LOCUS       NM_175565               4051 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus carnitine deficiency-associated gene expressed in
            ventricle 3 (Cdv3), transcript variant 1, mRNA.
ACCESSION   NM_175565
VERSION     NM_175565.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4051)
  AUTHORS   Tsuchiya,K., Kawano,Y., Kojima,T., Nagata,K., Takao,T., Okada,M.,
            Shinohara,H., Maki,K., Toyama-Sorimachi,N., Miyasaka,N.,
            Watanabe,M. and Karasuyama,H.
  TITLE     Molecular cloning and characterization of TPP36 and its isoform
            TPP32, novel substrates of Abl tyrosine kinase
  JOURNAL   FEBS Lett 537 (1-3), 203-209 (2003)
   PUBMED   12606058
REFERENCE   2  (bases 1 to 4051)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 4051)
  AUTHORS   Fukumaru,S., Horiuchi,M., Kobayashi,K., Jalil,M.A., Iijima,M.,
            Masuda,M., Begum,L., Higashi,M., Wakana,S., Kanzaki,T. and
            Saheki,T.
  TITLE     Novel mRNA molecules are induced in hypertrophied ventricles of
            carnitine-deficient mice and belong to a family of up-regulated
            gene in cells overexpressing c-erbB-2
  JOURNAL   Biochim Biophys Acta 1577 (3), 437-444 (2002)
   PUBMED   12359334
  REMARK    GeneRIF: identification and characterization of novel transcripts
            that may be involved in the development of cardiac hypertrophy
            caused by carnitine deficiency(carnitine deficiency-associated gene
            expressed in ventricle (CDV)- 3)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122747.11, AF215660.1 and AI851067.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_175565.4.
            
            On Apr 17, 2007 this sequence version replaced NM_175565.2.
            
            Transcript Variant: This variant represents the longest transcript
            and encodes the longest isoform (a), also known as CDV3A.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF215660.1, BF149586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AC122747.11        146743-147065       c
            324-1107            AF215660.1         82-865
            1108-3547           AC122747.11        134875-137314       c
            3548-4051           AI851067.1         1-504               c
FEATURES             Location/Qualifiers
     source          1..4051
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 55.26 cM"
     gene            1..4051
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /note="carnitine deficiency-associated gene expressed in
                     ventricle 3"
                     /db_xref="GeneID:321022"
                     /db_xref="MGI:MGI:2448759"
     exon            1..727
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1123
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /note="isoform a is encoded by transcript variant 1;
                     protein CDV3; tyrosine-phosphorylated protein 36;
                     carnitine deficiency-associated protein 3; carnitine
                     deficiency-associated protein CDV3B; carnitine
                     deficiency-associated protein CDV3A"
                     /codon_start=1
