LOCUS       NM_138651               8412 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus CDP-diacylglycerol synthase 2 (Cds2), transcript
            variant 1, mRNA.
ACCESSION   NM_138651
VERSION     NM_138651.7
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8412)
  AUTHORS   Collins,D.M., Janardan,V., Barneda,D., Anderson,K.E., Niewczas,I.,
            Taylor,D., Qiu,D., Jessen,H.J., Lopez-Clavijo,A.F., Walker,S.,
            Raghu,P., Clark,J., Stephens,L.R. and Hawkins,P.T.
  TITLE     CDS2 expression regulates de novo phosphatidic acid synthesis
  JOURNAL   Biochem J 481 (20), 1449-1473 (2024)
   PUBMED   39312194
REFERENCE   2  (bases 1 to 8412)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8412)
  AUTHORS   Xu,J., Chen,S., Wang,W., Man Lam,S., Xu,Y., Zhang,S., Pan,H.,
            Liang,J., Huang,X., Wang,Y., Li,T., Jiang,Y., Wang,Y., Ding,M.,
            Shui,G., Yang,H. and Huang,X.
  TITLE     Hepatic CDP-diacylglycerol synthase 2 deficiency causes
            mitochondrial dysfunction and promotes rapid progression of NASH
            and fibrosis
  JOURNAL   Sci Bull (Beijing) 67 (3), 299-314 (2022)
   PUBMED   36546079
  REMARK    GeneRIF: Hepatic CDP-diacylglycerol synthase 2 deficiency causes
            mitochondrial dysfunction and promotes rapid progression of NASH
            and fibrosis.
REFERENCE   4  (bases 1 to 8412)
  AUTHORS   Stratman,A.N., Farrelly,O.M., Mikelis,C.M., Miller,M.F., Wang,Z.,
            Pham,V.N., Davis,A.E., Burns,M.C., Pezoa,S.A., Castranova,D.,
            Yano,J.J., Kilts,T.M., Davis,G.E., Gutkind,J.S. and Weinstein,B.M.
  TITLE     Anti-angiogenic effects of VEGF stimulation on endothelium
            deficient in phosphoinositide recycling
  JOURNAL   Nat Commun 11 (1), 1204 (2020)
   PUBMED   32139674
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8412)
  AUTHORS   Zhao,W., Cao,L., Ying,H., Zhang,W., Li,D., Zhu,X., Xue,W., Wu,S.,
            Cao,M., Fu,C., Qi,H., Hao,Y., Tang,Y.C., Qin,J., Zhong,T.P.,
            Lin,X., Yu,L., Li,X., Li,L., Wu,D. and Pan,W.
  TITLE     Endothelial CDS2 deficiency causes VEGFA-mediated vascular
            regression and tumor inhibition
  JOURNAL   Cell Res 29 (11), 895-910 (2019)
   PUBMED   31501519
  REMARK    GeneRIF: Endothelial CDS2 deficiency causes VEGFA-mediated vascular
            regression and tumor inhibition.
REFERENCE   6  (bases 1 to 8412)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   7  (bases 1 to 8412)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 8412)
  AUTHORS   Jenner,J., Kerst,G., Handgretinger,R. and Muller,I.
  TITLE     Increased alpha2,6-sialylation of surface proteins on tolerogenic,
            immature dendritic cells and regulatory T cells
  JOURNAL   Exp Hematol 34 (9), 1212-1218 (2006)
   PUBMED   16939814
REFERENCE   9  (bases 1 to 8412)
  AUTHORS   Inglis-Broadgate,S.L., Ocaka,L., Banerjee,R., Gaasenbeek,M.,
            Chapple,J.P., Cheetham,M.E., Clark,B.J., Hunt,D.M. and Halford,S.
