LOCUS       NM_007672               2525 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cerebellar degeneration-related 2 (Cdr2), transcript
            variant 1, mRNA.
ACCESSION   NM_007672
VERSION     NM_007672.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Blachere,N.E., Orange,D.E., Gantman,E.C., Santomasso,B.D.,
            Couture,G.C., Ramirez-Montagut,T., Fak,J., O'Donovan,K.J., Ru,Z.,
            Parveen,S., Frank,M.O., Moore,M.J. and Darnell,R.B.
  TITLE     T cells presenting viral antigens or autoantigens induce cytotoxic
            T cell anergy
  JOURNAL   JCI Insight 2 (21), 96173 (2017)
   PUBMED   29093272
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Pritsker,M., Doniger,T.T., Kramer,L.C., Westcot,S.E. and
            Lemischka,I.R.
  TITLE     Diversification of stem cell molecular repertoire by alternative
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14290-14295 (2005)
   PUBMED   16183747
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Yoshida,S., Mears,A.J., Friedman,J.S., Carter,T., He,S., Oh,E.,
            Jing,Y., Farjo,R., Fleury,G., Barlow,C., Hero,A.O. and Swaroop,A.
  TITLE     Expression profiling of the developing and mature Nrl-/- mouse
            retina: identification of retinal disease candidates and
            transcriptional regulatory targets of Nrl
  JOURNAL   Hum Mol Genet 13 (14), 1487-1503 (2004)
   PUBMED   15163632
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Corradi,J.P., Yang,C., Darnell,J.C., Dalmau,J. and Darnell,R.B.
  TITLE     A post-transcriptional regulatory mechanism restricts expression of
            the paraneoplastic cerebellar degeneration antigen cdr2 to immune
            privileged tissues
  JOURNAL   J Neurosci 17 (4), 1406-1415 (1997)
   PUBMED   9006982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY713743.1, BC117530.1, DT902919.1, CF616011.1 and BX637405.1.
            
            On Dec 1, 2007 this sequence version replaced NM_007672.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148057.1, AK171706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               BY713743.1         1-111
            112-1737            BC117530.1         1-1626
            1738-2245           DT902919.1         285-792
            2246-2521           CF616011.1         481-756
            2522-2525           BX637405.1         4-7                 c
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.04 cM"
     gene            1..2525
                     /gene="Cdr2"
                     /note="cerebellar degeneration-related 2"
                     /db_xref="GeneID:12585"
                     /db_xref="MGI:MGI:1100885"
     exon            1..336
                     /gene="Cdr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             261..1628
                     /gene="Cdr2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cerebellar degeneration-related protein 2"
                     /codon_start=1
                     /product="cerebellar degeneration-related protein 2
                     isoform 1"
                     /protein_id="NP_031698.2"
                     /db_xref="CCDS:CCDS21798.1"
                     /db_xref="GeneID:12585"
                     /db_xref="MGI:MGI:1100885"
                     /translation="MLADNLVEEFEMEDEPWYDHRDLQQDLQLAAELGKTLLDRNTEL
                     EDSLQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLVA
                     ESKASQQKILSLTETIECLQTNIDHLQSQVEELKSSSQGRGRQKACDQEKPAPSFSCL
                     KELYDLRQHFVYDHVFAEKITSLQSQQSPDEEENEHLKKAVTMLQAQLSLERKKRVSV
                     EAEYKVVLKENSELEQQLGATDAYRARALELEAEVAEMRQMLQAEHPFVNGVEKLVPD
                     SLFVPFKEPSQSLLEEMFLAAPEAPRKPLKRSSSETALSSLAGDDIVKDHEDTCIRRA
                     KAVKQRGISLLHEVDTQYSALKVKYEELLKKCQQEQDSLSHKAVQTSRLLTRDLTGLV
