LOCUS       NM_001405246            8913 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus cell adhesion molecule-related/down-regulated by
            oncogenes (Cdon), transcript variant 1, mRNA.
ACCESSION   NM_001405246 XM_006510509
VERSION     NM_001405246.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8913)
  AUTHORS   Franks,N.E. and Allen,B.L.
  TITLE     Hedgehog-dependent and hedgehog-independent roles for growth arrest
            specific 1 in mammalian kidney morphogenesis
  JOURNAL   Development 151 (24) (2024)
   PUBMED   39629522
REFERENCE   2  (bases 1 to 8913)
  AUTHORS   Kumari,A., Franks,N.E., Li,L., Audu,G., Liskowicz,S., Johnson,J.D.,
            Mistretta,C.M. and Allen,B.L.
  TITLE     Distinct expression patterns of Hedgehog signaling components in
            mouse gustatory system during postnatal tongue development and
            adult homeostasis
  JOURNAL   PLoS One 19 (6), e0294835 (2024)
   PUBMED   38848388
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8913)
  AUTHORS   Leung,A.O.W., Poon,A.C.H., Wang,X., Feng,C., Chen,P., Zheng,Z.,
            To,M.K., Chan,W.C.W., Cheung,M. and Chan,D.
  TITLE     Suppression of apoptosis impairs phalangeal joint formation in the
            pathogenesis of brachydactyly type A1
  JOURNAL   Nat Commun 15 (1), 2229 (2024)
   PUBMED   38472182
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8913)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8913)
  AUTHORS   Kim,J.M., Min,K.W., Kim,Y.J., Smits,R., Basler,K. and Kim,J.W.
  TITLE     Wnt/beta-Catenin Signaling Pathway Is Necessary for the
            Specification but Not the Maintenance of the Mouse Retinal Pigment
            Epithelium
  JOURNAL   Mol Cells 46 (7), 441-450 (2023)
   PUBMED   37190767
REFERENCE   6  (bases 1 to 8913)
  AUTHORS   Cole,F. and Krauss,R.S.
  TITLE     Microform holoprosencephaly in mice that lack the Ig superfamily
            member Cdon
  JOURNAL   Curr Biol 13 (5), 411-415 (2003)
   PUBMED   12620190
REFERENCE   7  (bases 1 to 8913)
  AUTHORS   Kang,J.S., Mulieri,P.J., Hu,Y., Taliana,L. and Krauss,R.S.
  TITLE     BOC, an Ig superfamily member, associates with CDO to positively
            regulate myogenic differentiation
  JOURNAL   EMBO J 21 (1-2), 114-124 (2002)
   PUBMED   11782431
REFERENCE   8  (bases 1 to 8913)
  AUTHORS   Mulieri,P.J., Okada,A., Sassoon,D.A., McConnell,S.K. and
            Krauss,R.S.
  TITLE     Developmental expression pattern of the cdo gene
  JOURNAL   Dev Dyn 219 (1), 40-49 (2000)
   PUBMED   10974670
REFERENCE   9  (bases 1 to 8913)
  AUTHORS   Kang,J.S., Mulieri,P.J., Miller,C., Sassoon,D.A. and Krauss,R.S.
  TITLE     CDO, a robo-related cell surface protein that mediates myogenic
            differentiation
  JOURNAL   J Cell Biol 143 (2), 403-413 (1998)
   PUBMED   9786951
REFERENCE   10 (bases 1 to 8913)
  AUTHORS   Kang,J.S., Gao,M., Feinleib,J.L., Cotter,P.D., Guadagno,S.N. and
            Krauss,R.S.
  TITLE     CDO: an oncogene-, serum-, and anchorage-regulated member of the
            Ig/fibronectin type III repeat family
  JOURNAL   J Cell Biol 138 (1), 203-213 (1997)
   PUBMED   9214393
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159894.2 and AC118232.10.
