LOCUS       NM_177647               3013 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cerebral dopamine neurotrophic factor (Cdnf), mRNA.
ACCESSION   NM_177647
VERSION     NM_177647.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Matas-Navarro,P., Carratala-Ros,C., Olivares-Garcia,R.,
            Martinez-Verdu,A., Salamone,J.D. and Correa,M.
  TITLE     Sex and age differences in mice models of effort-based
            decision-making and anergia in depression: the role of dopamine,
            and cerebral-dopamine-neurotrophic-factor
  JOURNAL   Psychopharmacology (Berl) 240 (11), 2285-2302 (2023)
   PUBMED   37592005
  REMARK    GeneRIF: Sex and age differences in mice models of effort-based
            decision-making and anergia in depression: the role of dopamine,
            and cerebral-dopamine-neurotrophic-factor.
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Caglayan,A.B., Beker,M.C., Sertel Evren,E., Caglayan,B., Kilic,U.,
            Ates,N., Caglayan,A., Dasdelen,M.F., Doeppner,T.R., Saarma,M.,
            Hermann,D.M. and Kilic,E.
  TITLE     The Unconventional Growth Factors Cerebral Dopamine Neurotrophic
            Factor and Mesencephalic Astrocyte-Derived Neurotrophic Factor
            Promote Post-ischemic Neurological Recovery, Perilesional Brain
            Remodeling, and Lesion-Remote Axonal Plasticity
  JOURNAL   Transl Stroke Res 14 (2), 263-277 (2023)
   PUBMED   35583716
  REMARK    GeneRIF: The Unconventional Growth Factors Cerebral Dopamine
            Neurotrophic Factor and Mesencephalic Astrocyte-Derived
            Neurotrophic Factor Promote Post-ischemic Neurological Recovery,
            Perilesional Brain Remodeling, and Lesion-Remote Axonal Plasticity.
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Stepanova,P., Kumar,D., Cavonius,K., Korpikoski,J., Sirjala,J.,
            Lindholm,D. and Voutilainen,M.H.
  TITLE     Beneficial behavioral effects of chronic cerebral dopamine
            neurotrophic factor (CDNF) infusion in the N171-82Q transgenic
            model of Huntington's disease
  JOURNAL   Sci Rep 13 (1), 2953 (2023)
   PUBMED   36807563
  REMARK    GeneRIF: Beneficial behavioral effects of chronic cerebral dopamine
            neurotrophic factor (CDNF) infusion in the N171-82Q transgenic
            model of Huntington's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Eesmaa,A., Yu,L.Y., Goos,H., Danilova,T., Noges,K., Pakarinen,E.,
            Varjosalo,M., Lindahl,M., Lindholm,P. and Saarma,M.
  TITLE     CDNF Interacts with ER Chaperones and Requires UPR Sensors to
            Promote Neuronal Survival
  JOURNAL   Int J Mol Sci 23 (16), 9489 (2022)
   PUBMED   36012764
  REMARK    GeneRIF: CDNF Interacts with ER Chaperones and Requires UPR Sensors
            to Promote Neuronal Survival.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Pakarinen,E., Lindholm,P., Saarma,M. and Lindahl,M.
  TITLE     CDNF and MANF regulate ER stress in a tissue-specific manner
  JOURNAL   Cell Mol Life Sci 79 (2), 124 (2022)
   PUBMED   35129674
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Lindahl,M., Chalazonitis,A., Palm,E., Pakarinen,E., Danilova,T.,
            Pham,T.D., Setlik,W., Rao,M., Voikar,V., Huotari,J., Kopra,J.,
            Andressoo,J.O., Piepponen,P.T., Airavaara,M., Panhelainen,A.,
            Gershon,M.D. and Saarma,M.
  TITLE     Cerebral dopamine neurotrophic factor-deficiency leads to
            degeneration of enteric neurons and altered brain dopamine neuronal
            function in mice
  JOURNAL   Neurobiol Dis 134, 104696 (2020)
   PUBMED   31783118
  REMARK    GeneRIF: Cerebral dopamine neurotrophic factor-deficiency leads to
            degeneration of enteric neurons and altered brain dopamine neuronal
            function in mice.
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Danilova,T., Galli,E., Pakarinen,E., Palm,E., Lindholm,P.,
            Saarma,M. and Lindahl,M.
  TITLE     Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is
            Highly Expressed in Mouse Tissues With Metabolic Function
  JOURNAL   Front Endocrinol (Lausanne) 10, 765 (2019)
   PUBMED   31781038
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Norisada,J., Hirata,Y., Amaya,F., Kiuchi,K. and Oh-hashi,K.
