LOCUS       NM_001417860            3889 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CDP-diacylglycerol synthase 1 (Cds1), transcript
            variant 4, mRNA.
ACCESSION   NM_001417860
VERSION     NM_001417860.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Qi,Y., Kapterian,T.S., Du,X., Ma,Q., Fei,W., Zhang,Y., Huang,X.,
            Dawes,I.W. and Yang,H.
  TITLE     CDP-diacylglycerol synthases regulate the growth of lipid droplets
            and adipocyte development
  JOURNAL   J Lipid Res 57 (5), 767-780 (2016)
   PUBMED   26946540
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Araujo,D.J., Anderson,A.G., Berto,S., Runnels,W., Harper,M.,
            Ammanuel,S., Rieger,M.A., Huang,H.C., Rajkovich,K., Loerwald,K.W.,
            Dekker,J.D., Tucker,H.O., Dougherty,J.D., Gibson,J.R. and
            Konopka,G.
  TITLE     FoxP1 orchestration of ASD-relevant signaling pathways in the
            striatum
  JOURNAL   Genes Dev 29 (20), 2081-2096 (2015)
   PUBMED   26494785
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Inglis-Broadgate,S.L., Ocaka,L., Banerjee,R., Gaasenbeek,M.,
            Chapple,J.P., Cheetham,M.E., Clark,B.J., Hunt,D.M. and Halford,S.
  TITLE     Isolation and characterization of murine Cds (CDP-diacylglycerol
            synthase) 1 and 2
  JOURNAL   Gene 356, 19-31 (2005)
   PUBMED   16023307
  REMARK    GeneRIF: Cds1 showed a very restricted expression pattern and was
            mapped to chromosome 5E3.
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Volta,M., Bulfone,A., Gattuso,C., Rossi,E., Mariani,M.,
            Consalez,G.G., Zuffardi,O., Ballabio,A., Banfi,S. and Franco,B.
  TITLE     Identification and characterization of CDS2, a mammalian homolog of
            the Drosophila CDP-diacylglycerol synthase gene
  JOURNAL   Genomics 55 (1), 68-77 (1999)
   PUBMED   9889000
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Lykidis,A., Jackson,P.D., Rock,C.O. and Jackowski,S.
  TITLE     The role of CDP-diacylglycerol synthetase and phosphatidylinositol
            synthase activity levels in the regulation of cellular
            phosphatidylinositol content
  JOURNAL   J Biol Chem 272 (52), 33402-33409 (1997)
   PUBMED   9407135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121983.3 and AC172745.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1427480.1,
                                           SRR13422600.522165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC121983.3         137528-137818
            292-419             AC121983.3         153704-153831
            420-3889            AC172745.4         21325-24794         c
FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.93 cM"
     gene            1..3889
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /note="CDP-diacylglycerol synthase 1"
                     /db_xref="GeneID:74596"
                     /db_xref="MGI:MGI:1921846"
     exon            1..291
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..597
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /EC_number="2.7.7.41"
                     /note="isoform c is encoded by transcript variant 4;
                     phosphatidate cytidylyltransferase 1; CDS 1; CDP-DG
                     synthase 1; CDP-DAG synthase 1; CDP-diglyceride synthase
                     1; CDP-diglyceride pyrophosphorylase 1; CTP:phosphatidate
                     cytidylyltransferase 1"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase 1 isoform c"
                     /protein_id="NP_001404789.1"
                     /db_xref="GeneID:74596"
                     /db_xref="MGI:MGI:1921846"
                     /translation="MLELRHRGGCPGPGGAGAPPPREGEAAGGDHETESTSDKETDID
                     DRYGDLDARGDSDVPEVPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFL
                     IIYMGSFMLMLLVSDWRLPGCLWVLVRVYHGRHLSMSS"
     exon            292..419
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            420..3889
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3864..3869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3889
                     /gene="Cds1"
                     /gene_synonym="4833409J18Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgtgga acggcgcacc tggcaacggc gccgcgtccc cgcccgcgcc ggtccgcaca
       61 ccctgccggc ggcctcgagc gctcgctcgt tgatgccgtt ctgggggtga cccggcgcgg
      121 ctccgcggtg gcggggcgct agacgacgcc agcccagcga cgcgggagcg ggacatgctg
      181 gagctgcggc accgcggggg ctgccccggc cctgggggag cgggggcgcc gccaccccgc
      241 gagggagagg cggccggcgg tgaccacgaa accgagagca ccagcgacaa agaaacagat