                     /product="protein CDV3 isoform a"
                     /protein_id="NP_780774.1"
                     /db_xref="CCDS:CCDS40748.1"
                     /db_xref="GeneID:321022"
                     /db_xref="MGI:MGI:2448759"
                     /translation="MAETEERSLDNFFAKRDKKKKKERSSRAANAASGAGGSSAAAGS
                     RPGDGGSLGSGARSGDGGSLGSGSRSGDGGSSGSGARSGDGGSSRSGDGGSAGPAGKA
                     ITKDENEWKEFEQREVDYSGLRVQAMQISEKEDDDNEKREDPGDNWEEGGGGSGAEKS
                     SGPWNKTAPVQAPPAPVTVTETPEPAMPSGVYRPPGARLTTTRKTPQGPPEIYSDTQF
                     PSLQSTAKHVESRNRYLK"
     exon            728..804
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /inference="alignment:Splign:2.1.0"
     exon            805..947
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1107
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..4035
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4015..4020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /note="hexamer: AATAAA"
     polyA_site      4035
                     /gene="Cdv3"
                     /gene_synonym="2510010F10Rik; C230084J24Rik; TPP36"
                     /note="major polyA site"
ORIGIN      
        1 gcccacagcg gcgggcggaa ccgagcgcgc aggcgcggcg ctgcctctct ctgctggtgg
       61 cccgccctcc ctcctcccct ccctcccctc cccgtcccct ctccccctcc tcaggcccgc
      121 gcgtcttcct cccgcacgcg ccgtcgttag ccgagcgctc gccggtgcgc gccttccttg
      181 tccctcaggc agcggggcgg gcgcgaccct gctccacgct cgcggttccc agcgaggaac
      241 gtaccaccag agcacggggg gagccggccg ccctgccgcc cgcgcctcgg cgaccccgcg
      301 gggctgaggc gacgccgcac cctgcagcct gagcgcacag ccggccttga cccagagctc
      361 ggagccgcga gcgccgcgcc ctccgccggc cccacccatc cggaccgcgg ccatggccga
      421 gaccgaggag cggagcctgg acaacttctt cgccaagagg gacaagaaga agaagaagga
      481 acggagcagt cgcgcggcca acgcggcgag cggcgcgggc gggagcagcg cggcggcggg
      541 ctccaggccg ggcgatggcg ggagcctggg ctccggtgcc aggtcgggcg acggcgggag
      601 cttgggctcc ggctccaggt cgggcgacgg cgggagctcg ggctctggtg ctaggtccgg
      661 agacggcggg agctcgaggt ccggagacgg cgggagcgcg ggccccgccg gcaaggccat
      721 aacgaaggat gaaaatgagt ggaaagaatt tgagcaaaga gaggttgatt acagcggatt
      781 aagagttcag gcaatgcaaa taagtgaaaa ggaagatgat gataatgaga agagagaaga
      841 tccaggagat aattgggaag aaggtggagg tggcagtgga gcagaaaaat cttcaggtcc
      901 ctggaataaa accgctccgg tacaagcgcc tcctgctcca gtaacagtta cagaaacccc
      961 ggagccagca atgcccagtg gtgtatacag gcctcctggg gcaaggctaa ccacaacaag
     1021 gaaaacgcca caaggaccac cagaaatata cagtgacacg cagttcccat ccctgcagtc
     1081 cactgccaag catgtagaga gccggaacag gtacttaaaa tgaatactac ctgaagttaa
     1141 atgaccacat atggcacatc tacatcttat tagggacatg aattttcaaa aataaagtgg
     1201 gaagaaatgt aaatggcatc agatggaaaa tttttttggg tggttttaaa gtaaatccca
     1261 gccttttcac ctcgttgaga gcacagctgg cttgaattta gacctctact tggacttgct
     1321 tctccgttct gtcctcacat gtgggggact ctgggagagc agtgacttgc cacacacatc
     1381 tttctgtacc tgatctaatc agaccactcc cccaaagcaa aagggaggag aaattgttga
     1441 atgatgagaa cattacttga atgaggaaat tgttgccctt atgcataaag acgtattatc
     1501 tactaactgc gaaaacttag aagtgagtct tagaaggaat gtcattatac agcttctttc