  TITLE     A Comparative Analysis of the Molecular Features of MANF and CDNF
  JOURNAL   PLoS One 11 (1), e0146923 (2016)
   PUBMED   26820513
  REMARK    GeneRIF: secretion of mouse MANF and mouse CDNF is fundamentally
            regulated in the same manner, the variation of four C-terminal
            amino acids in the MANF and CDNF among species might influence
            their intracellular functions.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Tsybko,A.S., Ilchibaeva,T.V., Kulikov,A.V., Kulikova,E.A.,
            Krasnov,I.B., Sychev,V.N., Shenkman,B.S., Popova,N.K. and
            Naumenko,V.S.
  TITLE     Effect of microgravity on glial cell line-derived neurotrophic
            factor and cerebral dopamine neurotrophic factor gene expression in
            the mouse brain
  JOURNAL   J Neurosci Res 93 (9), 1399-1404 (2015)
   PUBMED   25944479
  REMARK    GeneRIF: This study demonstrated that decrease in mRNA level of
            CDNF in brain in microgravity.
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Lindholm,P., Voutilainen,M.H., Lauren,J., Peranen,J.,
            Leppanen,V.M., Andressoo,J.O., Lindahl,M., Janhunen,S.,
            Kalkkinen,N., Timmusk,T., Tuominen,R.K. and Saarma,M.
  TITLE     Novel neurotrophic factor CDNF protects and rescues midbrain
            dopamine neurons in vivo
  JOURNAL   Nature 448 (7149), 73-77 (2007)
   PUBMED   17611540
  REMARK    GeneRIF: CDNF (Armetl1) is expressed in several tissues, including
            the mouse embryonic and postnatal brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732620.14 and AL929080.7.
            
            On Nov 17, 2006 this sequence version replaced NM_177647.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034009.1, BB625884.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AL732620.14        223867-224043
            178-191             AL732620.14        230103-230116
            192-305             AL929080.7         2001-2114
            306-447             AL929080.7         3702-3843
            448-3013            AL929080.7         6497-9062
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 1.99 cM"
     gene            1..3013
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /note="cerebral dopamine neurotrophic factor"
                     /db_xref="GeneID:227526"
                     /db_xref="MGI:MGI:3606576"
     exon            1..177
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..626
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /note="conserved dopamine neurotrophic factor; ARMET-like
                     protein 1; arginine-rich, mutated in early stage
                     tumors-like 1"
                     /codon_start=1
                     /product="cerebral dopamine neurotrophic factor precursor"
                     /protein_id="NP_808315.1"
                     /db_xref="CCDS:CCDS15654.1"
                     /db_xref="GeneID:227526"
                     /db_xref="MGI:MGI:3606576"
                     /translation="MRCISPTALVTFCAGFCISNPVLAQGLEAGVGPRADCEVCKEFL
                     DRFYNSLLSRGIDFSADTIEKELLNFCSDAKGKENRLCYYLGATTDAATKILGEVTRP
                     MSVHIPAVKICEKLKKMDSQICELKYGKKLDLASVDLWKMRVAELKQILQRWGEECRA
                     CAEKSDYVNLIRELAPKYVEIYPQTEL"
     exon            178..305
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..447
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..3013
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2916..2921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /note="hexamer: ATTAAA"
     polyA_site      2942
                     /gene="Cdnf"
                     /gene_synonym="9330140G23; Armetl1"
                     /note="major polyA site"
ORIGIN      
