LOCUS       NM_009880               1750 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus caudal type homeobox 1 (Cdx1), mRNA.
ACCESSION   NM_009880
VERSION     NM_009880.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1750)
  AUTHORS   Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D,
            Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D,
            Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK,
            Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L,
            Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA,
            Ernst M, Dhillon AS, Clemons NJ and Mariadason JM.
  TITLE     Epithelial de-differentiation triggered by co-ordinate epigenetic
            inactivation of the EHF and CDX1 transcription factors drives
            colorectal cancer progression
  JOURNAL   Cell Death Differ 29 (11), 2288-2302 (2022)
   PUBMED   35606410
  REMARK    GeneRIF: Epithelial de-differentiation triggered by co-ordinate
            epigenetic inactivation of the EHF and CDX1 transcription factors
            drives colorectal cancer progression.
REFERENCE   2  (bases 1 to 1750)
  AUTHORS   Foley T and Lohnes D.
  TITLE     Cdx regulates gene expression through PRC2-mediated epigenetic
            mechanisms
  JOURNAL   Dev Biol 483, 22-33 (2022)
   PUBMED   34973175
REFERENCE   3  (bases 1 to 1750)
  AUTHORS   Zhu Y and Lohnes D.
  TITLE     Regulation of axial elongation by Cdx
  JOURNAL   Dev Biol 483, 118-127 (2022)
   PUBMED   34958748
REFERENCE   4  (bases 1 to 1750)
  AUTHORS   Gao H, Cao M, Deng K, Yang Y, Song J, Ni M, Xie C, Fan W, Ou C,
            Huang D, Lin L, Liu L, Li Y, Sun H, Cheng X, Wu J, Xia C, Deng X,
            Mou L and Chen P.
  TITLE     The Lineage Differentiation and Dynamic Heterogeneity of Thymic
            Epithelial Cells During Thymus Organogenesis
  JOURNAL   Front Immunol 13, 805451 (2022)
   PUBMED   35273595
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1750)
  AUTHORS   Yin Y, Haller ME, Chadchan SB, Kommagani R and Ma L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1750)
  AUTHORS   Subramanian V, Meyer BI and Gruss P.
  TITLE     Disruption of the murine homeobox gene Cdx1 affects axial skeletal
            identities by altering the mesodermal expression domains of Hox
            genes
  JOURNAL   Cell 83 (4), 641-653 (1995)
   PUBMED   7585967
REFERENCE   7  (bases 1 to 1750)
  AUTHORS   Johnson KR, Cook SA and Davisson MT.
  TITLE     Identification and genetic mapping of 151 dispersed members of 16
            ribosomal protein multigene families in the mouse
  JOURNAL   Mamm Genome 5 (11), 670-687 (1994)
   PUBMED   7873877
REFERENCE   8  (bases 1 to 1750)
  AUTHORS   Meyer BI and Gruss P.
  TITLE     Mouse Cdx-1 expression during gastrulation
  JOURNAL   Development 117 (1), 191-203 (1993)
   PUBMED   7900985
REFERENCE   9  (bases 1 to 1750)
  AUTHORS   Johnson KR and Davisson MT.
  TITLE     A multipoint genetic linkage map of mouse chromosome 18
  JOURNAL   Genomics 13 (4), 1143-1149 (1992)
   PUBMED   1354640
REFERENCE   10 (bases 1 to 1750)
  AUTHORS   Duprey P, Chowdhury K, Dressler GR, Balling R, Simon D, Guenet JL
            and Gruss P.
  TITLE     A mouse gene homologous to the Drosophila gene caudal is expressed
            in epithelial cells from the embryonic intestine
  JOURNAL   Genes Dev 2 (12A), 1647-1654 (1988)
   PUBMED   2905686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124448.4 and AC124431.4.
            
            [WARNING] On Apr 13, 2023 this sequence was replaced by
            NM_009880.4.
