LOCUS       NM_027839               2897 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus CEA cell adhesion molecule 20 (Ceacam20), mRNA.
ACCESSION   NM_027839 XM_355868
VERSION     NM_027839.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2897)
  AUTHORS   Murata,Y., Kotani,T., Supriatna,Y., Kitamura,Y., Imada,S.,
            Kawahara,K., Nishio,M., Daniwijaya,E.W., Sadakata,H., Kusakari,S.,
            Mori,M., Kanazawa,Y., Saito,Y., Okawa,K., Takeda-Morishita,M.,
            Okazawa,H., Ohnishi,H., Azuma,T., Suzuki,A. and Matozaki,T.
  TITLE     Protein tyrosine phosphatase SAP-1 protects against colitis through
            regulation of CEACAM20 in the intestinal epithelium
  JOURNAL   Proc Natl Acad Sci U S A 112 (31), E4264-E4271 (2015)
   PUBMED   26195794
  REMARK    GeneRIF: SAP-1 and CEACAM20 thus constitute a regulatory system
            through which the intestinal epithelium contributes to intestinal
            immunity.
REFERENCE   2  (bases 1 to 2897)
  AUTHORS   Kitamura,Y., Murata,Y., Park,J.H., Kotani,T., Imada,S., Saito,Y.,
            Okazawa,H., Azuma,T. and Matozaki,T.
  TITLE     Regulation by gut commensal bacteria of carcinoembryonic
            antigen-related cell adhesion molecule expression in the intestinal
            epithelium
  JOURNAL   Genes Cells 20 (7), 578-589 (2015)
   PUBMED   25908210
  REMARK    GeneRIF: Gram-positive bacteria promote the mRNA expression of
            CEACAM1 or CEACAM20 in the small intestine. Inflammatory cytokines
            or butyrate likely participates in such effects of commensal
            bacteria.
REFERENCE   3  (bases 1 to 2897)
  AUTHORS   Zebhauser,R., Kammerer,R., Eisenried,A., McLellan,A., Moore,T. and
            Zimmermann,W.
  TITLE     Identification of a novel group of evolutionarily conserved members
            within the rapidly diverging murine Cea family
  JOURNAL   Genomics 86 (5), 566-580 (2005)
   PUBMED   16139472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033581.2, AC130530.4 and AV374496.2.
            
            On Mar 13, 2008 this sequence version replaced NM_027839.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049361.1, AK033581.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2243              AK033581.2         2-2244
            2244-2253           AC130530.4         137806-137815       c
            2254-2360           AV374496.2         3-109
            2361-2888           AK033581.2         2362-2889
            2889-2897           AC130530.4         137162-137170       c
FEATURES             Location/Qualifiers
     source          1..2897
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.96 cM"
     gene            1..2897
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /note="CEA cell adhesion molecule 20"
                     /db_xref="GeneID:71601"
                     /db_xref="MGI:MGI:1918851"
     exon            1..128
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1810
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /note="CEA-related cell adhesion molecule 20;
                     carcinoembryonic antigen-related cell adhesion molecule
                     20; cell adhesion molecule CEACAM20"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM20 precursor"
                     /protein_id="NP_082115.2"
                     /db_xref="CCDS:CCDS20919.1"
                     /db_xref="GeneID:71601"
                     /db_xref="MGI:MGI:1918851"
                     /translation="MELAGFHCCSWTVILLSALLPTTWRPPAAAHFIHRADLLSNTQM
                     ERAPLAKLTLTVNQSTVTEQREMAVFYCNTNADNITIHWVSNNSLLVLNERMKLSADN
                     KTLTILIVQREDSGSYLCEVQHGFEVQRSNTASLTVNYGPDPVSIKLDSGVAAGDVVE
                     VMEGNTVNFRVEAQSSPVPAYAWYLPSDFIQPPTTGTFTIDAVSREHEGMYRCLVSNP
                     VTNLSRLGVVKVQVLEKVTAPNIEFPTLALVENATSVTLTCKTSHQRVGVHWFLKGQP
                     LRPSDRLTLSSQNRTLTIHGLQRDDIGPYECEVWNWGSQARSVPLKLTINYGPDQVEI
                     TQGPASGVVSTIEAMLNSSLTLYCRADSIPGARYQWTHEHSSKVLDGEQLSIEALRQE
                     HQGIYSCTSSNDVTGLARSASVLVMVVGLQSSSMSPGAIAGIVIGILVAIALAIGLGY
                     FLYSTKDRWTRRRSASDTTSSNTIPPTSVMQSTPESRHNKPMTVYDNTPKPEGEARGK
                     KMWSLPRDSPEQFYEKKPPSAAPEGPRKPLPQIPKQPLMPPGPGRNEESNYEKLLNSN
                     HSLYCKITPSA"
     exon            129..215
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            216..494
