LOCUS       NM_001113368            3827 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus CEA cell adhesion molecule 2 (Ceacam2), transcript
            variant 1, mRNA.
ACCESSION   NM_001113368
VERSION     NM_001113368.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3827)
  AUTHORS   Ghanem,S.S., Muturi,H.T., DeAngelis,A.M., Hu,J., Kulkarni,R.N.,
            Heinrich,G. and Najjar,S.M.
  TITLE     Age-dependent insulin resistance in male mice with null deletion of
            the carcinoembryonic antigen-related cell adhesion molecule 2 gene
  JOURNAL   Diabetologia 60 (9), 1751-1760 (2017)
   PUBMED   28567513
REFERENCE   2  (bases 1 to 3827)
  AUTHORS   Alshahrani,M.M., Kyriacou,R.P., O'Malley,C.J., Heinrich,G.,
            Najjar,S.M. and Jackson,D.E.
  TITLE     CEACAM2 positively regulates integrin alphaIIbbeta3-mediated
            platelet functions
  JOURNAL   Platelets 27 (8), 743-750 (2016)
   PUBMED   27161904
  REMARK    GeneRIF: disruption of CEACAM2 induces a moderate integrin
            alphaIIbbeta3-mediated platelet function defect, and that CEACAM2
            is essential to maintain a normal integrin alphaIIbbeta3-mediated
            platelet function.
REFERENCE   3  (bases 1 to 3827)
  AUTHORS   Ghanem,S.S., Heinrich,G., Lester,S.G., Pfeiffer,V.,
            Bhattacharya,S., Patel,P.R., DeAngelis,A.M., Dai,T.,
            Ramakrishnan,S.K., Smiley,Z.N., Jung,D.Y., Lee,Y., Kitamura,T.,
            Ergun,S., Kulkarni,R.N., Kim,J.K., Giovannucci,D.R. and Najjar,S.M.
  TITLE     Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in
            Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion
            Molecule 2 (CEACAM2)
  JOURNAL   J Biol Chem 291 (2), 980-988 (2016)
   PUBMED   26586918
  REMARK    GeneRIF: CEACAM2 regulates insulin secretion, at least in part, by
            a GLP-1-mediated mechanism, independent of confounding metabolic
            factors.
REFERENCE   4  (bases 1 to 3827)
  AUTHORS   Alshahrani,M.M., Yang,E., Yip,J., Ghanem,S.S., Abdallah,S.L.,
            deAngelis,A.M., O'Malley,C.J., Moheimani,F., Najjar,S.M. and
            Jackson,D.E.
  TITLE     CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2
            pathways and thrombus growth in vitro and in vivo
  JOURNAL   Blood 124 (15), 2431-2441 (2014)
   PUBMED   25085348
  REMARK    GeneRIF: Functional studies of platelets from
            Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves
            to negatively regulate collagen glycoprotein VI (platelet)
            (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2)
            signaling
REFERENCE   5  (bases 1 to 3827)
  AUTHORS   Salaheldeen,E., Howida,A., Wakayama,T. and Iida,H.
  TITLE     CEACAM2-L on spermatids interacts with poliovirus receptor on
            Sertoli cells in mouse seminiferous epithelium
  JOURNAL   J Histochem Cytochem 62 (9), 632-644 (2014)
   PUBMED   24948196
  REMARK    GeneRIF: Sertoli cells recognize the excess cytoplasm of elongated
            spermatids through the PVR-CEACAM2-L interaction in mouse testis
REFERENCE   6  (bases 1 to 3827)
  AUTHORS   Heinrich,G., Ghosh,S., Deangelis,A.M., Schroeder-Gloeckler,J.M.,
            Patel,P.R., Castaneda,T.R., Jeffers,S., Lee,A.D., Jung,D.Y.,
            Zhang,Z., Opland,D.M., Myers,M.G. Jr., Kim,J.K. and Najjar,S.M.
