LOCUS       NM_026014               2245 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus chromatin licensing and DNA replication factor 1
            (Cdt1), mRNA.
ACCESSION   NM_026014
VERSION     NM_026014.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Monteleone,G. and Stolfi,C.
  TITLE     CDT1 drives replication overlicensing and enhances tumorigenesis in
            the gutdagger
  JOURNAL   J Pathol 259 (3), 233-235 (2023)
   PUBMED   36541916
  REMARK    GeneRIF: CDT1 drives replication overlicensing and enhances
            tumorigenesis in the gut[dagger].
REFERENCE   2  (bases 1 to 2245)
  AUTHORS   Petropoulos,M., Champeris Tsaniras,S., Nikou,S., Maxouri,S.,
            Dionellis,V.S., Kalogeropoulou,A., Karamichali,A., Ioannidis,K.,
            Danalatos,I.R., Obst,M., Naumann,R., Delinasios,G.J.,
            Gorgoulis,V.G., Roukos,V., Anastassiadis,K., Halazonetis,T.D.,
            Bravou,V., Lygerou,Z. and Taraviras,S.
  TITLE     Cdt1 overexpression drives colorectal carcinogenesis through origin
            overlicensing and DNA damage
  JOURNAL   J Pathol 259 (1), 10-20 (2023)
   PUBMED   36210634
  REMARK    GeneRIF: Cdt1 overexpression drives colorectal carcinogenesis
            through origin overlicensing and DNA damage.
REFERENCE   3  (bases 1 to 2245)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2245)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   5  (bases 1 to 2245)
  AUTHORS   Wu,S., Wei,T., Fan,W., Wang,Y., Li,C. and Deng,J.
  TITLE     Cell cycle during neuronal migration and neocortical lamination
  JOURNAL   Int J Dev Neurosci 81 (2), 209-219 (2021)
   PUBMED   33448039
REFERENCE   6  (bases 1 to 2245)
  AUTHORS   Sugimoto,N., Tatsumi,Y., Tsurumi,T., Matsukage,A., Kiyono,T.,
            Nishitani,H. and Fujita,M.
  TITLE     Cdt1 phosphorylation by cyclin A-dependent kinases negatively
            regulates its function without affecting geminin binding
  JOURNAL   J Biol Chem 279 (19), 19691-19697 (2004)
   PUBMED   14993212
  REMARK    GeneRIF: Cdt1 function is negatively regulated by the Cdk
            phosphorylation independent of geminin binding
REFERENCE   7  (bases 1 to 2245)
  AUTHORS   Cook,J.G., Chasse,D.A. and Nevins,J.R.
  TITLE     The regulated association of Cdt1 with minichromosome maintenance
            proteins and Cdc6 in mammalian cells
  JOURNAL   J Biol Chem 279 (10), 9625-9633 (2004)
   PUBMED   14672932
REFERENCE   8  (bases 1 to 2245)
  AUTHORS   Luo,L., Yang,X., Takihara,Y., Knoetgen,H. and Kessel,M.
  TITLE     The cell-cycle regulator geminin inhibits Hox function through
            direct and polycomb-mediated interactions
  JOURNAL   Nature 427 (6976), 749-753 (2004)
   PUBMED   14973489
REFERENCE   9  (bases 1 to 2245)
  AUTHORS   Yanagi,K., Mizuno,T., You,Z. and Hanaoka,F.
  TITLE     Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a
            novel intrinsic Cdt1 DNA binding activity
  JOURNAL   J Biol Chem 277 (43), 40871-40880 (2002)
   PUBMED   12192004
REFERENCE   10 (bases 1 to 2245)
  AUTHORS   Arentson,E., Faloon,P., Seo,J., Moon,E., Studts,J.M., Fremont,D.H.
            and Choi,K.
  TITLE     Oncogenic potential of the DNA replication licensing protein CDT1
  JOURNAL   Oncogene 21 (8), 1150-1158 (2002)
   PUBMED   11850834
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048076.1.
