LOCUS       NP_034014                150 aa            linear   ROD 09-FEB-2025
DEFINITION  CCAAT/enhancer-binding protein gamma [Mus musculus].
ACCESSION   NP_034014 XP_485911
VERSION     NP_034014.1
DBSOURCE    REFSEQ: accession NM_009884.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 150)
  AUTHORS   Zhang,X., Zheng,X., Ying,X., Xie,W., Yin,Y. and Wang,X.
  TITLE     CEBPG suppresses ferroptosis through transcriptional control of
            SLC7A11 in ovarian cancer
  JOURNAL   J Transl Med 21 (1), 334 (2023)
   PUBMED   37210575
  REMARK    GeneRIF: CEBPG suppresses ferroptosis through transcriptional
            control of SLC7A11 in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 150)
  AUTHORS   Tian,F., Cheng,Y., Zhou,S., Wang,Q., Monavarfeshani,A., Gao,K.,
            Jiang,W., Kawaguchi,R., Wang,Q., Tang,M., Donahue,R., Meng,H.,
            Zhang,Y., Jacobi,A., Yan,W., Yin,J., Cai,X., Yang,Z., Hegarty,S.,
            Stanicka,J., Dmitriev,P., Taub,D., Zhu,J., Woolf,C.J., Sanes,J.R.,
            Geschwind,D.H. and He,Z.
  TITLE     Core transcription programs controlling injury-induced
            neurodegeneration of retinal ganglion cells
  JOURNAL   Neuron 110 (16), 2607-2624 (2022)
   PUBMED   35767995
  REMARK    Erratum:[Neuron. 2023 Feb 1;111(3):444. doi:
            10.1016/j.neuron.2023.01.008.. PMID: 36731430]
REFERENCE   3  (residues 1 to 150)
  AUTHORS   Kim,D., Kim,J., Yu,Y.S., Kim,Y.R., Baek,S.H. and Won,K.J.
  TITLE     Systemic approaches using single cell transcriptome reveal that
            C/EBPgamma regulates autophagy under amino acid starved condition
  JOURNAL   Nucleic Acids Res 50 (13), 7298-7309 (2022)
   PUBMED   35801910
  REMARK    GeneRIF: Systemic approaches using single cell transcriptome reveal
            that C/EBPgamma regulates autophagy under amino acid starved
            condition.
REFERENCE   4  (residues 1 to 150)
  AUTHORS   Nakano,H., Iida,Y., Murase,T., Oyama,N., Umemura,M., Takahashi,S.
            and Takahashi,Y.
  TITLE     Co-expression of C/EBPgamma and ATF5 in mouse vomeronasal sensory
            neurons during early postnatal development
  JOURNAL   Cell Tissue Res 378 (3), 427-440 (2019)
   PUBMED   31309319
  REMARK    GeneRIF: The results suggest the role of C/EBPgamma on ATF5
            (activating transcription factor 5)-regulated vomeronasal sensory
            neurons differentiation in early postnatal development.
REFERENCE   5  (residues 1 to 150)
  AUTHORS   Kardosova,M., Zjablovskaja,P., Danek,P., Angelisova,P., de
            Figueiredo-Pontes,L.L., Welner,R.S., Brdicka,T., Lee,S., Tenen,D.G.
            and Alberich-Jorda,M.
  TITLE     C/EBPgamma is dispensable for steady-state and emergency
            granulopoiesis
  JOURNAL   Haematologica 103 (8), e331-e335 (2018)
   PUBMED   29567783
  REMARK    GeneRIF: specific deletion of Cebpg in the murine hematopoietic
            system did not alter hematopoietic stem and progenitor cell
            properties, their ability to commit to the myeloid lineage, and
            produce granulocytes in normal and stress conditions.
REFERENCE   6  (residues 1 to 150)
  AUTHORS   Cooper,C., Henderson,A., Artandi,S., Avitahl,N. and Calame,K.
  TITLE     Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP
            family transcriptional activators
  JOURNAL   Nucleic Acids Res 23 (21), 4371-4377 (1995)
   PUBMED   7501458
REFERENCE   7  (residues 1 to 150)
  AUTHORS   Cooper,C., Johnson,D., Roman,C., Avitahl,N., Tucker,P. and
            Calame,K.
  TITLE     The C/EBP family of transcriptional activators is functionally
            important for Ig VH promoter activity in vivo and in vitro
  JOURNAL   J Immunol 149 (10), 3225-3231 (1992)
   PUBMED   1431100
REFERENCE   8  (residues 1 to 150)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   9  (residues 1 to 150)
  AUTHORS   Nishizawa,M., Wakabayashi-Ito,N. and Nagata,S.
  TITLE     Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP,
            a nuclear protein which binds to granulocyte colony-stimulating
            factor promoter element 1
  JOURNAL   FEBS Lett 282 (1), 95-97 (1991)
   PUBMED   1709121
REFERENCE   10 (residues 1 to 150)
  AUTHORS   Roman,C., Platero,J.S., Shuman,J. and Calame,K.
  TITLE     Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding
            protein that is similar to C/EBP and heterodimerizes with C/EBP
  JOURNAL   Genes Dev 4 (8), 1404-1415 (1990)
   PUBMED   2121606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ092456.1, AK159544.1, AC149058.7 and BE987706.1.
            
            On Mar 30, 2005 this sequence version replaced XP_485911.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CJ092456.1, BC011319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..150
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 20.91 cM"
     Protein         1..150
                     /product="CCAAT/enhancer-binding protein gamma"
                     /note="GPE1-BP (C/EBP gamma); IG/EBP-1; c/EBP gamma;
                     GPE1-binding protein; CCAAT/enhancer binding protein
                     (C/EBP), gamma; immunoglobulin enhancer-binding protein 1;
                     granulocyte colony-stimulating factor promoter element
                     1-binding protein; G-CSF promoter element 1 binding
                     protein"
                     /calculated_mol_wt=16268
     Region          27..94
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53568.1)"
     Region          60..120
                     /region_name="bZIP_CEBPG"
                     /note="Basic leucine zipper (bZIP) domain of
                     CCAAT/enhancer-binding protein gamma (CEBPG): a
                     DNA-binding and dimerization domain; cd14713"
                     /db_xref="CDD:269861"
     Region          62..120
                     /region_name="coiled coil"
                     /note="coiled coil [structural motif]"
                     /db_xref="CDD:269861"
     Site            order(65..66,68..69,71..73,75..80,82,86)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:269861"
     Region          66..93
                     /region_name="Basic motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P53568.1)"
     Site            order(87,90,93..94,97..98,100..101,103..105,107..108,
                     111..112,114..115,118..119)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:269861"
     Region          97..118
                     /region_name="Leucine-zipper.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00978"
                     /note="propagated from UniProtKB/Swiss-Prot (P53568.1)"
     Region          129..150
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P53568.1)"
     CDS             1..150
                     /gene="Cebpg"
                     /gene_synonym="C/EBPgamma; C/EBP[g]; GPE1-BP; Gpe1bp;
                     Ig/EBP"
                     /coded_by="NM_009884.3:288..740"
                     /db_xref="CCDS:CCDS21144.1"
                     /db_xref="GeneID:12611"
                     /db_xref="MGI:MGI:104982"
ORIGIN      
        1 msklsqpatt pgvngisvih tqahasglqq vpqlvpagpg gggkavppsk qskksspmdr
       61 nsdeyrqrre rnnmavkksr lkskqkaqdt lqrvnqlkee nerleakikl ltkelsvlkd
      121 lflehahsla dnvqpistet tatnsdnpgq
//