        1 ttcacgaggc agcccccact acagtaagga aggtgtgggt agttccgggt cccaggctca
       61 gcatgcggtg catcagtcca actgctctgg tgaccttttg cgccgggttt tgtatctcga
      121 accctgtgct ggcgcagggc ctggaggccg gtgtggggcc gagggctgac tgtgaagtat
      181 gtaaagaatt cttagaccga ttctacaact ccctgctaag cagaggcata gacttttctg
      241 cggacaccat agagaaagag ctgctcaact tttgctcaga tgccaaagga aaagaaaacc
      301 gcctgtgcta ttatctgggg gccaccacag atgcagccac caagatccta ggagaagtca
      361 ctcgtcccat gagtgtacac atacctgccg tgaagatttg tgagaagcta aagaagatgg
      421 acagccagat ctgtgagctg aaatacggga agaagctgga cttggcgtcg gtggacctgt
      481 ggaagatgag agtggcagag ctaaagcaga tccttcagag atggggggaa gagtgcaggg
      541 catgtgcgga gaaaagtgac tacgtgaacc tcattagaga gctggccccc aaatatgtag
      601 agatataccc ccaaacggag ctctgacccc gtcggctgtc aggaagcatg gactgcagtt
      661 agaagaaaat gactgtctaa gatgagagtg tgctggttag ggctaaccag ggactgccca
      721 gttggccgtc agttttgctg ttgtattgtg gagttgtgtt gtttaggcat atgatcaacc
      781 cgtgcttcct catggtcgct aaaattgcag agcacagaga cctcaaggtg cttttctcat
      841 ccttcttgga ggatgcagtg gttgcctttg cattgctatg acaataatgc ttattgagag
      901 aggctggcca tggccacatg gagagagggg gaagggagtg agagaaagag ggctagagat
      961 gagagtaaga aaggtgaggg cttaaagaga gagaggaagg gccaagcagc cccctttata
     1021 gtgggctggg ctaccttgct gttgccaggt aactgaaaca agtgtgggga gggaagagtc
     1081 acttgggctc agggatttgg tccatcacag cagggtagct aagggcagca cagctcagag
     1141 cagggcgaca agagcttgtc atagaggctg ttgtgattat agagaggcag aaagtgatgt
     1201 ccaaataatg ataaggctgt aaccttcaaa gggatagccc tattcatcca cttctgtcag
     1261 tcagacaccc acctcacagt ttccccaaat taccactagc tagggaacaa accttcaaat
     1321 caaaccgatg ccaggtgtgg tggtgaatgc ctttaatgcc agcactctgt ctggaggcag
     1381 atctctgtga gtctgaggcc agcctggtct acaaagtgag tctaggacag ccagggtcac
     1441 acagagaaac actgttttga aaaacaaaca aacaaacaaa caaacagaca aacactaaaa
     1501 taaaatccaa ccaatgaacc aaccaaacaa ccaaacaacc caaaccaaac aaaaaactga
     1561 gctggaggag gacagttcag atccaaggca cagcagaagg acaatgtagt ttatcactac
     1621 tgactcaagt gtgctatgga tatgatggga taatacattt taaggaagga aagagacaag
     1681 aggcatctct ttggtcaagg tttttaaaaa gagtgcataa cagaaactat agcttatcta
     1741 atgtgcgact tcaatctcaa taaccaccta acatagttca gaaggttctt gtttcatttt
     1801 gctttttaaa aatagatttt ttaaaaaact tcattcactc taaatatttt ctctcttttg
     1861 cacagcaagg agggaagcat tcattacttt ataggctctt gagacaaaat acctaaaaaa
     1921 acaatcgaga aaggagttaa tttagttcat ggtttgagat tacagttcat cacggcagca
     1981 ggagtgtgag gccattggtc aaactcatcc atgtcctaga agcagagatg gaagtagatg
     2041 ctctgctagc tgtcagtctg accccagcac gggaatgcca ctgctcacat tcaggatggg
     2101 gtcttccttc cacagttaaa ctctctctag caacgccctc ccactcgtgc ccagaggtat
     2161 gtgtcaccta ggcaattcta aattccacca agttaacaat ggcgattaag cattgcacag
     2221 cacgaatgga agtttccgtt tctcatataa agaaaactga tcggaagaat acaaatcagc
     2281 aatccataaa aagtctgtgc ttggcctatt tataactacc tttttttgtt gttgtttttt
     2341 gttttttgtt tttttgtttt tttgttttct tgaagcagga tttctctgta tagttctggc
     2401 tgtcctggaa ctcactctgt agaccaggct ggcctcaaac tcagaaatcc gcctgcctct
     2461 gctgggatta aaggcgtgcg ccaccacgcc cggcttgtaa ccaccttgaa ttgccacgtg
     2521 acccaagctc agagtcttct tcactgcccc gtgtcaggca ggatgaaagc atgctcccca
     2581 cgtgcaggca gcaggggcgc ttgtggtttc taatgctagc ctatcagtct taagaagcag
     2641 gcaatgtttc agctccattc tctgtccata gatcaataag aagcacatgg ttaaatggtt
     2701 gcctttggga aataggtcag ggtgtggcta ctcaagaaag cattctcttt aaagtttctg
     2761 gggtgatggg actgtacttt atcaaggcag gaggtgagag atatgatcat catattgata
     2821 tagaggtaca attaagatgt gggtattcta ttgtacatca attctatttc ataaaaagtt
     2881 gtaggagcta tttgaaaatt acccaaaatt aattgattaa aagcaactgt tcttttaaat
     2941 aatcaaatgt actcatagcc atcttttttg tagagtagag aataacttaa attcagataa
     3001 taaatataca ttg
//