            
            On Apr 21, 2022 this sequence version replaced XM_006510509.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.95879.1,
                                           SRR9219382.174780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1668              AC159894.2         81055-82722         c
            1669-1801           AC159894.2         53943-54075         c
            1802-2074           AC159894.2         53187-53459         c
            2075-2221           AC159894.2         51671-51817         c
            2222-2365           AC159894.2         50654-50797         c
            2366-2653           AC159894.2         49385-49672         c
            2654-2923           AC159894.2         48454-48723         c
            2924-3277           AC159894.2         41892-42245         c
            3278-3567           AC159894.2         35966-36255         c
            3568-3742           AC159894.2         34961-35135         c
            3743-3874           AC159894.2         32555-32686         c
            3875-4078           AC159894.2         29040-29243         c
            4079-4260           AC159894.2         27988-28169         c
            4261-4366           AC159894.2         27431-27536         c
            4367-4489           AC159894.2         22900-23022         c
            4490-4711           AC159894.2         19149-19370         c
            4712-4977           AC159894.2         16880-17145         c
            4978-5057           AC159894.2         14196-14275         c
            5058-5317           AC159894.2         2701-2960           c
            5318-7380           AC159894.2         1-2063              c
            7381-8913           AC118232.10        144175-145707       c
FEATURES             Location/Qualifiers
     source          1..8913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.24 cM"
     gene            1..8913
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /note="cell adhesion molecule-related/down-regulated by
                     oncogenes"
                     /db_xref="GeneID:57810"
                     /db_xref="MGI:MGI:1926387"
     exon            1..1668
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1801
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     CDS             1729..5481
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /note="oncogene-regulated cell adhesion molecule;
                     immunoglobulin superfamily member CDO;
                     CAM-related/down-regulated by oncogenes"
                     /codon_start=1
                     /product="cell adhesion molecule-related/down-regulated by
                     oncogenes precursor"
                     /protein_id="NP_001392175.1"
                     /db_xref="GeneID:57810"
                     /db_xref="MGI:MGI:1926387"
                     /translation="MHPDLGPLWTLLYVLVILCSSVSSDLAPYFISEPLSAVQKLGRP
                     VVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSV
                     GAVVSGPATVSAAALGDFDSSTMHVITAEEKNTGFIGCRVPESNPKAEVRYKIRGKWL
                     KHSTGNYIILPSGNLQVLNVSSKDKGSYKCAAYNPVTSELKVEPTGRKLLVSRPSSNG
                     FHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDAVAGSNWRRLYSHLAT
                     ASIDPADSGNYSCVVGNKSGDVKHVTYMVNVLEHASISKGLHDQKVSLGATVHFTCDV
                     HGNPAPNRTWFHNAQPIHPSSRHLTEGNVLKITRVVMEDSGLYQCVADNGIGFMQSTG