  TITLE     Isolation and characterization of murine Cds (CDP-diacylglycerol
            synthase) 1 and 2
  JOURNAL   Gene 356, 19-31 (2005)
   PUBMED   16023307
  REMARK    GeneRIF: Cds2 showed a ubiquitous pattern of expression and was
            mapped to chromosome 2G1.
REFERENCE   10 (bases 1 to 8412)
  AUTHORS   Volta,M., Bulfone,A., Gattuso,C., Rossi,E., Mariani,M.,
            Consalez,G.G., Zuffardi,O., Ballabio,A., Banfi,S. and Franco,B.
  TITLE     Identification and characterization of CDS2, a mammalian homolog of
            the Drosophila CDP-diacylglycerol synthase gene
  JOURNAL   Genomics 55 (1), 68-77 (1999)
   PUBMED   9889000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ112406.1, AK147541.1, CD351907.1, BQ572878.1, AK017677.1 and
            AI854580.1.
            
            On Mar 22, 2014 this sequence version replaced NM_138651.6.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147541.1, AK036328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               CJ112406.1         2-110
            110-4409            AK147541.1         2-4301
            4410-4978           CD351907.1         24-592
            4979-6000           AK147541.1         4872-5893
            6001-6597           BQ572878.1         16-612
            6598-7833           AK147541.1         6491-7726
            7834-8019           AK017677.1         852-1037
            8020-8412           AI854580.1         1-393               c
FEATURES             Location/Qualifiers
     source          1..8412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 64.15 cM"
     gene            1..8412
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /note="CDP-diacylglycerol synthase 2"
                     /db_xref="GeneID:110911"
                     /db_xref="MGI:MGI:1332236"
     exon            1..350
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1631
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /EC_number="2.7.7.41"
                     /note="isoform a is encoded by transcript variant 1;
                     phosphatidate cytidylyltransferase 2; CDP-DG synthase 2;
                     CDP-DAG synthase 2; CDP-diglyceride synthase 2;
                     CDP-diglyceride pyrophosphorylase 2; CTP:phosphatidate
                     cytidylyltransferase 2; CDP-diacylglycerol synthase
                     (phosphatidate cytidylyltransferase) 2"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase 2 isoform a"
                     /protein_id="NP_619592.1"
                     /db_xref="CCDS:CCDS16772.1"
                     /db_xref="GeneID:110911"
                     /db_xref="MGI:MGI:1332236"
                     /translation="MTELRQRVVREDAPPEDKESESEAKLDGETASDSESRAETAPLP
                     TSVDDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMMIVMCVQI
                     KCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRI
                     LSKYHRFISFALYLTGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLF
                     EGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLL
                     SYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSAIGWKTVRMYPF
                     QIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFV
                     NVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLKSHLTDKGILTSALEDE"
     exon            351..487
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            488..584
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            585..682
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            683..822
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            823..881
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            882..964
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1052
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1121
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1274
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1394
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1498
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..8396
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3938..3943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /note="hexamer: AATAAA"
     polyA_site      3968
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /note="major polyA site"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /note="hexamer: AATAAA"
     polyA_site      8396
                     /gene="Cds2"
                     /gene_synonym="5730450N06Rik; 5730460C18Rik; D2Wsu127e"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtctggg gttccaggcg gagatggcgg cagtgcgcgt gcgcgctggc tcgcagcttc
       61 ccgggaggag gagcgagcgg ccgctgggga aacagcggct ccgctctccg ggcaagggcg
      121 gcggcagcgg tgctgggcgg ggccgggctc ggggctagtg gcgctgctgc aggggctgtg
      181 cgaggcacgg tggggctgcg aggtgctcgg gcccgccgag agcccgtgct cactgagccg
      241 acccccgcgg ccaccgtgct gctcactcgg ggtgacgtcg cgccggggtc cccagcatga
      301 ccgaactacg gcagagggtt gtccgcgagg acgcacctcc ggaggacaag gaatcagagt
      361 ccgaagcaaa gctagatgga gagacagcgt ctgacagcga gagccgagcg gaaacagctc
      421 ccctaccaac ctccgtagat gacaccccag aggtccttaa cagggccctt tccaacctgt
      481 cctcaaggtg gaagaactgg tgggtgagag gcatcctgac tttggccatg atcgcgtttt
      541 tcttcattat catttacctg ggaccaatgg ttttgatgat gattgttatg tgtgtccaga
      601 ttaagtgttt ccatgaaata atcactattg gctacaatgt ataccactcc tacgacctgc
      661 cctggttcag gaccctcagc tggtacttcc tgctgtgtgt gaactacttc ttctatgggg
      721 agacagtgac ggactacttc ttcactctgg tccagagaga ggagcctttg cggatcctca
      781 gtaaatacca ccggttcatc tcctttgccc tgtatctgac aggattctgc atgtttgtac
      841 tgagtctagt taagaagcat tatcggctgc agttctacat gtttggctgg acccatgtga
      901 ccttgcttat tgtcgtaacg cagtcacacc ttgttatcca taacttgttt gaaggaatga
      961 tatggtttat tgttcccatc tcgtgcgtca tctgcaatga cattatggcc tatatgtttg
     1021 gctttttctt tggtcggacc ccactcatta agctctctcc aaagaagacc tgggaaggct
     1081 tcattggggg cttctttgcc actgtggtgt ttggcctttt gctctcctat gtgatgtctg
     1141 ggtacagatg cttcgtgtgt cccgtggaat acaacaatga caccaacagc ttcactgtgg