                     TQSEAGASGWEPTPVSPESISSPTTTPPEYKALFKEIFSCIKKTKQEIDEQRTKYPSL
                     SSYSY"
     exon            337..449
                     /gene="Cdr2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..598
                     /gene="Cdr2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..763
                     /gene="Cdr2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2525
                     /gene="Cdr2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdr2"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="Cdr2"
                     /note="major polyA site"
ORIGIN      
        1 tttgggaggg ttctgccaaa gtgccacgtt gggccgggca gcaggcgtga ggagccggct
       61 cccggcgcca cccggggcgc gctcgctagg gcgccggcct ttgggcggcg cgggatagcg
      121 gcgagagctg ctgcgggacc tgcgtgtccc gccccagggt ggctctggct gagggcggcg
      181 gggccggggg agagcccggg gcagcggccg aaacggcagg gcggcggcag agcccgctgc
      241 ccccggacgt ccccggcgac atgctggcag ataacctagt ggaggagttc gagatggagg
      301 atgagccgtg gtacgaccac cgggacctcc agcaagatct ccagcttgct gctgaacttg
      361 gaaagacgct actggatcgg aacacagagt tggaagattc tcttcagcag atgtacacaa
      421 ccaatcagga gcagttacag gaaatcgagt acctgaccaa gcaggtggag cttctacggc
      481 aaatgaatga gcagcatgcg aaagtttatg agcagttaga tgtcacagca agagaactgg
      541 aagaaaccaa ccagaagcta gttgctgaga gcaaggcctc acagcagaaa atcctcagcc
      601 tgacagaaac aattgaatgc ctgcaaacca acattgatca cctgcagagc caagtggagg
      661 agctgaagtc ttccagccaa ggaagaggga ggcagaaggc atgtgaccag gagaaaccag
      721 cacccagctt ctcctgtctg aaagagctgt atgacctccg ccaacacttt gtgtatgacc
      781 acgtgttcgc tgagaagatc acttccttgc agagccaaca gagccctgat gaagaagaaa
      841 atgagcacct gaaaaaggca gtgacgatgt tgcaggccca gctaagtcta gagaggaaga
      901 agcgagtgag cgtggaggca gagtataaag tggtgctgaa ggagaacagt gagctggagc
      961 agcagctggg ggccacagat gcctaccgag cccgggccct ggagttggag gcagaggtgg
     1021 ctgagatgcg gcagatgctg caggcagagc atccttttgt gaatggtgtg gagaagctgg
     1081 tgcccgactc tctgtttgtt cctttcaagg agcctagcca gagtctgctg gaggaaatgt
     1141 tcctggctgc tccagaagca cctagaaaac cactcaaacg aagcagcagt gagacggcgc
     1201 tcagcagttt ggcaggggat gacatcgtga aggaccatga ggacacttgc atcaggaggg
     1261 ctaaggctgt gaagcagagg ggcatctccc ttctgcatga agtggacact cagtacagtg
     1321 ccctgaaagt gaagtatgaa gagctactga agaagtgcca gcaggagcag gactcactgt
     1381 cacacaaggc tgtgcagacc tctagactac tgactaggga cctgacagga ctggtcacgc
     1441 agtctgaggc gggggccagt ggctgggaac ccacccctgt aagcccagag tccatcagtt
     1501 cccccaccac tacacctcca gaatacaaag cactatttaa ggagatattt agttgcatca
     1561 agaaaacaaa gcaggaaata gatgaacaga gaacaaaata cccttctctc tcctcttact
     1621 cgtactgaga ctccagttgt aactgcttgt tttcgctcac ttgcctcccc ttcagacatg
     1681 taagtgcagt ctccaaagct tgacgttgct aatgacacct gcctcgttgc tttgcttagt
     1741 tggcaaaagc aggaaaagag gtgacagaga atgttgactc caaggtccct aggaaatctc
     1801 acgatacact ggccgctggt tggtacactg atttccagga aaagccccag aagcagtaga
     1861 gggagagcca tgtacttggg agtaggctga agtacctaac agtgtagggt aaagaacaga
     1921 attggaacag aactaaggct gttgctttca tagcatctca gactacttgg aactccaagg
     1981 actgcctaac taaagtactt tcacaaacac taacattcag aaggatgttg agaaagcaag
     2041 atctaatctg aaatggatga cattaacaag ctccttaagc ccctgaagtt ttattgcatc
     2101 tgctagcact tgaatgctga ctgacaggca gatcctgata tatccaaatt cgaattaata
     2161 ccatttgaaa tggcaagtct tggcttaacg cctgtttgta tgcccagcat tcagctgttt
     2221 tactcaaagc taggcatgtc atagtaattg tcttttcaga tggaaactag agaactctcc
     2281 taggtgtgat ctgcactggc cacttggcag gcacaagctg cttccttccc ctcaggtctt
     2341 aacccttccc agacctgcag cgattcctgt cgactccctt acacagtatt gatcttctga
     2401 ctgtggaaac aaccttcctc tcactttcac acctttaatt taaatctatt taagagaacc
     2461 atggttctga ttgttgtgta tatttttcta aaggctgaat aaagctatct atgaatgtga
     2521 acaaa
//