                     RLQIEQDSGWKPVIVTAPANIEVMDGDFVTLSCNATGVPVPVIHWYGRHGLITSHPSQ
                     VLRSKPRKSHLFRPGDLDLEPVYLIMSQAGSSSLSIQAVTLEHAGKYTCEATNKHGST
                     QSEAFLTVVPFETNTKAESVTPSEASQNDERDPQDGSESSLLNLFPVKVHPSGVELPA
                     ERNASVPDAPNILSPPQTHMPDTYNLVWRAGRDGGMPINAYFVKYRKLDDGSGAVGSW
                     HTVRVPGSENELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQA
                     SFPPVGVPKRPVTAEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPR
                     ANGGSPITAFKVEYKRMRTSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIAINHYG
                     ESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYVPSSNNNTPIQ
                     GFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNV
                     MICETKVKRVPGASDYPVKELSTPPSSSGNAGNVGPATSPARSSDMLYLIVGCVLGVM
                     VLILMVFIALCLWKSRQQSTIQKYDPPGYLYQGSEINGQMVEYTTLSGAARINGSVHG
                     GFLSNGCSHLHHKGPSGVNGTLSGNINGGLYSAHTNSLTRACVEFEHPHHLVNSGGVY
                     TAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQGGLEMKPLNAMKVPVC
                     PASTVPDHGQLPDDCVKDSVAPIPTQHTCCQDNISDINSDSTEDTAEFSRGDSSGHSE
                     AEDKVFSWNPLILSPVLEDCGEKTARSPPGPPLDGLSVVLQQAQET"
     exon            1802..2074
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2221
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2365
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2653
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2923
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3277
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3567
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3742
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3874
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..4078
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4260
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4366
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4489
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4490..4711
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4712..4977
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            4978..5057
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5317
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..8913
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8885..8890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /note="hexamer: ATTAAA"
     polyA_site      8907
                     /gene="Cdon"
                     /gene_synonym="Cd0; CDO; Orcam"
                     /note="major polyA site"
ORIGIN      
        1 agtacaaaga accggaggat ctgacataca cgaatctagc ttgtgtaggt tgcttcctgc
       61 atctccctta cctctggcgg attttgcagg tggcttgact ttttgtggga ggctttaagt
      121 tcactttaag ataggacctc ccctatcctc agggcatata taaagagcag tgcccaggga
      181 tagaaacttg tgtcataggg tggtgctcca caggatcagg taaagtgtag tagctgcttc
      241 ttatgctccc ctcttgtttt cccactttgt gtgtgcactc tcgtggctct ctagacagcc
      301 cctttctgtt tttcttttta atggcagtag gatttttgtt ctttggggtg gtttctttgg
      361 agaacaagta gactaaaatt tgatgactgt ttctaagtaa aatactaggg aagtgatgtc
      421 aggaattaaa cgatatcttt gtgaaatcaa aaatataaag ggtaatgagt tagaaaattt
      481 gttttaacgt gtgttattag ttaacatcat gtgatcagca tctctactat gtagaattat
      541 agctaggaca gtacagttac ctaccagata gtcattcttt agcttaatga cattaatact
      601 taataaaaac caattcaaat aggaatttga actctaactg tacttctttg aaagagttgt
      661 ttttaatatc cggctatttt atttgtttat ttatttattt atttatgact gatgcttttt