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            495..776
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1055
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1334
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1452
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1541
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1603
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1645
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1756
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2897
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /note="hexamer: GATAAA"
     polyA_site      2897
                     /gene="Ceacam20"
                     /gene_synonym="9130012D09Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgcactgtg ggactggctg tgtgtgccag ccaggagagg gactacctgg cacactgagg
       61 ccaggcacca gaactcatgg agcttgctgg cttccactgc tgctcgtgga cagtgatcct
      121 tctctcagcc ttacttccga ccacatggag acccccagct gctgcccact tcatccaccg
      181 tgccgacctg cttagcaaca cccagatgga gagagctcca ctggccaagc tcaccctcac
      241 agtcaatcag agcactgtca cagagcagag ggaaatggca gttttctact gtaacactaa
      301 tgctgataac atcaccatcc actgggtctc caacaactct ctgcttgtgt tgaatgagcg
      361 catgaagctg tctgcagata acaagaccct caccatcctc attgtccagc gggaggactc
      421 ggggtcttac ctgtgtgaag tgcagcatgg ctttgaggtt cagagaagta acactgcctc
      481 gctgacggtg aactatggtc ctgatcctgt atcaatcaag ctggactcag gagtagctgc
      541 tggggatgtg gtggaggtga tggaaggcaa caccgtgaac ttcagggtgg aagcacagtc
      601 ctcccctgtc cctgcctatg cctggtatct ccccagcgac ttcatccagc cccctaccac
      661 aggaacattc acaatcgatg ctgtgtccag ggaacatgag ggcatgtaca ggtgcctggt
      721 gtccaaccct gtcaccaact tgtcccgcct aggtgtggtc aaagtccaag tgcttgaaaa
      781 agtgactgca ccgaatatcg agttcccaac cttggccctt gtggagaatg ccacctctgt
      841 gacactgacc tgcaaaacca gccaccagag ggttggtgtc cattggtttc taaagggtca
      901 gccactcagg cctagtgacc gcctgacact gtcatcccaa aacagaaccc tgaccatcca
      961 tggccttcag agagatgata ttgggcccta tgagtgtgag gtgtggaact ggggtagcca
     1021 ggcacgcagc gtccccctga agctcaccat caactatggc cccgaccaag tggaaatcac
     1081 ccaggggcca gcgtctggag tggtcagcac tattgaggca atgctcaact ccagcttgac
     1141 cctgtattgc cgggcagact ccataccagg tgccaggtat cagtggaccc atgagcactc
     1201 ctctaaggtg cttgatgggg agcagctgag catcgaagca ctgaggcagg agcatcaggg
     1261 catttacagc tgtacaagct ccaatgatgt caccggcctg gcccgatctg cctctgtcct
     1321 ggtcatggtg gtaggtctcc agtcatcctc tatgtctcct ggagccatcg ctggcatcgt
     1381 tatcgggatc ctggttgcca ttgctttggc gataggtctg ggctacttcc tctacagcac
     1441 aaaggacaga tggactcgca ggagatcagc cagtgataca acgagctcta ataccatacc
     1501 acccacctct gtgatgcaga gcaccccgga gtccaggcac aacaaaccaa tgactgtgta
     1561 tgacaatacc ccaaagcccg aaggagaggc cagaggcaaa aagatgtggt cactgccacg
     1621 tgactcccca gagcagttct atgagaagaa accaccttct gcagctcctg agggccccag
     1681 gaagccattg ccccaaatcc caaagcagcc attgatgccc ccaggaccag gcagaaatga
     1741 agagtcaaat tatgagaaac tgctgaattc aaaccatagt ctttactgca agatcacccc
     1801 atcagcctga cgcatgccaa gcttcttttc ccagttagac atgccatcct gggccacata
     1861 ctctgtgacc ttgatacctg cactttagaa tccagccatt ccttgccacc actgcggact
     1921 tcatgatgac ctagctggat cagactctgg acaaacaggt tccaccaaat cttagcttct
     1981 ggctcacgct tcatttatag caacagagct ataaatagct ggattttggg gagatggctc
     2041 agtcattaag atcacttgca gctcttccaa ataccacagg ttcagttccc agaacccttg
     2101 tatggagact tacctattct aactccagct tctagggatc caataccctc ctctggcctc
     2161 tgcagagaca tgaagacata cagattaaaa aaaaaaaaag caaatctcac tctcttttct
     2221 cttctcttct cttctcttct cttctcttct cttctcttct cttctcttct cttctcttct
     2281 cttcttttct tttctttcag acaatgtttc actatgcagc cctagctggc ctggaacttg
     2341 ctatgtacat caggatggcc ctgaactcat agagatccca ctgcctttgc tggggttaaa
     2401 ggcatatgcc atcataccca gctcagtgtg atgagaagct cagtggttaa gtgctttgcc
     2461 tgacaggcat tgaatctggg tccagtccct agtagcacac atacaaaatg caacaaaggg
     2521 tctggagagg tttctagtgc ttaagatgca catgtctctt caagaggacc caaggtcatc
     2581 tcccagggct taggtcagtg cctcacaact tcctgttagc tccagctcct gagcctcatg
     2641 tgcttatgtg cacacacata ataaatagtg cctgggtaca cataaaaaat cttccttttt
     2701 taaaaaaagc aatggcaggc tgcatagtgg aaagatggct cagcagttaa gagctctggc
     2761 tgttcttccg gaggacctaa gttcaattcc cagcacccac atggaaactt acaactatct
     2821 gtaactccag ctccagtggc acccctcaca ccagcataca ggcatataaa aataaagata
     2881 aactatttaa aagaaaa
//
