LOCUS       NM_001039185            3736 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus CEA cell adhesion molecule 1 (Ceacam1), transcript
            variant 1, mRNA.
ACCESSION   NM_001039185
VERSION     NM_001039185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Muturi,H.T., Ghadieh,H.E., Asalla,S., Lester,S.G., Belew,G.D.,
            Zaidi,S., Abdolahipour,R., Shrestha,A.P., Portuphy,A.O.,
            Stankus,H.L., Helal,R.A., Verhulst,S., Duarte,S., Zarrinpar,A., van
            Grunsven,L.A., Friedman,S.L., Schwabe,R.F., Hinds,T.D. Jr.,
            Kumarasamy,S. and Najjar,S.M.
  TITLE     Conditional deletion of CEACAM1 in hepatic stellate cells causes
            their activation
  JOURNAL   Mol Metab 88, 102010 (2024)
   PUBMED   39168268
  REMARK    GeneRIF: Conditional deletion of CEACAM1 in hepatic stellate cells
            causes their activation.
REFERENCE   2  (bases 1 to 3736)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3736)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   4  (bases 1 to 3736)
  AUTHORS   Zaidi,S., Asalla,S., Muturi,H.T., Russo,L., Abdolahipour,R.,
            Belew,G.D., Iglesias,M.B., Feraudo,M., Leon,L., Kuo,E., Liu,X.,
            Kumarasamy,S., Ghadieh,H.E., Gatto-Weis,C., Zarrinpar,A., Duarte,S.
            and Najjar,S.M.
  TITLE     Loss of CEACAM1 in hepatocytes causes hepatic fibrosis
  JOURNAL   Eur J Clin Invest 54 (7), e14177 (2024)
   PUBMED   38381498
  REMARK    GeneRIF: Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
REFERENCE   5  (bases 1 to 3736)
  AUTHORS   Dery,K.J., Kojima,H., Kageyama,S., Kadono,K., Hirao,H., Cheng,B.,
            Zhai,Y., Farmer,D.G., Kaldas,F.M., Yuan,X., Eltzschig,H.K. and
            Kupiec-Weglinski,J.W.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   6  (bases 1 to 3736)
  AUTHORS   Yokomori,K. and Lai,M.M.
  TITLE     The receptor for mouse hepatitis virus in the resistant mouse
            strain SJL is functional: implications for the requirement of a
            second factor for viral infection
  JOURNAL   J Virol 66 (12), 6931-6938 (1992)
   PUBMED   1279194
REFERENCE   7  (bases 1 to 3736)
  AUTHORS   Yokomori,K. and Lai,M.M.
  TITLE     Mouse hepatitis virus utilizes two carcinoembryonic antigens as
            alternative receptors
  JOURNAL   J Virol 66 (10), 6194-6199 (1992)
   PUBMED   1326665
REFERENCE   8  (bases 1 to 3736)
  AUTHORS   McCuaig,K., Turbide,C. and Beauchemin,N.
  TITLE     mmCGM1a: a mouse carcinoembryonic antigen gene family member,
            generated by alternative splicing, functions as an adhesion
            molecule
  JOURNAL   Cell Growth Differ 3 (3), 165-174 (1992)
   PUBMED   1633107
REFERENCE   9  (bases 1 to 3736)
  AUTHORS   Williams,R.K., Jiang,G.S. and Holmes,K.V.
  TITLE     Receptor for mouse hepatitis virus is a member of the
            carcinoembryonic antigen family of glycoproteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (13), 5533-5536 (1991)
   PUBMED   1648219
REFERENCE   10 (bases 1 to 3736)
  AUTHORS   Robbins,J., Robbins,P.F., Kozak,C.A. and Callahan,R.
