LOCUS       NM_009883               1518 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus CCAAT/enhancer binding protein beta (Cebpb),
            transcript variant 1, mRNA.
ACCESSION   NM_009883 XM_911538
VERSION     NM_009883.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   He,C., Wang,T., Han,Y., Zuo,C. and Wang,G.
  TITLE     Jun-activated SOCS1 enhances ubiquitination and degradation of
            CCAAT/enhancer-binding protein beta to ameliorate cerebral
            ischaemia/reperfusion injury
  JOURNAL   J Physiol 602 (19), 4959-4985 (2024)
   PUBMED   39197117
  REMARK    GeneRIF: Jun-activated SOCS1 enhances ubiquitination and
            degradation of CCAAT/enhancer-binding protein beta to ameliorate
            cerebral ischaemia/reperfusion injury.
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   Rojo,M.D., Bandyopadhyay,I., Burke,C.M., Sturtz,A.D.,
            Phillips,E.S., Matherne,M.G., Embrey,S.J., LaRue,R., Qiu,Y.,
            Schwertfeger,K.L. and Machado,H.L.
  TITLE     C/EBPbeta deletion in macrophages impairs mammary gland alveolar
            budding during the estrous cycle
  JOURNAL   Life Sci Alliance 7 (10), e202302516 (2024)
   PUBMED   39025525
  REMARK    GeneRIF: C/EBPbeta deletion in macrophages impairs mammary gland
            alveolar budding during the estrous cycle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Wethmar,K., Smink,J.J. and Leutz,A.
  TITLE     Upstream open reading frames: molecular switches in
            (patho)physiology
  JOURNAL   Bioessays 32 (10), 885-893 (2010)
   PUBMED   20726009
  REMARK    Review article
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   Wethmar,K., Begay,V., Smink,J.J., Zaragoza,K., Wiesenthal,V.,
            Dorken,B., Calkhoven,C.F. and Leutz,A.
  TITLE     C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated
            translational control in mammals
  JOURNAL   Genes Dev 24 (1), 15-20 (2010)
   PUBMED   20047998
REFERENCE   6  (bases 1 to 1518)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   7  (bases 1 to 1518)
  AUTHORS   Timchenko,N.A., Welm,A.L., Lu,X. and Timchenko,L.T.
  TITLE     CUG repeat binding protein (CUGBP1) interacts with the 5' region of
            C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms
  JOURNAL   Nucleic Acids Res 27 (22), 4517-4525 (1999)
   PUBMED   10536163
REFERENCE   8  (bases 1 to 1518)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   9  (bases 1 to 1518)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   10 (bases 1 to 1518)
  AUTHORS   Alam,T., An,M.R. and Papaconstantinou,J.
  TITLE     Differential expression of three C/EBP isoforms in multiple tissues
            during the acute phase response
  JOURNAL   J Biol Chem 267 (8), 5021-5024 (1992)
   PUBMED   1371993
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935060.17.
            
            On Dec 19, 2013 this sequence version replaced NM_009883.3.
