LOCUS       NM_001033419            1635 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus CEA cell adhesion molecule 16 (Ceacam16), mRNA.
ACCESSION   NM_001033419 XM_284274 XM_905491
VERSION     NM_001033419.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1635)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   3  (bases 1 to 1635)
  AUTHORS   Mansour,A., Sellon,J.B., Filizzola,D., Ghaffari,R., Cheatham,M.A.
            and Freeman,D.M.
  TITLE     Age-related degradation of tectorial membrane dynamics with loss of
            CEACAM16
  JOURNAL   Biophys J 120 (21), 4777-4785 (2021)
   PUBMED   34555361
  REMARK    GeneRIF: Age-related degradation of tectorial membrane dynamics
            with loss of CEACAM16.
REFERENCE   4  (bases 1 to 1635)
  AUTHORS   Goodyear,R.J., Cheatham,M.A., Naskar,S., Zhou,Y., Osgood,R.T.,
            Zheng,J. and Richardson,G.P.
  TITLE     Accelerated Age-Related Degradation of the Tectorial Membrane in
            the Ceacam16betagal/betagal Null Mutant Mouse, a Model for
            Late-Onset Human Hereditary Deafness DFNB113
  JOURNAL   Front Mol Neurosci 12, 147 (2019)
   PUBMED   31249509
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1635)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1635)
  AUTHORS   Cheatham,M.A., Goodyear,R.J., Homma,K., Legan,P.K., Korchagina,J.,
            Naskar,S., Siegel,J.H., Dallos,P., Zheng,J. and Richardson,G.P.
  TITLE     Loss of the tectorial membrane protein CEACAM16 enhances
            spontaneous, stimulus-frequency, and transiently evoked otoacoustic
            emissions
  JOURNAL   J Neurosci 34 (31), 10325-10338 (2014)
   PUBMED   25080593
  REMARK    GeneRIF: The data of this study indicated that CEACAM16 is required
            for striated-sheet matrix formation. Its continual expression may
            stabilize the noncollagenous TM matrix.
REFERENCE   7  (bases 1 to 1635)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1635)
  AUTHORS   Kammerer,R., Ruttiger,L., Riesenberg,R., Schauble,C., Krupar,R.,
            Kamp,A., Sunami,K., Eisenried,A., Hennenberg,M., Grunert,F.,
            Bress,A., Battaglia,S., Schrewe,H., Knipper,M., Schneider,M.R. and
            Zimmermann,W.
  TITLE     Loss of mammal-specific tectorial membrane component
            carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads
            to hearing impairment at low and high frequencies
  JOURNAL   J Biol Chem 287 (26), 21584-21598 (2012)
   PUBMED   22544735
  REMARK    GeneRIF: CEACAM16 can probably form higher order structures with
            other tectorial membrane proteins such as alpha-tectorin and
            beta-tectorin and influences the physical properties of the
            tectorial membrane
REFERENCE   9  (bases 1 to 1635)
  AUTHORS   Zheng,J., Miller,K.K., Yang,T., Hildebrand,M.S., Shearer,A.E.,
            DeLuca,A.P., Scheetz,T.E., Drummond,J., Scherer,S.E., Legan,P.K.,
            Goodyear,R.J., Richardson,G.P., Cheatham,M.A., Smith,R.J. and
            Dallos,P.
  TITLE     Carcinoembryonic antigen-related cell adhesion molecule 16
            interacts with alpha-tectorin and is mutated in autosomal dominant
            hearing loss (DFNA4)
  JOURNAL   Proc Natl Acad Sci U S A 108 (10), 4218-4223 (2011)
   PUBMED   21368133
REFERENCE   10 (bases 1 to 1635)
  AUTHORS   Zebhauser,R., Kammerer,R., Eisenried,A., McLellan,A., Moore,T. and
            Zimmermann,W.
  TITLE     Identification of a novel group of evolutionarily conserved members
            within the rapidly diverging murine Cea family
  JOURNAL   Genomics 86 (5), 566-580 (2005)
   PUBMED   16139472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149085.6.