     1201 actgtgagcc gtctgaccta ttccgcctgc aggagtacaa catccctggg gtgatccagt
     1261 cggccattgg ctggaaaacg gtgaggatgt accctttcca gatccacagc atcgccctct
     1321 ccaccttcgc ctcgctcatc ggccctttcg gagggttctt cgccagtgga ttcaaacggg
     1381 cctttaaaat caaagatttt gccaatacca ttcccggtca tggaggcatc atggatcgct
     1441 ttgactgcca gtacctgatg gccacctttg tcaatgtgta catcgccagc tttatcaggg
     1501 gtccaaaccc aagcaaactg atccagcagt ttctgacgtt gcggccagat cagcagcttc
     1561 acatcttcaa cacgctcaag tctcacctaa ctgacaaggg gattctgaca tctgccttgg
     1621 aagatgagta gagtccacct ggggcccaga gagctggagc aggatggagt gggggccagt
     1681 cgccaaggcc gcccagctgc tgtgacttag ataatgaaaa gcttcaactc accaccgtca
     1741 tttttttttc tttttccttt ttgtgcgtgt gtggttttta atctgtatat actgtctgtt
     1801 tatagtgtgg gcagtgagta agctgtagct ttgagttgca aagaagtcac aggaaagaac
     1861 catttgggtt tctgaagtac aagtattgag caacatgaag ggcagtgttg cccagctcag
     1921 ggtgtctgct tggtggctct aacccctgcc catccagttg tttctgggct gtgcgagaga
     1981 tcatacattg atctgtgtgt gatgagttga gggctttccc acctgcacgg gccttcacgg
     2041 gctccacgct tttgctgtcc ttgacacctc tcgttggggc ttctgcaggc atctctgtct
     2101 gagagcagtg ggggctgccc tctgtagagc tgtgagagca gtgggggctg ccctctgtag
     2161 agctgtgaga gcagtggggg gctgccctct gtagagctgt gagagcagtg gggggctgcc
     2221 ctctgtagag ctgtgagagc agtgggggct gccctctgta gagctgtgag agcagtgggg
     2281 gctgccctct gtagagctgt gagagcagtg ggggctgccc tctgtagagc tgtgagggag
     2341 aggctttctg atcagatgaa catctgtcca agccaaaatt ctgcagaggg caggtgagct
     2401 ttgcttatgt agtttgcttt caccatatag actgagagaa gatttcagac ttctttttct
     2461 cagaaagcat gaagaattta tgaagtatgg aaaagaagcc cttacatatt ccagatgtgt
     2521 gcagcagggg gcactgtccc agccctctct gccccagcca ggcacagtgg cctctagagg
     2581 gtggtcctgt agaccgcacc ttttagagtc gaggcctctg tggttgtgcc gcgggtttgc
     2641 tgctgtgctg agtccttctg ggggagccct aagaggtggg gagcagagga cttttgctca
     2701 gacacccttt gcctggaagc ccacttgtgt tgctgctgtg ttgtgtatat agtattctcg
     2761 agatgagcgt atgtgtgtct gtttaaaagt caccttgttt cctacatgat tttagtcata
     2821 cccaaacgtc ctcagaatcc ctacatcctg cttagaactg tggccggcct aatctgtcaa
     2881 gaggcttggc tcttcaagac tcagtgtcca ctttatcaaa tgtgaccggt gtagctgtag
     2941 tttgtacttt cctggggacc ttctgctggg gtttgtgtaa gctgtgattc tttcccttcc
     3001 taataggttg agcttgacat ggaaaggagc agttggcagg gaaggaactt attccccaag
     3061 agtggtaact aacccacagc cctgctcggt gtgcccaccg ctgagaggct gcagtgactt
     3121 ccccaagtac cgtggtctgt gctaatttgt tttcagatta gtcttcctgt ggcctccaac
     3181 actcagccag ccctcagagt gtccgctgtg cgcacggggg cggggcgggg cgggcagctc
     3241 cttgtctctc agctttgact gacttgtccg cattggggat ttttgttctc agctcccagg
     3301 ccgcactgaa cacagtgttg ctgccttcag tttggttctg gccatgaggc ccctagtggg
     3361 agctttgccc ttagggctgt cctctgactt gccctcaaag ttcaccaatt cggcaactcc
     3421 atggagacgg tcgtgtcact ctcagcccct gttgctatta agtcatgtca tgggcacccg
     3481 gaaaaggaaa tacactgagg tgtattttac aattgctcct taagattctc agtggagatt
     3541 aggagcaaca ctgcacttct gatagaaaaa tggccttgga tcactaaact aggtagagaa