  TITLE     Carcinoembryonic antigen-related cell adhesion molecule 2 controls
            energy balance and peripheral insulin action in mice
  JOURNAL   Gastroenterology 139 (2), 644-652 (2010)
   PUBMED   20381490
REFERENCE   7  (bases 1 to 3827)
  AUTHORS   Hirai,A., Ohtsuka,N., Ikeda,T., Taniguchi,R., Blau,D., Nakagaki,K.,
            Miura,H.S., Ami,Y., Yamada,Y.K., Itohara,S., Holmes,K.V. and
            Taguchi,F.
  TITLE     Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the
            resistance of mice to MHV infection: studies of mice with chimeric
            mCEACAM1a and mCEACAM1b
  JOURNAL   J Virol 84 (13), 6654-6666 (2010)
   PUBMED   20410265
REFERENCE   8  (bases 1 to 3827)
  AUTHORS   Han,E., Phan,D., Lo,P., Poy,M.N., Behringer,R., Najjar,S.M. and
            Lin,S.H.
  TITLE     Differences in tissue-specific and embryonic expression of mouse
            Ceacam1 and Ceacam2 genes
  JOURNAL   Biochem J 355 (Pt 2), 417-423 (2001)
   PUBMED   11284729
REFERENCE   9  (bases 1 to 3827)
  AUTHORS   Robitaille,J., Izzi,L., Daniels,E., Zelus,B., Holmes,K.V. and
            Beauchemin,N.
  TITLE     Comparison of expression patterns and cell adhesion properties of
            the mouse biliary glycoproteins Bbgp1 and Bbgp2
  JOURNAL   Eur J Biochem 264 (2), 534-544 (1999)
   PUBMED   10491101
REFERENCE   10 (bases 1 to 3827)
  AUTHORS   Nedellec,P., Dveksler,G.S., Daniels,E., Turbide,C., Chow,B.,
            Basile,A.A., Holmes,K.V. and Beauchemin,N.
  TITLE     Bgp2, a new member of the carcinoembryonic antigen-related gene
            family, encodes an alternative receptor for mouse hepatitis viruses
  JOURNAL   J Virol 68 (7), 4525-4537 (1994)
   PUBMED   8207827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162443.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC162443.3         14469-14772
            305-664             AC162443.3         15540-15899
            665-949             AC162443.3         23718-24002
            950-1204            AC162443.3         24469-24723
            1205-1480           AC162443.3         26457-26732
            1481-1598           AC162443.3         33542-33659
            1599-1651           AC162443.3         34458-34510
            1652-1683           AC162443.3         35283-35314
            1684-3827           AC162443.3         36288-38431
FEATURES             Location/Qualifiers
     source          1..3827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.87 cM"
     gene            1..3827
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /note="CEA cell adhesion molecule 2"
                     /db_xref="GeneID:26367"
                     /db_xref="MGI:MGI:1347246"
     exon            1..304
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1803
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; BGP-2; carcinoembryonic antigen-related cell
                     adhesion molecule 2- Long; CEA-related cell adhesion
                     molecule 2; biliary glycoprotein 2; cell adhesion molecule
                     CEACAM2"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM2 isoform a
                     precursor"
                     /protein_id="NP_001106839.1"