  TITLE     The mouse biliary glycoprotein gene (Bgp): partial nucleotide
            sequence, expression, and chromosomal assignment
  JOURNAL   Genomics 10 (3), 583-587 (1991)
   PUBMED   1653760
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AAHY01060000.1, M77196.1 and AB236328.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X67279.1, X67281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AAHY01060000.1     18704-18725
            23-1442             M77196.1           1-1420
            1443-1745           AB236328.2         812-1114
            1746-3736           AAHY01060000.1     32638-34628
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="BALB/c"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.84 cM"
     gene            1..3736
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /note="CEA cell adhesion molecule 1"
                     /db_xref="GeneID:26365"
                     /db_xref="MGI:MGI:1347245"
     exon            1..155
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1657
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hepatitis virus receptor; BGP-1; MHV-R; biliary
                     glycoprotein D; murine hepatitis virus receptor;
                     CEA-related cell adhesion molecule 1; biliary glycoprotein
                     1; carcinoembryonic antigen 1; carcinoembryonic antigen 7;
                     hepatitis virus (MHV-4) susceptibility; carcinoembryonic
                     antigen-related cell adhesion molecule 1; cell adhesion
                     molecule CEACAM1"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM1 isoform 1
                     precursor"
                     /protein_id="NP_001034274.1"
                     /db_xref="CCDS:CCDS20984.1"
                     /db_xref="GeneID:26365"
                     /db_xref="MGI:MGI:1347245"
                     /translation="MELASAHLHKGQVPWGGLLLTASLLASWSPATTAEVTIEAVPPQ
                     VAEDNNVLLLVHNLPLALGAFAWYKGNTTAIDKEIARFVPNSNMNFTGQAYSGREIIY
                     SNGSLLFQMITMKDMGVYTLDMTDENYRRTQATVRFHVHPILLKPNITSNNSNPVEGD
                     DSVSLTCDSYTDPDNINYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCE
                     TRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLIN
                     EKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPFLQVTNT
                     TVKELDSVTLTCLSNDIGANIQWLFNSQSLQLTERMTLSQNNSILRIDPIKREDAGEY
                     QCEISNPVSVRRSNSIKLDIIFDPTQGGLSDGAIAGIVIGVVAGVALIAGLAYFLYSR
                     KSGGGSDQRDLTEHKPSASNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSP
                     RATETVYSEVKKK"
     exon            156..515
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..800
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1055
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1331
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1452
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1505
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1537
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..3736
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3706..3711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /note="hexamer: AATAAA"
     polyA_site      3733
                     /gene="Ceacam1"
                     /gene_synonym="bb-1; Bgp; Bgp1; C-CAM; Cc1; CD66a; Cea-1;
                     Cea-7; Cea1; Cea7; Hv-2; Hv2; mCEA1; Mhv-1; MHVR; MHVR1;
                     mmCGM1; mmCGM1a; mmCGM2"
                     /note="major polyA site"
ORIGIN      
        1 aaagctcctt taagaaaagc agggcagata tcagggcagc ctggcttagc agtagtgttg
       61 gagaagaagc tagcaggcag gcagcagaga catggagctg gcctcagcac atctccacaa
      121 agggcaggtt ccctggggag gactactgct cacagcctca cttttagcct cctggagccc
      181 tgccaccact gctgaagtca ccattgaggc tgtgccgccc caggttgctg aagacaacaa
      241 tgttcttcta cttgttcaca atctgcccct ggcgcttgga gcctttgcct ggtacaaggg
      301 aaacactacg gctatagaca aagaaattgc acgatttgta ccaaatagta atatgaattt
      361 cacggggcaa gcatacagcg gcagagagat aatatacagc aatggatccc tgctcttcca
      421 aatgatcacc atgaaggata tgggagtcta cacactagat atgacagatg aaaactatcg