     1561 tggttgtttt caagttggtc ccaaaatatg cagaagatgg gacctcggag cttcagtaca
     1621 gtattacatg ttttctgttc aattgaagcc ttaaaatggt ttgataagga tttttgtatt
     1681 ctcttcctgt ctctccagga ttatccttag ggtctttttt tttttttttt tttttttttt
     1741 ttctttttaa attcgaggaa gagtactttc aaaattccct agtgaagaag aaatatttac
     1801 tgattacatt tcttttccct tagggataaa gaaatggaga agagctttga agtagtaaga
     1861 cacaaaaata gagataggga ggaggtttca aaaaaccagg cccttaaact tcagctagac
     1921 aaccagtatg ctgtgcttga gaatcagaag tacagccaca cacagtacag ctaaggaatg
     1981 gtctttgcta agccttccaa ggtaactaga ccacagctaa ccaccaagaa cagccattca
     2041 tcgttttgat ttctggatct acagtgactg actgaagacc tcaagtccag tgactgtccc
     2101 tgttgcacta tggaagttca agagtcacga ctgatcttga tgtgtgttgg atttaggggt
     2161 gtttcattgt cttaaatatt tgtgaattag attcaacagt gtttccatag ttgctctgcg
     2221 tataaaacca aacctgcagc cagtggtcat tcaaacatct ttatgttcag atactgagcc
     2281 ttcgcaaggt tgactacctc agatttgctg cccttagttg tggatttcat gtggatcaca
     2341 tcttctacat aaggttacag ctactagtgt ctgtgtgaac cttgaaacca actctactgg
     2401 attcctgtca gaaagccttc agaagtcagc catctgggtt ctgagccgct gtaaaagatg
     2461 aagagttaag tgaccttaat taacctgttc tgtgccccat cctaaggcat actctgtagg
     2521 ctgtggctgt gttagactcc ctggaacaag ccgctgtcag aaatgatgtg tttggatcat
     2581 ctgtgtgggg cttatgattt ataatttaag tttttagttt tatgcggtaa ctggatttaa
     2641 ttcaaccaaa ctctggtcca ccaaatgggg agtgggtggg ggggtagtct tatttctttg
     2701 aataattttt cattcagata gtgcttgttc ggttccacat taaggccttg ctttgactca
     2761 gagtaagttc tttaagggca tattgtctga aatatgtctg aaagaagcat tggaattgta
     2821 aaatgcccta tgaatttgcc aatccttagg tggaaccaga tagcctttga tgcatataaa
     2881 ggacagcgga tccgctgcac tccaggtgct gctcaagcct cctaatcagg tctaattgaa
     2941 ctgctgtgga cagagtgtgg cgtctgctca ctgctgtgga cagagtgtga cgtctgctca
     3001 ggaggagagg gtttcactga cctggctttt aacagttcaa agcaacagga gcaaaacacc
     3061 caagttgcgc atgaatctgg catggtgtct gataaatcct tgtgtgtgcc ccaaatgtga
     3121 aggttatggg ctattcattg tttagccagc tcttgacatt caccttggga gtatgtttgg
     3181 taatcacttg gagacgcagg ggaatagtca gtaatgtagc atttctgttg taatttcaat
     3241 ttaactatct agtagtactt ggctcttaga agaggtttct gctaaatttc tttctaccta
     3301 atgaaatagc ctgtcagtta cctaccttgt cactacagat ggttcagtac acatactcta
     3361 tgttggcata tgactatgtg atacaatact agtgcctggg tttctctctg taaacgaatc
     3421 cctttgccaa acacaggtca gacttgctca ctactgacag gagtggaaca ggaaatggat
     3481 gttttcccag cttgagagca tgtttagtgg atttagggca gcagtgtagg aagcaggagg
     3541 tggaggccag tgtcacctga ccagactgta tgccacttca gagcaataat gttggcatga
     3601 tctgaaccag ccaggaggag gttgagtgat tagaggcttg agattcttag ttgaactgaa
     3661 gacttcattt gggcaccaga aacgttaaca ccttgagcca caaacttccc ttaaagtatg
     3721 cttcactcca gcgtgacaca caaacacaga ttctgtttgg ggttatggtt taagacgtga
     3781 acagaaacat gatgaggttt gtttaatggc atactgtact ggaacgctga agaactgcag
     3841 cagatgtaaa ttccaagtct tgttattttt taagattgtg aaattatcaa aatgcatatg
     3901 aatcaagttt taatacactg tctgggtgga tgaggctgtc cattgcacca tttctttctt
     3961 tgggttctca ggcatggttc tgacagtgta agaactctgt aacatttaac attgaataaa
     4021 cagtaaacca atggaaaaaa aaaaaaaaaa a
//