                     /db_xref="CCDS:CCDS52153.1"
                     /db_xref="GeneID:26367"
                     /db_xref="MGI:MGI:1347246"
                     /translation="MELASAHLHKGQVPWFGLLLTASLLASWSPPTTAQVTVMAFPLH
                     AAEGNNVILVVYNMMKGVSAFSWHKGSTTSTNAEIVRFVTGTNKTIKGPVHSGRETLY
                     SNGSLLIQRVTMKDTGVYTIEMTDQNYRRRVLTGQFHVHTLLLKSNITSNNSNPVEGD
                     DSVSLTCDSYTDPDNITYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCE
                     TRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLIN
                     EKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPSLQVTNT
                     TVKELDSVTLTCLSKDRQAHIHWIFNNDTLLITEKMTTSQAGLILKIDPIKREDAGEY
                     QCEISNPVSVKRSNSIKLEVIFDSTYDISDVPIAVIITGAVAGVILIAGLAYRLCSRK
                     SRWGSDQRDLTEHKPSASNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPR
                     ATETVYSEVKKK"
     exon            305..664
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            665..949
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1204
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1480
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1598
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1651
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1683
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..3827
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /note="hexamer: AATAAA"
     polyA_site      2810
                     /gene="Ceacam2"
                     /gene_synonym="Bgp2; Ceacam2-L"
                     /note="major polyA site"
ORIGIN      
        1 agaacactgc tcagagtatg ttctagaaca atgaactggg aagagaggaa tagaaggatg
       61 ggaggcccgc actgacagaa cagcattgtt agagtcacag gctccacccc caccccacgt
      121 gaatctggga ggtgcccttc tctgggagga gaatcaattc tgctatgaaa agcagggcag
      181 atatcagggc agccaggctt agcagtagtg ttggagaaga agctagcagg cagaagagac
      241 atggagctgg cctcagcaca tctccacaaa gggcaggttc cctggtttgg actactgctc
      301 acagcctcac ttttagcctc ctggagccct cccaccactg cacaagtgac tgttatggct
      361 tttccactcc acgctgctga aggcaacaat gttattctag ttgtttacaa tatgatgaag
      421 ggagtctcgg cctttagctg gcacaaggga tctactacgt ctacaaatgc tgaaattgta
      481 cgatttgtaa caggcactaa taagactata aaagggcctg tacacagtgg cagagagaca
      541 ctatacagca atggatccct gctcatccaa agggtcacca tgaaggatac gggagtctac
      601 acaatagaaa tgacagatca aaactatcgt cgtagggtcc tgactggaca atttcatgta
      661 cacaccctat tactaaagtc caacatcaca agcaacaact ccaatcccgt agagggtgac
      721 gactccgtat cattaacctg tgactcttac actgaccctg ataatataac ctacctgtgg
      781 agcagaaatg gtgaaagcct ttcagaaggt gacaggctga agctgtctga gggcaacagg
      841 actctcactt tactcaatgt cacgaggaat gacacaggac cctatgtgtg tgaaacccgg
      901 aacccagtga gtgtcaaccg aagtgaccca ttcagcctga acattatcta tggtccggac
      961 accccgatta tatccccctc agatatttat ttgcatccag ggtcaaacct caacctctcc
     1021 tgccatgcag cctctaaccc acctgcacag tacttttggc ttatcaatga gaagccccat
     1081 gcatcctccc aagagctctt tatccccaac atcactacta ataatagcgg aacctatacc
     1141 tgcttcgtca ataactctgt cactggcctc agtaggacca cagtcaagaa cattacagtc
     1201 cttgagccag tgactcagcc ctccctccaa gtcaccaaca ccacagtcaa agaactagac
