgaggaggac ttctacaggc
     1141 tagtcagtgg acacactgtc gccaaggggc tgaagggggc ccaagccacc tttgacatct
     1201 acactgagtc ctgggcccag gacccgtccc aggagaacat gaagaagaca gtggtggcct
     1261 ttgagactga tgtactcttc ctgatcccca cggagatagc gctggcccag cacaaagccc
     1321 atgccaagag cgccaagacc tattcttacc tgttttccca cccttcacgg atgcctatct
     1381 accccaaatg gatgggggca gaccatgctg atgacctcca gtacgtcttt ggaaagcctt
     1441 ttgccacccc actgggctac cggccccaag atagggctgt ctccaaggcc atgatcgcct
     1501 attggaccaa ctttgccagg agtggggacc ccaacatggg caactcacct gtgcccacac
     1561 actggtaccc ttataccttg gagaatggca actacctgga catcactaag acgataacca
     1621 gcgcttccat gaaggagcac ctgagagaaa agttcctgaa gttctgggct gtgacattcg
     1681 aggtgctgcc cacagtgact ggtgaccagg acaccctcac tccccctgag gatgactcag
     1741 aggttgcccc tgacccacct tcagacgact cccaggttgt tcctgtccca cctacagatg
     1801 actctgtgga ggctcagatg cctgccacca ttggcttcta aagtcttata agctggggct
     1861 ggagagatgg gtcaggaatt aagatcactc actgttcttc taaaggtcct gtgttcaatt
     1921 cccagcacct acatggctgc tcacaactgt ctgactccat ctactggtgt gcagatgtac
     1981 atgcagacta agtacccata tacataaaat acatacataa ataaagtcat ataagccttg
     2041 gtcccagggt tctgtttcaa taaagctctc cttcaataaa
//
