LOCUS       NM_001287514            2636 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus CCAAT/enhancer binding protein alpha (Cebpa),
            transcript variant 1, mRNA.
ACCESSION   NM_001287514
VERSION     NM_001287514.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2636)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 2636)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   3  (bases 1 to 2636)
  AUTHORS   Tan,Q., Wellmerling,J.H., Song,S., Dresler,S.R., Meridew,J.A.,
            Choi,K.M., Li,Y., Prakash,Y.S. and Tschumperlin,D.J.
  TITLE     Targeting CEBPA to restore cellular identity and tissue homeostasis
            in pulmonary fibrosis
  JOURNAL   JCI Insight 9 (16), e175290 (2024)
   PUBMED   39012710
  REMARK    GeneRIF: Targeting CEBPA to restore cellular identity and tissue
            homeostasis in pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2636)
  AUTHORS   Muller,C., Bremer,A., Schreiber,S., Eichwald,S. and Calkhoven,C.F.
  TITLE     Nucleolar retention of a translational C/EBPalpha isoform
            stimulates rDNA transcription and cell size
  JOURNAL   EMBO J 29 (5), 897-909 (2010)
   PUBMED   20075868
REFERENCE   5  (bases 1 to 2636)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
REFERENCE   6  (bases 1 to 2636)
  AUTHORS   Hsieh,C.C., Xiong,W., Xie,Q., Rabek,J.P., Scott,S.G., An,M.R.,
            Reisner,P.D., Kuninger,D.T. and Papaconstantinou,J.
  TITLE     Effects of age on the posttranscriptional regulation of
            CCAAT/enhancer binding protein alpha and CCAAT/enhancer binding
            protein beta isoform synthesis in control and LPS-treated livers
  JOURNAL   Mol Biol Cell 9 (6), 1479-1494 (1998)
   PUBMED   9614188
REFERENCE   7  (bases 1 to 2636)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   8  (bases 1 to 2636)
  AUTHORS   Stephens,J.M. and Pekala,P.H.
  TITLE     Transcriptional repression of the C/EBP-alpha and GLUT4 genes in
            3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is
            coordinate and independent of protein synthesis
  JOURNAL   J Biol Chem 267 (19), 13580-13584 (1992)
   PUBMED   1618860
REFERENCE   9  (bases 1 to 2636)
  AUTHORS   Alam,T., An,M.R. and Papaconstantinou,J.
  TITLE     Differential expression of three C/EBP isoforms in multiple tissues
            during the acute phase response
  JOURNAL   J Biol Chem 267 (8), 5021-5024 (1992)
   PUBMED   1371993
REFERENCE   10 (bases 1 to 2636)
  AUTHORS   Cao,Z., Umek,R.M. and McKnight,S.L.
  TITLE     Regulated expression of three C/EBP isoforms during adipose
            conversion of 3T3-L1 cells
  JOURNAL   Genes Dev 5 (9), 1538-1552 (1991)
   PUBMED   1840554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC150683.3.
            
            Summary: This intronless gene encodes a transcription factor that
            contains a basic leucine zipper (bZIP) domain and recognizes the
            CCAAT motif in the promoters of target genes. The encoded protein
            functions in homodimers and also heterodimers with
            CCAAT/enhancer-binding proteins beta and gamma. Activity of this
            protein can modulate the expression of genes involved in cell cycle
            regulation as well as in body weight homeostasis. The use of
            alternative in-frame non-AUG (CUG) and AUG start codons results in
            several protein isoforms with different lengths. Differential
            translation initiation is mediated by an out-of-frame, upstream
            open reading frame which is located between the CUG and the first
            AUG start codons. [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) can initiate translation from
            an upstream non-AUG (CUG) site, and also from four downstream,
            in-frame AUG sites. The isoform (c, also known as extended)
            represented in this RefSeq results from translation initiation at
            the upstream CUG start codon. Isoform c is the longest isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC058161.1, AK155281.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: PMID: 20075868
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2636              AC150683.3         50041-52676
FEATURES             Location/Qualifiers
     source          1..2636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 21.02 cM"
     gene            1..2636
                     /gene="Cebpa"
                     /gene_synonym="C/ebpalpha; CBF-A; Cebp"
                     /note="CCAAT/enhancer binding protein alpha"
                     /db_xref="GeneID:12606"
                     /db_xref="MGI:MGI:99480"
     exon            1..2636
                     /gene="Cebpa"
                     /gene_synonym="C/ebpalpha; CBF-A; Cebp"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1206