            
            On Jun 19, 2003 this sequence version replaced NM_026014.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048076.1, AK012041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.91 cM"
     gene            1..2245
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /note="chromatin licensing and DNA replication factor 1"
                     /db_xref="GeneID:67177"
                     /db_xref="MGI:MGI:1914427"
     exon            1..257
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1715
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /note="retroviral integration site 2; retroviral
                     integration site 1; double parked homolog; retroviral
                     insertion site 2 protein"
                     /codon_start=1
                     /product="DNA replication factor Cdt1"
                     /protein_id="NP_080290.3"
                     /db_xref="CCDS:CCDS22741.1"
                     /db_xref="GeneID:67177"
                     /db_xref="MGI:MGI:1914427"
                     /translation="MAQSRVTDFYACRRPGLTTPRAKSICLTPSPGGLVAPAFTRSSS
                     RKRARPPAEPGSDQPAPLARRRLRLPGLDSCPSSLPEPSSPAEPSPPADPSPPADPGS
                     PVCPSPVKRTKSTTVYVGQQPGKIPSEDSVSELQSCLRRARKLGAQARALRARVQENA
                     VEPSTPDAKVPTEQPCVEKAPAYQRFHALAQPGLPGLVLPYKYQVLVEMFRSMDTIVS
                     MLHNRSETVTFAKVKQGVQEMMRKRFEERNVGQIKTVYPTSYRFRQECNVPTFKDSIK
                     RSDYQLTIEPLLGQEAGGATQLTATCLLQRRQVFRQNLVERVKEQHKVFLASLNPPMA
                     VPDDQLTRWHPRFNVDEVPDIEPAELPQPPVTEKLTTAQEVLARARSLMTPKMEKALS
                     NLALRSAEPGSPGTSTPPLPATPPATPPAASPSALKGVSQALLERIRAKEVQKQLARM
                     TRCPEQELRLQRLERLPELARVLRNVFVSERKPALTMEVVCARMVDSCQTALSPGEME
                     KHLVLLAELLPDWLSLHRIRTDTYVKLDKAVDLAGLTARLAHHVHAEGL"
     exon            258..416
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..568
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..766
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..912
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1010
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1199
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1352
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1554
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..2191
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2149..2154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /note="hexamer: AATAAA"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
     polyA_site      2191
                     /gene="Cdt1"
                     /gene_synonym="2610318F11Rik; DUP; Ris2"
                     /note="major polyA site"
ORIGIN      
        1 gaaagttgcg cggaatccgc gggaactacc tttttggcgc catggcgcaa agtcgtgtta
       61 ccgatttcta tgcgtgccgt cgccctggcc ttacgactcc gcgggccaag tcgatctgtc
      121 tcaccccgag ccctggtggc ctcgtggctc ctgcgttcac ccggagcagc agccgcaagc
      181 gcgcccggcc cccagccgaa cccgggagtg accagcccgc gccgctcgcg cgccggaggt
      241 tacggctgcc tggattggac tcctgcccca gttctctgcc tgagcccagt tccccagctg
      301 agcccagccc tccagctgac cctagccctc cagctgaccc tggctccccc gtttgcccat
      361 cccccgtcaa gcgaacaaag agtacaactg tttatgttgg tcaacagccg ggcaagatcc
      421 cctcagagga ctccgtctct gagctccagt cctgcctgag gcgggcacgg aagttgggag
      481 cccaggcacg ggccctgaga gcccgagtcc aagagaatgc tgtggagcct agtaccccag
      541 atgccaaggt gcccacagag caaccatgtg tcgagaaagc tcctgcctac cagcgcttcc
      601 atgctctggc tcagcctggt ctcccaggcc ttgtcctacc ctacaagtat caggtgctag
      661 ttgagatgtt ccgcagcatg gacaccattg tgagcatgct ccacaatcgc tctgagactg
      721 tgacctttgc caaagtcaag caaggtgttc aggagatgat gcgcaagcgc tttgaagagc
      781 gcaatgtggg ccagatcaaa accgtgtatc ccacgtcgta tcgcttccgc caggagtgca
      841 atgtccccac cttcaaggac agcatcaaga gatctgatta ccagctcacc atcgagccct
      901 tgctgggcca ggaggctggc ggtgccaccc agctcacagc cacgtgcctc ctgcagcgcc
      961 ggcaagtctt ccggcagaac ctggtggaac gtgtcaagga acagcacaag gtcttcctgg
     1021 cttcactgaa cccccccatg gcggtgccgg acgaccagct gacccgctgg catccgcgct
     1081 tcaatgtgga cgaggtgcct gacattgagc cagctgaact gccccagcct cctgtcacag
     1141 agaagctcac cactgcccag gaagtgctgg cccgtgcccg gagcttgatg acacccaaga
     1201 tggagaaggc cctgagcaac ctggccctgc gctcggctga gcccggtagc cctgggacct
     1261 ctactccacc actcccggcc actccgccag ccaccccacc tgctgcctct ccgagcgccc
     1321 tgaagggtgt gtcccaagca ctgctagagc ggataagggc caaggaggtc cagaagcagc
     1381 tggcaaggat gacacggtgc cccgagcagg agcttcgcct gcagcggtta gagcgtctgc
     1441 cagagctggc ccgcgtgctg cgcaatgtct tcgtgtctga gcggaagccg gcactcacta
     1501 tggaggtggt ctgtgcaagg atggtggaca gttgccaaac tgctctgagt ccaggggaga
     1561 tggagaaaca tctggtgctc ctggcagagt tgctgccgga ctggctcagc ctgcatcgca
     1621 tccgcacgga tacctacgtc aagctggaca aggctgttga cctggctggc ctcactgcga
     1681 ggctggccca ccacgtccac gccgaggggc tgtgactttg agctccttgc ctgtttcttt
     1741 catcagtaca cgacgcactt acgcctttaa gcctcgccag tgtgggcagc tatcgttgcc
     1801 catggatctc ataaagtgct ggcattaagt tgcttcctga ggctttgggg catcccagac
     1861 tcagctctag gggaagtaga ctctgaagag tagggtatgt tggatggcca ttgcacaaac
     1921 tactcaagca ttaggtatgg tcaagaccca agatcaaggt ccaggtggaa gcctaggctg
     1981 gcatagcctt gcttccccat gagacttaag aatcacacag accttggact ttcctgattt
     2041 cacgggacgc tgctctgaga gtgaaattgg gccttctgta aatatgtgaa gtgtggtttc
     2101 ttttcaaacc ttatatggcc ctgcatgtga ctgctagttt tggcttttaa taaagtcatg
     2161 taagatttaa ataaaatact actgagatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa aaaaa
//
