LOCUS       NM_033037               1702 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus cysteine dioxygenase 1, cytosolic (Cdo1), transcript
            variant 1, mRNA.
ACCESSION   NM_033037
VERSION     NM_033037.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Chen,J., Matye,D., Dai Clayton,Y., Du,Y., Nazmul Hasan,M., Gu,L.
            and Li,T.
  TITLE     Deletion of hepatocyte cysteine dioxygenase type 1, a bile acid
            repressed gene, enhances glutathione synthesis and ameliorates
            acetaminophen hepatotoxicity
  JOURNAL   Biochem Pharmacol 222, 116103 (2024)
   PUBMED   38428825
  REMARK    GeneRIF: Deletion of hepatocyte cysteine dioxygenase type 1, a bile
            acid repressed gene, enhances glutathione synthesis and ameliorates
            acetaminophen hepatotoxicity.
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Sunny,S.S., Lachova,J., Kasparek,P., Palkova,M., Spoutil,F.,
            Prochazka,J., Sedlacek,R., Liskova,P. and Kozmik,Z.
  TITLE     Ovol2 promoter mutations in mice and human illuminate
            species-specific phenotypic divergence
  JOURNAL   Hum Mol Genet 33 (6), 491-500 (2024)
   PUBMED   37971355
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Chen,M., Zhu,J.Y., Mu,W.J., Luo,H.Y., Li,Y., Li,S., Yan,L.J.,
            Li,R.Y. and Guo,L.
  TITLE     Cdo1-Camkk2-AMPK axis confers the protective effects of exercise
            against NAFLD in mice
  JOURNAL   Nat Commun 14 (1), 8391 (2023)
   PUBMED   38110408
  REMARK    GeneRIF: Cdo1-Camkk2-AMPK axis confers the protective effects of
            exercise against NAFLD in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Matern,M.S., Durruthy-Durruthy,R., Birol,O., Darmanis,S.,
            Scheibinger,M., Groves,A.K. and Heller,S.
  TITLE     Transcriptional dynamics of delaminating neuroblasts in the mouse
            otic vesicle
  JOURNAL   Cell Rep 42 (6), 112545 (2023)
   PUBMED   37227818
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Lutz,C.M., Richards,J.E., Scott,K.L., Sinha,S., Yang-Feng,T.L.,
            Frankel,W.N. and Thompson,D.A.
  TITLE     Neuropeptide Y receptor genes mapped in human and mouse: receptors
            with high affinity for pancreatic polypeptide are not clustered
            with receptors specific for neuropeptide Y and peptide YY
  JOURNAL   Genomics 46 (2), 287-290 (1997)
   PUBMED   9417917
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Klingenspor,M., Bodnar,J., Welch,C., Xia,Y.R., Lusis,A.J. and
            Reue,K.
  TITLE     Localization of ubiquitin gene family members to mouse chromosomes
            5, 11, and 18
  JOURNAL   Mamm Genome 8 (10), 789-790 (1997)
   PUBMED   9321482
REFERENCE   8  (bases 1 to 1702)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 1702)
  AUTHORS   Jeremiah,S., McCann,K.P., Williams,A.C., Ramsden,D.B., Pilz,A.J.,
            Fox,M.F. and Povey,S.
  TITLE     Chromosomal localisation of genes coding for human and mouse liver
            cytosolic cysteine dioxygenase
  JOURNAL   Ann Hum Genet 60 (1), 29-33 (1996)
   PUBMED   8835096
REFERENCE   10 (bases 1 to 1702)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX222492.1 and AK149582.1.