                     /gene="Cebpa"
                     /gene_synonym="C/ebpalpha; CBF-A; Cebp"
                     /note="isoform c is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon; C/EBP alpha;
                     CCAAT/enhancer binding protein (C/EBP), alpha"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein alpha isoform c"
                     /protein_id="NP_001274443.1"
                     /db_xref="GeneID:12606"
                     /db_xref="MGI:MGI:99480"
                     /translation="MRGREPVGALGGRRRQRRHAQAGGRRGSPCRENSNSPMESADFY
                     EVEPRPPMSSHLQSPPHAPSNAAFGFPRGAGPAPPPAPPAAPEPLGGICEHETSIDIS
                     AYIDPAAFNDEFLADLFQHSRQQEKAKAAAGPAGGGGDFDYPGAPAGPGGAVMSAGAH
                     GPPPGYGCAAAGYLDGRLEPLYERVGAPALRPLVIKQEPREEDEAKQLALAGLFPYQP
                     PPPPPPPHPHASPAHLAAPHLQFQIAHCGQTTMHLQPGHPTPPPTPVPSPHAAPALGA
                     AGLPGPGSALKGLAGAHPDLRTGGGGGGSGAGAGKAKKSVDKNSNEYRVRRERNNIAV
                     RKSRDKAKQRNVETQQKVLELTSDNDRLRKRVEQLSRELDTLRGIFRQLPESSLVKAM
                     GNCA"
     regulatory      2617..2622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cebpa"
                     /gene_synonym="C/ebpalpha; CBF-A; Cebp"
                     /note="hexamer: TATAAA"
     polyA_site      2636
                     /gene="Cebpa"
                     /gene_synonym="C/ebpalpha; CBF-A; Cebp"
                     /note="major polyA site"
ORIGIN      
        1 attcgcgacc cgaagctgcg cgggcgcgag ccagttgggg cactgggtgg gcggcggcga
       61 cagcggcgcc acgcgcaggc tggaggccgc cgaggctcgc catgccggga gaactctaac
      121 tcccccatgg agtcggccga cttctacgag gtggagccgc ggcccccgat gagcagtcac
      181 ctccagagcc ccccgcacgc gcccagcaac gccgcctttg gctttccccg gggcgcgggc
      241 cccgcgccgc ccccagcccc acctgccgcc ccggagccgc tgggcggcat ctgcgagcac
      301 gagacgtcta tagacatcag cgcctacatc gacccggccg ccttcaacga cgagttcctg
      361 gccgacctct tccagcacag ccgacagcag gagaaggcca aggcggcggc gggccccgcg
      421 ggtggcggcg gtgactttga ctacccggga gccccggcgg gccccggcgg cgcggtcatg
      481 tccgcggggg cgcacgggcc ccctcccggc tacggctgtg cggcggccgg ctacctggac
      541 ggcaggctgg agcccctgta cgagcgcgtc ggggcgcccg cgctacggcc gctggtgatc
      601 aaacaagagc cccgcgagga ggacgaggcg aagcagctgg cgctggccgg cctcttcccc
      661 taccagccac cgccgccacc gccaccgccg cacccgcacg cgtctcccgc gcacctggcc
      721 gccccccact tgcagttcca gatcgcgcac tgcggccaga ccaccatgca cctgcagcct
      781 ggccacccca caccgccgcc cacgcccgtg cccagcccgc acgctgcgcc cgccttgggt
      841 gctgcgggcc tgcctggccc cgggagcgcg ctcaagggct tggccggtgc gcaccccgac
      901 ctccgcacgg gaggcggcgg cggtggcagc ggtgccggtg cgggcaaagc caagaagtcg
      961 gtggacaaga acagcaacga gtaccgggta cggcgggaac gcaacaacat cgcggtgcgc
     1021 aagagccgag ataaagccaa acaacgcaac gtggagacgc aacagaaggt gctggagttg
     1081 accagtgaca atgaccgcct gcgcaagcgg gtggaacagc tgagccgtga actggacacg
     1141 ctgcggggca tcttccgcca gctgcctgag agctccttgg tcaaggccat gggcaactgc
     1201 gcgtgaggcg cgcggctgcg ggaccgcctt gggccggccc cctggctgga gacccagagg
     1261 atggtttcgg gtcgctggat ctctaggctg cccgggccgc gcaagccagg actaggagat
     1321 tccggtgtgg cctgaaagcc tggcctgctc cgcgtgtccc ctcccttcct ctgagccgga
     1381 ctcggtgcgt ctaagatgag ggagtcaggc cgtggtggtt tctccttgag accgagagac
     1441 tttccgcgga gctgagctgg gggcccggca gtactagtat taaggaagta accttgtgcc
     1501 ttggatactc aaaactcgct ccttttccta ccgagtaggg ggagcaaaaa tgtgccttga
     1561 tattttattt ggaggattcc tgcttcctct cgggcctcag ctggccccgt gagaaaaatg
     1621 aagggtgcag gcccagggca ggaggaagat acaggaagct gagatcccgg cagtgccctg
     1681 agctgcccct cagtccctgt ctttagaggg gagggactta ggtgttgggg atttgagtct
     1741 gtgtcctcac ccccagctac agggaggtgg agggctccta atcccttgct ttttgcacct
     1801 ccacctacat cccccccccc ccactcagct tacaacaggc caggtttcct gggtgagttc
     1861 atggagaatg ggggcaccac ccccagtcag accagaaagc tgagttgtga gttagccatg
     1921 tggtaggaga cagagaccta ggtttctggg ctttgtgggg tgggggatag gaggacacgg
     1981 ggaccattag ccttgtgtgt actgtatgtc gccagccgct gttgctgaag gaacttgaag
     2041 cacaatcgat ccatcccaga gggactggag ttatgacaag cttcccaaat attttgcttt
     2101 atcatccgat atcaacactt gtatctggtc tctgtgtccc agcggtgcct tgtgcaatgg
     2161 cagtgtgcac gtctatgcta aaccaccatt ttatttggtc ttttgttttg ttttggtttt
     2221 gctctgattc ttgccaaact gagactcttc actaacggct gggggaagga gctgagtgag
     2281 gctctcattc tttttggttt agggatgttt gggttttttc gtctgcctcc cagaggacca
     2341 atgaaatgaa gtgggcttcc ccctctcccc tagttgtcca agggtgtatg tagtagtggg
     2401 tcttagcttc ctccggctaa gacttaggct tccccaccca cccaacccca tccccaacgg
     2461 ccctggctct gggtctggaa agaaggccac ctccagccag ttcatacaca cacccctgtg
     2521 gctgggagca gggctggacc gcttccttct cttctttttt ttgggggggg gggacacaaa
     2581 gtttcatgct agatgtcgta tgtattatat ctataatata aacatatcaa actcaa
//
