LOCUS       NM_001008424            2366 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus corneodesmosin (Cdsn), transcript variant 1, mRNA.
ACCESSION   NM_001008424 XM_359287
VERSION     NM_001008424.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   Godsel,L.M., Roth-Carter,Q.R., Koetsier,J.L., Tsoi,L.C.,
            Huffine,A.L., Broussard,J.A., Fitz,G.N., Lloyd,S.M., Kweon,J.,
            Burks,H.E., Hegazy,M., Amagai,S., Harms,P.W., Xing,X., Kirma,J.,
            Johnson,J.L., Urciuoli,G., Doglio,L.T., Swindell,W.R.,
            Awatramani,R., Sprecher,E., Bao,X., Cohen-Barak,E., Missero,C.,
            Gudjonsson,J.E. and Green,K.J.
  TITLE     Translational implications of Th17-skewed inflammation due to
            genetic deficiency of a cadherin stress sensor
  JOURNAL   J Clin Invest 132 (3) (2022)
   PUBMED   34905516
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Lecland,N., Hsu,C.Y., Chemin,C., Merdes,A. and Bierkamp,C.
  TITLE     Epidermal development requires ninein for spindle orientation and
            cortical microtubule organization
  JOURNAL   Life Sci Alliance 2 (2), e201900373 (2019)
   PUBMED   30923192
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Zaafouri,S., Pichery,M., Huchenq,A., Valentin,F., Oji,V.,
            Mazereeuw-Hautier,J., Serre,G. and Jonca,N.
  TITLE     Transcriptomic Analysis of Two Cdsn-Deficient Mice Shows Gene
            Signatures Biologically Relevant for Peeling Skin Disease
  JOURNAL   J Invest Dermatol 138 (6), 1431-1435 (2018)
   PUBMED   29277537
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   Sevilla,L.M., Nachat,R., Groot,K.R., Klement,J.F., Uitto,J.,
            Djian,P., Maatta,A. and Watt,F.M.
  TITLE     Mice deficient in involucrin, envoplakin, and periplakin have a
            defective epidermal barrier
  JOURNAL   J Cell Biol 179 (7), 1599-1612 (2007)
   PUBMED   18166659
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Patel,S., Xi,Z.F., Seo,E.Y., McGaughey,D. and Segre,J.A.
  TITLE     Klf4 and corticosteroids activate an overlapping set of
            transcriptional targets to accelerate in utero epidermal barrier
            acquisition
  JOURNAL   Proc Natl Acad Sci U S A 103 (49), 18668-18673 (2006)
   PUBMED   17130451
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Indra,A.K., Dupe,V., Bornert,J.M., Messaddeq,N., Yaniv,M., Mark,M.,
            Chambon,P. and Metzger,D.
  TITLE     Temporally controlled targeted somatic mutagenesis in embryonic
            surface ectoderm and fetal epidermal keratinocytes unveils two
            distinct developmental functions of BRG1 in limb morphogenesis and
            skin barrier formation
  JOURNAL   Development 132 (20), 4533-4544 (2005)
   PUBMED   16192310
REFERENCE   9  (bases 1 to 2366)
  AUTHORS   Yang,T., Liang,D., Koch,P.J., Hohl,D., Kheradmand,F. and
            Overbeek,P.A.
  TITLE     Epidermal detachment, desmosomal dissociation, and destabilization
            of corneodesmosin in Spink5-/- mice
  JOURNAL   Genes Dev 18 (19), 2354-2358 (2004)
   PUBMED   15466487
REFERENCE   10 (bases 1 to 2366)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU467494.10.
            
            On Jan 10, 2022 this sequence version replaced NM_001008424.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055373.1, BY734776.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               CU467494.10        131243-131354
            113-2366            CU467494.10        133730-135983
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.7 cM"
     gene            1..2366
                     /gene="Cdsn"
                     /note="corneodesmosin"
                     /db_xref="GeneID:386463"
                     /db_xref="MGI:MGI:3505689"
     exon            1..112
                     /gene="Cdsn"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1713
                     /gene="Cdsn"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="corneodesmosin isoform 1 precursor"
                     /protein_id="NP_001008424.2"
                     /db_xref="CCDS:CCDS28699.1"
                     /db_xref="GeneID:386463"