            
            On Mar 1, 2007 this sequence version replaced NM_001033419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC149085.6         118639-118829       c
            192-536             AC149085.6         116124-116468       c
            537-812             AC149085.6         115349-115624       c
            813-1091            AC149085.6         113604-113882       c
            1092-1418           AC149085.6         111102-111428       c
            1419-1635           AC149085.6         109627-109843       c
FEATURES             Location/Qualifiers
     source          1..1635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.95 cM"
     gene            1..1635
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /note="CEA cell adhesion molecule 16"
                     /db_xref="GeneID:330483"
                     /db_xref="MGI:MGI:2685615"
     exon            1..191
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1429
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /note="CEA-related cell adhesion molecule 16;
                     carcinoembryonic antigen-related cell adhesion molecule
                     16; cell adhesion molecule CEACAM16"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM16 precursor"
                     /protein_id="NP_001028591.2"
                     /db_xref="CCDS:CCDS39805.1"
                     /db_xref="GeneID:330483"
                     /db_xref="MGI:MGI:2685615"
                     /translation="MKMPLTWYSWFLLSAWILNTGAEISITPEPAQPAEGDNVTLVVH
                     GLSGELLAYNWYAGPTLSLTFLVASYIVSTGDETPGPAHTGREAVRPDGSLDIHGALP
                     GHTGTYILQTLNRQFQTEVGYGHMQVYEILAPPTVMANDTALVERRDTLRLVCSSPSP
                     AEVRWFFNGDALPVAVRLGMSPDGRMLTRHGVRREEAGAYQCEVWNPVSVSRSEPLNL
                     TVYFGPERVAILQDSTTRTGCTIKVDFNMSLTLWCVARSCPEPEYVWAFNGKALKNGQ
                     DHLNISSMTAAHEGTYTCIAKNSKTLLSGSASVVVKLSAAAVAMMIVPVPTKPTEGQD
                     VTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFANCSLLVQ
                     KLNLTDAGRYTLKTVTLQGKTDTLEVELQVAPLE"
     exon            192..536
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /inference="alignment:Splign:2.1.0"
     exon            537..812
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1091
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1418
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1635
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1614..1619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /note="hexamer: CATAAA"
     polyA_site      1635
                     /gene="Ceacam16"
                     /gene_synonym="Gm769"
                     /note="major polyA site"
ORIGIN      
        1 gatccctcca aattccggtg atccgccccg gttccaaatt gccgaaagat cccaggtcca
       61 gtggcagact gagccaagcc tcaaccagga agggcctctg agcaactggg acaccatcac
      121 caccaaccat ctcgaacatc agccttggat gaaaatgcca ttgacctggt acagctggtt
      181 cctcctcagt gcctggatcc tgaacactgg ggccgagatc tccatcaccc ccgagcctgc
      241 acaacctgca gagggggaca atgtcacgct ggtagtccat gggctttcag gggaactgct
      301 tgcctacaat tggtacgcag ggcctacgct cagcctgacc ttcctggtgg ccagttacat
      361 tgtcagcact ggtgatgaga cccccggacc agcccacaca gggcgggaag ctgtccgtcc
      421 tgatggcagc cttgatatcc atggtgcctt acctgggcac acaggcacct acatcctgca
      481 gactcttaac aggcagtttc agacggaggt gggctacgga cacatgcagg tctatgagat
      541 cctggcccct cccacggtca tggccaacga cactgcgctg gtggagcgta gggataccct
      601 tcgtctcgtc tgtagcagcc ccagccccgc tgaggtccgc tggttcttca atggtgacgc
      661 tctgccagtt gccgtccgct tgggcatgtc ccccgatggc aggatgctga cccggcatgg
      721 cgtccgcagg gaggaggcag gtgcctacca gtgcgaggtg tggaaccccg tcagcgtcag
      781 ccgcagcgag ccactgaact tgacggtata cttcggccct gaacgagtag ctatccttca
      841 agactctacc acccgcacgg gctgcactat taaagtggac ttcaacatgt ccctcaccct
      901 gtggtgtgtg gcgcggtctt gccctgagcc agagtacgtg tgggccttca atggaaaggc
      961 cttgaagaat ggccaggatc acctgaacat cagcagtatg actgcagccc atgagggcac
     1021 gtacacgtgc atcgctaaga actccaagac gctgctgtct ggctctgcct cagtggtagt
     1081 caagctgtcc gcggcagctg tagccatgat gatcgttcct gtaccgacta agccaacgga
     1141 gggccaggac gtgaccctga ctgtccaggg ctaccccaag gacctgctag tctatgcctg
     1201 gtatcgtgga cctgcctcgg aacccaaccg actgctcagc cagctgccgt cagggaactg
     1261 gatcgctggc ccggcgcaca caggccggga ggtgggcttc gctaattgct cactgctggt
     1321 gcaaaagctg aacctcactg atgccgggcg ctacacactc aagaccgtca cactgcaggg
     1381 caagaccgac actctggagg tggagctaca ggtggccccc ctggagtagc caccgccgcc
     1441 tcttcagctg cagcgcaggc cgctgagacc tggagagaaa cgccccttgc agcatctccc
     1501 cgcatccgcc cctgagccca ggaccgctca cctgcagcac ggatgccggc catggtcccg
     1561 ccatcctgcc tccatctagt cttagcgccg agctgtggga gagctgccaa gtccataaat
     1621 gtcccaatga acgca
//