      481 tcgtactcag gcgactgtgc gatttcatgt acaccccata ttattaaagc ccaacatcac
      541 aagcaacaac tccaatcccg tggagggtga cgactccgta tcattaacct gtgactctta
      601 cactgaccct gataatataa actacctgtg gagcagaaat ggtgaaagcc tttcagaagg
      661 tgacaggctg aagctgtctg agggcaacag gactctcact ttactcaatg tcacgaggaa
      721 tgacacagga ccctatgtgt gtgaaacccg gaatccagtg agtgtcaacc gaagtgaccc
      781 attcagcctg aacattatct atggtccgga caccccgatt atatccccct cagatattta
      841 tttgcatcca gggtcaaacc tcaacctctc ctgccatgca gcctctaacc cacctgcaca
      901 gtacttttgg cttatcaatg agaagcccca tgcatcctcc caagagctct ttatccccaa
      961 catcactact aataatagcg gaacctatac ctgcttcgtc aataactctg tcactggcct
     1021 cagtaggacc acagtcaaga acattacagt ccttgagcca gtgactcagc ccttcctcca
     1081 agtcaccaac accacagtca aagaactaga ctctgtgacc ctgacctgct tgtcgaatga
     1141 cattggagcc aacatccagt ggctcttcaa tagccagagt cttcagctca cagagagaat
     1201 gacactctcc cagaacaaca gcatcctcag aatagaccct attaagaggg aagatgccgg
     1261 cgagtatcag tgtgaaatct cgaatccagt cagcgtcagg aggagcaact caatcaagct
     1321 ggacataata tttgacccaa cacaaggagg cctctcagat ggcgccattg ctggcatcgt
     1381 gattggagtt gtggctgggg tggctctaat agcagggctg gcatatttcc tctattccag
     1441 gaagtctggc gggggaagtg accagcgaga tctcacagag cacaaaccct cagcctccaa
     1501 ccacaatctg gctccttctg acaactctcc taacaaggtg gatgacgtcg catacactgt
     1561 cctgaacttc aattcccagc aacccaaccg gccaacttca gccccttctt ctccaagagc
     1621 cacagaaaca gtttattcag aagtaaaaaa gaagtgagca taatctgtcc gtctgtcctg
     1681 ctggctgcac cagtgatgca ttcccggatt ctgttcctca ctggagggtc tcagcacaca
     1741 cacacacgta cacatgcgcg cgcgcacaca cacacacaca cacacacaca cacacttaca
     1801 cacacactca tgcattcact ctattgactc cttcagtgtc tatagaagaa aaggtggatc
     1861 ctggagccta cagaaaactc aacccttcta ggctttcaaa tttggctgag agtgaggtat
     1921 caaaatttct caccctttca ctttcctgac ccagattgtt gaaaattgac ctattcagag
     1981 caccttcatt cccctcccaa ctccaagtcc tgccctatca gagtctgact tgaatttcca
     2041 taaaccttgg aggtcaccta agtgcttacg ccaaacaaaa caaaacaaaa caaaacaaaa
     2101 caaaacaaaa caaaacaaaa caaaccagaa gcaggaaatg gccagtccca tatctttaaa
     2161 ggctgattgg aagccaccat acatgagaag atcaaacctc catgggcaat ctacacaccc
     2221 gacaactgtc atgcttaccc atctgggaca ttcgagtctc tgaaccttgt gccctcacgc
     2281 ctgagccctt ctctgagcct ttctccagaa aatccactca cagcaactag agaggctctt
     2341 tgtcagcaac tccaagcaaa ctgctaggca ggattcagaa gaaaagacag catctctaac
     2401 atccaccagg aaggtgccca gaaaagcaga gctggtgact ttggactgac agacatctgg
     2461 agtgtgaaaa agcagcacag agctaacctt cggagagtgt tgaaattatt tgaaaagaag
     2521 ccatatttgg aggtattgga gttttcctct ttctgagaca atccactatt tgaaaattgt
     2581 agctactgaa ttgcctctca gtatgcgagc tgatcacttt gccttagggc cactagattt
     2641 ctgtctccct tagcccctca agcccttttg atcatgagtt ccaaaccaaa aataaataaa
     2701 tgaacagtga ggcagtccct tgcagtacca ctgtcatggg tcaggctaag cctcctgctt
     2761 ttctgaatta gtcaagaaaa gccttggttt ccctttttcc atctctttat cttgtctttc
     2821 agatactggc cagagcctgg acactcttcc tctgagatct ccagcttctc tgccttcttg
     2881 tgtttctttt aaactctaac aaaaactgtt ctcaccttca aaaaataaaa taataacaag
     2941 ctttccacat ccccaccaaa gagggaccca gctaggtttc tggaaaccca gcaccagcct
     3001 ccagctgccc ttctgcagtg tttctgcctc tgtttccctt tcgttttgac ttttttcctt
     3061 cttttgagac agagttccag catggagcct gtgcaggttt caatcccaca gtaacacctt
     3121 ctgcagcacc ccacctgctc agactgcagc cctggccacc aggcctggct acctggacat
     3181 tctgtctgcc ctgcactctc aggaaacctt ggcctctgct actgtctgtt tggctcattc
     3241 aaagtgtgtc cttaaaggaa tgcagtcacc catgccagag gcagtgttta cagcctggaa
     3301 tgctctgcac ttccagtgga ccagtgctcc accggaagtg ggctgttagc agggtcctct
     3361 cacctggccc tggcctttct gtagccttga atcctgcctt ccccaccagg gcaccaggga
     3421 tgagtgcagc agcaggagga gaggcaaaca gtcacctcag gaaccttctg agctaaggca
     3481 caccctctgt gcctgtcaag caaaggttgt attggatatc aagtgtttgg tctcacgcca
     3541 agccaacagg ctttggagag aattaattag ttctcctact cagggatttc tttcagtcct
     3601 aacacagcct gtgtatattt tgcttcaccc acgcaatgct ggattattta attttgcccg
     3661 gcttaagaca aatctgagtt acttgtaaat ttgctctatg ttcataataa aaatgtatta
     3721 tatatcactg atagca
//