      301 attgatgaca ggtatggaga tctcgatgcc agaggcgatt ccgacgtgcc tgaggtccca
      361 ccgtcctcag acaggacccc cgagattctc aagaaagccc tgtccggact atcttcaaga
      421 tggaagaact ggtggattcg cgggatcctc accctcacca tgatctccct cttcttcctg
      481 attatctata tggggtcctt catgctgatg cttctggtaa gtgattggcg tcttcctggg
      541 tgcctctggg ttttagtgcg tgtgtatcat ggaaggcatc tgagcatgtc atcataacaa
      601 aggtagctga agtcttggca acagcaaatt cagttccttt aagtattttc cagttcatga
      661 aatgatctgg actcatcttt actgtctgca aaatggttcc tcagtgtgct cattcagcag
      721 agacgagtgt acttttctat ggaggcgcct gtgtatccag catcatgcag agcattgaac
      781 cacttccatg tatttaccta tgactagttc cccgacttca agcaagttag tttagcagca
      841 gaaacgttca gttgaccaga taactcgcta gcattaagta aatcgtgata agtcttgttg
      901 cggatgatgt gttaagcaga agggcagaga ggcgttgtta tgcagtgtga gacaggggta
      961 acaaaaggca tacagagaga tgatacccaa gtctgatcct gaaggctaca cagagaaaat
     1021 aaggtggatt tcagggtgga tccccagtgg caaggcaggg gatagtgaga gagatggcgc
     1081 ggcttctgca caggatctgg gttggcctgt ggatggccgc cagggatgag actggagagc
     1141 tgggtagaag cctttctggg aggtttagat gtgcatggga agccaaacaa gtcatgaggg
     1201 caaacggata acttaagctc ttacttcatc ctttgataag tgccttcgag gtgactggtg
     1261 tgtgccagcc attacagtag cactggggta tgctagtggt ggcgctgaga aaatcatccc
     1321 agtcttcatt ttgatggagc ttattgttta tactgtaaag aatggattag ctgcttctaa
     1381 taacaaactg cagtgtgtta aataaagacc ggttctctga gagcaggaga ggaaggagtc
     1441 agaggacttt ctggaagcat tgtgcaacac gggagcttcc ttctgaaggt tgtgtaggaa
     1501 tcagggagga gaaggaagga ggtgggagta gaggtgctcc tcacagagag tgtgggccca
     1561 ggagtggaag ccaggagtcc atgagttcta tagacttagc aggagttcca aggtctccaa
     1621 gcatggtttt gcagtgaata gtgacacaca tcctcagggg catatacatg tccctcatta
     1681 tgaggatgac ctgagaaggt gacaatgctc tctgggtaaa acggtactcc ctctcctagc
     1741 cagtccccac tgctaccagg ttctcccagt gcacacttgt gcagtgggta gctgcaccag
     1801 gctctcctcg tgcacacatg tgcagcaggc agctgtgcct tactgctttc ttatcttgtc
     1861 tcagtttgtt cagcccctcc ctgcgtgtac cttcccattt tcctgcctcc tagagcatct
     1921 gaatgcattt accagtcttc ctgtctttca ccccagtact gtgctcctct tcccacacct
     1981 cctgtgtttg tcttgagcgg tatatgttat tcctaccatg ccttagcttg tcctgtcagc
     2041 actttacagt gctcagttca ggggagtttc atagaaagcc catttctaac aagcatggtg
     2101 gaatgacacg cctgttgttc ccgcagagac gggagggtca aagtgtgaag gtgtgagacg
     2161 tgaaggagtt ctaggccagt ctgcagctgc tagcaagacc tcatctcaaa aacaaacaaa
     2221 caaataaaaa gataaagaag atgaagtact ttctttaagc cctcacttta gggagtgctg
     2281 gctgcctcgg gacacatctt agtttacacg gagtgtccct ctgtcccctg gttatagttg
     2341 ggttgtgctc gctgaagcca gctttctagt gatgtcatta ctgtgcacac tgggagataa
     2401 aggcatctga gagcatagag aaggtacagt gggaggtttc cttgccctct ctaataattg
     2461 ttagttcaca ttataggatt cactgtgaat ccttagcctt tctattgtga ggatggaagt
     2521 accccaagtc taccatcaac tgcccaaacc cacaccaggc tgctgctggc tatctctcat
     2581 ttgctctttt agtttttgct ttaaaaatca ttgctataac aatactatga ttaaagtttt
     2641 gtgccctatt tttcaaagtg tggtattgtt ccaccatctc taccctccag ctgtggtatg
     2701 ttccgctata taagggactg tgaagcgtcg tgggatttaa gtcacttgct atttttaaac
     2761 actcaggtta cgctcagttt ctgtaatgag taacactatg gtgaacatac cccagctcaa
     2821 aaacgttctg gtttcttctt agactagatt cctcagataa aaataggctt tcttgtttgc
     2881 atatccctta gatgacattc aacatgccca aatcctgtgt ctggtctgtt gcgccaggtt
     2941 ttcctggcca ctccgtgttc ctcctcatcc ttaactcttt tgcttatggc gtaatgcccc
     3001 cctcaaaagg ttcctaagtg aaggcttggt tcccacctgg aggatgtcca cactgagaga
     3061 tgccagatcg cggggcccga cctagtcagg gagtccacct gacggaagtg ttgggaggtg
     3121 tttggaggaa gtagatcaga gatgtgggtt tgggggctgt atcttgtcct ggacttgtct
     3181 ctattccagt ccgtgcttcc tggcctcgtc tgtgccctcc tgcagtggtg ttctgcctca
     3241 gcacagatgc cccaaaccta aattgaaacc tctgaagtaa atccttttat gtcatttttg
     3301 tcaggtggta cattcccagt ttccttgttg acagactcca gtctccctgt gtcctctgcg
     3361 agatgccctc tgctggtgtg gtcatgtcat atcttgtagc ctgcattact gtctgctttg
     3421 ccacctcccc agtccatgct cactccctct gttgacaaat actcgggccc ttcctctcct
     3481 gccacccctc gctgtggagc tctgttcgca cccacgtctg tacactgaca gctcggaagt
     3541 actcatactt accttagcat gctccagtcc tctgcaggca tggctgccga tcccccgcct
     3601 cccacaggtg tgcacgctca tttccacata atttctacgt gccatcattg ttttgagctt
     3661 atcccatgcg ctctgagagc acatgtcctg actcatttcc aggcatcctc agtaacaaga
     3721 gcactgagct tctaaagaat tggctgttgt ttttaaggct cttaacgcat cagttgggtc
     3781 aatgaacttt tttcagtgat tattgctacc aatatcaatg gtacagggta tcaattccta
     3841 tgtaatctcc tagtccttaa taaaataaat gcattttaaa gatttttaa
//