            
            Transcript Variant: This variant (1) encodes multiple isoforms
            through the use of alternative translation initiation codons. The
            isoform (a, also known as LAP*) represented in this RefSeq results
            from translation initiation at the 5' most AUG start codon and is
            the longest isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X62600.1, AK143374.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1518              AL935060.17        20756-22273
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 87.58 cM"
     gene            1..1518
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /note="CCAAT/enhancer binding protein beta"
                     /db_xref="GeneID:12608"
                     /db_xref="MGI:MGI:88373"
     exon            1..1518
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..998
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /note="isoform a is encoded by transcript variant 1;
                     AGP/EBP; interleukin-6-dependent-binding protein;
                     liver-enriched transcriptional activator; nuclear protein
                     Il6; C/EBP BETA; CCAAT/enhancer binding protein (C/EBP),
                     beta"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein beta isoform a"
                     /protein_id="NP_034013.1"
                     /db_xref="CCDS:CCDS17105.1"
                     /db_xref="GeneID:12608"
                     /db_xref="MGI:MGI:88373"
                     /translation="MHRLLAWDAACLPPPPAAFRPMEVANFYYEPDCLAYGAKAARAA
                     PRAPAAEPAIGEHERAIDFSPYLEPLAPAADFAAPAPAHHDFLSDLFADDYGAKPSKK
                     PADYGYVSLGRAGAKAAPPACFPPPPPAALKAEPGFEPADCKRADDAPAMAAGFPFAL
                     RAYLGYQATPSGSSGSLSTSSSSSPPGTPSPADAKAAPAACFAGPPAAPAKAKAKKTV
                     DKLSDEYKMRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELS
                     TLRNLFKQLPEPLLASAGHC"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /note="hexamer: ATTAAA"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /note="hexamer: AATAAA"
     polyA_site      1479
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /note="major polyA site"
     polyA_site      1501
                     /gene="Cebpb"
                     /gene_synonym="C/EBPbeta; CRP2; IL-6DBP; LAP; LIP; NF-IL6;
                     NF-M; Nfil6"
                     /note="major polyA site"
ORIGIN      
        1 gcccgttgcc aggcgccgcc ttataaacct cccgctcggc cgccgccgcg ccgagtccga
       61 gccgcgcacg ggaccgggac gcagcggagc ccgcgggccc cgcgttcatg caccgcctgc
      121 tggcctggga cgcagcatgc ctcccgccgc cgcccgccgc ctttagaccc atggaagtgg
      181 ccaacttcta ctacgagccc gactgcctgg cctacggggc caaggcggcc cgcgccgcgc
      241 cgcgcgcccc cgccgccgag ccggccattg gcgagcacga gcgcgccatc gacttcagcc
      301 cctacctgga gccgctcgcg cccgccgcgg acttcgccgc gcccgcgccc gcgcaccacg
      361 acttcctctc cgacctcttc gccgacgact acggcgccaa gccgagcaag aagccggccg
      421 actacggtta cgtgagcctc ggccgcgcgg gcgccaaggc cgcgccgccc gcctgcttcc
      481 cgccgccgcc tcccgccgcg ctcaaggcgg agccgggctt cgaacccgcg gactgcaagc
      541 gcgcggacga cgcgcccgcc atggcggccg gtttcccgtt cgccctgcgc gcctacctgg
      601 gctaccaggc gacgccgagc ggcagcagcg gcagcctgtc cacgtcgtcg tcgtccagcc
      661 cgcccggcac gccgagcccc gccgacgcca aggccgcgcc cgccgcctgc ttcgcggggc
      721 cgccggccgc gcccgccaag gccaaggcca agaagacggt ggacaagctg agcgacgagt
      781 acaagatgcg gcgcgagcgc aacaacatcg cggtgcgcaa gagccgcgac aaggccaaga
      841 tgcgcaacct ggagacgcag cacaaggtgc tggagctgac ggcggagaac gagcggctgc
      901 agaagaaggt ggagcagctg tcgcgagagc tcagcaccct gcggaacttg ttcaagcagc
      961 tgcccgagcc gctgctggcc tcggcgggcc actgctagcg cggcgcgggt ggcgtggggg
     1021 gcgccgcggc caccctgggc accgtgcgcc ctgccccgcg cgctccggcc ccgcgcgcgc
     1081 gcccggacca ccgtgcgtgc cctgcgcgca cctgcacctg caccgagggg acaccgcggg
     1141 cacaccgcgg gcaccgcgcg cacgcacctg cacagcgcac cgggtttcgg gacttgatgc
     1201 aatccggatc aaacgtggct gagcgcgtgt ggacacggga ctgacgcaac acacgtgtaa
     1261 ctgtcagccg ggccctgagt aatcacttaa agatgttcct gcggggttgt tgatgttttt
     1321 ggttttgttt ttgttttttg ttttgttttg tttttttttt tggtcttatt attttttttg
     1381 tattatataa aaaagttcta tttctatgag aaaagaggcg tatgtatatt ttgagaacct
     1441 tttccgtttc gagcattaaa gtgaagacat tttaataaac ttttttggag aatgtttaaa
     1501 agccttttgg gggcagta
//