      721 tcaagagatt tttttttact cacctagatt gaattagaaa atgttacatt gtttttattt
      781 acacttttat attgtatcca aacttttgtt gtgtaggtgg cctgcatcca ctatgcacag
      841 gaggggaggg ctgtaattgt ttactgttaa aattaaggga ctgggcacaa gaatatactt
      901 aacgtcactt ttaaatactg gaatcctggg ttacattgaa atgaaaagct gtgggttttt
      961 tattgttgtt gtttttaaat ccttcaagtt ttctctcatt gtttgggcac tctccctcca
     1021 ttgtcaggct taaaacatac agtatcattg tcatctgtcc cttgaataat ggtcctgagg
     1081 tgatattatt aatgtggctt tttaaaatca aactaattat acttgcctaa aagagccaca
     1141 tgtgtgtgat tctagctgcc tggtgccttt tgagagccct ggagacaagc tagtgaatag
     1201 agctgaaaat tcatgctgta tttgattaaa tggaacagac tcgctgctcc ttaccccagc
     1261 aggggctgtg agatctcttg atccccgaag cggctcctag accctgggaa ttccattagc
     1321 gagcacctga ggaatttctg ccctgcagtg ccttttttgt atgtgtgtat gtgtatgcgt
     1381 ggagagggag cagcactgag tagtgaatgg gagggggagt agagggggcg gagagcaggc
     1441 tgcattagaa ggctccatat gttagcagat ctaaaatcaa ggcatgactt aacagcttat
     1501 cttgtaagag aaaagcccaa cccaaaggca gactgctagt ggggacttta ttacaggcag
     1561 ggctgtggtg gtgtgcttta gcactgaagc gaaccctagt gtaagcacag agaggcgctg
     1621 ctttctgctc tccttctaag ttcaagcgta tacatatttg cagccttgta agcggaggcc
     1681 tgggctttct ctgcaagtct tcccagccta cttctgtaat tgggcgatat gcatccagac
     1741 ctcggaccct tatggacatt gctgtatgtt cttgtgattc tgtgttcttc tgtgagctca
     1801 gacttggcac cttattttat ttctgagcca ctctctgctg tccagaagct tggtagaccc
     1861 gtggtcctac attgttctgc taaacctgtt actgcccgaa tctcatggtt gcataatgga
     1921 aaacggttgg acagaaacac agaacagata aagattcatc gggggacttt gaccattctg
     1981 tctcttaacc cttccctttc tggttgctac cagtgcgttg ccaacaacag cgttggtgcc
     2041 gttgtgagcg gccccgcaac agtgtccgct gcagccctgg gtgatttcga ttcatcaaca
     2101 atgcacgtta ttactgcaga agagaaaaac acaggcttca ttggctgcag ggtaccagag
     2161 agtaacccca aagctgaggt gcgctataag atccggggaa agtggctgaa gcattccaca
     2221 gggaactaca taatccttcc ctcaggaaac cttcaggttc tgaatgtgtc ctctaaggat
     2281 aagggatcct acaaatgtgc tgcctataac cctgtcacca gtgaactgaa ggttgagccc
     2341 actggccgga agctccttgt gagtcgtcct tcctcgaatg gctttcacat tcttcaccct
     2401 gctctttctc aggcattagc tgtccttcct cacagccccg ttaccttgga gtgtgtggtg
     2461 agtggggttc cggcctcaca agtgtattgg ctgaaggacg gtcaggatgc cgtggcagga
     2521 agcaactgga gaaggctgta ctctcatctg gccacagcta gcatcgaccc agcggattcg
     2581 gggaactatt cctgtgtggt gggcaacaag tccggagatg tgaaacacgt cacttacatg
     2641 gtcaatgtac tggagcatgc gtcaatttct aaagggctgc acgatcagaa ggtgtccctg
     2701 ggggccaccg tacattttac ctgtgatgtt catgggaacc cagcccccaa ccgcacctgg
     2761 tttcataacg cacagcctat ccacccctcc tcacggcatc tcactgaagg aaacgtgctg
     2821 aagatcaccc gggttgtcat ggaagattct gggctatatc agtgcgtagc agacaatggc
     2881 attggattca tgcagtctac tgggagactt caaattgaac aagacagtgg atggaagcct
     2941 gttattgtca ccgcaccagc aaacatagag gtgatggatg gagactttgt gactttgtct
     3001 tgtaatgcca ccggagtgcc tgtcccagtc attcattggt acggccgcca tggattgata
     3061 accagccatc catctcaggt ccttaggtcc aaaccccgaa agtcccacct gttccggcct
     3121 ggggacctgg acctggagcc tgtctacctc atcatgtccc aagctggctc gagctctctg
     3181 tctattcagg cagtcactct ggagcatgct gggaaatata cttgtgaagc tacaaacaaa
     3241 catggcagca cacagtcaga agcattcctc acagttgttc ctttcgagac aaacacaaag
     3301 gcagagtcag tcacaccttc tgaagcttct cagaatgatg agcgagaccc acaagacggt
     3361 tcagagtcca gcctgctgaa cttgtttcca gtgaaggtgc atcccagtgg agtggaattg