     1261 tctgtcaccc tgacctgctt gtcgaaagac cgtcaagccc acatccattg gatcttcaac
     1321 aatgatactc ttctaatcac agagaagatg acaacctctc aggcgggact catcctcaaa
     1381 atagacccta ttaagaggga agatgccggc gagtatcagt gtgaaatctc gaatccagtc
     1441 agcgtcaaga ggagcaactc aatcaaactg gaagtaatat ttgactcaac atatgacatt
     1501 tcagatgtcc ccattgctgt aatcataact ggagctgtgg ccggggtgat tctaatagca
     1561 gggctggcat atcgcctctg ttccaggaag tctcgctggg gaagtgacca gcgagatctc
     1621 acagagcaca aaccctcagc ctccaaccac aatctggctc cttctgacaa ctctcctaac
     1681 aaggtggatg acgtcgcata cactgtcctg aacttcaatt cccagcaacc caaccggcca
     1741 acttcagccc cttcttctcc aagagccaca gaaacagttt attcagaagt aaaaaagaag
     1801 tgagcataat ctgtccgtct gtcctgctgg ctgcaccagt gatgcattcc cagattctct
     1861 ccctcactgg agggtctctg cacacacaca cacacacaca cacacacaca cacacacaca
     1921 cacacacaca cactcactca tgcatttact ctgttgactc cttcagtgtc tatagaagaa
     1981 aaggtggatc ctggagccta cagaaaactc aacccttcta ggctttcaaa tttggctgag
     2041 agtgaggtat caaaatttct caccctttca ctttcctgac ccagactgtt taaaattgac
     2101 ctattcagag caccttcatt cccctcccaa ctccaagtcc tgccctgtca gagtctgact
     2161 tgaatttcca taaaccttgg aggtcaccta agtgcttacg ccaaacaaaa caaaacaaaa
     2221 caaaccagaa gcaggaaatg gccagtccca tctctttaaa ggctgattgg aagccaccac
     2281 acatgagaag atcaaacctc catgggcaat ctacacaccc gacaactgtc atgcttaccc
     2341 atctggggca ttcgagtctc tgaaccttgt gtcctcacgc ctgagccctt ctctgagcct
     2401 ttctccagaa aatccactca cagcaactag agaggctctt tgtcagcaac tccaagcaaa
     2461 ctgctaggca ggattcagaa gaaaagacag catctctaac atccaccagg aaggtgccca
     2521 gaaaagcaga gctggtgact ttggactgac agacatctgg agtgtgaaaa agcagcacag
     2581 agctaacctt cggagagtgt tgaaattatt tgaaaagaag ccatatttgg aggtattgga
     2641 gttttcctct ttctgagaca atccactatt tgaaaattgt agctactgaa ttgcctctca
     2701 gtatgcaagc tgatcacttt gccttagggc cactagattt ctgtctccct tggcccctca
     2761 agcccttttg atcatgagtc ccaaaccaaa aataaatgaa cactgaggca gtcccttgca
     2821 gaaccactgt catgggtcag gctaagcctc ctgcttttct gaattagtca agaaaagcct
     2881 tggtttccct ttttccatct ttttatcttg tctttcagat actggccaga gcctggacac
     2941 tcttcctctg agatctccag cttctctgcc ttcttgtgtt tcttttaaac tctaacaaaa
     3001 actgttctca ccttcaaaaa ataaaataat aacaagcttt ccacatcccc accaaagagg
     3061 gacccagcta ggtttctggg aacccagcac cagcctccag ctgcccttct gcagtgtttc
     3121 tgcctctgtt tccctttcgt tttgactttt ttccttcttt tgagacagag ttccagcatg
     3181 gagcctgtgc aggtttcaat cccacagtaa caccttctgc agcaccccac ctgctcagac
     3241 tgcagccctg gccaccaggc ctggctacct ggacattctg tctgtcctgc actctcagga
     3301 aaccttggcc tctgctactg tctgtttggc tcattcaaag tgtgtcctta aaggaatgca
     3361 gtcacccatg ccagaggcag tgtttacagc ctggaatgct ctgcacttcc agtggaccag
     3421 tgctccaccg gaagtgggct gttagcaggg tcctctcacc tggccctggc ctttctgtag
     3481 ccttgaatcc tgccttcccc accagggcac cagggatgag tgcagcagca ggaggagagg
     3541 caaacagtca cctcaggaac cttctgagct aaggcacacc ctctgtgcct gtcaagcaaa
     3601 ggttgtattg gatatcaagt gtttggtctc acgccaagcc aacaggcttt ggagagaatt
     3661 aattagttct cctactcagg gatttctttc agtcctaaca cagcctgtgt atattttgct
     3721 tcacccacgc aatgctggat tatttaattt tgcccggctt aagacaaatc tgagttactt
     3781 gtaaatttgc tctatgttca taaaaaaagt tcattatata tcactga
//