                     /db_xref="MGI:MGI:3505689"
                     /translation="MGSSRAPRMGSVGGHGLMALLMAGLILPGILAKSIGTLSDPCKD
                     PTRITSPNDPCLIGKTGSNSISSQGGSSSFSSQGGSSSFSSHGGSSSSQGSSSGSLIY
                     KPGTGYSQSSYSYGSGGSRPGGSGSQSGSSGSQSGSSGSQSGSSGSQSGSSGSQSGSS
                     GSQSGSSGSQSGSSGSQSGSSGSQSGRWVSSSSQWVSSSSQSGSSGSSRDRPGSGSAL
                     PTGDKTSGMSQSGGSSTSQSSSSNLRPCSSNVPDSPCSGGPVITHSGPYISGTHTVSG
                     GQRPVVVVVEQHGSGGPGFQGMPCSNGGPAGKPCPPITSVQKPYGGYEVVGGSANSYL
                     VPGMTYSGGKIYPVGYFTKDNPIRGSPGAPSFAAGPPVSEGKYFSSNPIIPSRGSSSS
                     SGYPVGVAFQPVGSGGVQPCGTGSVSSKGPCSGTRIQITSSSSSTSYHPCSGGPSQGP
                     CSSPGTGSISGGSSSLSSGKIVLQPCGSKSTSSGYPCLSVPSSPLNGGLNGSPQPVPS
                     VGVKLCGLNSPGRVPCRSIRNILTQVKPLGPQLMDPKVSLPQGEPQGEPLEKS"
     exon            113..2366
                     /gene="Cdsn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdsn"
                     /note="hexamer: AATAAA"
     polyA_site      2366
                     /gene="Cdsn"
                     /note="major polyA site"
ORIGIN      
        1 gtcagtcagg aggccacgct gtgcacaatg ggttcctctc gggcaccccg gatggggagt
       61 gtgggagggc acgggctgat ggcattgctg atggccggtc ttattctgcc aggaatcttg
      121 gctaagagca ttgggaccct ctcagacccc tgtaaggacc ccacgaggat cacctccccg
      181 aatgaccctt gtctcattgg aaagactggc tccaacagca tcagcagcca aggtggatcc
      241 agcagcttca gcagccaagg tggatccagc agtttcagca gccatggtgg atccagcagc
      301 tcccagggaa gttcttcagg atccttgata tataaaccag gaacagggta ttcccagagt
      361 agctactctt atggctctgg cggctcccgg ccaggaggca gtggctctca gtcaggaagc
      421 agcggctctc agtcaggaag cagcggctct cagtcaggaa gcagcggctc tcagtcagga
      481 agcagcggct cccagtcagg aagcagtggc tcccagtcag gaagcagtgg ctctcagtca
      541 ggaagcagtg gctcccagtc aggaagcagc ggctctcagt caggaagatg ggtaagcagc
      601 agttctcaat gggtaagcag cagttctcag tccggaagtt caggaagcag tcgcgacaga
      661 cccggaagtg gctctgctct accaaccggt gacaagacat caggcatgtc tcagtctgga
      721 ggctcgtcca cttcccagag cagcagctcc aacctgcggc cctgtagctc caacgtgccc
      781 gactctccct gcagcggggg gcctgtcatc acacactcgg ggccctacat ctctggcacc
      841 cacactgtat ccggtggcca gagacctgta gtggtggtgg tggagcaaca tggctctggt
      901 ggccctgggt ttcaaggcat gccctgtagc aatggaggcc ccgcaggtaa gccctgccct
      961 cccatcacct ctgtccagaa accctatggc ggctatgagg tggtgggtgg ctctgccaac
     1021 agttatctgg tcccaggcat gacctacagt gggggtaaaa tctaccccgt gggctacttc
     1081 accaaggaca accctatcag gggctcgcca ggggccccct cctttgcagc tgggccccca
     1141 gtctctgagg gcaagtactt ctctagcaac cccatcatcc ccagccgtgg ctcttccagt
     1201 tccagtggct acccagtggg cgttgcgttc cagcccgtgg gctctggcgg ggttcagccc
     1261 tgtggcactg gctctgtcag ctctaagggc ccttgctcgg gtacgagaat tcagatcacc
     1321 tccagcagct ccagtacctc ctaccacccc tgcagcggtg gtccttccca gggtccttgc
     1381 tcctcaccag gcaccggctc catcagtggg ggaagctcct ccctctcctc tggcaaaatc
     1441 gtccttcagc cctgcggcag caaatctacc tcttcgggtt acccctgcct ttctgttccc
     1501 tcctccccgt tgaatggtgg tctgaatggc tctcctcagc ctgtcccctc cgtgggtgtc
     1561 aagctctgtg gcctcaacag ccctggaaga gtgccctgcc gttccatccg caacattctg
     1621 acccaagtga agcctttggg accccagtta atggatccca aagtttctct gccacaggga
     1681 gagccacagg gagagccact tgagaagtct taagtcacgc atgccagcta ttttccaatt
     1741 gccagtcacc tcccaactgg aagacgtcca ggggcccagt ttcctgccct ccccccggga
     1801 gagctgcctc acatgctgcg gttagccgga tgatgctctt gactttattc aacactccaa
     1861 atggtggact ccatcctcct cgtcttttcc tggtgcttct gcaccatgct gctggggtgt
     1921 tctctctgtc cgattacctg ccttaaaaca cacttttttg actgggaagt cctcgaacgc
     1981 acacctcaac cttgggtgcc tggataagtc aagcatgctt ctgcccgttt gccaaataag
     2041 gcaaagtcca atccatcgcc tgagaaccaa actgcatgtc tcagcgaccc cccccccccc
     2101 accatccgtt cagtcagccc tctaaattgt tgggttccca ccattcatca tgagtttcac
     2161 cacaccctac cagacccatt tccagcacac ctgtgcctct ccttccccag ctctccatgt
     2221 cggtttctgc ctggttgtgc ttcatccaca gcacagatgt tactctgtgt gtgtgtgtgc
     2281 cccagggcag ccacagaatc tggcacagac tcccagttcc ctctggatcc tagacagggc
     2341 tcaataaact ttgtggactt tgtgca
//
