LOCUS       NM_001360041             784 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cyclin dependent kinase inhibitor 3 (Cdkn3),
            transcript variant 1, mRNA.
ACCESSION   NM_001360041 XM_006519592
VERSION     NM_001360041.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 784)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 784)
  AUTHORS   Tan,L., Yu,M., Li,Y., Xue,S., Chen,J., Zhai,Y., Fang,X., Liu,J.,
            Liu,J., Wu,X., Xu,H. and Shen,Q.
  TITLE     Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary
            Malformations in Mice
  JOURNAL   Front Cell Dev Biol 9, 594640 (2021)
   PUBMED   33681192
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 784)
  AUTHORS   Zhang,M., Wang,X., Yao,J. and Qiu,Z.
  TITLE     Long non-coding RNA NEAT1 inhibits oxidative stress-induced
            vascular endothelial cell injury by activating the
            miR-181d-5p/CDKN3 axis
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 3129-3137 (2019)
   PUBMED   31352814
  REMARK    GeneRIF: NEAT1 may exert a protective effect on HUVECs by
            regulating the miR-181d-5p/CDKN3A axis
REFERENCE   4  (bases 1 to 784)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 784)
  AUTHORS   Yu,C., Cao,H., He,X., Sun,P., Feng,Y., Chen,L. and Gong,H.
  TITLE     Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role
            in prostate cancer via regulating cell cycle and DNA replication
            signaling
  JOURNAL   Biomed Pharmacother 96, 1109-1118 (2017)
   PUBMED   29196103
  REMARK    GeneRIF: Knockdown of CDKN3 expression inhibited prostate cancer
            tumor growth in the nude mouse model.
REFERENCE   6  (bases 1 to 784)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   7  (bases 1 to 784)
  AUTHORS   Khoury-Haddad,H., Guttmann-Raviv,N., Ipenberg,I., Huggins,D.,
            Jeyasekharan,A.D. and Ayoub,N.
  TITLE     PARP1-dependent recruitment of KDM4D histone demethylase to DNA
            damage sites promotes double-strand break repair
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), E728-E737 (2014)
   PUBMED   24550317
REFERENCE   8  (bases 1 to 784)
  AUTHORS   Zhu,Y., Pires,K.M., Whitehead,K.J., Olsen,C.D., Wayment,B.,
            Zhang,Y.C., Bugger,H., Ilkun,O., Litwin,S.E., Thomas,G., Kozma,S.C.
            and Abel,E.D.
  TITLE     Mechanistic target of rapamycin (Mtor) is essential for murine
            embryonic heart development and growth
  JOURNAL   PLoS One 8 (1), e54221 (2013)
   PUBMED   23342106
REFERENCE   9  (bases 1 to 784)
  AUTHORS   Kutok,J.L., Yang,X., Folkerth,R.D., Imitola,J., Raddassi,K.,
            Yano,Y., Salahuddin,S., Lawitts,J., Imboden,H., Chinami,M.,
            Shirakawa,T., Turner,H., Khoury,S., Sayegh,M.H., Scadden,D. and
            Adra,C.
  TITLE     The cell cycle associated protein, HTm4, is expressed in
            differentiating cells of the hematopoietic and central nervous
            system in mice
  JOURNAL   J Mol Histol 36 (1-2), 77-87 (2005)
   PUBMED   15704002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084534.1, AA510251.1 and AA218046.1.
            
            On Jan 26, 2018 this sequence version replaced XM_006519592.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB057437.1, CK792453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               BY084534.1         2-113
            113-677             AA510251.1         5-569
            678-784             AA218046.1         570-676
FEATURES             Location/Qualifiers
     source          1..784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 24.28 cM"
     gene            1..784
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /note="cyclin dependent kinase inhibitor 3"
                     /db_xref="GeneID:72391"
                     /db_xref="MGI:MGI:1919641"
     exon            1..108
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            109..191
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            192..247
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            248..292
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            293..515
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            516..547
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            548..651
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     exon            652..772
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /note="hexamer: AATAAA"
     polyA_site      772
                     /gene="Cdkn3"
                     /gene_synonym="2410006H10Rik; KAP"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcggac caatggactg acgggggcgg gctcttcgcg ggcggtgtcc taaaggctgc
       61 gagggcggcg gcactggtta cggcgagtgg cgacccgcga tgaagccgcc catttcaata
      121 caagcaagtg agtttgattc ttcagacgaa gaacctgttg atgaagaaca gactccaatt
      181 caaatttcat ggctacctct gtcgcgagtg aattgttccc agtttctcgg tttatgtgct
      241 cttccaggtt gtaagtttaa agatgttaga agaaatattc agaaagatac agaagaacta
      301 aagagctacg ggatccaaga cgtgtttgtt ttctgcacca gaggggagct gtcaaaatat
      361 agagtcccaa accttctgga cctctaccaa caatatggaa ttgtcaccca tcatcatccg
      421 atcccagatg gagggactcc cgacattggc agctgctggg aaatcatgga ggagctggcc
      481 acctgcctca aaaacaaccg gaaaaccctg atacattgtt acggaggact tggaagatcc
      541 tgtcttgtag ctgcttgtct cctcctatac ttgtctgact caatctcacc acagcaagcc
      601 atagacagcc ttcgagatgt cagaggatct ggggcgatac agaccatcaa gcaatataac
      661 tatcttcatg aattccggga taaattagct gcgtatctat catcaagaga ttcactatca
      721 agatctgtgt ccagataatg aagatcccaa ataaacgagc acatctaggg tcaaaaaaaa
      781 aaaa
//