            
            On Oct 26, 2017 this sequence version replaced NM_033037.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149582.1, BC013638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               CX222492.1         46-192
            148-1702            AK149582.1         2-1556
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 24.75 cM"
     gene            1..1702
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /note="cysteine dioxygenase 1, cytosolic"
                     /db_xref="GeneID:12583"
                     /db_xref="MGI:MGI:105925"
     exon            1..530
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..963
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /EC_number="1.13.11.20"
                     /note="CDO-I; cysteine dioxygenase type I"
                     /codon_start=1
                     /product="cysteine dioxygenase type 1"
                     /protein_id="NP_149026.1"
                     /db_xref="CCDS:CCDS29234.1"
                     /db_xref="GeneID:12583"
                     /db_xref="MGI:MGI:105925"
                     /translation="MERTELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNP
                     AEWALYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNL
                     KETLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSLHLYSPP
                     FDTCHAFDQRTGHKNKVTMTFHSKFGIRTPFTTSGSLENN"
     exon            531..608
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /inference="alignment:Splign:2.1.0"
     exon            609..763
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..933
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1702
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1367..1372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /note="hexamer: AGTAAA"
     polyA_site      1388
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="Cdo1"
                     /gene_synonym="1300002L19Rik; Cdo; D18Ucla3"
                     /note="major polyA site"
ORIGIN      
        1 gtgctgtgcc agggccttcc ctctggctct ctccacctcc ggccccttcc tcaggtctct
       61 ccccgcctca ctccaccccc tgaaggcggt tggtacgttc tagatgactc caagagctta
      121 aaaagggccc gggagggcgg actcctcaga tttggtcttg accagccagg gcttcaagct
      181 ggtctccggt gactcctagt ccttagtttt gatacccacc cttgcgagag ctttgagcgt
      241 ggcgggtccc cggcgtttgg ggtccggggt gtgtgtggtt gtctagcctg cagccggggt
      301 cctcggcgcg ctcgcgtcct ccgccgctgg ccagaagaga cgcgccccag ccctgcgggg
      361 atggaacgga ccgagctgct gaagccccgg accctggcgg acctcatccg catcttacat
      421 gagctcttcg cgggggacga agtcaacgtg gaggaggtgc aggctgtact ggaagcctac
      481 gagagcaatc ccgccgagtg ggctttgtat gccaaattcg atcaatacag gtatactcga
      541 aatcttgtgg atcaaggaaa tgggaagttt aatctgatga ttctgtgctg gggtgaaggg
      601 cacggcagca gtattcatga tcacacggac tcccactgct ttctgaagct gctgcaagga
      661 aatctaaagg agacattgtt tgactggcct gacaaaaaat ccaacgagat gatcaagaag
      721 tctgaaagaa ccctgaggga aaaccagtgt gcctacatta atgattccat tggcttacac
      781 cgagtagaga acgtcagcca cacagagcct gccgtgagcc tccacttgta cagtccaccc
      841 ttcgatacat gccacgcctt tgaccagaga acagggcata aaaacaaagt caccatgaca
      901 ttccacagca agtttggaat caggactcca tttacaactt cagggtcact ggagaacaac
      961 tagggcccac caagcccttg gaagtttcgc tttctgatcc tctgaatgtt ttcccttgga
     1021 cagagaggcc acccaccatt tgctgtccag ttacacagtt aaacaaaggc tatgctcagt
     1081 tctactgcaa agggtgtgtc ctaaggaagc aaacaatacc ctgagctatg caggtggaaa
     1141 atcctactaa agaaaaagtc acttgatttt tttaaattag gtatttactt catttacatt
     1201 tcaaatgcta tcctgaaaag tttaagtttt taaggaccag gttcttttgt cctctaactc
     1261 tattgggggt gggggagagg ttgtccatgg aaactctact tgggcttctg gtgggttttt
     1321 ttcagcctta ggaaacactc tggtctctga actctaataa tcaataagta aaaataagaa
     1381 acctcaaact atcacgtgtc tgttttcata cctggaagtc tcaatgtgga aatccttaat
     1441 atactttgta tgttcttaat atttgacaag aatttttttt ttcaacccta tttgacaaat
     1501 tcctatgctg tggagactag ggacgcatag agcagtttgg tgcttggtag tgaccagcag
     1561 ggggttagag atgtgcgtga acccagacct cccgcaaaca aaaactgaga ctcgtgtgta
     1621 atgtgtgcca ccaccttgag ctgccaccaa aattgccaaa caactttaat aaaactggat
     1681 ttgaaaagaa ctacacattg cc
//