     3421 ccagcagaga gaaatgcctc ggtccccgat gctcctaaca tactgagccc cccacagact
     3481 cacatgccag acacgtacaa cctggtgtgg agggcaggga gggatggcgg aatgcccatc
     3541 aacgcctatt tcgtgaagta ccgaaagctg gacgatggta gtggtgcagt gggcagctgg
     3601 cacacagttc gtgtcccagg gagtgaaaat gagctgcatc taactgagct ggagccatca
     3661 agtctctatg aagttttgat ggtggctaga agtgcagttg gtgaaggaca gcctgccatg
     3721 cttaccttcc ggaccagcaa agaaaaaatg gcgtcatcaa aaaacaccca ggcctccttt
     3781 ccgcctgtgg gcgtccccaa gcggcctgtt actgcagagg cttccaacag caattttgga
     3841 gttgtgctta cggattcctc caggcatagt ggagtcccag aggcaccaga tcgacctact
     3901 atctctatgg cgtcggagac ctcagtctat gtcacctgga ttccccgagc aaatggtggc
     3961 tctcccatca ccgccttcaa ggtggaatat aaacggatga gaactagtga ttggctggta
     4021 gcggctgaag acattcctcc ttccaaactc tctgtggaag ttcgtagttt agagccaggt
     4081 tcaatataca aatttagggt cattgctatc aaccattacg gtgagagttt tcggagctca
     4141 gcatcccgtc cttaccaggt ggccggcttc ccaaatcgtt tttccaatcg cccaataact
     4201 ggacctcaca tcgcatacac agaggctgtt agcgacactc agatcatgct gaaatggacg
     4261 tatgttccat caagtaacaa taatactccc attcaaggat tctatatcta ctaccggcca
     4321 acagacagtg acaatgacag tgactacaag agagacgttg tggaaggctc aaagcagtgg
     4381 cacaccattg gtcacctgca gccagagacc tcctatgaca ttaagatgca gtgctttaat
     4441 gaaggagggg agagtgagtt cagcaacgtg atgatctgcg agactaaagt aaaacgtgtt
     4501 cctggagctt ccgactatcc cgtgaaagag ttgagtaccc ctcccagttc ctcgggaaac
     4561 gcagggaacg tggggcctgc aaccagcccc gccaggagca gcgatatgtt gtacctcatc
     4621 gttggctgtg tgcttggggt tatggtcctc attcttatgg ttttcattgc gctgtgtctg
     4681 tggaagagtc gccaacagag caccatacag aaatatgatc ctccaggata tctctaccag
     4741 gggtcagaga ttaatgggca gatggtagag tataccactc tctcaggagc agcccggatc
     4801 aacgggagtg ttcacggagg cttcctcagc aatggctgtt ctcatctgca ccataaaggc
     4861 cccagtggag tcaacgggac cctgagtgga aacataaatg gaggccttta ttctgcacac
     4921 acaaactccc tgaccagggc gtgtgtggag tttgagcatc ctcaccatct agtgaatagt
     4981 ggaggagtgt acacagccgt ccctcagatg gacccactgg aatgcattaa ttgtcggaat
     5041 tgccggaaca acaataggtg tttcaccaaa accaacagtc cccttcctgt ggtcccagtg
     5101 gtagcctctt atcctcaggg tggtctggaa atgaagcccc tcaatgccat gaaggtgcct
     5161 gtgtgcccag cttccacagt tcctgaccat ggccagttac ctgacgattg tgtcaaggac
     5221 agtgtggcac caatacctac ccagcatact tgctgccagg acaacataag tgacatcaat
     5281 tctgattcca cagaagacac agcagagttc agcagaggag acagcagtgg tcattctgaa
     5341 gcagaggaca aagttttcag ttggaatcct cttattttgt cacctgtctt ggaggactgt
     5401 ggtgagaaga cagcgaggtc tccccctgga cctcctctag acgggctgtc ggtggtcctt
     5461 cagcaagccc aagagacctg agaggagtgt gagcagacct cttcgtgttc ccactgcaag
     5521 ccagtaactg taccacacag gcctggggac aaactgtgtg aaggacatta attcaaatca
     5581 gagaaaacca ttatttattt tttgtaatag tcatgtcatg aatgtatctt aaaatgtgtg
     5641 ccctttcata ttatttatgc cttacctttt cccttctcca tttcgtcctg cccctggata
     5701 ggaccccccc cccgtttttg ttttgtttgt tttgttttaa cagagctttt caatcatctg
     5761 gaaaacaggg gatcactctg tgtcttccag ggtcttccgt ggcagtagga acttgtgctg
     5821 ggtcccatcc tcaggcctgt tcagttgtgg ggaggagggt tgcccaagcc acttcacatt
     5881 tgtcaccagt cattcctaga tggaaaactg tcacttctcc cgtgtcatca gactttctgg
     5941 gaacatttag aaatcaacca tagttgtgat catttgttta taatagccaa cccaactgac
     6001 agattttttt tgactgcctt ccagaaaaac actaatactg atttattttc tctctggcct
     6061 ggctacgaat agtgatcagt cttctaggtt tcaaccagcc agtgttgtta tgaacacgga
     6121 agcatgtaaa gtctgtctgg attattgtat tatgtagaca gggaaccaga ctcagaaaga