     3601 gggcacacca caccccagcg ccccaggagc caaaactcac gctcgggcag cagcagctga
     3661 ggcttgagga agctggtgtc ctaagacact gaaacccagt gctcattgga gctgccagcc
     3721 acaggtttct attctgagtt ctccagtctt gtgaaagagg agaatttccc agtcaggtag
     3781 ccaggagaac agtgccaccc tgcgattgtg ccaccctgtg attgtatagc gtgttgtttg
     3841 ttccagtaag caggcaggcc cagagactgc tttctcagca ccgcacagat ctcagtgggt
     3901 cacataactt gctttacact catcttgttg tgtcagaaat aaagtgttcg tgcttttcct
     3961 tgtcaggagt cccgtgtttg tcacttgttg tgtggtttta tgtttcccgc tgtgtgagca
     4021 taaacactgt gcagttttcc tgcttgccag cctgtgtgcc atctgttctc acagcctctg
     4081 agatgtctca ggtgagagcc atggggtgga accataaagt ccccatctca aagtgtgcct
     4141 gtgggacagg gttagtagct actccccgag gccccaaccc gggaaatact gcagtgttcc
     4201 ttcctgcagg ccttggagcc ctgaccaggc cagtcctggg cactgcttag atggctgtta
     4261 gcttagaact ggtgaagtaa agatttggtc ccagaaacca gcctgacatg agaacaagcc
     4321 agggtgtctt cctggtgagt tctactcatg gtcgttctca ggaaaactgt gttccctttg
     4381 tgtgtacgtt tctcacccct taaccacttc agtgtcaaaa aagttcccat tgtgtcttct
     4441 gaaagtgaag tcccataagg aagttgggag agaatgtgca gggtgcacac acgcatgtac
     4501 aaacacacac acacacacac acacacacac acacacacac acacagagcc tatttcacat
     4561 tctcagactt ttagtttctg ctttataacc gcatttaaaa tgtattctta atgtgctgta
     4621 gtgtgtgtga gccggtgtcc agaggtgtga aatataccat gtaatctcac acaggtggac
     4681 tgtggaaccg tttttatgga ttttgcccct gcttgctttc atcctgtaac ctagcctgta
     4741 ttatacaaga aaacttgagc aggacatttc aagagaatat gttggcctaa ttgttgggtt
     4801 ggctgggacc tgctctgaag ggatccctca gttcaccgat tggcaagcca aggtcagtcc
     4861 ttgctgttga tggagctggg aggaggaggg acctaaggac tcaggacaga gcatctcacg
     4921 cgaagttctg tgtggcagtc aagtgttcct cgtggagtca gcctgaggta gatttccagg
     4981 aaagcctttt cctcgttacc agtgtgtgat gtcacaactg aaacttgtgt tagtaacgtc
     5041 taaggccatg ttgcctttgt ctttagagta attcctggct gtgcctacca ctcctgcata
     5101 ctgtgcttat gtgcgtgctg cgctttgatg gggaggaggg caggtccctg tgcagccagg
     5161 gttcttgctc cttccatggc aggatgagaa ggaaggccta agaggctggc caggggcctg
     5221 gtgtagacac agtagaagac agtcaactat gggcgcattc tgtctggagc tcccagaagg
     5281 agctgtgtgc tgctggagag gaggctaatt gttggttcag actcctccgc ttgggtaaaa
     5341 gactcccctt atcactctcc tcacagttgc tctgcatctt taaagagtat tagcttctgc
     5401 ttccggactc agtctttgtt gagtgggcca cttccagggg tgtgcccggg gttaggcaag
     5461 tggcagacga gggttcttat ttgaggcttt gctaggctca tctgctgtgt cctgggtagt
     5521 ccactcatat tcttgcaggg tgagtccatg ctcaggagaa tgcggtccac ctttctatgt
     5581 actctagctt ccctctcttc aggttgatat agcgacatta cctgggctct gtgctgtcct
     5641 gtgggtggag gccattatca ctgggctgct gctttcctgg gcaagccact ctctattttt
     5701 ctgcaaaggt caaaagaccc tggtgttggg ggccctttag agggtgtgct ttggacgctg
     5761 acctcttagg gctttaggac agagggacga tgttgagtct agaagggcac aatatgccag
     5821 agttttatgg ccagtgatcc tcaaatccat tggctgtttg aagaccctgt cctcacttct
     5881 ccttttttca ggtgactctc tgcttggctc tttatcttac tcttcagcta atgaagtagc
     5941 aacagtgtgt tactaatgat tgcaatcata cagtgcttaa tatgtgccag acacagtgcc