            
            On Jun 13, 2009 this sequence version replaced NM_009880.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019986.1, M37163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               AC124448.4         100601-101124
            525-670             AC124431.4         137232-137377       c
            671-1750            AC124431.4         135720-136799       c
FEATURES             Location/Qualifiers
     source          1..1750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..1750
                     /gene="Cdx1"
                     /gene_synonym="Cdx; Cdx-1"
                     /note="caudal type homeobox 1"
                     /db_xref="GeneID:12590"
                     /db_xref="MGI:MGI:88360"
     exon            1..524
                     /gene="Cdx1"
                     /gene_synonym="Cdx; Cdx-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..886
                     /gene="Cdx1"
                     /gene_synonym="Cdx; Cdx-1"
                     /note="caudal type homeobox transcription factor 1;
                     caudal-type homeobox protein 1; caudal type homeo box 1"
                     /codon_start=1
                     /product="homeobox protein CDX-1"
                     /protein_id="NP_034010.3"
                     /db_xref="CCDS:CCDS29279.1"
                     /db_xref="GeneID:12590"
                     /db_xref="MGI:MGI:88360"
                     /translation="MYVGYVLDKDSPVYPGPARPSSLGLGPPTYAPPGPAPAPPQYPD
                     FAGYTHVEPAPAPPPTWAAPFPAPKDDWAAAYGPGPTASAASPAPLAFGPPPDFSPVP
                     APPGPGPGILAQSLGAPGAPSSPGAPRRTPYEWMRRSVAAAGGGGSGKTRTKDKYRVV
                     YTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQ
                     QQQPLPPTQLPLPLDGTPTPSGPPLGSLCPTNAGLLGTPSPVPVKEEFLP"
     exon            525..670
                     /gene="Cdx1"
                     /gene_synonym="Cdx; Cdx-1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..1750
                     /gene="Cdx1"
                     /gene_synonym="Cdx; Cdx-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcgctg gtcgtcgggg cggccggccg ggcgcggcgg ctccagggcc cagcatgcgc
       61 gggggaccct gcggtcacca tgtacgtggg ctatgtgctg gacaaggact cccccgtgta
      121 cccaggcccc gccagaccct ccagcctcgg cctgggccct ccgacctatg cgccccctgg
      181 cccggcgccc gcgcccccgc agtaccccga cttcgcgggt tacacgcacg tggagccggc
      241 gcccgcgccc cctccgacct gggctgcgcc cttccctgcg cccaaggacg actgggcagc
      301 tgcctatggc ccgggcccca cggcctcagc cgccagcccg gccccgctgg ccttcgggcc
      361 ccctccggac tttagcccgg tgcccgcgcc tcccgggcct ggtcccggca tcctggcgca
      421 gtccctcggg gctccgggcg caccgtcctc gccaggagcg ccaaggcgga cgccctacga
      481 atggatgcgg cgcagcgtgg cggctgcagg cggcggtggc agcggtaaga cccgaaccaa
      541 ggacaagtac cgtgtggtct acacagacca ccaacgccta gagctggaaa aggagtttca
      601 ctacagccgg tacatcacta tccggcgcaa gtccgagctg gctgctaacc tggggctcac
      661 agagcggcag gtaaagatct ggttccagaa ccgccgggcc aaggagcgca aagtaaacaa
      721 gaagaaacag cagcagcagc agcccctgcc tcccacacag ctgcccctgc ccctggatgg
      781 cactcccaca ccatcagggc cacccctagg aagtctatgc cctactaatg ctggccttct
      841 gggcaccccc tccccagtgc ccgtcaagga ggagtttcta ccctagcccc ttgcagcctg
      901 gggtctaggg atctagggac ttgaatgctg ggcagctggc ttttctgggg cccaaggacc
      961 tgttctgagt tgcagccctg ctgctgccct ttggggtcac tgtggacaaa ctgcctacct
     1021 aggacaagta gcttgccctc ttcctgcctt ccgttggctg ggctgtgtgg tgagcctgtt
     1081 ggacaaggac ctcttccagc tcttgtgtcc taggccacag ggtgatgggg aagcccaatg
     1141 agaagtctca atcacctgga gatttcccaa gattcagagg gctcaacgag ctgtcaagac
     1201 aagattgagg cttcaccgtc tcctccaagg gttccagagt gaggtgggag gctggtatct
     1261 ggaccagact ggctctggag agtaggcggc attgaaagaa ggtggtacac cagagtctag
     1321 actcccatgt gaagcacaag gatgctatct gccccacctg tctcctcttc cagcctcact
     1381 ttcacctgcc ctagcacccc atgctctggc cctccccagc ctggagctac aaagccatca
     1441 ggactggaca tgaggtagag gctgggcaat tggccactgc tcttgagaca gaactcgccc
     1501 cctccttagt gtccagggag gcctgcggat ggagaggaag gctctatgag tctacctacc
     1561 tgctcatgcc caccttccca caggctgccc atcacaccca gggagccccc agaccatggg
     1621 ggactcgcag ctgtacaggg cttatgtaga gtggaatctc ttggatgcag cttcagaaat
     1681 aagttttccc ccttttaaac aatttataaa aatcatacat ggcattaaag gaatttttta
     1741 aaaagtttaa
//