     6181 aaattaattc cttcatggtc cactgctttc ttaatttaca aaatggttgt catgagttct
     6241 ttgcactgct tgcaagggta tataatacaa aaatgaggct tttaaagtga tagtttgaag
     6301 agaaagctgt tacacgcctc aagaaagaga agggctgaag ggacctctga gtgaagctct
     6361 tccgttgatc ctatagtact tgtgatgctc aactacttgg agactgatat ttgtgtcact
     6421 tctaacatag acagtgtcct ggaggatctg agtgagcatg tgtgagtcaa ccttctgcca
     6481 ctatagcaaa attcctgagg tgattgtctt ataaggacgc agggttatct tggttcccaa
     6541 gcttagttct agtttgtgat tgaatagacc tgtagctttg ggcctgtgtt gagggagcac
     6601 atcatggtgg atatgcatgg cagagcaaaa tagcttatac cacaaaccag aagaggggga
     6661 gaacgagaag aacagagtgt acaagtcccc ctctccccca agagcatgcc tcagtgatca
     6721 gaagacctca cacttccctg ctcaagattc taccatctcg ggaacatgtt gtcatgggac
     6781 tcagaccttg aacacagaga tggataggcc tttggaaaac agtatccaaa ccaaagcaga
     6841 atgccgggaa aggcttagtt tgaagaaagg gtttgagggc atttttggat agtttttctg
     6901 gtcgctgtca ttatgaacag taactgaggc ttcagtcagc aggatccatg caagcagtta
     6961 ctggtctctg agtgacaagg acatcgcggc tgcctttgga aggcttttca tacaaacgtg
     7021 tgaaatagaa accccaggtg ctacaaatgc atttcagtaa cttgaaccag gccctgatgg
     7081 atcacagatc tgcttttgaa tggtgtatcc cttggggggg ggggggcgcg gggggggggg
     7141 acaacaaaat tattctcttt atgtggaatc agacaattcc aggatacatt ttgttttcat
     7201 ttcccacaaa ttgcagtgaa agagaataag atactgtact aatcaacttt atatacattt
     7261 gtcagtattc ccttacatat gtctgtatct tttataaata gaactgtttg tggaaatgta
     7321 ctgtttcagc aggggccact acgcaagcgt tccttctgaa aaatgcagta aatagaattc
     7381 catagctggg tagcgggctg ctgtagaagc gagttctatg atcctggggt tcatggccat
     7441 agtataagag atatgcagtt agttttggag gtagtttgta gccttacatc ttgacttgca
     7501 aagtacggtg tagagaccta ctgtgtgctt tgccagttga gttgaaacaa agttgtctca
     7561 gagtcggggt tttggaaagc gggaaacaaa tgtctgtggg cagtcagttg ttcactgtaa
     7621 ctcatgaaac aggtatgctg gctcgagcct taggtcagaa ctgcttttaa agattgaatt
     7681 tgacatgggg cttgcccatg aggaagatga aattccttta cctttagggc aatctcattg
     7741 tggactgctt tatttatgat tagtaacgct gttttaagtg ttaacccttt tattgtattt
     7801 tatttataaa aatggcttta tatattgaga tatataaata taaatataaa tctatataat
     7861 tgcctttata tttaggagtt tgagttctcc ttattgtgag tttctgtgaa cttttgtgcc
     7921 ctgcacagtc accagaaatg gtcctagtaa gtgtcacttc cccaggaatc aagaggacat
     7981 aggaaaatgt gggggagggg tcaccagtca ttccaaaatg gaatggtgcg catttgtgga
     8041 gaaacgattg tttattagcc ccctgttttc tcatctgacc tccacaacaa atagagtagg
     8101 catggaattc ccggccgaca agtgagctag agcctgctct ggagcctact ctacctgacc
     8161 catcaccacg ccccctttac ctgctttctg gaagtgttat ggttcactct ccgtggaacc
     8221 agtccagaac gtgtgctgtt gtccacccct gctgcagctg gtggggcttc cctctgtcca
     8281 cccgcatctc agactggcag agctctttac caagtacttc atgttcggga atctctcctt
     8341 gatactctac ccttaccctc acccaatccc accctttcct aacctcatga agatttaacc
     8401 atcaactggc ccactgacca tgaagctggt aggggctctt cgtggttcgg gagagccttt
     8461 gttcagcatt aagcttccct agtcctagta aatcatgtct ccttttcctg gttttgttca
     8521 ccaattatgt gactggctct ggtgacgggt gctgtacagg gtacaggtta attgtgtcat
     8581 tctaaactgt tgaggtgatc tcattgttaa acggttcttg ctgggttctc tttgtacagt
     8641 tgttactcca ggctgatcac gtcacatctc tgcgtcagct ccagcactac cgagagactg
     8701 ttcggaactg tcctttcttt acctgtattg ctcgctctta cagcattggc cctgcgatgc
     8761 atgccttgtg ctatattgaa aaaatatgtt ttattttcct taaagttgtg ctgttatgtg
     8821 tgaagttgta catactctaa gtgatgtagt tttgacaggt tttatttggt tggcatgatt
     8881 ttatattaaa agagaatgct gctttcacgt gca
//