     6001 aagggcttgc atgcattatc tcctttaatc cacaagcagc tctggcgagg tggtattagc
     6061 ccatcttaca gatgggaaaa ctgaagttct gtgctagaga ttgagaacaa tgtaaagact
     6121 tgaggcttag gtagtgctct atctggtcag gctataggct gcgggcagcc ttcacttcca
     6181 accagccgct gtgaggattt agtgagctaa cgcatgtaag catttagcaa ggtgcctggc
     6241 acatagtaag cactcaataa atggtagttt ttttgttctt ttaaactgag ctcagcgagt
     6301 ttggcccaca ctggtgggct gctgggtatt cagccaccac actcttcact gcttggacct
     6361 agttggtgtt tgtgttctgt aaagtgagca cgttgtcctc ccaagagaag cacttcagtg
     6421 gtgcagtggt aagagcccac agcattgagg ccagcctgac tgaaggatga tgtgaggctg
     6481 tttgtcactt ctgttctttt ccccgtggtt gagactgccc acaggaaaag ggctggctgc
     6541 tctgacatgg tggggcgtct cctggggcct ggctcgctct ggaccctgct ctccccagcc
     6601 acgttctgta gtctgttgta catctcagga accctcggtt cctccacgga tggacgactg
     6661 cagaatagag cagaatagag aaagtaagcc tgaagctgag tgcctcagcc acaaacctaa
     6721 aggagctgcc tgtgtctgac agcacagcca ttccatctct tccgtccgtc tgtctgtctg
     6781 ggttgttttg ttttgttgtt gttttgagac agggtttctt tgtgtagccc tgactgttct
     6841 ggaacttgct ctgaagacca ggctgacctc gaactcagag atctgcctgc ctctgcttcc
     6901 caagtgctgg gattaaaggc atgcgccacc ttcacctggg ttttctttct taaaggaaca
     6961 ggttagagca agtgaccgtt gaggacaggt gatgtgaatg tttgttctag atttaattca
     7021 gttttctgaa tggacacagg gagttgggag tatgtgtgtg tgtgtgtgtg tgtgtgtgtg
     7081 tgtgtgtgcg cgcgcgcgcg cgcgtgtgtg tgtgcttcac cttgattgag tggcattggc
     7141 tcacatgacc caggagattc ccagactctg ttagtagtgt ctaggaactt gtgttccagc
     7201 tgaggagtgt cccaggtgtt aacgagactg aggcctattg ctggagttca gatactgcag
     7261 ctcctcttgt ttttctgcac tgtgtttgcc agccctgccc ccatctgatg gaccaggcag
     7321 tcctttatct ggagggaaaa gtctgatgcc agcagaggtc ctggggcgct gctctcccag
     7381 gtcctggtca gactcagctc catagctctt ggaggctttc cctggattcc ctgagtacag
     7441 tgttaaaagg cctaaccaca cagccacctg ccctaagtga cattgtgttt ttaggtgtca
     7501 ccgtcttagc cctttgtttt ccttactaga gtatctttcc cgcaccccta ggtttgtatt
     7561 ctggttctac tggcttttct cagtgggaca ccaaggtaga aagggagtaa gaatggtttt
     7621 ccagtgagtt gaatgtgcac acgtttatga gaggcctttg ggtgagcttt ctgctcattc
     7681 cttggtttgt cttgggtccc actgggcagg tgtctagcac tgagagggag agtgtagaca
     7741 agggagccac ggaggtactg gaggcagcaa ttcctcatcc agctcaggga ctcctgacag
     7801 ccaaggggac agcaagagga cccagagcag ggaaaggggt cggggagtca cacaaccaaa
     7861 ggtagactca gaccagttca gtgctcctgg tggccatagg gaccagaaag cagcttagga
     7921 aatctatcca ttggcccttt tagagtctct gtgtgaaccc aactctactg aacttaaaca
     7981 ccttccaaac agtggcaggg gccacagtgg cagacagggt agagtacccc aggcagtttc
     8041 tcagcctcgt ccgttgtgtg gagggaatac tgaattcagt tatctcacct gactgctttc
     8101 ctgccctcag acctggacac tgggcctcag cccctggccg tgtggaatcc atgggatcct
     8161 cgggactccc cagacaggcg tgtgtgagtg tgttctgtca tgcagcctca gcccaggcta
     8221 acccagtcag tgttttcacc acgtctgacc tttctctctg cacttaggat tggtgtccac
     8281 ttgtagattt ctttcaacac agtataagaa tgtgatatat tgtatattgg aaagtattta
     8341 ccttatttat atacctgaat gttcctatta aacaaataaa catatactaa attctaaaaa
     8401 aaaaaaaaaa aa
//
